BrainRegionFAM FT SEP MED
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Medial Septal Nucleus
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This page covers biological details of component Medial Septal Nucleus. Region is part of aHuman target integrated biological model.
- Top-down path to region: Forebrain Telencephalon -> Extended Amygdala (FAM.FT.EXTAM) -> Septal Nuclei (FAM.FT.SEP) -> Dorsal Septal Nucleus (FAM.FT.SEP.DS) -> Medial Septal Group (FAM.FT.SEP.MG) -> Medial Septal Nucleus (FAM.FT.SEP.MED) (see Mind Maps)
- Type: nucleus
- Quality: L0
- Brain area: Forebrain - Affective Motivations Area (FAM)
- Area circuit: Memory Formation Affective Focus (FAMXMF)
- Role: processor.affective.memory
- Function: affect HC for spatial learning, generation of theta waves
- Notes to function:
- output nucleus
- projections from AM and HC overlap
- control theta rythm and exprolatory behavior
- from/to MFB to fornix fimbria
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Components
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- no child items defined
Connectivity
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Inbound Region Connections:
| Source Area | Source Region | Source Name | Type | Role | Reference |
| LAC | LAC.FD.HT.SUM | Supramammillary Nucleus | excitatory-glu | uncertain | Medial mammillary nucleus and theta rhythm (SupraMM -> SEP, abstract) |
Outbound Region Connections:
| Target Area | Target Region | Target Name | Type | Role | Reference |
| FAM | FAM.FD.MHB | Medial Habenula | modulatory-ach | uncertain | Both LHb and MHb control the dopaminergic and serotonergic systems (MS -> MHb) |
| FEC | FEC.FD.TH.PF | Parafascicular Nucleus of Thalamus | modulatory-ach | uncertain | (unknown reference) |
| FMM | FMM.FD.MB.LMB | Lateral Mammillary Nucleus | modulatory-ach | uncertain | Cingulate Gyrus (SEP -> HT, abstract) |
| FMM.FD.MB.MMB | Medial Mammillary Nucleus | inhibitory-gaba | uncertain | Cingulate Gyrus (SEP -> HT, abstract) | |
| NCP | NCP.NC.MPL.RSC | Retrosplenial Cortex | modulatory-ach | uncertain | Medial mammillary nucleus and theta rhythm (SEP -> RSP, abstract) |
| NDM | NDM.FD.TH.MDM | Medial Mediodorsal Nucleus of Thalamus | modulatory-ach | uncertain | Thalamocortical relationships (s1MD -> MD, abstract) |
Thirdparty Circuits
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- Medial mammillary nucleus and theta rhythm - see Reference (CT.MMB-THETA)
AVTH=Anteroventral Nucleus,FMM.FD.TH.AV HF=Hippocampal Formation,FMM.FT.HF MMB=Medial Mammillary Nucleus,FMM.FD.MB.MMB RSP=Retrosplenial Cortex,NCP.NC.MPL.RSC SEP=Septal Nuclei,FAM.FT.SEP SupraMM=Supramammillary Nucleus,LAC.FD.HT.SUM VTN=Ventral Tegmental Area,LMC.MM.VTA
- Cingulate Gyrus - see Reference (CT.CINGULATE-CORTEX)
CG=Posterior Cingulate Cortex,NCP.NC.MPL.PSCG ET=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex) HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation) HT=Hypothalamus,FD.HT MB=Mammillary Body,FD.MB (see Hypothalamus) SEP=Septal Nuclei,FAM.FT.SEP TH=Anterior Nucleus of Thalamus,FD.TH.AN (see Cognitive Thalamus)
- Thalamocortical relationships - see Reference (CL.THALAMUS-PROJECTIONS)
A=Anterior Nucleus of Thalamus,FD.TH.AN (see Cognitive Thalamus) CM=Centromedian Nucleus of Thalamus,FEC.FD.TH.CM LD=Lateral Dorsal Nucleus of Thalamus,FMM.FD.TH.LD LGN=Lateral Geniculate Nucleus,NSA.FD.LGN LP=Lateral Posterior Nucleus of Thalamus,NPE.FD.TH.LP MD=Mediodorsal Nucleus of Thalamus,FD.TH.MD (see Cognitive Thalamus) MGN=Medial Geniculate Body,NSA.FD.TH.MGB P=Ventral Posterior Nuclei,NSA.FD.TH.VP (see Sensory Thalamus) VA=Ventral Anterior Nucleus,NMA.FD.TH.VA VL=Ventral Lateral Nucleus,NMA.FD.TH.VL VPL=Ventral Posterolateral Nucleus,NCP.FD.TH.VPL VPM=Ventral Posteromedial Nucleus,NCP.FD.TH.VPM pA=Posterior Cingulate Cortex,NCP.NC.MPL.PSCG pCM=Dorsal Putamen,FEC.FT.DPU (see Basal Ganglia) pLD=Anterior Cingulate Cortex,NC.AL.ACG (see Anterior Cingulate Area) pLGN=Primary Visual Cortex,NSA.NC.OCC.V1 pLP=Superior Parietal Lobule,NC.SPL pMD=Prefrontal Cortex,NC.AL.PFC pMGN=Primary Auditory Cortex,NSA.NC.TTG.A1 pP=Insular Cortex,NC.INS pVA=Supplementary Motor Cortex,NMA.NC.SMC pVL=Motor Cortex,NMA.NC.MC pVPL=Primary Somatosensory Cortex,NCP.NC.PG.S1 pVPM=Precentral Cortex,NCP.NC.PO.PCC s1A=Subiculum,FMM.FT.HF.SUB (see Hippocampal Formation) s1MD=Septal Nuclei,FAM.FT.SEP s1P=Central Cervical Nucleus,LPC.SC.IZ.CCV s1VL=Dentate Nucleus,LLC.HT.CR.DN s2A=Mammillary Body,FD.MB (see Hypothalamus) s2MD=Piriform Cortex,NSA.NC.PH.PIR s2P=Principal Trigeminal Nucleus,LPC.HT.PN.PTR s2VL=Basal Ganglia,FEC.FT.BG s3MD=Prefrontal Cortex,NC.AL.PFC sCM=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia) sLD=Superior Parietal Lobule,NC.SPL sLP=Superior Colliculus,MM.SC (see Reflexes Nuclei of Midbrain Mesencephalon) sVA=Basal Ganglia,FEC.FT.BG sVPL=Marginal Nucleus,LPC.SC.PH.MG (see Posterior/Dorsal Horn) sVPM=Solitary Nucleus,LPC.HL.SOL
- Both LHb and MHb control the dopaminergic and serotonergic systems - see Reference (CF.HB-DA5HT)
DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB DRN=Dorsal Raphe Nucleus,LMC.MM.RP.DRN GPb=Dorsal Pallidum,FEC.FT.DP (see Basal Ganglia) IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN LHbL=Lateral Habenula Lateral Part,FAM.FD.LHB.LT LHbM=Lateral Habenula Medial Part,FAM.FD.LHB.MED LPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO LS=Lateral Septal Nucleus,FAM.FT.SEP.LT MHb=Medial Habenula,FAM.FD.MHB MRN=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation) MS=Medial Septal Nucleus,FAM.FT.SEP.MED PS=Posterior Septal Group,FAM.FT.SEP.PG (see Septal Nuclei) RMTg=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia) VP=Ventral Pallidum,FEC.FT.VP (see Basal Ganglia) VTA=Ventral Tegmental Area,LMC.MM.VTA
References
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