BrainRegionFAM FD LHB LT
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Lateral Habenula Lateral Part
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This page covers biological details of component Lateral Habenula Lateral Part. Region is part of aHuman target integrated biological model.
- Top-down path to region: Forebrain Diencephalon -> Habenula (FAM.FD.HB) -> Lateral Habenula (FAM.FD.LHB) -> Lateral Habenula Lateral Part (FAM.FD.LHB.LT) (see Mind Maps)
- Type: nucleus
- Quality: L0
- Brain area: Forebrain - Affective Motivations Area (FAM)
- Area circuit: Acquisition of Avoidance Responses (FAMXAA)
- Role: processor.affective.avoidance
- Function: Encoding negative feedback, direct, Pallidal
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Components
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- no child items defined
Connectivity
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Inbound Region Connections:
| Source Area | Source Region | Source Name | Type | Role | Reference |
| FAM | FAM.FT.EPF | Endopiriform Nucleus | excitatory-glu | uncertain | Regulation of the rapid eye movement (REM) sleep by habenular projection (EPN -> LHbL) |
| FEC | FEC.FT.ACC.CORE | Nucleus Accumbens Core | inhibitory-gaba | uncertain | Connectivity map of the habenula (NAc -> L, abstract) |
| FEC.FT.GPI.DS | Globus Pallidus Internal Dorsal | inhibitory-gaba | uncertain | Habenula Connections (GPi -> LHb, abstract) | |
| LAC | LAC.FD.HT.LTN | Lateral Hypothalamic Nucleus | excitatory-glu | uncertain | Regulation of the rapid eye movement (REM) sleep by habenular projection (LHT -> LHbL) |
| LAC.FD.HT.VLPO | Ventrolateral Preoptic Nucleus | excitatory-glu | uncertain | Habenula Connections (LPO -> LHb, abstract) | |
| LMC | LMC.HT.LC | Locus Coeruleus | modulatory-ne | uncertain | Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract) |
Outbound Region Connections:
| Target Area | Target Region | Target Name | Type | Role | Reference |
| FEC | FEC.HT.TG.RMTG | Rostromedial Tegmental Nucleus | excitatory-glu | uncertain | Both LHb and MHb control the dopaminergic and serotonergic systems (LHbL -> RMTg) |
Thirdparty Circuits
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- Both LHb and MHb control the dopaminergic and serotonergic systems - see Reference (CF.HB-DA5HT)
DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB DRN=Dorsal Raphe Nucleus,LMC.MM.RP.DRN GPb=Dorsal Pallidum,FEC.FT.DP (see Basal Ganglia) IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN LHbL=Lateral Habenula Lateral Part,FAM.FD.LHB.LT LHbM=Lateral Habenula Medial Part,FAM.FD.LHB.MED LPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO LS=Lateral Septal Nucleus,FAM.FT.SEP.LT MHb=Medial Habenula,FAM.FD.MHB MRN=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation) MS=Medial Septal Nucleus,FAM.FT.SEP.MED PS=Posterior Septal Group,FAM.FT.SEP.PG (see Septal Nuclei) RMTg=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia) VP=Ventral Pallidum,FEC.FT.VP (see Basal Ganglia) VTA=Ventral Tegmental Area,LMC.MM.VTA
- Regulation of the rapid eye movement (REM) sleep by habenular projection - see Reference (CF.REM-HB)
DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB DTG=Laterodorsal Tegmental Nucleus,LMC.HT.TG.DTG EPN=Endopiriform Nucleus,FAM.FT.EPF GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia) LHT=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN LHbL=Lateral Habenula Lateral Part,FAM.FD.LHB.LT LHbM=Lateral Habenula Medial Part,FAM.FD.LHB.MED NI=Incertus Nucleus,FAM.HT.TG.NI RMTg=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation) SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia) VTA=Ventral Tegmental Area,LMC.MM.VTA VTG=Ventral Tegmental Area,LMC.MM.VTG
References
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