BrainRegionLMC HT TG LDT
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Laterodorsal Tegmental Nucleus
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This page covers biological details of component Laterodorsal Tegmental Nucleus. Region is part of aHuman target integrated biological model.
- Top-down path to region: Hindbrain Metencephalon -> Pontine Tegmental Nuclei (HT.TG) -> Laterodorsal Tegmental Nucleus (LMC.HT.TG.LDT) (see Mind Maps)
- Type: nucleus
- Quality: L0
- Brain area: Lower Brain - Modulatory Contol Area (LMC)
- Area circuit: Acetylcholine - PNS Actions and CNS plasticity, arousal and reward (ACH)
- Role: processor.autonomic
- Function: Modulating sustained attention or in mediating alerting responses
- Notes to function:
- sleep, waking, motor function, learning and reward
(generated)
Components
(generated)
Component items:
- Lateral Tegmental Nucleus
- Dorsal Tegmental Nucleus (LMC.HT.TG.DTG): accurate landmark navigation
- Dorsal Tegmental Nucleus Pars Dorsalis
- Dorsal Tegmental Nucleus Pars Ventralis
Connectivity
(generated)
Inbound Region Connections:
| Source Area | Source Region | Source Name | Type | Role | Reference |
| FAM | FAM.FD.LHB.MED | Lateral Habenula Medial Part | excitatory-glu | uncertain | Regulation of the rapid eye movement (REM) sleep by habenular projection (LHbM -> DTG) |
| FEC | FEC.HT.TG.IPD | Interpeduncular Nucleus | modulatory-ach | uncertain | Head Direction Cell Circuit (IPD -> DTN) |
| FEC.HT.TG.RMTG | Rostromedial Tegmental Nucleus | inhibitory-gaba | uncertain | (unknown reference) | |
| FMM | FMM.FD.MB.LMB | Lateral Mammillary Nucleus | excitatory-glu | uncertain | Head Direction Cell Circuit (LMB -> DTN) |
| LAC | LAC.FD.HT.VLPO | Ventrolateral Preoptic Nucleus | excitatory-glu | uncertain | Simplified NREM sleep-promoting pathway (VLPO -> LDTg) |
| LRC | LRC.HL.NPH | Prepositus Nucleus | excitatory-glu | uncertain | (unknown reference) |
| NSA | NSA.FD.TH.SG | Suprageniculate Nucleus of Thalamus | excitatory-glu | uncertain | (unknown reference) |
Outbound Region Connections:
| Target Area | Target Region | Target Name | Type | Role | Reference |
| FEC | FEC.HT.TG.IPD | Interpeduncular Nucleus | modulatory-ach | uncertain | (unknown reference) |
| FMM | FMM.FD.MB.LMB | Lateral Mammillary Nucleus | modulatory-ach | uncertain | Hippocampal Formation (DTN -> LMam) |
| LAC | LAC.HL.SAL.ISL | Inferior Salivatory Nucleus | modulatory-ach | uncertain | (unknown reference) |
| LAC.HL.SAL.SSL | Superior Salivatory Nucleus | modulatory-ach | uncertain | (unknown reference) | |
| LRC | LRC.HL.NPH | Prepositus Nucleus | modulatory-ach | uncertain | Head Direction Cell Circuit (DTN -> NPRP) |
| NSA | NSA.FD.TH.SG | Suprageniculate Nucleus of Thalamus | modulatory-ach | uncertain | Head Direction Cell Circuit (DTN -> SUPGEN) |
Thirdparty Circuits
(generated)
- Hippocampal Formation - see Reference (CT.HIPPOCAMPAL-FORMATION)
ATN=Anterior Nucleus of Thalamus,FD.TH.AN (see Cognitive Thalamus) CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (see Hippocampal Formation) CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (see Hippocampal Formation) DG=Dentate Gyrus,FMM.FT.HC.DG DTN=Laterodorsal Tegmental Nucleus,LMC.HT.TG.LDT EC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex) LDN=Lateral Dorsal Nucleus of Thalamus,FMM.FD.TH.LD LMam=Lateral Mammillary Nucleus,FMM.FD.MB.LMB PoS=Postsubiculum,FMM.NC.PH.POS Rsp=Retrosplenial Cortex,NCP.NC.MPL.RSC Sub=Subiculum,FMM.FT.HF.SUB (see Hippocampal Formation)
- Head Direction Cell Circuit - see Reference (CT.HEAD-DIRECTION)
AD=Anterodorsal Nucleus,FMM.FD.TH.AD DTN=Laterodorsal Tegmental Nucleus,LMC.HT.TG.DTG EC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex) HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation) IPD=Interpeduncular Nucleus,FEC.HT.TG.IPD LD=Lateral Dorsal Nucleus of Thalamus,FMM.FD.TH.LD LHAB=Habenula,FAM.FD.HB LMB=Lateral Mammillary Nucleus,FMM.FD.MB.LMB MVSN=Medial Vestibular Nucleus,LPC.HT.MVBN NPRP=Prepositus Nucleus,LRC.HL.NPH PC=Parietal Lobe,NC.LOBE.PAR PRHC=Postrhinal Cortex,FMM.NC.PH.POR PSUB=Postsubiculum,FMM.NC.PH.POS RSP=Retrosplenial Cortex,NCP.NC.MPL.RSC SUPGEN=Suprageniculate Nucleus of Thalamus,NSA.FD.TH.SG VC=Occipital Lobe,NC.LOBE.OCC
- Regulation of the rapid eye movement (REM) sleep by habenular projection - see Reference (CF.REM-HB)
DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB DTG=Laterodorsal Tegmental Nucleus,LMC.HT.TG.DTG EPN=Endopiriform Nucleus,FAM.FT.EPF GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia) LHT=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN LHbL=Lateral Habenula Lateral Part,FAM.FD.LHB.LT LHbM=Lateral Habenula Medial Part,FAM.FD.LHB.MED NI=Incertus Nucleus,FAM.HT.TG.NI RMTg=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation) SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia) VTA=Ventral Tegmental Area,LMC.MM.VTA VTG=Ventral Tegmental Area,LMC.MM.VTG
- Mammillary bodies: two memory systems in one - see Reference (CT.MB-MEMORY)
ADTH=Anterodorsal Nucleus,FMM.FD.TH.AD AMTH=Anteromedial Nucleus,NCP.FD.TH.AM AVTH=Anteroventral Nucleus,FMM.FD.TH.AV DTN=Laterodorsal Tegmental Nucleus,LMC.HT.TG.LDT LMB=Lateral Mammillary Nucleus,FMM.FD.MB.LMB MMB=Medial Mammillary Nucleus,FMM.FD.MB.MMB MedialEC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex) PAS=Parasubiculum,FMM.NC.PH.PAS POS=Postsubiculum,FMM.NC.PH.POS PRS=Presubiculum,FMM.NC.PH.PRS SEP=Septal Nuclei,FAM.FT.SEP SUB=Subiculum,FMM.FT.HF.SUB (see Hippocampal Formation) SupraMM=Supramammillary Nucleus,LAC.FD.HT.SUM TuberoMM=Lateral Tuberal Nuclei,LAC.FD.HT.LTUB (see Hypothalamus) VTN=Ventral Tegmental Area,LMC.MM.VTA
- Simplified NREM sleep-promoting pathway - see Reference (CL.TBM-PO)
LC=Locus Coeruleus,LMC.HT.LC LDTg=Laterodorsal Tegmental Nucleus,LMC.HT.TG.LDT TMN=Tuberomammillary Nucleus,LAC.FD.HT.TBM VLPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO
References
(generated)
