BrainRegionFEC FT SNC LT

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Substantia Nigra Pars Compacta Lateral

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This page covers biological details of component Substantia Nigra Pars Compacta Lateral. Region is part of aHuman target integrated biological model.

  • Top-down path to region: Forebrain Telencephalon -> Basal Ganglia (FEC.FT.BG) -> Substantia Nigra (FEC.FT.SN) -> Substantia Nigra Pars Compacta (FEC.FT.SNC) -> Substantia Nigra Pars Compacta Lateral (FEC.FT.SNC.LT) (see Mind Maps)
  • Type: nucleus
  • Quality: L0
  • Brain area: Forebrain - Execution Control Area (FEC)
  • Area circuit: Executive/Cognitive Loop (FECEXE)
  • Role: basal.ganglia.nigracompacta
  • Function: executive loop
  • Notes to function:
    • DP, dorsal circuits

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Components

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  • no child items defined

Connectivity

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FEC.FT.SNC.LT.dot.png

Inbound Region Connections:

Source Area Source Region Source Name Type Role Reference
FAM FAM.FD.LHB.MED Lateral Habenula Medial Part excitatory-glu uncertain Habenula Connections (LHb -> SNc, abstract)
FEC FEC.FT.CN.HD Caudate Nucleus Head inhibitory-gaba uncertain Saccades and smooth movements (CN -> SN, abstract)
FEC.FT.GPI.DS Globus Pallidus Internal Dorsal inhibitory-gaba uncertain Prefrontal Cortex (PFC) in motor behavior (GP -> SN, abstract)
FEC.FT.SNR.DL Substantia Nigra Pars Reticulata Dorsolateral inhibitory-gaba uncertain Oculomotor decision-making (SNr -> SNc)
FEC.FT.SNR.RM Substantia Nigra Pars Reticulata Rostromedial inhibitory-gaba uncertain (unknown reference)
FEC.HT.TG.IPD Interpeduncular Nucleus modulatory-ach uncertain Both LHb and MHb control the dopaminergic and serotonergic systems (IPN -> SNc, abstract)
LRC LRC.MM.SC.DEEP Deep Superior Colliculus excitatory-glu uncertain Global visual system (SCi -> SNc, abstract)

Outbound Region Connections:

Target Area Target Region Target Name Type Role Reference
FEC FEC.FT.ACC.SH Nucleus Accumbens Shell modulatory-da uncertain Connectivity map of the habenula (SNc -> CPu, abstract)
FEC.FT.PU.LT Dorsal Putamen Lateral modulatory-da uncertain Physiology and pathophysiology of lower urinary tract (SNC -> PU)
FEC.FT.PU.MED Dorsal Putamen Medial modulatory-da uncertain Connectivity map of the habenula (SNc -> CPu, abstract)
LLC LLC.HT.CR.CC Cerebellar Lateral Lobe modulatory-da uncertain Prefrontal Cortex (PFC) in motor behavior (SN -> CR, abstract)
LLC.MM.RD.MG Magnocellular Part of Red Nucleus modulatory-da uncertain (unknown reference)

Thirdparty Circuits

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BG=Basal Ganglia,FEC.FT.BG
CN=Caudate Nucleus,FEC.FT.CN (see Basal Ganglia)
CR=Cerebellum,LLC.HT.CR (see Cerebellar Complex)
FrontalCortex=Anterior Lobe,NC.LOBE.ANT
GPe=Globus Pallidus External,FEC.FT.GPE (see Basal Ganglia)
LGN=Lateral Geniculate Nucleus,NSA.FD.LGN
LIP=Lateral Intraparietal Sulcus,NPE.NC.IPS.LIP
RF=Pontine Reticular Formation,HT.RF
Retina=Retinal Nucleus,LPC.FD.RT
SCi=Superior Colliculus,MM.SC (see Reflexes Nuclei of Midbrain Mesencephalon)
SCs=Superior Colliculus,MM.SC (see Reflexes Nuclei of Midbrain Mesencephalon)
SNpr=Substantia Nigra Pars Reticulata Dorsolateral,FEC.FT.SNR.DL
STN=Subthalamic Nucleus,FEC.FD.STN (see Subthalamus Area)
Thalamus=Thalamus,FD.TH
VisualCortex=Occipital Lobe,NC.LOBE.OCC


GPe=Globus Pallidus External,FEC.FT.GPE (see Basal Ganglia)
GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia)
PPN=Pedunculopontine Tegmental Nuclei,LMC.HT.TG.PPN
SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia)
SNr=Substantia Nigra Pars Reticulata,FEC.FT.SNR (see Basal Ganglia)
STN=Subthalamic Nucleus,FEC.FD.STN (see Subthalamus Area)


CN.PU=Striatum,FEC.FT.ST (see Basal Ganglia)
CR=Cerebellar Complex,LLC.HT.CRC
GP=Globus Pallidus,FEC.FT.GP (see Basal Ganglia)
LPFC=Mid-Dorsolateral Prefrontal Cortex,NDM.NC.AL.DLPFC (see Lateral Prefrontal Cortex)
MC=Motor Cortex,NMA.NC.MC
PMC=Premotor Cortex,NC.PMC
PN=Pontine Nuclear Complex,HT.PN (see Metencephalic Sensory Nuclei)
SN=Substantia Nigra,FEC.FT.SN (see Basal Ganglia)
TH=Ventral Thalamus,FD.TH.VTH (see Motor Thalamus)


CN=Caudate Nucleus,FEC.FT.CN (see Basal Ganglia)
DVM=Vagus Nucleus,LAC.HL.VGN
IMG=Inferior Mesenteric Ganglion,LAC.PN.SYM.IMG
IML=Intermediolateral Nucleus,LAC.SC.IZ.IML
LC=Locus Coeruleus,LMC.HT.LC
MPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
MPOA=Median Preoptic Nucleus,LAC.FD.HT.MPO
NBM=Basal Nucleus of Meynert,LMC.FT.NBM
ONF=Onuf's Nucleus,LPC.SC.VH.ONF
PBN=Parabrachial Nucleus,LPC.HT.PRF.PB
PEL=Pelvic Peripheral Ganglion,LAC.PN.PSYM.PPG
PU=Dorsal Putamen Lateral,FEC.FT.PU.LT
PVN=Paraventricular Nucleus,LAC.FD.HT.PV
SNC=Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT
SPS=Sacral Parasympathetic Nucleus,LAC.SC.IZ.SPS
VTA=Ventral Tegmental Area,LMC.MM.VTA
ZI=Subthalamic Nucleus Caudal,BGA.FD.STN.ZI


CPu=Striatum,FEC.FT.ST (see Basal Ganglia)
EP=Endopiriform Nucleus,FAM.FT.EPF
Hippo=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD
L=Lateral Habenula,FAM.FD.LHB (see Habenula)
LH=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
M=Medial Habenula,FAM.FD.MHB
NAc=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia)
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation)
SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia)
Septum=Septal Nuclei,FAM.FT.SEP
VTA=Ventral Tegmental Area,LMC.MM.VTA


AMYG=Amygdala,FAM.FT.AM
CGa=Anterior Cingulate Cortex,NC.AL.ACG (see Anterior Cingulate Area)
CGp=Posterior Cingulate Cortex,NCP.NC.MPL.PSCG
Caudate=Caudate Nucleus,FEC.FT.CN (see Basal Ganglia)
FEF=Frontal Eye Field,NMA.NC.PMC.FEF (see Premotor Cortex)
LIP=Lateral Intraparietal Sulcus,NPE.NC.IPS.LIP
NAC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia)
OFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
PFC=Mid-Dorsolateral Prefrontal Cortex,NDM.NC.AL.DLPFC (see Lateral Prefrontal Cortex)
SC=Superior Colliculus,MM.SC (see Reflexes Nuclei of Midbrain Mesencephalon)
SEF=Supplementary Eye Field,NPE.NC.SMC.SEF
SNc=Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT
SNr=Substantia Nigra Pars Reticulata Dorsolateral,FEC.FT.SNR.DL
Thalamus=Thalamus,FD.TH
VTA=Ventral Tegmental Area,LMC.MM.VTA


ATH=Anterior Nucleus of Thalamus,FD.TH.AN (see Cognitive Thalamus)
BGA=Basal Ganglia,FEC.FT.BG
FrontalCortex=Anterior Lobe,NC.LOBE.ANT
LGN=Lateral Geniculate Nucleus,NSA.FD.LGN
OPN=Oculomotor Nucleus,LPC.MM.OCN
ParietalCortex=Parietal Lobe,NC.LOBE.PAR
Pulvinar=Pulvinar,FD.PV (see Sensory Thalamus)
RF=Pontine Reticular Formation,HT.RF
Retina=Retinal Nucleus,LPC.FD.RT
SCi=Superior Colliculus,MM.SC (see Reflexes Nuclei of Midbrain Mesencephalon)
SCs=Superior Colliculus,MM.SC (see Reflexes Nuclei of Midbrain Mesencephalon)
SNc=Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT
SNr=Substantia Nigra Pars Reticulata Dorsolateral,FEC.FT.SNR.DL
SpinalCord=Lamina IX,SC.VH.L9 (see Anterior/Ventral Horn)
Striatum=Striatum,FEC.FT.ST (see Basal Ganglia)
VisualCortex=Occipital Lobe,NC.LOBE.OCC


GPe=Globus Pallidus External,FEC.FT.GPE (see Basal Ganglia)
GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia)
SNc=Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT
SNr=Substantia Nigra Pars Reticulata Dorsolateral,FEC.FT.SNR.DL
STN=Subthalamic Nucleus,FEC.FD.STN (see Subthalamus Area)
VA=Ventral Anterior Nucleus,NMA.FD.TH.VA
VL=Ventral Lateral Nucleus,NMA.FD.TH.VL


CPu=Striatum,FEC.FT.ST (see Basal Ganglia)
DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB
DR=Dorsal Raphe Nucleus,LMC.MM.RP.DRN
GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia)
IP=Interpeduncular Nucleus,FEC.HT.TG.IPD
LH=Lateral Hypothalamic Area,LAC.FD.HT.LT (see Hypothalamus)
LHb=Lateral Habenula,FAM.FD.LHB (see Habenula)
LPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO
MHb=Medial Habenula,FAM.FD.MHB
MR=Superior Central Raphe Nucleus,LMC.MM.RP.SUC
PB=Endocrine Glands,TARGET.TEA.ENDOCRINE
S=Septal Nuclei,FAM.FT.SEP
SNc=Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT
VTA=Ventral Tegmental Area,LMC.MM.VTA


References

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