Latest revision as of 18:24, 28 April 2019

Modulatory Contol Area

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Local Circuits

(generated)

ID	Name	Regions	Quality
5HT	Serotonin - Feelings of Well-Being and Happiness	LMC.HL.RP.MG, LMC.HL.RP.OB, LMC.HL.RP.PL, LMC.HP.RP.LI, LMC.HP.RP.PRN, LMC.MM.RP.DRN, LMC.MM.RP.SUC	L0
ACH	Acetylcholine - PNS Actions and CNS plasticity, arousal and reward	LMC.FT.NBM, LMC.HT.TG.LDT, LMC.HT.TG.PPN	L0
DA	Dopamine - Reward-Motivated Behavior, Cognitive Alertness	LMC.MM.VTA	L0
ENK	Enkephalin - Regulating Nociception in Body	LMC.MM.PAG	L0
NE	Norepinephrine - Vigilant Concentration, Stress Hormone, Fight-or-Flight Response	LMC.HT.LC	L0

Serotonin - Feelings of Well-Being and Happiness

unavailable

Component ID	Component Name	Type	Service	Function	Comments	Quality
LMC.HL.RP.MG	Raphe Magnus Nucleus	nucleus	LUS	Inhibit head and spinal pain		L0
LMC.HL.RP.OB	Raphe Obscurus Nucleus	nucleus	LUS	Regulate cardiovascular function via sympathetic spinal column		L0
LMC.HL.RP.PL	Raphe Pallidus Nucleus	nucleus	LUS	Spinal pain control		L0
LMC.HP.RP.LI	Raphe Nucleus Linearis	nucleus	LUS	Release of 5-HT was only obtained on stimulation of this nucleus		L0
LMC.HP.RP.PRN	Pontine Raphe Nucleus	nucleus	LUS	Regulation of sleep cycle		L0
LMC.MM.RP.DRN	Dorsal Raphe Nucleus	nucleus	LUS	Regulation of sleep and mood		L0
LMC.MM.RP.SUC	Superior Central Raphe Nucleus	nucleus	LUS	Block or temporarily suspend mnemonic processes in the hippocampus; Hallucinations		L0

Internal Region Connections:

Source Region	Target Region	Type	Role	Reference
LMC.HP.RP.LI	LMC.MM.RP.DRN	nucleus-nucleus-5HT	uncertain	(unknown reference)

External Inbound Region Connections:

Source Area	Local Region	Source Region	Source Name	Type	Role	Reference
Subcortical
FAM	LMC.HL.RP.MG	FAM.FD.LHB.MED	Lateral Habenula Medial Part	nucleus-nucleus	uncertain	Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> MRN, abstract)
	LMC.MM.RP.DRN	FAM.FD.LHB.MED	Lateral Habenula Medial Part	nucleus-nucleus	uncertain	Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> DRN)
	LMC.MM.RP.SUC	FAM.FD.LHB.MED	Lateral Habenula Medial Part	nucleus-nucleus	uncertain	Habenula Connections (LHb -> MR, abstract)
FEC	LMC.HL.RP.MG	FEC.HT.TG.IPD	Interpeduncular Nucleus	nucleus-nucleus-ACh	uncertain	Connectivity map of the habenula (IPN -> Raphe, abstract)
		FEC.HT.TG.RMTG	Rostromedial Tegmental Nucleus	nucleus-nucleus-gaba	uncertain	Both LHb and MHb control the dopaminergic and serotonergic systems (RMTg -> MRN, abstract)
	LMC.MM.RP.DRN	FEC.HT.TG.IPD	Interpeduncular Nucleus	nucleus-nucleus-ACh	uncertain	Both LHb and MHb control the dopaminergic and serotonergic systems (IPN -> DRN)
		FEC.HT.TG.RMTG	Rostromedial Tegmental Nucleus	nucleus-nucleus-gaba	uncertain	Both LHb and MHb control the dopaminergic and serotonergic systems (RMTg -> DRN)
LAC	LMC.HL.RP.MG	LAC.FD.HT.LTN	Lateral Hypothalamic Nucleus	nucleus-nucleus	uncertain	(unknown reference)
		LAC.FD.HT.PV	Paraventricular Nucleus	nucleus-nucleus	uncertain	(unknown reference)
	LMC.HL.RP.OB	LAC.FD.HT.MPO	Median Preoptic Nucleus	nucleus-nucleus	uncertain	(unknown reference)
LLC	LMC.MM.RP.DRN	LLC.FD.TH.SF	Subfascicular Nucleus of Thalamus	nucleus-nucleus-gaba	uncertain	(unknown reference)
LMC	LMC.HL.RP.MG	LMC.MM.PAG	Periaqueductal Gray Matter	nucleus-nucleus-ENK	uncertain	Connectivity map of the habenula (PAG -> Raphe, abstract)
	LMC.HL.RP.PL	LMC.MM.PAG	Periaqueductal Gray Matter	nucleus-nucleus-ENK	uncertain	Connectivity map of the habenula (PAG -> Raphe, abstract)
LRC	LMC.HL.RP.MG	LRC.MM.SCNF	Subcuneiform Nucleus	nucleus-nucleus	uncertain	(unknown reference)
	LMC.HP.RP.PRN	LRC.MM.SCNF	Subcuneiform Nucleus	nucleus-nucleus	uncertain	(unknown reference)

External Outbound Region Connections:

Target Area	Local Region	Target Region	Target Name	Type	Role	Reference
Cortical
NDM	LMC.MM.RP.DRN	NDM.FD.TH.PV	Paraventricular Nucleus of Thalamus	nucleus-nucleus-5HT	uncertain	(unknown reference)
Subcortical
FAM	LMC.MM.RP.SUC	FAM.FT.SEP.LT	Lateral Septal Nucleus	nucleus-nucleus-5HT	uncertain	(unknown reference)
FEC	LMC.MM.RP.SUC	FEC.FD.STN.ICD	Subthalamic Nucleus Internal Caudal	nucleus-nucleus-5HT	uncertain	(unknown reference)
FMM	LMC.MM.RP.SUC	FMM.FD.MB.MMB	Medial Mammillary Nucleus	nucleus-nucleus-5HT	uncertain	(unknown reference)
LAC	LMC.MM.RP.SUC	LAC.FD.HT.PN	Posterior Hypothalamic Nucleus	nucleus-nucleus-5HT	uncertain	(unknown reference)
		LAC.FD.HT.SUM	Supramammillary Nucleus	nucleus-nucleus-5HT	uncertain	(unknown reference)
LLC	LMC.HL.RP.OB	LLC.HT.CR.PV	Cerebellar Paravermis	nucleus-allocortex-5HT	uncertain	(unknown reference)
	LMC.HP.RP.PRN	LLC.HT.CR.PV	Cerebellar Paravermis	nucleus-allocortex-5HT	uncertain	(unknown reference)
LPC	LMC.HL.RP.MG	LPC.SC.PH.LSG	Lower Substantia Gelatinosa	nucleus-nucleus-5HT	uncertain	(unknown reference)
		LPC.SC.PH.USG	Upper Substantia Gelatinosa	nucleus-nucleus-5HT	uncertain	(unknown reference)
	LMC.HL.RP.OB	LPC.SC.IZ.IMM	Intermediomedial Nucleus	nucleus-nucleus-5HT	uncertain	(unknown reference)
	LMC.HL.RP.PL	LPC.SC.PH.LMG	Lower Marginal Nucleus	nucleus-nucleus-5HT	uncertain	(unknown reference)
		LPC.SC.PH.UMG	Upper Marginal Nucleus	nucleus-nucleus-5HT	uncertain	(unknown reference)

Acetylcholine - PNS Actions and CNS plasticity, arousal and reward

unavailable

Component ID	Component Name	Type	Service	Function	Comments	Quality
LMC.FT.NBM	Basal Nucleus of Meynert	nucleus	FAU	Control imagination vs perception		L0
LMC.HT.TG.LDT	Laterodorsal Tegmental Nucleus	nucleus	LUS	Modulating sustained attention or in mediating alerting responses		L0
LMC.HT.TG.PPN	Pedunculopontine Tegmental Nuclei	nucleus	LUS	Provide sensory feedback to cerebral cortex; modulatory		L0

Internal Region Connections:

no connections

External Inbound Region Connections:

Source Area	Local Region	Source Region	Source Name	Type	Role	Reference
Cortical
NSA	LMC.HT.TG.LDT	NSA.FD.TH.SG	Suprageniculate Nucleus of Thalamus	nucleus-nucleus	uncertain	(unknown reference)
Subcortical
FAM	LMC.FT.NBM	FAM.FT.AM.AB	Accessory Basal Amygdaloid Nucleus	nucleus-nucleus	uncertain	(unknown reference)
		FAM.FT.AM.BP	Parvicellular Basal Amygdaloid Nucleus	nucleus-nucleus	uncertain	(unknown reference)
		FAM.FT.AM.CEM	Medial Central Amygdaloid Nucleus	nucleus-nucleus	uncertain	(unknown reference)
		FAM.FT.BNST	Bed Nucleus of Stria Terminalis	nucleus-nucleus	uncertain	(unknown reference)
	LMC.HT.TG.LDT	FAM.FD.LHB.MED	Lateral Habenula Medial Part	nucleus-nucleus	uncertain	Regulation of the rapid eye movement (REM) sleep by habenular projection (LHbM -> DTG)
FEC	LMC.FT.NBM	FEC.FD.STN.CD	Subthalamic Nucleus Caudal	nucleus-nucleus	uncertain	(unknown reference)
		FEC.FT.ACC.SH	Nucleus Accumbens Shell	nucleus-nucleus-gaba	uncertain	Affective basal ganglia circuit (NACC -> nBM, abstract)
	LMC.HT.TG.LDT	FEC.HT.TG.IPD	Interpeduncular Nucleus	nucleus-nucleus-ACh	uncertain	Head Direction Cell Circuit (IPD -> DTN)
		FEC.HT.TG.RMTG	Rostromedial Tegmental Nucleus	nucleus-nucleus-gaba	uncertain	(unknown reference)
	LMC.HT.TG.PPN	FEC.FT.VP.VM	Ventral Pallidum Ventromedial	nucleus-nucleus-gaba	uncertain	Combining Novelty, Motivational Salience, and Reward to Control Attention and Learning (VPAL -> PPTG, abstract)
FMM	LMC.HT.TG.LDT	FMM.FD.MB.LMB	Lateral Mammillary Nucleus	nucleus-nucleus	uncertain	Head Direction Cell Circuit (LMB -> DTN)
LAC	LMC.HT.TG.LDT	LAC.FD.HT.VLPO	Ventrolateral Preoptic Nucleus	nucleus-nucleus	uncertain	Simplified NREM sleep-promoting pathway (VLPO -> LDTg)
LRC	LMC.HT.TG.LDT	LRC.HL.NPH	Prepositus Nucleus	nucleus-nucleus	uncertain	(unknown reference)

External Outbound Region Connections:

Target Area	Local Region	Target Region	Target Name	Type	Role	Reference
Cortical
NDM	LMC.FT.NBM	NDM.NC.AL.FPC	Lateral Frontopolar Cortex	nucleus-neocortex-ACh	uncertain	Physiology and pathophysiology of lower urinary tract (NBM -> MPFC, abstract)
NSA	LMC.FT.NBM	NSA.NC.OCC.V1	Primary Visual Cortex	nucleus-neocortex-ACh	uncertain	(unknown reference)
	LMC.HT.TG.LDT	NSA.FD.TH.SG	Suprageniculate Nucleus of Thalamus	nucleus-nucleus-ACh	uncertain	Head Direction Cell Circuit (DTN -> SUPGEN)
	LMC.HT.TG.PPN	NSA.FD.LGN	Lateral Geniculate Nucleus	nucleus-nucleus	uncertain	Geniculate and Extyrageniculate Paths (PPN -> LGN)
Subcortical
FAM	LMC.FT.NBM	FAM.FT.AM.BM	Magnocellular Basal Amygdaloid Nucleus	nucleus-nucleus-ACh	uncertain	(unknown reference)
FEC	LMC.HT.TG.LDT	FEC.HT.TG.IPD	Interpeduncular Nucleus	nucleus-nucleus-ACh	uncertain	(unknown reference)
	LMC.HT.TG.PPN	FEC.FD.STN.MED	Subthalamic Nucleus Medial	nucleus-nucleus-ACh	uncertain	Summary of the organization of the substantia nigra pars reticulata and pedunculopontine nucleus in lamprey (PPN -> STN, abstract)
		FEC.FT.SNR.DL	Substantia Nigra Pars Reticulata Dorsolateral	nucleus-nucleus-ACh	uncertain	Summary of the organization of the substantia nigra pars reticulata and pedunculopontine nucleus in lamprey (PPN -> SNr, abstract)
FMM	LMC.HT.TG.LDT	FMM.FD.MB.LMB	Lateral Mammillary Nucleus	nucleus-nucleus-ACh	uncertain	Hippocampal Formation (DTN -> LMam)
LAC	LMC.HT.TG.LDT	LAC.HL.SAL.ISL	Inferior Salivatory Nucleus	nucleus-nucleus-ACh	uncertain	(unknown reference)
		LAC.HL.SAL.SSL	Superior Salivatory Nucleus	nucleus-nucleus-ACh	uncertain	(unknown reference)
LRC	LMC.HT.TG.LDT	LRC.HL.NPH	Prepositus Nucleus	nucleus-nucleus-ACh	uncertain	Head Direction Cell Circuit (DTN -> NPRP)
	LMC.HT.TG.PPN	LRC.MM.SC.INT	Intermediate Superior Colliculus	nucleus-nucleus	uncertain	Geniculate and Extyrageniculate Paths (PPN -> SC, abstract)

Dopamine - Reward-Motivated Behavior, Cognitive Alertness

unavailable

Component ID	Component Name	Type	Service	Function	Comments	Quality
LMC.MM.VTA	Ventral Tegmental Area	nucleus	LUS	Respond to novel stimuli, unexpected rewards, and reward predictive sensory cues		L0

Internal Region Connections:

no connections

External Inbound Region Connections:

Source Area	Local Region	Source Region	Source Name	Type	Role	Reference
Subcortical
FAM	LMC.MM.VTA	FAM.FD.LHB.MED	Lateral Habenula Medial Part	nucleus-nucleus	uncertain	Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> VTA)
		FAM.FT.BNST	Bed Nucleus of Stria Terminalis	nucleus-nucleus	uncertain	(unknown reference)
FEC	LMC.MM.VTA	FEC.FT.ACC.CORE	Nucleus Accumbens Core	nucleus-nucleus-gaba	uncertain	Reward circuit of human brain (NACC -> VTA, abstract)
		FEC.FT.VP.VM	Ventral Pallidum Ventromedial	nucleus-nucleus-gaba	uncertain	Craving (VPAL -> VTA, abstract)
		FEC.HT.TG.IPD	Interpeduncular Nucleus	nucleus-nucleus-ACh	uncertain	Both LHb and MHb control the dopaminergic and serotonergic systems (IPN -> VTA)
		FEC.HT.TG.RMTG	Rostromedial Tegmental Nucleus	nucleus-nucleus-gaba	uncertain	Amygdala and its network (RMTG -> VTA)
LPC	LMC.MM.VTA	LPC.HL.SOL	Solitary Nucleus	nucleus-nucleus	uncertain	Bowels control brain: gut hormones and obesity (NTS -> VTA)

External Outbound Region Connections:

Target Area	Local Region	Target Region	Target Name	Type	Role	Reference
Cortical
NDM	LMC.MM.VTA	NDM.NC.AL.DACG	Dorsal Anterior Cingulate Area	nucleus-neocortex-DA	uncertain	(unknown reference)
		NDM.NC.AL.FPC	Lateral Frontopolar Cortex	nucleus-neocortex-DA	uncertain	Amygdala and its network (VTA -> MPFC, abstract)
Subcortical
FAM	LMC.MM.VTA	FAM.FT.AM.CEC	Central Amygdaloid Nucleus, capsular subdivision	nucleus-nucleus-DA	uncertain	Reward circuit of human brain (VTA -> AM, abstract)
FEC	LMC.MM.VTA	FEC.FT.ACC.SH	Nucleus Accumbens Shell	nucleus-nucleus-DA	uncertain	Craving (VTA -> NACC, abstract)
		FEC.FT.PU.LT	Dorsal Putamen Lateral	nucleus-nucleus-DA	uncertain	Bowels control brain: gut hormones and obesity (VTA -> DS, abstract)
		FEC.FT.PU.MED	Dorsal Putamen Medial	nucleus-nucleus-DA	uncertain	Bowels control brain: gut hormones and obesity (VTA -> DS, abstract)
FMM	LMC.MM.VTA	FMM.FD.MB.MMB	Medial Mammillary Nucleus	nucleus-nucleus-DA	uncertain	Mammillary bodies: two memory systems in one (VTN -> MMB)
		FMM.FT.HC.CA1D	Distal CA1 of Hippocampus	nucleus-allocortex-DA	uncertain	Reward circuit of human brain (VTA -> HC, abstract)
		FMM.NC.PH.LEC	Lateral Entorhinal Cortex	nucleus-neocortex-DA	uncertain	Combining Novelty, Motivational Salience, and Reward to Control Attention and Learning (VTA -> EC, abstract)
LAC	LMC.MM.VTA	LAC.FD.HT.PRM	Premammillary Nucleus	nucleus-nucleus-DA	uncertain	(unknown reference)
		LAC.FD.HT.PV	Paraventricular Nucleus	nucleus-nucleus-DA	uncertain	Physiology and pathophysiology of lower urinary tract (VTA -> PVN)

Enkephalin - Regulating Nociception in Body

unavailable

Component ID	Component Name	Type	Service	Function	Comments	Quality
LMC.MM.PAG	Periaqueductal Gray Matter	nucleus	LUS	Descending modulation of pain and in defensive behaviour		L0

Internal Region Connections:

no connections

External Inbound Region Connections:

Source Area	Local Region	Source Region	Source Name	Type	Role	Reference
Cortical
NCP	LMC.MM.PAG	NCP.NC.AL.SGCG	Subgenual Cingulate Cortex	neocortex-nucleus	uncertain	(unknown reference)
Subcortical
FAM	LMC.MM.PAG	FAM.FT.AM.CEM	Medial Central Amygdaloid Nucleus	nucleus-nucleus	uncertain	Amygdalar disruption of prefrontal cortex (AM -> PAG, abstract)
FEC	LMC.MM.PAG	FEC.HT.TG.IPD	Interpeduncular Nucleus	nucleus-nucleus-ACh	uncertain	Connectivity map of the habenula (IPN -> PAG)

External Outbound Region Connections:

Target Area	Local Region	Target Region	Target Name	Type	Role	Reference
Cortical
NDM	LMC.MM.PAG	NDM.FD.TH.PV	Paraventricular Nucleus of Thalamus	nucleus-nucleus-ENK	uncertain	(unknown reference)
Subcortical
LAC	LMC.MM.PAG	LAC.HT.BR	Barrington's Nucleus	nucleus-nucleus-ENK	uncertain	Schematic overview of spinobulbospinal micturition reflex pathway (PAG -> BAR)
LLC	LMC.MM.PAG	LLC.FD.TH.SF	Subfascicular Nucleus of Thalamus	nucleus-nucleus-ENK	uncertain	(unknown reference)
LMC	LMC.MM.PAG	LMC.HL.RP.MG	Raphe Magnus Nucleus	nucleus-nucleus-ENK	uncertain	Connectivity map of the habenula (PAG -> Raphe, abstract)
		LMC.HL.RP.PL	Raphe Pallidus Nucleus	nucleus-nucleus-ENK	uncertain	Connectivity map of the habenula (PAG -> Raphe, abstract)
LPC	LMC.MM.PAG	LPC.HL.AMB	Ambiguus Nucleus	nucleus-nucleus-ENK	uncertain	(unknown reference)
LRC	LMC.MM.PAG	LRC.HL.RA	Retroambigualis Nucleus	nucleus-nucleus-ENK	uncertain	(unknown reference)
		LRC.HT.NSC	Nucleus Subceruleus	nucleus-nucleus-ENK	uncertain	(unknown reference)

Norepinephrine - Vigilant Concentration, Stress Hormone, Fight-or-Flight Response

unavailable

Component ID	Component Name	Type	Service	Function	Comments	Quality
LMC.HT.LC	Locus Coeruleus	nucleus	LUS	Regulate the intensity of responses to salient stimuli, arousal and autonomic activity		L0

Internal Region Connections:

no connections

External Inbound Region Connections:

Source Area	Local Region	Source Region	Source Name	Type	Role	Reference
Cortical
NDM	LMC.HT.LC	NDM.NC.AL.VACG	Ventral Anterior Cingulate Area	neocortex-nucleus	uncertain	(unknown reference)
Subcortical
FAM	LMC.HT.LC	FAM.FT.AM.CEM	Medial Central Amygdaloid Nucleus	nucleus-nucleus	uncertain	Amygdalar disruption of prefrontal cortex (AM -> LC, abstract)
		FAM.FT.BNST	Bed Nucleus of Stria Terminalis	nucleus-nucleus	uncertain	(unknown reference)
LAC	LMC.HT.LC	LAC.FD.HT.DM	Dorsomedial Hypothalamic Nucleus	nucleus-nucleus	uncertain	Effect of light on pupil diameter (DMH -> LC)
		LAC.FD.HT.TBM	Tuberomammillary Nucleus	nucleus-nucleus	uncertain	(unknown reference)
LRC	LMC.HT.LC	LRC.HL.RF.MED	Central Medullary Reticular Nucleus	nucleus-nucleus	uncertain	(unknown reference)

External Outbound Region Connections:

Target Area	Local Region	Target Region	Target Name	Type	Role	Reference
Subcortical
FAM	LMC.HT.LC	FAM.FD.LHB.LT	Lateral Habenula Lateral Part	nucleus-nucleus-NE	uncertain	Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract)
		FAM.FD.LHB.MED	Lateral Habenula Medial Part	nucleus-nucleus-NE	uncertain	Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract)
		FAM.FD.MHB	Medial Habenula	nucleus-nucleus-NE	uncertain	Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> MHB)
		FAM.FT.SEP.DBB	Diagonal Band of Broca	nucleus-nucleus-NE	uncertain	(unknown reference)
FEC	LMC.HT.LC	FEC.FT.SNC.MED	Substantia Nigra Pars Compacta Medial	nucleus-nucleus-NE	uncertain	(unknown reference)
		FEC.HT.TG.IPD	Interpeduncular Nucleus	nucleus-nucleus-NE	uncertain	Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> IPN)
LAC	LMC.HT.LC	LAC.FD.HT.VLPO	Ventrolateral Preoptic Nucleus	nucleus-nucleus-NE	uncertain	Simplified NREM sleep-promoting pathway (LC -> VLPO)
		LAC.SC.IZ.CSC	Ciliospinal Center	nucleus-nucleus-NE	uncertain	Effect of light on pupil diameter (LC -> IML)
		LAC.SC.IZ.IML	Intermediolateral Nucleus	nucleus-nucleus-NE	uncertain	Physiology and pathophysiology of lower urinary tract (LC -> IML)

Thirdparty Circuits

(generated)

Habenula Connections - see Reference (CF.HB-CONNECTIONS)

CPu=Striatum,FEC.FT.ST (see Basal Ganglia)
DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB
DR=Dorsal Raphe Nucleus,LMC.MM.RP.DRN
GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia)
IP=Interpeduncular Nucleus,FEC.HT.TG.IPD
LH=Lateral Hypothalamic Area,LAC.FD.HT.LT (see Hypothalamus)
LHb=Lateral Habenula,FAM.FD.LHB (see Habenula)
LPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO
MHb=Medial Habenula,FAM.FD.MHB
MR=Superior Central Raphe Nucleus,LMC.MM.RP.SUC
PB=Endocrine Glands,TARGET.TEA.ENDOCRINE
S=Septal Nuclei,FAM.FT.SEP
SNc=Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT
VTA=Ventral Tegmental Area,LMC.MM.VTA

Regulation of the rapid eye movement (REM) sleep by habenular projection - see Reference (CF.REM-HB)

DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB
DTG=Laterodorsal Tegmental Nucleus,LMC.HT.TG.DTG
EPN=Endopiriform Nucleus,FAM.FT.EPF
GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia)
LHT=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
LHbL=Lateral Habenula Lateral Part,FAM.FD.LHB.LT
LHbM=Lateral Habenula Medial Part,FAM.FD.LHB.MED
NI=Incertus Nucleus,FAM.HT.TG.NI
RMTg=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG
Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation)
SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia)
VTA=Ventral Tegmental Area,LMC.MM.VTA
VTG=Ventral Tegmental Area,LMC.MM.VTG

Physiology and pathophysiology of lower urinary tract - see Reference (CM.ONUF)

CN=Caudate Nucleus,FEC.FT.CN (see Basal Ganglia)
DVM=Vagus Nucleus,LAC.HL.VGN
IMG=Inferior Mesenteric Ganglion,LAC.PN.SYM.IMG
IML=Intermediolateral Nucleus,LAC.SC.IZ.IML
LC=Locus Coeruleus,LMC.HT.LC
MPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
MPOA=Median Preoptic Nucleus,LAC.FD.HT.MPO
NBM=Basal Nucleus of Meynert,LMC.FT.NBM
ONF=Onuf's Nucleus,LPC.SC.VH.ONF
PBN=Parabrachial Nucleus,LPC.HT.PRF.PB
PEL=Pelvic Peripheral Ganglion,LAC.PN.PSYM.PPG
PU=Dorsal Putamen Lateral,FEC.FT.PU.LT
PVN=Paraventricular Nucleus,LAC.FD.HT.PV
SNC=Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT
SPS=Sacral Parasympathetic Nucleus,LAC.SC.IZ.SPS
VTA=Ventral Tegmental Area,LMC.MM.VTA
ZI=Subthalamic Nucleus Caudal,BGA.FD.STN.ZI

Both LHb and MHb control the dopaminergic and serotonergic systems - see Reference (CF.HB-DA5HT)

DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB
DRN=Dorsal Raphe Nucleus,LMC.MM.RP.DRN
GPb=Dorsal Pallidum,FEC.FT.DP (see Basal Ganglia)
IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD
LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
LHbL=Lateral Habenula Lateral Part,FAM.FD.LHB.LT
LHbM=Lateral Habenula Medial Part,FAM.FD.LHB.MED
LPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO
LS=Lateral Septal Nucleus,FAM.FT.SEP.LT
MHb=Medial Habenula,FAM.FD.MHB
MRN=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation)
MS=Medial Septal Nucleus,FAM.FT.SEP.MED
PS=Posterior Septal Group,FAM.FT.SEP.PG (see Septal Nuclei)
RMTg=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG
SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia)
VP=Ventral Pallidum,FEC.FT.VP (see Basal Ganglia)
VTA=Ventral Tegmental Area,LMC.MM.VTA

Connectivity map of the habenula - see Reference (CF.HB-CONN)

CPu=Striatum,FEC.FT.ST (see Basal Ganglia)
EP=Endopiriform Nucleus,FAM.FT.EPF
Hippo=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD
L=Lateral Habenula,FAM.FD.LHB (see Habenula)
LH=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
M=Medial Habenula,FAM.FD.MHB
NAc=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia)
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation)
SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia)
Septum=Septal Nuclei,FAM.FT.SEP
VTA=Ventral Tegmental Area,LMC.MM.VTA

Amygdala and its network - see Reference (CF.AM-NET)

BLN=Parvicellular Basal Amygdaloid Nucleus,FAM.FT.AM.BP
CEA=Central Amygdala,FAM.FT.AM.CEA (see Amygdala)
EC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)
HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
HTS=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
ITC=Inferotemporal Cortex,NSA.NC.IT.TE
LA=Lateral Amygdaloid Nucleus,FAM.FT.AM.LA (see Amygdala)
LHB=Lateral Habenula,FAM.FD.LHB (see Habenula)
MD=Mediodorsal Nucleus of Thalamus,FD.TH.MD (see Cognitive Thalamus)
MPFC=Orbitomedial Prefrontal Cortex,NC.AL.OMPFC
NACC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia)
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
RMTG=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG
STC=Wernicke's area A3,NSA.NC.STG.A3
VGDM=Vagus Nucleus,LAC.HL.VGN
VTA=Ventral Tegmental Area,LMC.MM.VTA

Combining Novelty, Motivational Salience, and Reward to Control Attention and Learning - see Reference (CT.LONG-TERM-MEMORY-VTA)

ACC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia)
CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (see Hippocampal Formation)
CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (see Hippocampal Formation)
DG=Dentate Gyrus,FMM.FT.HC.DG
EC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)
PFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
PPTG=Pedunculopontine Tegmental Nuclei,LMC.HT.TG.PPN
SUB=Subiculum,FMM.FT.HF.SUB (see Hippocampal Formation)
VPAL=Ventral Pallidum,FEC.FT.VP (see Basal Ganglia)
VTA=Ventral Tegmental Area,LMC.MM.VTA

Mammillary bodies: two memory systems in one - see Reference (CT.MB-MEMORY)

ADTH=Anterodorsal Nucleus,FMM.FD.TH.AD
AMTH=Anteromedial Nucleus,NCP.FD.TH.AM
AVTH=Anteroventral Nucleus,FMM.FD.TH.AV
DTN=Laterodorsal Tegmental Nucleus,LMC.HT.TG.LDT
LMB=Lateral Mammillary Nucleus,FMM.FD.MB.LMB
MMB=Medial Mammillary Nucleus,FMM.FD.MB.MMB
MedialEC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)
PAS=Parasubiculum,FMM.NC.PH.PAS
POS=Postsubiculum,FMM.NC.PH.POS
PRS=Presubiculum,FMM.NC.PH.PRS
SEP=Septal Nuclei,FAM.FT.SEP
SUB=Subiculum,FMM.FT.HF.SUB (see Hippocampal Formation)
SupraMM=Supramammillary Nucleus,LAC.FD.HT.SUM
TuberoMM=Lateral Tuberal Nuclei,LAC.FD.HT.LTUB (see Hypothalamus)
VTN=Ventral Tegmental Area,LMC.MM.VTA

Amygdalar disruption of prefrontal cortex - see Reference (CF.AM-DISRUPTION)

ACG=Anterior Cingulate Cortex,NC.AL.ACG (see Anterior Cingulate Area)
AM=Amygdala,FAM.FT.AM
HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
HT.L=Lateral Hypothalamic Area,LAC.FD.HT.LT (see Hypothalamus)
HT.PV=Paraventricular Nucleus,LAC.FD.HT.PV
INS=Insular Cortex,NC.INS
LC=Locus Coeruleus,LMC.HT.LC
MPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
PB=Parabrachial Nucleus,LPC.HT.PRF.PB
PUT=Endocrine Glands,TARGET.TEA.ENDOCRINE
SOL=Solitary Nucleus,LPC.HL.SOL
TH=Thalamus,FD.TH

Simplified NREM sleep-promoting pathway - see Reference (CL.TBM-PO)

LC=Locus Coeruleus,LMC.HT.LC
LDTg=Laterodorsal Tegmental Nucleus,LMC.HT.TG.LDT
TMN=Tuberomammillary Nucleus,LAC.FD.HT.TBM
VLPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO

Regulation of Social Brain - see Reference (CT.SOCIAL-BRAIN)

AMG=Amygdala,FAM.FT.AM
Caud=Caudate Nucleus,FEC.FT.CN (see Basal Ganglia)
DACC=Dorsal Anterior Cingulate Area,NDM.NC.AL.DACG
DLPFC=Mid-Dorsolateral Prefrontal Cortex,NDM.NC.AL.DLPFC (see Lateral Prefrontal Cortex)
Hipp=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
IFG=Inferior Prefrontal Gyrus,NDM.NC.AL.IPG
LSN=Lateral Spinal Nucleus,LAC.SC.LH.LSN
MPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
NACC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia)
OFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
PhippG=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)
Put=Dorsal Putamen,FEC.FT.DPU (see Basal Ganglia)
SGC=Subgenual Cingulate Cortex,NCP.NC.AL.SGCG
SN=Substantia Nigra,FEC.FT.SN (see Basal Ganglia)
VACC=Ventral Anterior Cingulate Area,NDM.NC.AL.VACG
VTA=Ventral Tegmental Area,LMC.MM.VTA
VentPal=Ventral Pallidum,FEC.FT.VP (see Basal Ganglia)

Medial mammillary nucleus and theta rhythm - see Reference (CT.MMB-THETA)

AVTH=Anteroventral Nucleus,FMM.FD.TH.AV
HF=Hippocampal Formation,FMM.FT.HF
MMB=Medial Mammillary Nucleus,FMM.FD.MB.MMB
RSP=Retrosplenial Cortex,NCP.NC.MPL.RSC
SEP=Septal Nuclei,FAM.FT.SEP
SupraMM=Supramammillary Nucleus,LAC.FD.HT.SUM
VTN=Ventral Tegmental Area,LMC.MM.VTA

Oculomotor decision-making - see Reference (CP.OCULOMOTOR-DECISION-MAKING)

AMYG=Amygdala,FAM.FT.AM
CGa=Anterior Cingulate Cortex,NC.AL.ACG (see Anterior Cingulate Area)
CGp=Posterior Cingulate Cortex,NCP.NC.MPL.PSCG
Caudate=Caudate Nucleus,FEC.FT.CN (see Basal Ganglia)
FEF=Frontal Eye Field,NMA.NC.PMC.FEF (see Premotor Cortex)
LIP=Lateral Intraparietal Sulcus,NPE.NC.IPS.LIP
NAC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia)
OFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
PFC=Mid-Dorsolateral Prefrontal Cortex,NDM.NC.AL.DLPFC (see Lateral Prefrontal Cortex)
SC=Superior Colliculus,MM.SC (see Reflexes Nuclei of Midbrain Mesencephalon)
SEF=Supplementary Eye Field,NPE.NC.SMC.SEF
SNc=Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT
SNr=Substantia Nigra Pars Reticulata Dorsolateral,FEC.FT.SNR.DL
Thalamus=Thalamus,FD.TH
VTA=Ventral Tegmental Area,LMC.MM.VTA

Bowels control brain: gut hormones and obesity - see Reference (CP.BOWELS)

AMY=Amygdala,FAM.FT.AM
ARC=Arcuate Nucleus of Hypothalamus,LAC.FD.HT.AR
DS=Dorsal Striatum,FEC.FT.DST (see Basal Ganglia)
LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
ME=Endocrine Glands,TARGET.TEA.ENDOCRINE
NAc=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia)
NTS=Solitary Nucleus,LPC.HL.SOL
OFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
PBN=Parabrachial Nucleus,LPC.HT.PRF.PB
PVN=Paraventricular Nucleus,LAC.FD.HT.PV
VMN=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM
VTA=Ventral Tegmental Area,LMC.MM.VTA

Reward circuit of human brain - see Reference (CF.REWARD-CIRCUIT)

AM=Amygdala,FAM.FT.AM
HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
NACC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia)
PFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
VPAL=Ventral Pallidum,FEC.FT.VP (see Basal Ganglia)
VTA=Ventral Tegmental Area,LMC.MM.VTA

Craving - see Reference (CF.CRAVING)

NACC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia)
OMPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
SNr=Substantia Nigra Pars Reticulata Medial,FEC.FT.SNR.MED
VPAL=Ventral Pallidum,FEC.FT.VP (see Basal Ganglia)
VTA=Ventral Tegmental Area,LMC.MM.VTA

Schematic overview of spinobulbospinal micturition reflex pathway - see Reference (CM.BARRINGTON)

BAR=Barrington's Nucleus,LAC.HT.BR
IMG=Inferior Mesenteric Ganglion,LAC.PN.SYM.IMG
IML=Intermediolateral Nucleus,LAC.SC.IZ.IML
ONF=Onuf's Nucleus,LPC.SC.VH.ONF
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
PEL=Pelvic Peripheral Ganglion,LAC.PN.PSYM.PPG
SPS=Sacral Parasympathetic Nucleus,LAC.SC.IZ.SPS

Spine induction on short primary dendrites in the ventrolateral VMH - see Reference (CL.VMH-PAG)

PAG=Periaqueductal Gray Matter,LMC.MM.PAG
VMH=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM

Afferent pain pathways - see Reference (CF.PAIN-PATH)

ACC=Anterior Cingulate Cortex,NC.AL.ACG (see Anterior Cingulate Area)
AMY=Amygdala,FAM.FT.AM
BG=Basal Ganglia,FEC.FT.BG
Cerebellum=Cerebellar Complex,LLC.HT.CRC
Insula=Insular Cortex,NC.INS
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
PB=Parabrachial Nucleus,LPC.HT.PRF.PB
PFC=Prefrontal Cortex,NC.AL.PFC
S1=Primary Somatosensory Cortex,NCP.NC.PG.S1
S2=Secondary Somatosensory Cortex,NCP.NC.PG.S2
SC=Posterior/Dorsal Horn,BMA.SC.PH
Thalamus=Sensory Thalamus,FD.TH.SR

Pain matrix - see Reference (CF.PAIN-MATRIX)

ACC=Anterior Cingulate Cortex,NC.AL.ACG (see Anterior Cingulate Area)
AM=Amygdala,FAM.FT.AM
INS=Insular Cortex,NC.INS
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
PFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
PPC=Superior Parietal Lobule,NC.SPL
S1=Primary Somatosensory Cortex,NCP.NC.PG.S1
SMA=Supplementary Motor Cortex,NMA.NC.SMC
TH=Thalamus,FD.TH

Geniculate and Extyrageniculate Paths - see Reference (CP.GENICULATE-PATHS)

LGN=Lateral Geniculate Nucleus,NSA.FD.LGN
PPN=Pedunculopontine Tegmental Nuclei,LMC.HT.TG.PPN
RF=Pontine Reticular Formation,HT.RF
Retina=Retinal Nucleus,LPC.FD.RT
SC=Superior Colliculus,MM.SC (see Reflexes Nuclei of Midbrain Mesencephalon)
VC=Occipital Lobe,NC.LOBE.OCC

Serotonin regulation of subthalamic neurons - see Reference (CM.SUBTHALAMUS)

CTX=Anterior Lobe,NC.LOBE.ANT
GPe=Globus Pallidus External,FEC.FT.GPE (see Basal Ganglia)
GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia)
PPN=Pedunculopontine Tegmental Nuclei,LMC.HT.TG.PPN
SNr=Substantia Nigra Pars Reticulata,FEC.FT.SNR (see Basal Ganglia)
STN=Subthalamic Nucleus,FEC.FD.STN (see Subthalamus Area)

Summary of the organization of the substantia nigra pars reticulata and pedunculopontine nucleus in lamprey - see Reference (CM.SN-PPN)

GPe=Globus Pallidus External,FEC.FT.GPE (see Basal Ganglia)
GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia)
PPN=Pedunculopontine Tegmental Nuclei,LMC.HT.TG.PPN
SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia)
SNr=Substantia Nigra Pars Reticulata,FEC.FT.SNR (see Basal Ganglia)
STN=Subthalamic Nucleus,FEC.FD.STN (see Subthalamus Area)

Hippocampal Formation - see Reference (CT.HIPPOCAMPAL-FORMATION)

ATN=Anterior Nucleus of Thalamus,FD.TH.AN (see Cognitive Thalamus)
CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (see Hippocampal Formation)
CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (see Hippocampal Formation)
DG=Dentate Gyrus,FMM.FT.HC.DG
DTN=Laterodorsal Tegmental Nucleus,LMC.HT.TG.LDT
EC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)
LDN=Lateral Dorsal Nucleus of Thalamus,FMM.FD.TH.LD
LMam=Lateral Mammillary Nucleus,FMM.FD.MB.LMB
PoS=Postsubiculum,FMM.NC.PH.POS
Rsp=Retrosplenial Cortex,NCP.NC.MPL.RSC
Sub=Subiculum,FMM.FT.HF.SUB (see Hippocampal Formation)

Head Direction Cell Circuit - see Reference (CT.HEAD-DIRECTION)

AD=Anterodorsal Nucleus,FMM.FD.TH.AD
DTN=Laterodorsal Tegmental Nucleus,LMC.HT.TG.DTG
EC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)
HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
IPD=Interpeduncular Nucleus,FEC.HT.TG.IPD
LD=Lateral Dorsal Nucleus of Thalamus,FMM.FD.TH.LD
LHAB=Habenula,FAM.FD.HB
LMB=Lateral Mammillary Nucleus,FMM.FD.MB.LMB
MVSN=Medial Vestibular Nucleus,LPC.HT.MVBN
NPRP=Prepositus Nucleus,LRC.HL.NPH
PC=Parietal Lobe,NC.LOBE.PAR
PRHC=Postrhinal Cortex,FMM.NC.PH.POR
PSUB=Postsubiculum,FMM.NC.PH.POS
RSP=Retrosplenial Cortex,NCP.NC.MPL.RSC
SUPGEN=Suprageniculate Nucleus of Thalamus,NSA.FD.TH.SG
VC=Occipital Lobe,NC.LOBE.OCC

Effect of light on pupil diameter - see Reference (CP.PUPIL-REFLEX)

DMH=Dorsomedial Hypothalamic Nucleus,LAC.FD.HT.DM
EW=Edinger-Westphal Nucleus,LAC.MM.EWN
EYE=Eye,TARGET.TSA.EYE
GC=Ciliary Ganglion,LAC.PN.PSYM.CLG
IML=Ciliospinal Center,LAC.SC.IZ.CSC
LC=Locus Coeruleus,LMC.HT.LC
OPN=Pretectal Olivary Nucleus,LRC.MM.PT.PON
PVN=Paraventricular Nucleus,LAC.FD.HT.PV
RET=Retinal Nucleus,LPC.FD.RT
SCG=Superior Cervical Ganglion,LAC.PN.SYM.SCG
SCN=Suprachiasmatic Nucleus,LAC.FD.HT.SCN

Contribution of nAChR subunits to nicotine withdrawal symptoms - see Reference (CF.HB-NICOTINE)

IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD
LC=Locus Coeruleus,LMC.HT.LC
LHB=Lateral Habenula,FAM.FD.LHB (see Habenula)
MHB=Medial Habenula,FAM.FD.MHB

Basal Nucleus of Meynert - see Reference (CF.MEYNERT)

AM=Amygdala,FAM.FT.AM
BMN=Basal Nucleus of Meynert,LMC.FT.NBM
CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (see Hippocampal Formation)
EC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)
PRR=Perirhinal Cortex,FMM.NC.PH.PER

Affective basal ganglia circuit - see Reference (CF.AFFECTIVE-BG)

NACC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia)
OMPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
nBM=Basal Nucleus of Meynert,LMC.FT.NBM

References

(generated)

Difference between revisions of "BrainAreaLMC"

Latest revision as of 18:24, 28 April 2019

Contents

Local Circuits

Serotonin - Feelings of Well-Being and Happiness

Acetylcholine - PNS Actions and CNS plasticity, arousal and reward

Dopamine - Reward-Motivated Behavior, Cognitive Alertness

Enkephalin - Regulating Nociception in Body

Norepinephrine - Vigilant Concentration, Stress Hormone, Fight-or-Flight Response

Thirdparty Circuits

References

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@@ Line 9: / Line 9: @@
 {| class=wikitable width=80%
-| '''ID''' || '''Name''' || '''Regions'''
+| '''ID''' || '''Name''' || '''Regions''' || '''Quality'''
 |-
-| 5HT || Serotonin - Feelings of Well-Being and Happiness || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]], [[BrainRegionLMC_HL_RP_OB|LMC.HL.RP.OB]], [[BrainRegionLMC_HL_RP_PL|LMC.HL.RP.PL]], [[BrainRegionLMC_HP_RP_LI|LMC.HP.RP.LI]], [[BrainRegionLMC_HP_RP_PRN|LMC.HP.RP.PRN]], [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]], [[BrainRegionLMC_MM_RP_SUC|LMC.MM.RP.SUC]]
+| 5HT || Serotonin - Feelings of Well-Being and Happiness || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]], [[BrainRegionLMC_HL_RP_OB|LMC.HL.RP.OB]], [[BrainRegionLMC_HL_RP_PL|LMC.HL.RP.PL]], [[BrainRegionLMC_HP_RP_LI|LMC.HP.RP.LI]], [[BrainRegionLMC_HP_RP_PRN|LMC.HP.RP.PRN]], [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]], [[BrainRegionLMC_MM_RP_SUC|LMC.MM.RP.SUC]] || L0
 |-
-| ACH || Acetylcholine - PNS Actions and CNS plasticity, arousal and reward || [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]], [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]], [[BrainRegionLMC_HT_TG_PPN|LMC.HT.TG.PPN]]
+| ACH || Acetylcholine - PNS Actions and CNS plasticity, arousal and reward || [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]], [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]], [[BrainRegionLMC_HT_TG_PPN|LMC.HT.TG.PPN]] || L0
 |-
-| DA || Dopamine - Reward-Motivated Behavior, Cognitive Alertness || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]]
+| DA || Dopamine - Reward-Motivated Behavior, Cognitive Alertness || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || L0
 |-
-| ENK || Enkephalin -  Regulating Nociception in Body || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]]
+| ENK || Enkephalin -  Regulating Nociception in Body || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || L0
 |-
-| NE || Norepinephrine - Vigilant Concentration, Stress Hormone, Fight-or-Flight Response || [[BrainRegionLMC_HT_LC|LMC.HT.LC]]
+| NE || Norepinephrine - Vigilant Concentration, Stress Hormone, Fight-or-Flight Response || [[BrainRegionLMC_HT_LC|LMC.HT.LC]] || L0
 |}
@@ Line 28: / Line 28: @@
 {| class=wikitable width=80%
-| '''Component ID''' || '''Component Name''' || '''Type''' || '''Service''' || '''Function''' || '''Comments'''
+| '''Component ID''' || '''Component Name''' || '''Type''' || '''Service''' || '''Function''' || '''Comments''' || '''Quality'''
 |-
-| [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || Raphe Magnus Nucleus || nucleus || LUS || Inhibit head and spinal pain || B3, contacts with enkephalenic neurons in<BR>substantia gelatinosa
+| [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || Raphe Magnus Nucleus || nucleus || LUS || Inhibit head and spinal pain ||  || L0
 |-
-| [[BrainRegionLMC_HL_RP_OB|LMC.HL.RP.OB]] || Raphe Obscurus Nucleus || nucleus || LUS || Regulate cardiovascular function via sympathetic spinal column || B2
+| [[BrainRegionLMC_HL_RP_OB|LMC.HL.RP.OB]] || Raphe Obscurus Nucleus || nucleus || LUS || Regulate cardiovascular function via sympathetic spinal column ||  || L0
 |-
-| [[BrainRegionLMC_HL_RP_PL|LMC.HL.RP.PL]] || Raphe Pallidus Nucleus || nucleus || LUS || Spinal pain control || B1
+| [[BrainRegionLMC_HL_RP_PL|LMC.HL.RP.PL]] || Raphe Pallidus Nucleus || nucleus || LUS || Spinal pain control ||  || L0
 |-
-| [[BrainRegionLMC_HP_RP_LI|LMC.HP.RP.LI]] || Raphe Nucleus Linearis || nucleus || LUS || Release of 5-HT was only obtained on stimulation of this nucleus || B8, Does not project to CR, but to forebrain, to<BR>dorsal raphe nucleus (lies above DRN); dendrites to<BR>vascular plexus, maybe sensing blood pressure
+| [[BrainRegionLMC_HP_RP_LI|LMC.HP.RP.LI]] || Raphe Nucleus Linearis || nucleus || LUS || Release of 5-HT was only obtained on stimulation of this nucleus ||  || L0
 |-
-| [[BrainRegionLMC_HP_RP_PRN|LMC.HP.RP.PRN]] || Pontine Raphe Nucleus || nucleus || LUS || Regulation of sleep cycle || Projects to CR, forebrain; inhibitory nucleus
+| [[BrainRegionLMC_HP_RP_PRN|LMC.HP.RP.PRN]] || Pontine Raphe Nucleus || nucleus || LUS || Regulation of sleep cycle ||  || L0
 |-
-| [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]] || Dorsal Raphe Nucleus || nucleus || LUS || Regulation of sleep and mood || Major source of 5HT; inhibitory nucleus
+| [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]] || Dorsal Raphe Nucleus || nucleus || LUS || Regulation of sleep and mood ||  || L0
 |-
-| [[BrainRegionLMC_MM_RP_SUC|LMC.MM.RP.SUC]] || Superior Central Raphe Nucleus || nucleus || LUS || Block or temporarily suspend mnemonic processes in the hippocampus;<BR>Hallucinations || Directs HC to disregard insignificant events;<BR>inhibitory nucleus; B6,B8; Insomnia; inhibitory<BR>nucleus
+| [[BrainRegionLMC_MM_RP_SUC|LMC.MM.RP.SUC]] || Superior Central Raphe Nucleus || nucleus || LUS || Block or temporarily suspend mnemonic processes in the hippocampus;<BR>Hallucinations ||  || L0
 |}
@@ Line 48: / Line 48: @@
 {| class=wikitable width=80%
-| '''Source Region''' || '''Target Region''' || '''Type''' || '''Reference'''
+| '''Source Region''' || '''Target Region''' || '''Type''' || '''Role''' || '''Reference'''
 |-
-| [[BrainRegionLMC_HP_RP_LI|LMC.HP.RP.LI]] || [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]] || nucleus-nucleus-5HT || (unknown reference)
+| [[BrainRegionLMC_HP_RP_LI|LMC.HP.RP.LI]] || [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]] || nucleus-nucleus-5HT || uncertain || (unknown reference)
 |}
@@ Line 56: / Line 56: @@
 {| class=wikitable width=80%
-| '''Source Area''' || '''Local Region''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Reference'''
+| '''Source Area''' || '''Local Region''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Role''' || '''Reference'''
 |-
-| <font color="red">Subcortical</font> || || || || ||
+| <font color="red">Subcortical</font> || || || || || ||
 |-
-| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || nucleus-nucleus || [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> MRN, abstract)]
+| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || nucleus-nucleus || uncertain || [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> MRN, abstract)]
 |-
-|  || [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]] || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || nucleus-nucleus || [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> DRN)]
+|  || [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]] || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || nucleus-nucleus || uncertain || [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> DRN)]
 |-
-|  || [[BrainRegionLMC_MM_RP_SUC|LMC.MM.RP.SUC]] || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || nucleus-nucleus || [http://www.scholarpedia.org/article/Habenula Habenula Connections (LHb -> MR, abstract)]
+|  || [[BrainRegionLMC_MM_RP_SUC|LMC.MM.RP.SUC]] || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || nucleus-nucleus || uncertain || [http://www.scholarpedia.org/article/Habenula Habenula Connections (LHb -> MR, abstract)]
 |-
-| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || [[BrainRegionFEC_HT_TG_IPD|FEC.HT.TG.IPD]] || Interpeduncular Nucleus || nucleus-nucleus-ACh || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (IPN -> Raphe, abstract)]
+| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || [[BrainRegionFEC_HT_TG_IPD|FEC.HT.TG.IPD]] || Interpeduncular Nucleus || nucleus-nucleus-ACh || uncertain || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (IPN -> Raphe, abstract)]
 |-
-|  ||  || [[BrainRegionFEC_HT_TG_RMTG|FEC.HT.TG.RMTG]] || Rostromedial Tegmental Nucleus || nucleus-nucleus-gaba || [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (RMTg -> MRN, abstract)]
+|  ||  || [[BrainRegionFEC_HT_TG_RMTG|FEC.HT.TG.RMTG]] || Rostromedial Tegmental Nucleus || nucleus-nucleus-gaba || uncertain || [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (RMTg -> MRN, abstract)]
 |-
-|  || [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]] || [[BrainRegionFEC_HT_TG_IPD|FEC.HT.TG.IPD]] || Interpeduncular Nucleus || nucleus-nucleus-ACh || [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (IPN -> DRN)]
+|  || [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]] || [[BrainRegionFEC_HT_TG_IPD|FEC.HT.TG.IPD]] || Interpeduncular Nucleus || nucleus-nucleus-ACh || uncertain || [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (IPN -> DRN)]
 |-
-|  ||  || [[BrainRegionFEC_HT_TG_RMTG|FEC.HT.TG.RMTG]] || Rostromedial Tegmental Nucleus || nucleus-nucleus-gaba || [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (RMTg -> DRN)]
+|  ||  || [[BrainRegionFEC_HT_TG_RMTG|FEC.HT.TG.RMTG]] || Rostromedial Tegmental Nucleus || nucleus-nucleus-gaba || uncertain || [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (RMTg -> DRN)]
 |-
-| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || [[BrainRegionLAC_FD_HT_LTN|LAC.FD.HT.LTN]] || Lateral Hypothalamic Nucleus || nucleus-nucleus || (unknown reference)
+| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || [[BrainRegionLAC_FD_HT_LTN|LAC.FD.HT.LTN]] || Lateral Hypothalamic Nucleus || nucleus-nucleus || uncertain || (unknown reference)
 |-
-|  ||  || [[BrainRegionLAC_FD_HT_PV|LAC.FD.HT.PV]] || Paraventricular Nucleus || nucleus-nucleus || (unknown reference)
+|  ||  || [[BrainRegionLAC_FD_HT_PV|LAC.FD.HT.PV]] || Paraventricular Nucleus || nucleus-nucleus || uncertain || (unknown reference)
 |-
-|  || [[BrainRegionLMC_HL_RP_OB|LMC.HL.RP.OB]] || [[BrainRegionLAC_FD_HT_MPO|LAC.FD.HT.MPO]] || Median Preoptic Nucleus || nucleus-nucleus || (unknown reference)
+|  || [[BrainRegionLMC_HL_RP_OB|LMC.HL.RP.OB]] || [[BrainRegionLAC_FD_HT_MPO|LAC.FD.HT.MPO]] || Median Preoptic Nucleus || nucleus-nucleus || uncertain || (unknown reference)
 |-
-| [[BrainAreaLLC|LLC]] || [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]] || [[BrainRegionLLC_FD_TH_SF|LLC.FD.TH.SF]] || Subfascicular Nucleus of Thalamus || nucleus-nucleus-gaba || (unknown reference)
+| [[BrainAreaLLC|LLC]] || [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]] || [[BrainRegionLLC_FD_TH_SF|LLC.FD.TH.SF]] || Subfascicular Nucleus of Thalamus || nucleus-nucleus-gaba || uncertain || (unknown reference)
 |-
-| [[BrainAreaLMC|LMC]] || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || Periaqueductal Gray Matter || nucleus-nucleus-ENK || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (PAG -> Raphe, abstract)]
+| [[BrainAreaLMC|LMC]] || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || Periaqueductal Gray Matter || nucleus-nucleus-ENK || uncertain || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (PAG -> Raphe, abstract)]
 |-
-|  || [[BrainRegionLMC_HL_RP_PL|LMC.HL.RP.PL]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || Periaqueductal Gray Matter || nucleus-nucleus-ENK || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (PAG -> Raphe, abstract)]
+|  || [[BrainRegionLMC_HL_RP_PL|LMC.HL.RP.PL]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || Periaqueductal Gray Matter || nucleus-nucleus-ENK || uncertain || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (PAG -> Raphe, abstract)]
 |-
-| [[BrainAreaLRC|LRC]] || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || [[BrainRegionLRC_MM_SCNF|LRC.MM.SCNF]] || Subcuneiform Nucleus || nucleus-nucleus || (unknown reference)
+| [[BrainAreaLRC|LRC]] || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || [[BrainRegionLRC_MM_SCNF|LRC.MM.SCNF]] || Subcuneiform Nucleus || nucleus-nucleus || uncertain || (unknown reference)
 |-
-|  || [[BrainRegionLMC_HP_RP_PRN|LMC.HP.RP.PRN]] || [[BrainRegionLRC_MM_SCNF|LRC.MM.SCNF]] || Subcuneiform Nucleus || nucleus-nucleus || (unknown reference)
+|  || [[BrainRegionLMC_HP_RP_PRN|LMC.HP.RP.PRN]] || [[BrainRegionLRC_MM_SCNF|LRC.MM.SCNF]] || Subcuneiform Nucleus || nucleus-nucleus || uncertain || (unknown reference)
 |}
@@ Line 94: / Line 94: @@
 {| class=wikitable width=80%
-| '''Target Area''' || '''Local Region''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Reference'''
+| '''Target Area''' || '''Local Region''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Role''' || '''Reference'''
 |-
-| <font color="red">Cortical</font> || || || || ||
+| <font color="red">Cortical</font> || || || || || ||
 |-
-| [[BrainAreaNDM|NDM]] || [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]] || [[BrainRegionNDM_FD_TH_PV|NDM.FD.TH.PV]] || Paraventricular Nucleus of Thalamus || nucleus-nucleus-5HT || (unknown reference)
+| [[BrainAreaNDM|NDM]] || [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]] || [[BrainRegionNDM_FD_TH_PV|NDM.FD.TH.PV]] || Paraventricular Nucleus of Thalamus || nucleus-nucleus-5HT || uncertain || (unknown reference)
 |-
-| <font color="red">Subcortical</font> || || || || ||
+| <font color="red">Subcortical</font> || || || || || ||
 |-
-| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_MM_RP_SUC|LMC.MM.RP.SUC]] || [[BrainRegionFAM_FT_SEP_LT|FAM.FT.SEP.LT]] || Lateral Septal Nucleus || nucleus-nucleus-5HT || (unknown reference)
+| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_MM_RP_SUC|LMC.MM.RP.SUC]] || [[BrainRegionFAM_FT_SEP_LT|FAM.FT.SEP.LT]] || Lateral Septal Nucleus || nucleus-nucleus-5HT || uncertain || (unknown reference)
 |-
-| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_MM_RP_SUC|LMC.MM.RP.SUC]] || [[BrainRegionFEC_FD_STN_ICD|FEC.FD.STN.ICD]] || Subthalamic Nucleus Internal Caudal || nucleus-nucleus-5HT || (unknown reference)
+| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_MM_RP_SUC|LMC.MM.RP.SUC]] || [[BrainRegionFEC_FD_STN_ICD|FEC.FD.STN.ICD]] || Subthalamic Nucleus Internal Caudal || nucleus-nucleus-5HT || uncertain || (unknown reference)
 |-
-| [[BrainAreaFMM|FMM]] || [[BrainRegionLMC_MM_RP_SUC|LMC.MM.RP.SUC]] || [[BrainRegionFMM_FD_MB_MMB|FMM.FD.MB.MMB]] || Medial Mammillary Nucleus || nucleus-nucleus-5HT || (unknown reference)
+| [[BrainAreaFMM|FMM]] || [[BrainRegionLMC_MM_RP_SUC|LMC.MM.RP.SUC]] || [[BrainRegionFMM_FD_MB_MMB|FMM.FD.MB.MMB]] || Medial Mammillary Nucleus || nucleus-nucleus-5HT || uncertain || (unknown reference)
 |-
-| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_MM_RP_SUC|LMC.MM.RP.SUC]] || [[BrainRegionLAC_FD_HT_PN|LAC.FD.HT.PN]] || Posterior Hypothalamic Nucleus || nucleus-nucleus-5HT || (unknown reference)
+| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_MM_RP_SUC|LMC.MM.RP.SUC]] || [[BrainRegionLAC_FD_HT_PN|LAC.FD.HT.PN]] || Posterior Hypothalamic Nucleus || nucleus-nucleus-5HT || uncertain || (unknown reference)
 |-
-|  ||  || [[BrainRegionLAC_FD_HT_SUM|LAC.FD.HT.SUM]] || Supramammillary Nucleus || nucleus-nucleus-5HT || (unknown reference)
+|  ||  || [[BrainRegionLAC_FD_HT_SUM|LAC.FD.HT.SUM]] || Supramammillary Nucleus || nucleus-nucleus-5HT || uncertain || (unknown reference)
 |-
-| [[BrainAreaLLC|LLC]] || [[BrainRegionLMC_HL_RP_OB|LMC.HL.RP.OB]] || [[BrainRegionLLC_HT_CR_PV|LLC.HT.CR.PV]] || Cerebellar Paravermis || nucleus-allocortex-5HT || (unknown reference)
+| [[BrainAreaLLC|LLC]] || [[BrainRegionLMC_HL_RP_OB|LMC.HL.RP.OB]] || [[BrainRegionLLC_HT_CR_PV|LLC.HT.CR.PV]] || Cerebellar Paravermis || nucleus-allocortex-5HT || uncertain || (unknown reference)
 |-
-|  || [[BrainRegionLMC_HP_RP_PRN|LMC.HP.RP.PRN]] || [[BrainRegionLLC_HT_CR_PV|LLC.HT.CR.PV]] || Cerebellar Paravermis || nucleus-allocortex-5HT || (unknown reference)
+|  || [[BrainRegionLMC_HP_RP_PRN|LMC.HP.RP.PRN]] || [[BrainRegionLLC_HT_CR_PV|LLC.HT.CR.PV]] || Cerebellar Paravermis || nucleus-allocortex-5HT || uncertain || (unknown reference)
 |-
-| [[BrainAreaLPC|LPC]] || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || [[BrainRegionLPC_SC_PH_LSG|LPC.SC.PH.LSG]] || Lower Substantia Gelatinosa || nucleus-nucleus-5HT || (unknown reference)
+| [[BrainAreaLPC|LPC]] || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || [[BrainRegionLPC_SC_PH_LSG|LPC.SC.PH.LSG]] || Lower Substantia Gelatinosa || nucleus-nucleus-5HT || uncertain || (unknown reference)
 |-
-|  ||  || [[BrainRegionLPC_SC_PH_USG|LPC.SC.PH.USG]] || Upper Substantia Gelatinosa || nucleus-nucleus-5HT || (unknown reference)
+|  ||  || [[BrainRegionLPC_SC_PH_USG|LPC.SC.PH.USG]] || Upper Substantia Gelatinosa || nucleus-nucleus-5HT || uncertain || (unknown reference)
 |-
-|  || [[BrainRegionLMC_HL_RP_OB|LMC.HL.RP.OB]] || [[BrainRegionLPC_SC_IZ_IMM|LPC.SC.IZ.IMM]] || Intermediomedial Nucleus || nucleus-nucleus-5HT || (unknown reference)
+|  || [[BrainRegionLMC_HL_RP_OB|LMC.HL.RP.OB]] || [[BrainRegionLPC_SC_IZ_IMM|LPC.SC.IZ.IMM]] || Intermediomedial Nucleus || nucleus-nucleus-5HT || uncertain || (unknown reference)
 |-
-|  || [[BrainRegionLMC_HL_RP_PL|LMC.HL.RP.PL]] || [[BrainRegionLPC_SC_PH_LMG|LPC.SC.PH.LMG]] || Lower Marginal Nucleus || nucleus-nucleus-5HT || (unknown reference)
+|  || [[BrainRegionLMC_HL_RP_PL|LMC.HL.RP.PL]] || [[BrainRegionLPC_SC_PH_LMG|LPC.SC.PH.LMG]] || Lower Marginal Nucleus || nucleus-nucleus-5HT || uncertain || (unknown reference)
 |-
-|  ||  || [[BrainRegionLPC_SC_PH_UMG|LPC.SC.PH.UMG]] || Upper Marginal Nucleus || nucleus-nucleus-5HT || (unknown reference)
+|  ||  || [[BrainRegionLPC_SC_PH_UMG|LPC.SC.PH.UMG]] || Upper Marginal Nucleus || nucleus-nucleus-5HT || uncertain || (unknown reference)
 |}
@@ Line 133: / Line 133: @@
 {| class=wikitable width=80%
-| '''Component ID''' || '''Component Name''' || '''Type''' || '''Service''' || '''Function''' || '''Comments'''
+| '''Component ID''' || '''Component Name''' || '''Type''' || '''Service''' || '''Function''' || '''Comments''' || '''Quality'''
 |-
-| [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]] || Basal Nucleus of Meynert || nucleus || FAU || Control imagination vs perception || ACh source, attention; modulatory nucleus
+| [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]] || Basal Nucleus of Meynert || nucleus || FAU || Control imagination vs perception ||  || L0
 |-
-| [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]] || Laterodorsal Tegmental Nucleus || nucleus || LUS || Modulating sustained attention or in mediating alerting responses || sleep, waking, motor function, learning and reward
+| [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]] || Laterodorsal Tegmental Nucleus || nucleus || LUS || Modulating sustained attention or in mediating alerting responses ||  || L0
 |-
-| [[BrainRegionLMC_HT_TG_PPN|LMC.HT.TG.PPN]] || Pedunculopontine Tegmental Nuclei || nucleus || LUS || Provide sensory feedback to cerebral cortex; modulatory || contains Rostral (Pars dissipata, anterior,<BR>dissipated subnucleus, GABA), Caudal (Pars<BR>compacta, anterior, compact subnucleus, ACh)
+| [[BrainRegionLMC_HT_TG_PPN|LMC.HT.TG.PPN]] || Pedunculopontine Tegmental Nuclei || nucleus || LUS || Provide sensory feedback to cerebral cortex; modulatory ||  || L0
 |}
@@ Line 148: / Line 148: @@
 {| class=wikitable width=80%
-| '''Source Area''' || '''Local Region''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Reference'''
+| '''Source Area''' || '''Local Region''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Role''' || '''Reference'''
 |-
-| <font color="red">Cortical</font> || || || || ||
+| <font color="red">Cortical</font> || || || || || ||
 |-
-| [[BrainAreaNSA|NSA]] || [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]] || [[BrainRegionNSA_FD_TH_SG|NSA.FD.TH.SG]] || Suprageniculate Nucleus of Thalamus || nucleus-nucleus || (unknown reference)
+| [[BrainAreaNSA|NSA]] || [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]] || [[BrainRegionNSA_FD_TH_SG|NSA.FD.TH.SG]] || Suprageniculate Nucleus of Thalamus || nucleus-nucleus || uncertain || (unknown reference)
 |-
-| <font color="red">Subcortical</font> || || || || ||
+| <font color="red">Subcortical</font> || || || || || ||
 |-
-| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]] || [[BrainRegionFAM_FT_AM_AB|FAM.FT.AM.AB]] || Accessory Basal Amygdaloid Nucleus || nucleus-nucleus || (unknown reference)
+| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]] || [[BrainRegionFAM_FT_AM_AB|FAM.FT.AM.AB]] || Accessory Basal Amygdaloid Nucleus || nucleus-nucleus || uncertain || (unknown reference)
 |-
-|  ||  || [[BrainRegionFAM_FT_AM_BP|FAM.FT.AM.BP]] || Parvicellular Basal Amygdaloid Nucleus || nucleus-nucleus || (unknown reference)
+|  ||  || [[BrainRegionFAM_FT_AM_BP|FAM.FT.AM.BP]] || Parvicellular Basal Amygdaloid Nucleus || nucleus-nucleus || uncertain || (unknown reference)
 |-
-|  ||  || [[BrainRegionFAM_FT_AM_CEM|FAM.FT.AM.CEM]] || Medial Central Amygdaloid Nucleus || nucleus-nucleus || (unknown reference)
+|  ||  || [[BrainRegionFAM_FT_AM_CEM|FAM.FT.AM.CEM]] || Medial Central Amygdaloid Nucleus || nucleus-nucleus || uncertain || (unknown reference)
 |-
-|  ||  || [[BrainRegionFAM_FT_BNST|FAM.FT.BNST]] || Bed Nucleus of Stria Terminalis || nucleus-nucleus || (unknown reference)
+|  ||  || [[BrainRegionFAM_FT_BNST|FAM.FT.BNST]] || Bed Nucleus of Stria Terminalis || nucleus-nucleus || uncertain || (unknown reference)
 |-
-|  || [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]] || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || nucleus-nucleus || [http://journal.frontiersin.org/article/10.3389/fnhum.2013.00826/full Regulation of the rapid eye movement (REM) sleep by habenular projection (LHbM -> DTG)]
+|  || [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]] || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || nucleus-nucleus || uncertain || [http://journal.frontiersin.org/article/10.3389/fnhum.2013.00826/full Regulation of the rapid eye movement (REM) sleep by habenular projection (LHbM -> DTG)]
 |-
-| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]] || [[BrainRegionFEC_FD_STN_CD|FEC.FD.STN.CD]] || Subthalamic Nucleus Caudal || nucleus-nucleus || (unknown reference)
+| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]] || [[BrainRegionFEC_FD_STN_CD|FEC.FD.STN.CD]] || Subthalamic Nucleus Caudal || nucleus-nucleus || uncertain || (unknown reference)
 |-
-|  ||  || [[BrainRegionFEC_FT_ACC_SH|FEC.FT.ACC.SH]] || Nucleus Accumbens Shell || nucleus-nucleus-gaba || [http://www.expertsmind.com/topic/emotion/affective-basal-ganglia-circuit-93570.aspx Affective basal ganglia circuit (NACC -> nBM, abstract)]
+|  ||  || [[BrainRegionFEC_FT_ACC_SH|FEC.FT.ACC.SH]] || Nucleus Accumbens Shell || nucleus-nucleus-gaba || uncertain || [http://www.expertsmind.com/topic/emotion/affective-basal-ganglia-circuit-93570.aspx Affective basal ganglia circuit (NACC -> nBM, abstract)]
 |-
-|  || [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]] || [[BrainRegionFEC_HT_TG_IPD|FEC.HT.TG.IPD]] || Interpeduncular Nucleus || nucleus-nucleus-ACh || [http://www.scholarpedia.org/article/Head_direction_cells Head Direction Cell Circuit (IPD -> DTN)]
+|  || [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]] || [[BrainRegionFEC_HT_TG_IPD|FEC.HT.TG.IPD]] || Interpeduncular Nucleus || nucleus-nucleus-ACh || uncertain || [http://www.scholarpedia.org/article/Head_direction_cells Head Direction Cell Circuit (IPD -> DTN)]
 |-
-|  ||  || [[BrainRegionFEC_HT_TG_RMTG|FEC.HT.TG.RMTG]] || Rostromedial Tegmental Nucleus || nucleus-nucleus-gaba || (unknown reference)
+|  ||  || [[BrainRegionFEC_HT_TG_RMTG|FEC.HT.TG.RMTG]] || Rostromedial Tegmental Nucleus || nucleus-nucleus-gaba || uncertain || (unknown reference)
 |-
-|  || [[BrainRegionLMC_HT_TG_PPN|LMC.HT.TG.PPN]] || [[BrainRegionFEC_FT_VP_VM|FEC.FT.VP.VM]] || Ventral Pallidum Ventromedial || nucleus-nucleus-gaba || [http://www.impulsecontroldisorders.org/html/cravings.html Combining Novelty, Motivational Salience, and Reward to Control Attention and Learning (VPAL -> PPTG, abstract)]
+|  || [[BrainRegionLMC_HT_TG_PPN|LMC.HT.TG.PPN]] || [[BrainRegionFEC_FT_VP_VM|FEC.FT.VP.VM]] || Ventral Pallidum Ventromedial || nucleus-nucleus-gaba || uncertain || [http://www.impulsecontroldisorders.org/html/cravings.html Combining Novelty, Motivational Salience, and Reward to Control Attention and Learning (VPAL -> PPTG, abstract)]
 |-
-| [[BrainAreaFMM|FMM]] || [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]] || [[BrainRegionFMM_FD_MB_LMB|FMM.FD.MB.LMB]] || Lateral Mammillary Nucleus || nucleus-nucleus || [http://www.scholarpedia.org/article/Head_direction_cells Head Direction Cell Circuit (LMB -> DTN)]
+| [[BrainAreaFMM|FMM]] || [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]] || [[BrainRegionFMM_FD_MB_LMB|FMM.FD.MB.LMB]] || Lateral Mammillary Nucleus || nucleus-nucleus || uncertain || [http://www.scholarpedia.org/article/Head_direction_cells Head Direction Cell Circuit (LMB -> DTN)]
 |-
-| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]] || [[BrainRegionLAC_FD_HT_VLPO|LAC.FD.HT.VLPO]] || Ventrolateral Preoptic Nucleus || nucleus-nucleus || [http://www.nature.com/neuro/journal/v5/n10/fig_tab/nn913_F1.html Simplified NREM sleep-promoting pathway (VLPO -> LDTg)]
+| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]] || [[BrainRegionLAC_FD_HT_VLPO|LAC.FD.HT.VLPO]] || Ventrolateral Preoptic Nucleus || nucleus-nucleus || uncertain || [http://www.nature.com/neuro/journal/v5/n10/fig_tab/nn913_F1.html Simplified NREM sleep-promoting pathway (VLPO -> LDTg)]
 |-
-| [[BrainAreaLRC|LRC]] || [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]] || [[BrainRegionLRC_HL_NPH|LRC.HL.NPH]] || Prepositus Nucleus || nucleus-nucleus || (unknown reference)
+| [[BrainAreaLRC|LRC]] || [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]] || [[BrainRegionLRC_HL_NPH|LRC.HL.NPH]] || Prepositus Nucleus || nucleus-nucleus || uncertain || (unknown reference)
 |}
@@ Line 186: / Line 186: @@
 {| class=wikitable width=80%
-| '''Target Area''' || '''Local Region''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Reference'''
+| '''Target Area''' || '''Local Region''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Role''' || '''Reference'''
 |-
-| <font color="red">Cortical</font> || || || || ||
+| <font color="red">Cortical</font> || || || || || ||
 |-
-| [[BrainAreaNDM|NDM]] || [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]] || [[BrainRegionNDM_NC_AL_FPC|NDM.NC.AL.FPC]] || Lateral Frontopolar Cortex || nucleus-neocortex-ACh || [http://www.intechopen.com/books/computational-intelligence-in-electromyography-analysis-a-perspective-on-current-applications-and-future-challenges/sphincter-emg-for-diagnosing-multiple-system-atrophy-and-related-disorders Physiology and pathophysiology of lower urinary tract (NBM -> MPFC, abstract)]
+| [[BrainAreaNDM|NDM]] || [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]] || [[BrainRegionNDM_NC_AL_FPC|NDM.NC.AL.FPC]] || Lateral Frontopolar Cortex || nucleus-neocortex-ACh || uncertain || [http://www.intechopen.com/books/computational-intelligence-in-electromyography-analysis-a-perspective-on-current-applications-and-future-challenges/sphincter-emg-for-diagnosing-multiple-system-atrophy-and-related-disorders Physiology and pathophysiology of lower urinary tract (NBM -> MPFC, abstract)]
 |-
-| [[BrainAreaNSA|NSA]] || [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]] || [[BrainRegionNSA_NC_OCC_V1|NSA.NC.OCC.V1]] || Primary Visual Cortex || nucleus-neocortex-ACh || (unknown reference)
+| [[BrainAreaNSA|NSA]] || [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]] || [[BrainRegionNSA_NC_OCC_V1|NSA.NC.OCC.V1]] || Primary Visual Cortex || nucleus-neocortex-ACh || uncertain || (unknown reference)
 |-
-|  || [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]] || [[BrainRegionNSA_FD_TH_SG|NSA.FD.TH.SG]] || Suprageniculate Nucleus of Thalamus || nucleus-nucleus-ACh || [http://www.scholarpedia.org/article/Head_direction_cells Head Direction Cell Circuit (DTN -> SUPGEN)]
+|  || [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]] || [[BrainRegionNSA_FD_TH_SG|NSA.FD.TH.SG]] || Suprageniculate Nucleus of Thalamus || nucleus-nucleus-ACh || uncertain || [http://www.scholarpedia.org/article/Head_direction_cells Head Direction Cell Circuit (DTN -> SUPGEN)]
 |-
-|  || [[BrainRegionLMC_HT_TG_PPN|LMC.HT.TG.PPN]] || [[BrainRegionNSA_FD_LGN|NSA.FD.LGN]] || Lateral Geniculate Nucleus || nucleus-nucleus || [http://www.sciencedirect.com/science/article/pii/S0387760401003308 Geniculate and Extyrageniculate Paths (PPN -> LGN)]
+|  || [[BrainRegionLMC_HT_TG_PPN|LMC.HT.TG.PPN]] || [[BrainRegionNSA_FD_LGN|NSA.FD.LGN]] || Lateral Geniculate Nucleus || nucleus-nucleus || uncertain || [http://www.sciencedirect.com/science/article/pii/S0387760401003308 Geniculate and Extyrageniculate Paths (PPN -> LGN)]
 |-
-| <font color="red">Subcortical</font> || || || || ||
+| <font color="red">Subcortical</font> || || || || || ||
 |-
-| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]] || [[BrainRegionFAM_FT_AM_BM|FAM.FT.AM.BM]] || Magnocellular Basal Amygdaloid Nucleus || nucleus-nucleus-ACh || (unknown reference)
+| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]] || [[BrainRegionFAM_FT_AM_BM|FAM.FT.AM.BM]] || Magnocellular Basal Amygdaloid Nucleus || nucleus-nucleus-ACh || uncertain || (unknown reference)
 |-
-| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]] || [[BrainRegionFEC_HT_TG_IPD|FEC.HT.TG.IPD]] || Interpeduncular Nucleus || nucleus-nucleus-ACh || (unknown reference)
+| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]] || [[BrainRegionFEC_HT_TG_IPD|FEC.HT.TG.IPD]] || Interpeduncular Nucleus || nucleus-nucleus-ACh || uncertain || (unknown reference)
 |-
-|  || [[BrainRegionLMC_HT_TG_PPN|LMC.HT.TG.PPN]] || [[BrainRegionFEC_FD_STN_MED|FEC.FD.STN.MED]] || Subthalamic Nucleus Medial || nucleus-nucleus-ACh || [http://www.endurance-education.com/endurance-education-com/does-only-our-brainstem-select-our-motor-programs Summary of the organization of the substantia nigra pars reticulata and pedunculopontine nucleus in lamprey (PPN -> STN, abstract)]
+|  || [[BrainRegionLMC_HT_TG_PPN|LMC.HT.TG.PPN]] || [[BrainRegionFEC_FD_STN_MED|FEC.FD.STN.MED]] || Subthalamic Nucleus Medial || nucleus-nucleus-ACh || uncertain || [http://www.endurance-education.com/endurance-education-com/does-only-our-brainstem-select-our-motor-programs Summary of the organization of the substantia nigra pars reticulata and pedunculopontine nucleus in lamprey (PPN -> STN, abstract)]
 |-
-|  ||  || [[BrainRegionFEC_FT_SNR_DL|FEC.FT.SNR.DL]] || Substantia Nigra Pars Reticulata Dorsolateral || nucleus-nucleus-ACh || [http://www.endurance-education.com/endurance-education-com/does-only-our-brainstem-select-our-motor-programs Summary of the organization of the substantia nigra pars reticulata and pedunculopontine nucleus in lamprey (PPN -> SNr, abstract)]
+|  ||  || [[BrainRegionFEC_FT_SNR_DL|FEC.FT.SNR.DL]] || Substantia Nigra Pars Reticulata Dorsolateral || nucleus-nucleus-ACh || uncertain || [http://www.endurance-education.com/endurance-education-com/does-only-our-brainstem-select-our-motor-programs Summary of the organization of the substantia nigra pars reticulata and pedunculopontine nucleus in lamprey (PPN -> SNr, abstract)]
 |-
-| [[BrainAreaFMM|FMM]] || [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]] || [[BrainRegionFMM_FD_MB_LMB|FMM.FD.MB.LMB]] || Lateral Mammillary Nucleus || nucleus-nucleus-ACh || [http://ahuman.org/svn/ahengine/research/articles/2009-Hippocampus-Thesis.pdf Hippocampal Formation (DTN -> LMam)]
+| [[BrainAreaFMM|FMM]] || [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]] || [[BrainRegionFMM_FD_MB_LMB|FMM.FD.MB.LMB]] || Lateral Mammillary Nucleus || nucleus-nucleus-ACh || uncertain || [http://ahuman.org/svn/ahengine/research/articles/2009-Hippocampus-Thesis.pdf Hippocampal Formation (DTN -> LMam)]
 |-
-| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]] || [[BrainRegionLAC_HL_SAL_ISL|LAC.HL.SAL.ISL]] || Inferior Salivatory Nucleus || nucleus-nucleus-ACh || (unknown reference)
+| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]] || [[BrainRegionLAC_HL_SAL_ISL|LAC.HL.SAL.ISL]] || Inferior Salivatory Nucleus || nucleus-nucleus-ACh || uncertain || (unknown reference)
 |-
-|  ||  || [[BrainRegionLAC_HL_SAL_SSL|LAC.HL.SAL.SSL]] || Superior Salivatory Nucleus || nucleus-nucleus-ACh || (unknown reference)
+|  ||  || [[BrainRegionLAC_HL_SAL_SSL|LAC.HL.SAL.SSL]] || Superior Salivatory Nucleus || nucleus-nucleus-ACh || uncertain || (unknown reference)
 |-
-| [[BrainAreaLRC|LRC]] || [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]] || [[BrainRegionLRC_HL_NPH|LRC.HL.NPH]] || Prepositus Nucleus || nucleus-nucleus-ACh || [http://www.scholarpedia.org/article/Head_direction_cells Head Direction Cell Circuit (DTN -> NPRP)]
+| [[BrainAreaLRC|LRC]] || [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]] || [[BrainRegionLRC_HL_NPH|LRC.HL.NPH]] || Prepositus Nucleus || nucleus-nucleus-ACh || uncertain || [http://www.scholarpedia.org/article/Head_direction_cells Head Direction Cell Circuit (DTN -> NPRP)]
 |-
-|  || [[BrainRegionLMC_HT_TG_PPN|LMC.HT.TG.PPN]] || [[BrainRegionLRC_MM_SC_INT|LRC.MM.SC.INT]] || Intermediate Superior Colliculus || nucleus-nucleus || [http://www.sciencedirect.com/science/article/pii/S0387760401003308 Geniculate and Extyrageniculate Paths (PPN -> SC, abstract)]
+|  || [[BrainRegionLMC_HT_TG_PPN|LMC.HT.TG.PPN]] || [[BrainRegionLRC_MM_SC_INT|LRC.MM.SC.INT]] || Intermediate Superior Colliculus || nucleus-nucleus || uncertain || [http://www.sciencedirect.com/science/article/pii/S0387760401003308 Geniculate and Extyrageniculate Paths (PPN -> SC, abstract)]
 |}
@@ Line 225: / Line 225: @@
 {| class=wikitable width=80%
-| '''Component ID''' || '''Component Name''' || '''Type''' || '''Service''' || '''Function''' || '''Comments'''
+| '''Component ID''' || '''Component Name''' || '''Type''' || '''Service''' || '''Function''' || '''Comments''' || '''Quality'''
 |-
-| [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || Ventral Tegmental Area || nucleus || LUS || Respond to novel stimuli, unexpected rewards, and reward predictive sensory cues ||
+| [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || Ventral Tegmental Area || nucleus || LUS || Respond to novel stimuli, unexpected rewards, and reward predictive sensory cues ||  || L0
 |}
@@ Line 236: / Line 236: @@
 {| class=wikitable width=80%
-| '''Source Area''' || '''Local Region''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Reference'''
+| '''Source Area''' || '''Local Region''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Role''' || '''Reference'''
 |-
-| <font color="red">Subcortical</font> || || || || ||
+| <font color="red">Subcortical</font> || || || || || ||
 |-
-| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || nucleus-nucleus || [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> VTA)]
+| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || nucleus-nucleus || uncertain || [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> VTA)]
 |-
-|  ||  || [[BrainRegionFAM_FT_BNST|FAM.FT.BNST]] || Bed Nucleus of Stria Terminalis || nucleus-nucleus || (unknown reference)
+|  ||  || [[BrainRegionFAM_FT_BNST|FAM.FT.BNST]] || Bed Nucleus of Stria Terminalis || nucleus-nucleus || uncertain || (unknown reference)
 |-
-| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionFEC_FT_ACC_CORE|FEC.FT.ACC.CORE]] || Nucleus Accumbens Core || nucleus-nucleus-gaba || [http://neurowiki2012.wikispaces.com/Presynaptic+Mechanisms+of+Synaptic+Plasticity Reward circuit of human brain (NACC -> VTA, abstract)]
+| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionFEC_FT_ACC_CORE|FEC.FT.ACC.CORE]] || Nucleus Accumbens Core || nucleus-nucleus-gaba || uncertain || [http://neurowiki2012.wikispaces.com/Presynaptic+Mechanisms+of+Synaptic+Plasticity Reward circuit of human brain (NACC -> VTA, abstract)]
 |-
-|  ||  || [[BrainRegionFEC_FT_VP_VM|FEC.FT.VP.VM]] || Ventral Pallidum Ventromedial || nucleus-nucleus-gaba || [http://www.impulsecontroldisorders.org/html/cravings.html Craving (VPAL -> VTA, abstract)]
+|  ||  || [[BrainRegionFEC_FT_VP_VM|FEC.FT.VP.VM]] || Ventral Pallidum Ventromedial || nucleus-nucleus-gaba || uncertain || [http://www.impulsecontroldisorders.org/html/cravings.html Craving (VPAL -> VTA, abstract)]
 |-
-|  ||  || [[BrainRegionFEC_HT_TG_IPD|FEC.HT.TG.IPD]] || Interpeduncular Nucleus || nucleus-nucleus-ACh || [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (IPN -> VTA)]
+|  ||  || [[BrainRegionFEC_HT_TG_IPD|FEC.HT.TG.IPD]] || Interpeduncular Nucleus || nucleus-nucleus-ACh || uncertain || [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (IPN -> VTA)]
 |-
-|  ||  || [[BrainRegionFEC_HT_TG_RMTG|FEC.HT.TG.RMTG]] || Rostromedial Tegmental Nucleus || nucleus-nucleus-gaba || [http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin Amygdala and its network (RMTG -> VTA)]
+|  ||  || [[BrainRegionFEC_HT_TG_RMTG|FEC.HT.TG.RMTG]] || Rostromedial Tegmental Nucleus || nucleus-nucleus-gaba || uncertain || [http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin Amygdala and its network (RMTG -> VTA)]
 |-
-| [[BrainAreaLPC|LPC]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionLPC_HL_SOL|LPC.HL.SOL]] || Solitary Nucleus || nucleus-nucleus || [http://www.nature.com/nrendo/journal/v6/n8/fig_tab/nrendo.2010.93_F1.html Bowels control brain: gut hormones and obesity (NTS -> VTA)]
+| [[BrainAreaLPC|LPC]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionLPC_HL_SOL|LPC.HL.SOL]] || Solitary Nucleus || nucleus-nucleus || uncertain || [http://www.nature.com/nrendo/journal/v6/n8/fig_tab/nrendo.2010.93_F1.html Bowels control brain: gut hormones and obesity (NTS -> VTA)]
 |}
@@ Line 258: / Line 258: @@
 {| class=wikitable width=80%
-| '''Target Area''' || '''Local Region''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Reference'''
+| '''Target Area''' || '''Local Region''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Role''' || '''Reference'''
 |-
-| <font color="red">Cortical</font> || || || || ||
+| <font color="red">Cortical</font> || || || || || ||
 |-
-| [[BrainAreaNDM|NDM]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionNDM_NC_AL_DACG|NDM.NC.AL.DACG]] || Dorsal Anterior Cingulate Area || nucleus-neocortex-DA || (unknown reference)
+| [[BrainAreaNDM|NDM]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionNDM_NC_AL_DACG|NDM.NC.AL.DACG]] || Dorsal Anterior Cingulate Area || nucleus-neocortex-DA || uncertain || (unknown reference)
 |-
-|  ||  || [[BrainRegionNDM_NC_AL_FPC|NDM.NC.AL.FPC]] || Lateral Frontopolar Cortex || nucleus-neocortex-DA || [http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin Amygdala and its network (VTA -> MPFC, abstract)]
+|  ||  || [[BrainRegionNDM_NC_AL_FPC|NDM.NC.AL.FPC]] || Lateral Frontopolar Cortex || nucleus-neocortex-DA || uncertain || [http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin Amygdala and its network (VTA -> MPFC, abstract)]
 |-
-| <font color="red">Subcortical</font> || || || || ||
+| <font color="red">Subcortical</font> || || || || || ||
 |-
-| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionFAM_FT_AM_CEC|FAM.FT.AM.CEC]] || Central Amygdaloid Nucleus, capsular subdivision || nucleus-nucleus-DA || [http://neurowiki2012.wikispaces.com/Presynaptic+Mechanisms+of+Synaptic+Plasticity Reward circuit of human brain (VTA -> AM, abstract)]
+| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionFAM_FT_AM_CEC|FAM.FT.AM.CEC]] || Central Amygdaloid Nucleus, capsular subdivision || nucleus-nucleus-DA || uncertain || [http://neurowiki2012.wikispaces.com/Presynaptic+Mechanisms+of+Synaptic+Plasticity Reward circuit of human brain (VTA -> AM, abstract)]
 |-
-| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionFEC_FT_ACC_SH|FEC.FT.ACC.SH]] || Nucleus Accumbens Shell || nucleus-nucleus-DA || [http://www.impulsecontroldisorders.org/html/cravings.html Craving (VTA -> NACC, abstract)]
+| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionFEC_FT_ACC_SH|FEC.FT.ACC.SH]] || Nucleus Accumbens Shell || nucleus-nucleus-DA || uncertain || [http://www.impulsecontroldisorders.org/html/cravings.html Craving (VTA -> NACC, abstract)]
 |-
-|  ||  || [[BrainRegionFEC_FT_PU_LT|FEC.FT.PU.LT]] || Dorsal Putamen Lateral || nucleus-nucleus-DA || [http://www.nature.com/nrendo/journal/v6/n8/fig_tab/nrendo.2010.93_F1.html Bowels control brain: gut hormones and obesity (VTA -> DS, abstract)]
+|  ||  || [[BrainRegionFEC_FT_PU_LT|FEC.FT.PU.LT]] || Dorsal Putamen Lateral || nucleus-nucleus-DA || uncertain || [http://www.nature.com/nrendo/journal/v6/n8/fig_tab/nrendo.2010.93_F1.html Bowels control brain: gut hormones and obesity (VTA -> DS, abstract)]
 |-
-|  ||  || [[BrainRegionFEC_FT_PU_MED|FEC.FT.PU.MED]] || Dorsal Putamen Medial || nucleus-nucleus-DA || [http://www.nature.com/nrendo/journal/v6/n8/fig_tab/nrendo.2010.93_F1.html Bowels control brain: gut hormones and obesity (VTA -> DS, abstract)]
+|  ||  || [[BrainRegionFEC_FT_PU_MED|FEC.FT.PU.MED]] || Dorsal Putamen Medial || nucleus-nucleus-DA || uncertain || [http://www.nature.com/nrendo/journal/v6/n8/fig_tab/nrendo.2010.93_F1.html Bowels control brain: gut hormones and obesity (VTA -> DS, abstract)]
 |-
-| [[BrainAreaFMM|FMM]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionFMM_FD_MB_MMB|FMM.FD.MB.MMB]] || Medial Mammillary Nucleus || nucleus-nucleus-DA || [http://www.nature.com/nrn/journal/v5/n1/fig_tab/nrn1299_F2.html Mammillary bodies: two memory systems in one (VTN -> MMB)]
+| [[BrainAreaFMM|FMM]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionFMM_FD_MB_MMB|FMM.FD.MB.MMB]] || Medial Mammillary Nucleus || nucleus-nucleus-DA || uncertain || [http://www.nature.com/nrn/journal/v5/n1/fig_tab/nrn1299_F2.html Mammillary bodies: two memory systems in one (VTN -> MMB)]
 |-
-|  ||  || [[BrainRegionFMM_FT_HC_CA1D|FMM.FT.HC.CA1D]] || Distal CA1 of Hippocampus || nucleus-allocortex-DA || [http://neurowiki2012.wikispaces.com/Presynaptic+Mechanisms+of+Synaptic+Plasticity Reward circuit of human brain (VTA -> HC, abstract)]
+|  ||  || [[BrainRegionFMM_FT_HC_CA1D|FMM.FT.HC.CA1D]] || Distal CA1 of Hippocampus || nucleus-allocortex-DA || uncertain || [http://neurowiki2012.wikispaces.com/Presynaptic+Mechanisms+of+Synaptic+Plasticity Reward circuit of human brain (VTA -> HC, abstract)]
 |-
-|  ||  || [[BrainRegionFMM_NC_PH_LEC|FMM.NC.PH.LEC]] || Lateral Entorhinal Cortex || nucleus-neocortex-DA || [http://www.impulsecontroldisorders.org/html/cravings.html Combining Novelty, Motivational Salience, and Reward to Control Attention and Learning (VTA -> EC, abstract)]
+|  ||  || [[BrainRegionFMM_NC_PH_LEC|FMM.NC.PH.LEC]] || Lateral Entorhinal Cortex || nucleus-neocortex-DA || uncertain || [http://www.impulsecontroldisorders.org/html/cravings.html Combining Novelty, Motivational Salience, and Reward to Control Attention and Learning (VTA -> EC, abstract)]
 |-
-| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionLAC_FD_HT_PRM|LAC.FD.HT.PRM]] || Premammillary Nucleus || nucleus-nucleus-DA || (unknown reference)
+| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionLAC_FD_HT_PRM|LAC.FD.HT.PRM]] || Premammillary Nucleus || nucleus-nucleus-DA || uncertain || (unknown reference)
 |-
-|  ||  || [[BrainRegionLAC_FD_HT_PV|LAC.FD.HT.PV]] || Paraventricular Nucleus || nucleus-nucleus-DA || [http://www.intechopen.com/books/computational-intelligence-in-electromyography-analysis-a-perspective-on-current-applications-and-future-challenges/sphincter-emg-for-diagnosing-multiple-system-atrophy-and-related-disorders Physiology and pathophysiology of lower urinary tract (VTA -> PVN)]
+|  ||  || [[BrainRegionLAC_FD_HT_PV|LAC.FD.HT.PV]] || Paraventricular Nucleus || nucleus-nucleus-DA || uncertain || [http://www.intechopen.com/books/computational-intelligence-in-electromyography-analysis-a-perspective-on-current-applications-and-future-challenges/sphincter-emg-for-diagnosing-multiple-system-atrophy-and-related-disorders Physiology and pathophysiology of lower urinary tract (VTA -> PVN)]
 |}
@@ Line 293: / Line 293: @@
 {| class=wikitable width=80%
-| '''Component ID''' || '''Component Name''' || '''Type''' || '''Service''' || '''Function''' || '''Comments'''
+| '''Component ID''' || '''Component Name''' || '''Type''' || '''Service''' || '''Function''' || '''Comments''' || '''Quality'''
 |-
-| [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || Periaqueductal Gray Matter || nucleus || LUS || Descending modulation of pain and in defensive behaviour || if there is a lesion in the PAG, then consciousness<BR>is lost; electrical stimulation of the PAG results<BR>in immediate and profound analgesia; modulatory<BR>nucleus
+| [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || Periaqueductal Gray Matter || nucleus || LUS || Descending modulation of pain and in defensive behaviour ||  || L0
 |}
@@ Line 304: / Line 304: @@
 {| class=wikitable width=80%
-| '''Source Area''' || '''Local Region''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Reference'''
+| '''Source Area''' || '''Local Region''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Role''' || '''Reference'''
 |-
-| <font color="red">Cortical</font> || || || || ||
+| <font color="red">Cortical</font> || || || || || ||
 |-
-| [[BrainAreaNCP|NCP]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionNCP_NC_AL_SGCG|NCP.NC.AL.SGCG]] || Subgenual Cingulate Cortex || neocortex-nucleus || (unknown reference)
+| [[BrainAreaNCP|NCP]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionNCP_NC_AL_SGCG|NCP.NC.AL.SGCG]] || Subgenual Cingulate Cortex || neocortex-nucleus || uncertain || (unknown reference)
 |-
-| <font color="red">Subcortical</font> || || || || ||
+| <font color="red">Subcortical</font> || || || || || ||
 |-
-| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionFAM_FT_AM_CEM|FAM.FT.AM.CEM]] || Medial Central Amygdaloid Nucleus || nucleus-nucleus || [http://neuropolitics.org/defaultmay10.asp Amygdalar disruption of prefrontal cortex (AM -> PAG, abstract)]
+| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionFAM_FT_AM_CEM|FAM.FT.AM.CEM]] || Medial Central Amygdaloid Nucleus || nucleus-nucleus || uncertain || [http://neuropolitics.org/defaultmay10.asp Amygdalar disruption of prefrontal cortex (AM -> PAG, abstract)]
 |-
-| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionFEC_HT_TG_IPD|FEC.HT.TG.IPD]] || Interpeduncular Nucleus || nucleus-nucleus-ACh || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (IPN -> PAG)]
+| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionFEC_HT_TG_IPD|FEC.HT.TG.IPD]] || Interpeduncular Nucleus || nucleus-nucleus-ACh || uncertain || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (IPN -> PAG)]
 |}
@@ Line 320: / Line 320: @@
 {| class=wikitable width=80%
-| '''Target Area''' || '''Local Region''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Reference'''
+| '''Target Area''' || '''Local Region''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Role''' || '''Reference'''
 |-
-| <font color="red">Cortical</font> || || || || ||
+| <font color="red">Cortical</font> || || || || || ||
 |-
-| [[BrainAreaNDM|NDM]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionNDM_FD_TH_PV|NDM.FD.TH.PV]] || Paraventricular Nucleus of Thalamus || nucleus-nucleus-ENK || (unknown reference)
+| [[BrainAreaNDM|NDM]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionNDM_FD_TH_PV|NDM.FD.TH.PV]] || Paraventricular Nucleus of Thalamus || nucleus-nucleus-ENK || uncertain || (unknown reference)
 |-
-| <font color="red">Subcortical</font> || || || || ||
+| <font color="red">Subcortical</font> || || || || || ||
 |-
-| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionLAC_HT_BR|LAC.HT.BR]] || Barrington's Nucleus || nucleus-nucleus-ENK || [http://jp.physoc.org/content/557/1/287/F9.expansion.html Schematic overview of spinobulbospinal micturition reflex pathway (PAG -> BAR)]
+| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionLAC_HT_BR|LAC.HT.BR]] || Barrington's Nucleus || nucleus-nucleus-ENK || uncertain || [http://jp.physoc.org/content/557/1/287/F9.expansion.html Schematic overview of spinobulbospinal micturition reflex pathway (PAG -> BAR)]
 |-
-| [[BrainAreaLLC|LLC]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionLLC_FD_TH_SF|LLC.FD.TH.SF]] || Subfascicular Nucleus of Thalamus || nucleus-nucleus-ENK || (unknown reference)
+| [[BrainAreaLLC|LLC]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionLLC_FD_TH_SF|LLC.FD.TH.SF]] || Subfascicular Nucleus of Thalamus || nucleus-nucleus-ENK || uncertain || (unknown reference)
 |-
-| [[BrainAreaLMC|LMC]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || Raphe Magnus Nucleus || nucleus-nucleus-ENK || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (PAG -> Raphe, abstract)]
+| [[BrainAreaLMC|LMC]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || Raphe Magnus Nucleus || nucleus-nucleus-ENK || uncertain || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (PAG -> Raphe, abstract)]
 |-
-|  ||  || [[BrainRegionLMC_HL_RP_PL|LMC.HL.RP.PL]] || Raphe Pallidus Nucleus || nucleus-nucleus-ENK || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (PAG -> Raphe, abstract)]
+|  ||  || [[BrainRegionLMC_HL_RP_PL|LMC.HL.RP.PL]] || Raphe Pallidus Nucleus || nucleus-nucleus-ENK || uncertain || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (PAG -> Raphe, abstract)]
 |-
-| [[BrainAreaLPC|LPC]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionLPC_HL_AMB|LPC.HL.AMB]] || Ambiguus Nucleus || nucleus-nucleus-ENK || (unknown reference)
+| [[BrainAreaLPC|LPC]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionLPC_HL_AMB|LPC.HL.AMB]] || Ambiguus Nucleus || nucleus-nucleus-ENK || uncertain || (unknown reference)
 |-
-| [[BrainAreaLRC|LRC]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionLRC_HL_RA|LRC.HL.RA]] || Retroambigualis Nucleus || nucleus-nucleus-ENK || (unknown reference)
+| [[BrainAreaLRC|LRC]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionLRC_HL_RA|LRC.HL.RA]] || Retroambigualis Nucleus || nucleus-nucleus-ENK || uncertain || (unknown reference)
 |-
-|  ||  || [[BrainRegionLRC_HT_NSC|LRC.HT.NSC]] || Nucleus Subceruleus || nucleus-nucleus-ENK || (unknown reference)
+|  ||  || [[BrainRegionLRC_HT_NSC|LRC.HT.NSC]] || Nucleus Subceruleus || nucleus-nucleus-ENK || uncertain || (unknown reference)
 |}
@@ Line 349: / Line 349: @@
 {| class=wikitable width=80%
-| '''Component ID''' || '''Component Name''' || '''Type''' || '''Service''' || '''Function''' || '''Comments'''
+| '''Component ID''' || '''Component Name''' || '''Type''' || '''Service''' || '''Function''' || '''Comments''' || '''Quality'''
 |-
-| [[BrainRegionLMC_HT_LC|LMC.HT.LC]] || Locus Coeruleus || nucleus || LUS || Regulate the intensity of responses to salient stimuli || NE Source, enhance signal-to-noise ratio,<BR>suppressing irrelevant stimuli (lateral<BR>inhibition); inhibitory nucleus
+| [[BrainRegionLMC_HT_LC|LMC.HT.LC]] || Locus Coeruleus || nucleus || LUS || Regulate the intensity of responses to salient stimuli, arousal and autonomic<BR>activity ||  || L0
 |}
@@ Line 360: / Line 360: @@
 {| class=wikitable width=80%
-| '''Source Area''' || '''Local Region''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Reference'''
+| '''Source Area''' || '''Local Region''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Role''' || '''Reference'''
 |-
-| <font color="red">Cortical</font> || || || || ||
+| <font color="red">Cortical</font> || || || || || ||
 |-
-| [[BrainAreaNDM|NDM]] || [[BrainRegionLMC_HT_LC|LMC.HT.LC]] || [[BrainRegionNDM_NC_AL_VACG|NDM.NC.AL.VACG]] || Ventral Anterior Cingulate Area || neocortex-nucleus || (unknown reference)
+| [[BrainAreaNDM|NDM]] || [[BrainRegionLMC_HT_LC|LMC.HT.LC]] || [[BrainRegionNDM_NC_AL_VACG|NDM.NC.AL.VACG]] || Ventral Anterior Cingulate Area || neocortex-nucleus || uncertain || (unknown reference)
 |-
-| <font color="red">Subcortical</font> || || || || ||
+| <font color="red">Subcortical</font> || || || || || ||
 |-
-| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_HT_LC|LMC.HT.LC]] || [[BrainRegionFAM_FT_AM_CEM|FAM.FT.AM.CEM]] || Medial Central Amygdaloid Nucleus || nucleus-nucleus || [http://neuropolitics.org/defaultmay10.asp Amygdalar disruption of prefrontal cortex (AM -> LC, abstract)]
+| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_HT_LC|LMC.HT.LC]] || [[BrainRegionFAM_FT_AM_CEM|FAM.FT.AM.CEM]] || Medial Central Amygdaloid Nucleus || nucleus-nucleus || uncertain || [http://neuropolitics.org/defaultmay10.asp Amygdalar disruption of prefrontal cortex (AM -> LC, abstract)]
 |-
-|  ||  || [[BrainRegionFAM_FT_BNST|FAM.FT.BNST]] || Bed Nucleus of Stria Terminalis || nucleus-nucleus || (unknown reference)
+|  ||  || [[BrainRegionFAM_FT_BNST|FAM.FT.BNST]] || Bed Nucleus of Stria Terminalis || nucleus-nucleus || uncertain || (unknown reference)
 |-
-| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_HT_LC|LMC.HT.LC]] || [[BrainRegionLAC_FD_HT_DM|LAC.FD.HT.DM]] || Dorsomedial Hypothalamic Nucleus || nucleus-nucleus || [http://journal.frontiersin.org/article/10.3389/fnint.2012.00094/full Effect of light on pupil diameter (DMH -> LC)]
+| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_HT_LC|LMC.HT.LC]] || [[BrainRegionLAC_FD_HT_DM|LAC.FD.HT.DM]] || Dorsomedial Hypothalamic Nucleus || nucleus-nucleus || uncertain || [http://journal.frontiersin.org/article/10.3389/fnint.2012.00094/full Effect of light on pupil diameter (DMH -> LC)]
 |-
-|  ||  || [[BrainRegionLAC_FD_HT_TBM|LAC.FD.HT.TBM]] || Tuberomammillary Nucleus || nucleus-nucleus || (unknown reference)
+|  ||  || [[BrainRegionLAC_FD_HT_TBM|LAC.FD.HT.TBM]] || Tuberomammillary Nucleus || nucleus-nucleus || uncertain || (unknown reference)
 |-
-| [[BrainAreaLRC|LRC]] || [[BrainRegionLMC_HT_LC|LMC.HT.LC]] || [[BrainRegionLRC_HL_RF_MED|LRC.HL.RF.MED]] || Central Medullary Reticular Nucleus || nucleus-nucleus || (unknown reference)
+| [[BrainAreaLRC|LRC]] || [[BrainRegionLMC_HT_LC|LMC.HT.LC]] || [[BrainRegionLRC_HL_RF_MED|LRC.HL.RF.MED]] || Central Medullary Reticular Nucleus || nucleus-nucleus || uncertain || (unknown reference)
 |}
@@ Line 382: / Line 382: @@
 {| class=wikitable width=80%
-| '''Target Area''' || '''Local Region''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Reference'''
+| '''Target Area''' || '''Local Region''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Role''' || '''Reference'''
 |-
-| <font color="red">Subcortical</font> || || || || ||
+| <font color="red">Subcortical</font> || || || || || ||
 |-
-| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_HT_LC|LMC.HT.LC]] || [[BrainRegionFAM_FD_LHB_LT|FAM.FD.LHB.LT]] || Lateral Habenula Lateral Part || nucleus-nucleus-NE || [http://www.nature.com/nrn/journal/v11/n6/fig_tab/nrn2849_F7.html Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract)]
+| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_HT_LC|LMC.HT.LC]] || [[BrainRegionFAM_FD_LHB_LT|FAM.FD.LHB.LT]] || Lateral Habenula Lateral Part || nucleus-nucleus-NE || uncertain || [http://www.nature.com/nrn/journal/v11/n6/fig_tab/nrn2849_F7.html Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract)]
 |-
-|  ||  || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || nucleus-nucleus-NE || [http://www.nature.com/nrn/journal/v11/n6/fig_tab/nrn2849_F7.html Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract)]
+|  ||  || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || nucleus-nucleus-NE || uncertain || [http://www.nature.com/nrn/journal/v11/n6/fig_tab/nrn2849_F7.html Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract)]
 |-
-|  ||  || [[BrainRegionFAM_FD_MHB|FAM.FD.MHB]] || Medial Habenula || nucleus-nucleus-NE || [http://www.nature.com/nrn/journal/v11/n6/fig_tab/nrn2849_F7.html Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> MHB)]
+|  ||  || [[BrainRegionFAM_FD_MHB|FAM.FD.MHB]] || Medial Habenula || nucleus-nucleus-NE || uncertain || [http://www.nature.com/nrn/journal/v11/n6/fig_tab/nrn2849_F7.html Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> MHB)]
 |-
-|  ||  || [[BrainRegionFAM_FT_SEP_DBB|FAM.FT.SEP.DBB]] || Diagonal Band of Broca || nucleus-nucleus-NE || (unknown reference)
+|  ||  || [[BrainRegionFAM_FT_SEP_DBB|FAM.FT.SEP.DBB]] || Diagonal Band of Broca || nucleus-nucleus-NE || uncertain || (unknown reference)
 |-
-| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_HT_LC|LMC.HT.LC]] || [[BrainRegionFEC_FT_SNC_MED|FEC.FT.SNC.MED]] || Substantia Nigra Pars Compacta Medial || nucleus-nucleus-NE || (unknown reference)
+| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_HT_LC|LMC.HT.LC]] || [[BrainRegionFEC_FT_SNC_MED|FEC.FT.SNC.MED]] || Substantia Nigra Pars Compacta Medial || nucleus-nucleus-NE || uncertain || (unknown reference)
 |-
-|  ||  || [[BrainRegionFEC_HT_TG_IPD|FEC.HT.TG.IPD]] || Interpeduncular Nucleus || nucleus-nucleus-NE || [http://www.nature.com/nrn/journal/v11/n6/fig_tab/nrn2849_F7.html Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> IPN)]
+|  ||  || [[BrainRegionFEC_HT_TG_IPD|FEC.HT.TG.IPD]] || Interpeduncular Nucleus || nucleus-nucleus-NE || uncertain || [http://www.nature.com/nrn/journal/v11/n6/fig_tab/nrn2849_F7.html Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> IPN)]
 |-
-| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_HT_LC|LMC.HT.LC]] || [[BrainRegionLAC_FD_HT_VLPO|LAC.FD.HT.VLPO]] || Ventrolateral Preoptic Nucleus || nucleus-nucleus-NE || [http://www.nature.com/neuro/journal/v5/n10/fig_tab/nn913_F1.html Simplified NREM sleep-promoting pathway (LC -> VLPO)]
+| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_HT_LC|LMC.HT.LC]] || [[BrainRegionLAC_FD_HT_VLPO|LAC.FD.HT.VLPO]] || Ventrolateral Preoptic Nucleus || nucleus-nucleus-NE || uncertain || [http://www.nature.com/neuro/journal/v5/n10/fig_tab/nn913_F1.html Simplified NREM sleep-promoting pathway (LC -> VLPO)]
 |-
-|  ||  || [[BrainRegionLAC_SC_IZ_CSC|LAC.SC.IZ.CSC]] || Ciliospinal Center || nucleus-nucleus-NE || [http://journal.frontiersin.org/article/10.3389/fnint.2012.00094/full Effect of light on pupil diameter (LC -> IML)]
+|  ||  || [[BrainRegionLAC_SC_IZ_CSC|LAC.SC.IZ.CSC]] || Ciliospinal Center || nucleus-nucleus-NE || uncertain || [http://journal.frontiersin.org/article/10.3389/fnint.2012.00094/full Effect of light on pupil diameter (LC -> IML)]
 |-
-|  ||  || [[BrainRegionLAC_SC_IZ_IML|LAC.SC.IZ.IML]] || Intermediolateral Nucleus || nucleus-nucleus-NE || [http://www.intechopen.com/books/computational-intelligence-in-electromyography-analysis-a-perspective-on-current-applications-and-future-challenges/sphincter-emg-for-diagnosing-multiple-system-atrophy-and-related-disorders Physiology and pathophysiology of lower urinary tract (LC -> IML)]
+|  ||  || [[BrainRegionLAC_SC_IZ_IML|LAC.SC.IZ.IML]] || Intermediolateral Nucleus || nucleus-nucleus-NE || uncertain || [http://www.intechopen.com/books/computational-intelligence-in-electromyography-analysis-a-perspective-on-current-applications-and-future-challenges/sphincter-emg-for-diagnosing-multiple-system-atrophy-and-related-disorders Physiology and pathophysiology of lower urinary tract (LC -> IML)]
 |}