BrainRegionLMC HT LC

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Locus Coeruleus

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This page covers biological details of component Locus Coeruleus. Region is part of aHuman target integrated biological model.

  • Top-down path to region: Hindbrain Metencephalon -> Locus Coeruleus (LMC.HT.LC) (see Mind Maps)
  • Type: nucleus
  • Quality: L0
  • Brain area: Lower Brain - Modulatory Contol Area (LMC)
  • Area circuit: Norepinephrine - Vigilant Concentration, Stress Hormone, Fight-or-Flight Response (NE)
  • Role: processor.autonomic
  • Function: Regulate the intensity of responses to salient stimuli, arousal and autonomic activity
  • Notes to function:
    • NE Source, enhance signal-to-noise ratio, suppressing irrelevant stimuli (lateral inhibition)
    • inhibitory nucleus
    • wakefulness-promoting nucleus, enhancement of alertness, increase in sympathetic activity and a decrease in parasympathetic activity, to all neocortex, medial septal area, medial preoptic area and substantia innominata, central and basal amygdala, dorsal thalamus

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Components

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  • no child items defined

Connectivity

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LMC.HT.LC.dot.png

Inbound Region Connections:

Source Area Source Region Source Name Type Role Reference
FAM FAM.FT.AM.CEM Medial Central Amygdaloid Nucleus excitatory-glu uncertain Amygdalar disruption of prefrontal cortex (AM -> LC, abstract)
FAM.FT.BNST Bed Nucleus of Stria Terminalis excitatory-glu uncertain (unknown reference)
LAC LAC.FD.HT.DM Dorsomedial Hypothalamic Nucleus excitatory-glu uncertain Effect of light on pupil diameter (DMH -> LC)
LAC.FD.HT.TBM Tuberomammillary Nucleus excitatory-glu uncertain (unknown reference)
LRC LRC.HL.RF.MED Central Medullary Reticular Nucleus excitatory-glu uncertain (unknown reference)
NDM NDM.NC.AL.VACG Ventral Anterior Cingulate Area excitatory-glu uncertain (unknown reference)

Outbound Region Connections:

Target Area Target Region Target Name Type Role Reference
FAM FAM.FD.LHB.LT Lateral Habenula Lateral Part modulatory-ne uncertain Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract)
FAM.FD.LHB.MED Lateral Habenula Medial Part modulatory-ne uncertain Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract)
FAM.FD.MHB Medial Habenula modulatory-ne uncertain Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> MHB)
FAM.FT.SEP.DBB Diagonal Band of Broca modulatory-ne uncertain (unknown reference)
FEC FEC.FT.SNC.MED Substantia Nigra Pars Compacta Medial modulatory-ne uncertain (unknown reference)
FEC.HT.TG.IPD Interpeduncular Nucleus modulatory-ne uncertain Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> IPN)
LAC LAC.FD.HT.VLPO Ventrolateral Preoptic Nucleus modulatory-ne uncertain Simplified NREM sleep-promoting pathway (LC -> VLPO)
LAC.SC.IZ.CSC Ciliospinal Center modulatory-ne uncertain Effect of light on pupil diameter (LC -> IML)
LAC.SC.IZ.IML Intermediolateral Nucleus modulatory-ne uncertain Physiology and pathophysiology of lower urinary tract (LC -> IML)

Thirdparty Circuits

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DMH=Dorsomedial Hypothalamic Nucleus,LAC.FD.HT.DM
EW=Edinger-Westphal Nucleus,LAC.MM.EWN
EYE=Eye,TARGET.TSA.EYE
GC=Ciliary Ganglion,LAC.PN.PSYM.CLG
IML=Ciliospinal Center,LAC.SC.IZ.CSC
LC=Locus Coeruleus,LMC.HT.LC
OPN=Pretectal Olivary Nucleus,LRC.MM.PT.PON
PVN=Paraventricular Nucleus,LAC.FD.HT.PV
RET=Retinal Nucleus,LPC.FD.RT
SCG=Superior Cervical Ganglion,LAC.PN.SYM.SCG
SCN=Suprachiasmatic Nucleus,LAC.FD.HT.SCN


CN=Caudate Nucleus,FEC.FT.CN (see Basal Ganglia)
DVM=Vagus Nucleus,LAC.HL.VGN
IMG=Inferior Mesenteric Ganglion,LAC.PN.SYM.IMG
IML=Intermediolateral Nucleus,LAC.SC.IZ.IML
LC=Locus Coeruleus,LMC.HT.LC
MPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
MPOA=Median Preoptic Nucleus,LAC.FD.HT.MPO
NBM=Basal Nucleus of Meynert,LMC.FT.NBM
ONF=Onuf's Nucleus,LPC.SC.VH.ONF
PBN=Parabrachial Nucleus,LPC.HT.PRF.PB
PEL=Pelvic Peripheral Ganglion,LAC.PN.PSYM.PPG
PU=Dorsal Putamen Lateral,FEC.FT.PU.LT
PVN=Paraventricular Nucleus,LAC.FD.HT.PV
SNC=Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT
SPS=Sacral Parasympathetic Nucleus,LAC.SC.IZ.SPS
VTA=Ventral Tegmental Area,LMC.MM.VTA
ZI=Subthalamic Nucleus Caudal,BGA.FD.STN.ZI


IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD
LC=Locus Coeruleus,LMC.HT.LC
LHB=Lateral Habenula,FAM.FD.LHB (see Habenula)
MHB=Medial Habenula,FAM.FD.MHB


LC=Locus Coeruleus,LMC.HT.LC
LDTg=Laterodorsal Tegmental Nucleus,LMC.HT.TG.LDT
TMN=Tuberomammillary Nucleus,LAC.FD.HT.TBM
VLPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO


ACG=Anterior Cingulate Cortex,NC.AL.ACG (see Anterior Cingulate Area)
AM=Amygdala,FAM.FT.AM
HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
HT.L=Lateral Hypothalamic Area,LAC.FD.HT.LT (see Hypothalamus)
HT.PV=Paraventricular Nucleus,LAC.FD.HT.PV
INS=Insular Cortex,NC.INS
LC=Locus Coeruleus,LMC.HT.LC
MPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
PB=Parabrachial Nucleus,LPC.HT.PRF.PB
PUT=Endocrine Glands,TARGET.TEA.ENDOCRINE
SOL=Solitary Nucleus,LPC.HL.SOL
TH=Thalamus,FD.TH


References

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