BrainRegionFAM FD LHB MED

Lateral Habenula Medial Part

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This page covers biological details of component Lateral Habenula Medial Part. Region is part of aHuman target integrated biological model.

• Top-down path to region: Forebrain Diencephalon -> Habenula (FAM.FD.HB) -> Lateral Habenula (FAM.FD.LHB) -> Lateral Habenula Medial Part (FAM.FD.LHB.MED) (see Mind Maps)
• Type: nucleus
• Quality: L0
• Brain area: Forebrain - Affective Motivations Area (FAM)
• Area circuit: Acquisition of Avoidance Responses (FAMXAA)
• Role: processor.affective.avoidance
• Function: Encoding negative feedback, direct, Septal

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Components

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• no child items defined

Connectivity

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Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Role	Reference
FAM	FAM.FD.MHB	Medial Habenula	excitatory-glu	uncertain	Connectivity map of the habenula (M -> L, abstract)
	FAM.FT.SEP.DBB	Diagonal Band of Broca	inhibitory-gaba	uncertain	Both LHb and MHb control the dopaminergic and serotonergic systems (DBB -> LHbM)
	FAM.FT.SEP.LT	Lateral Septal Nucleus	inhibitory-gaba	uncertain	Both LHb and MHb control the dopaminergic and serotonergic systems (LS -> LHbM)
FEC	FEC.FT.VP.VM	Ventral Pallidum Ventromedial	inhibitory-gaba	uncertain	Both LHb and MHb control the dopaminergic and serotonergic systems (VP -> LHbM, abstract)
LAC	LAC.FD.HT.LTN	Lateral Hypothalamic Nucleus	excitatory-glu	uncertain	Both LHb and MHb control the dopaminergic and serotonergic systems (LHA -> LHbM)
	LAC.FD.HT.VLPO	Ventrolateral Preoptic Nucleus	excitatory-glu	uncertain	Both LHb and MHb control the dopaminergic and serotonergic systems (LPO -> LHbM)
LMC	LMC.HT.LC	Locus Coeruleus	modulatory-ne	uncertain	Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Role	Reference
FAM	FAM.HT.TG.NI	Incertus Nucleus	excitatory-glu	uncertain	Regulation of the rapid eye movement (REM) sleep by habenular projection (LHbM -> NI)
FEC	FEC.FT.SNC.LT	Substantia Nigra Pars Compacta Lateral	excitatory-glu	uncertain	Habenula Connections (LHb -> SNc, abstract)
	FEC.HT.TG.RMTG	Rostromedial Tegmental Nucleus	excitatory-glu	uncertain	Regulation of the rapid eye movement (REM) sleep by habenular projection (LHbM -> RMTg)
LMC	LMC.HL.RP.MG	Raphe Magnus Nucleus	excitatory-glu	uncertain	Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> MRN, abstract)
	LMC.HT.TG.LDT	Laterodorsal Tegmental Nucleus	excitatory-glu	uncertain	Regulation of the rapid eye movement (REM) sleep by habenular projection (LHbM -> DTG)
	LMC.MM.RP.DRN	Dorsal Raphe Nucleus	excitatory-glu	uncertain	Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> DRN)
	LMC.MM.RP.SUC	Superior Central Raphe Nucleus	excitatory-glu	uncertain	Habenula Connections (LHb -> MR, abstract)
	LMC.MM.VTA	Ventral Tegmental Area	excitatory-glu	uncertain	Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> VTA)

Thirdparty Circuits

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• Regulation of the rapid eye movement (REM) sleep by habenular projection - see Reference (CF.REM-HB)

DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB
DTG=Laterodorsal Tegmental Nucleus,LMC.HT.TG.DTG
EPN=Endopiriform Nucleus,FAM.FT.EPF
GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia)
LHT=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
LHbL=Lateral Habenula Lateral Part,FAM.FD.LHB.LT
LHbM=Lateral Habenula Medial Part,FAM.FD.LHB.MED
NI=Incertus Nucleus,FAM.HT.TG.NI
RMTg=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG
Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation)
SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia)
VTA=Ventral Tegmental Area,LMC.MM.VTA
VTG=Ventral Tegmental Area,LMC.MM.VTG

• Both LHb and MHb control the dopaminergic and serotonergic systems - see Reference (CF.HB-DA5HT)

DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB
DRN=Dorsal Raphe Nucleus,LMC.MM.RP.DRN
GPb=Dorsal Pallidum,FEC.FT.DP (see Basal Ganglia)
IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD
LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
LHbL=Lateral Habenula Lateral Part,FAM.FD.LHB.LT
LHbM=Lateral Habenula Medial Part,FAM.FD.LHB.MED
LPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO
LS=Lateral Septal Nucleus,FAM.FT.SEP.LT
MHb=Medial Habenula,FAM.FD.MHB
MRN=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation)
MS=Medial Septal Nucleus,FAM.FT.SEP.MED
PS=Posterior Septal Group,FAM.FT.SEP.PG (see Septal Nuclei)
RMTg=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG
SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia)
VP=Ventral Pallidum,FEC.FT.VP (see Basal Ganglia)
VTA=Ventral Tegmental Area,LMC.MM.VTA

• Habenula Connections - see Reference (CF.HB-CONNECTIONS)

CPu=Striatum,FEC.FT.ST (see Basal Ganglia)
DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB
DR=Dorsal Raphe Nucleus,LMC.MM.RP.DRN
GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia)
IP=Interpeduncular Nucleus,FEC.HT.TG.IPD
LH=Lateral Hypothalamic Area,LAC.FD.HT.LT (see Hypothalamus)
LHb=Lateral Habenula,FAM.FD.LHB (see Habenula)
LPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO
MHb=Medial Habenula,FAM.FD.MHB
MR=Superior Central Raphe Nucleus,LMC.MM.RP.SUC
PB=Endocrine Glands,TARGET.TEA.ENDOCRINE
S=Septal Nuclei,FAM.FT.SEP
SNc=Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT
VTA=Ventral Tegmental Area,LMC.MM.VTA

References

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• http://journal.frontiersin.org/article/10.3389/fnhum.2013.00826/full
• http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html
• http://www.scholarpedia.org/article/Habenula