BrainRegionLMC MM RP DRN
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Dorsal Raphe Nucleus
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This page covers biological details of component Dorsal Raphe Nucleus. Region is part of aHuman target integrated biological model.
- Top-down path to region: Midbrain Mesencephalon -> Mesencephalic Reticular Formation (MM.RF) -> Mesencephalic Reticular Formation, Midline Column (MM.RF.MID) -> Dorsal Raphe Nucleus (LMC.MM.RP.DRN) (see Mind Maps)
- Type: nucleus
- Quality: L0
- Brain area: Lower Brain - Modulatory Contol Area (LMC)
- Area circuit: Serotonin - Feelings of Well-Being and Happiness (5HT)
- Role: processor.autonomic
- Function: Regulation of sleep and mood
- Notes to function:
- Major source of 5HT
- inhibitory nucleus
(generated)
Components
(generated)
Component items:
- Serotonergic cell group B7
Connectivity
(generated)
Inbound Region Connections:
| Source Area | Source Region | Source Name | Type | Role | Reference |
| FAM | FAM.FD.LHB.MED | Lateral Habenula Medial Part | excitatory-glu | uncertain | Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> DRN) |
| FEC | FEC.HT.TG.IPD | Interpeduncular Nucleus | modulatory-ach | uncertain | Both LHb and MHb control the dopaminergic and serotonergic systems (IPN -> DRN) |
| FEC.HT.TG.RMTG | Rostromedial Tegmental Nucleus | inhibitory-gaba | uncertain | Both LHb and MHb control the dopaminergic and serotonergic systems (RMTg -> DRN) | |
| LLC | LLC.FD.TH.SF | Subfascicular Nucleus of Thalamus | inhibitory-gaba | uncertain | (unknown reference) |
| LMC | LMC.HP.RP.LI | Raphe Nucleus Linearis | modulatory-5ht | uncertain | (unknown reference) |
Outbound Region Connections:
| Target Area | Target Region | Target Name | Type | Role | Reference |
| NDM | NDM.FD.TH.PV | Paraventricular Nucleus of Thalamus | modulatory-5ht | uncertain | (unknown reference) |
Thirdparty Circuits
(generated)
- Both LHb and MHb control the dopaminergic and serotonergic systems - see Reference (CF.HB-DA5HT)
DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB DRN=Dorsal Raphe Nucleus,LMC.MM.RP.DRN GPb=Dorsal Pallidum,FEC.FT.DP (see Basal Ganglia) IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN LHbL=Lateral Habenula Lateral Part,FAM.FD.LHB.LT LHbM=Lateral Habenula Medial Part,FAM.FD.LHB.MED LPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO LS=Lateral Septal Nucleus,FAM.FT.SEP.LT MHb=Medial Habenula,FAM.FD.MHB MRN=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation) MS=Medial Septal Nucleus,FAM.FT.SEP.MED PS=Posterior Septal Group,FAM.FT.SEP.PG (see Septal Nuclei) RMTg=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia) VP=Ventral Pallidum,FEC.FT.VP (see Basal Ganglia) VTA=Ventral Tegmental Area,LMC.MM.VTA
- Habenula Connections - see Reference (CF.HB-CONNECTIONS)
CPu=Striatum,FEC.FT.ST (see Basal Ganglia) DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB DR=Dorsal Raphe Nucleus,LMC.MM.RP.DRN GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia) IP=Interpeduncular Nucleus,FEC.HT.TG.IPD LH=Lateral Hypothalamic Area,LAC.FD.HT.LT (see Hypothalamus) LHb=Lateral Habenula,FAM.FD.LHB (see Habenula) LPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO MHb=Medial Habenula,FAM.FD.MHB MR=Superior Central Raphe Nucleus,LMC.MM.RP.SUC PB=Endocrine Glands,TARGET.TEA.ENDOCRINE S=Septal Nuclei,FAM.FT.SEP SNc=Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT VTA=Ventral Tegmental Area,LMC.MM.VTA
References
(generated)
