BrainRegionFEC FT ACC SH
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Nucleus Accumbens Shell
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This page covers biological details of component Nucleus Accumbens Shell. Region is part of aHuman target integrated biological model.
- Top-down path to region: Forebrain Telencephalon -> Basal Ganglia (FEC.FT.BG) -> Striatum (FEC.FT.ST) -> Ventral Striatum (FEC.FT.VST) -> Accumbens Nucleus (FEC.FT.ACC) -> Nucleus Accumbens Shell (FEC.FT.ACC.SH) (see Mind Maps)
- Type: nucleus
- Quality: L0
- Brain area: Forebrain - Execution Control Area (FEC)
- Area circuit: Cognitive Motivational Salience (FECAF)
- Role: basal.ganglia.striatum
- Function: cognitive processing of motivational salience (wanting) as well as reward and reinforcement effects
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Components
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- no child items defined
Connectivity
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Inbound Region Connections:
| Source Area | Source Region | Source Name | Type | Role | Reference |
| FEC | FEC.FT.SNC.LT | Substantia Nigra Pars Compacta Lateral | modulatory-da | uncertain | Connectivity map of the habenula (SNc -> CPu, abstract) |
| FEC.FT.SNC.MED | Substantia Nigra Pars Compacta Medial | modulatory-da | uncertain | Connectivity map of the habenula (SNc -> CPu, abstract) | |
| LAC | LAC.FD.HT.VM | Ventromedial Hypothalamic Nucleus | excitatory-glu | uncertain | Bowels control brain: gut hormones and obesity (VMN -> NAc, abstract) |
| LMC | LMC.MM.VTA | Ventral Tegmental Area | modulatory-da | uncertain | Craving (VTA -> NACC, abstract) |
| LPC | LPC.HL.SOL | Solitary Nucleus | excitatory-glu | uncertain | Bowels control brain: gut hormones and obesity (NTS -> NAc, abstract) |
| LPC.HT.PRF.PB | Parabrachial Nucleus | excitatory-glu | uncertain | Bowels control brain: gut hormones and obesity (PBN -> NAc, abstract) | |
| NCP | NCP.NC.MPL.PSCG | Posterior Cingulate Cortex | excitatory-glu | uncertain | (unknown reference) |
| NDM | NDM.NC.AL.VACG | Ventral Anterior Cingulate Area | excitatory-glu | uncertain | Global visual system (FrontalCortex -> BGA, abstract) |
Outbound Region Connections:
| Target Area | Target Region | Target Name | Type | Role | Reference |
| FAM | FAM.FD.MHB | Medial Habenula | inhibitory-gaba | uncertain | Connectivity map of the habenula (NAc -> M, abstract) |
| FEC | FEC.FT.IPAC.LT | Lateral Interstitial Anterior Commissural Nucleus | inhibitory-gaba | uncertain | (unknown reference) |
| FEC.FT.VP.VM | Ventral Pallidum Ventromedial | inhibitory-gaba | uncertain | Craving (NACC -> VPAL, abstract) | |
| LAC | LAC.FD.HT.LTN | Lateral Hypothalamic Nucleus | inhibitory-gaba | uncertain | (unknown reference) |
| LMC | LMC.FT.NBM | Basal Nucleus of Meynert | inhibitory-gaba | uncertain | Affective basal ganglia circuit (NACC -> nBM, abstract) |
Thirdparty Circuits
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- Reward circuit of human brain - see Reference (CF.REWARD-CIRCUIT)
AM=Amygdala,FAM.FT.AM HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation) NACC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia) PFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex) VPAL=Ventral Pallidum,FEC.FT.VP (see Basal Ganglia) VTA=Ventral Tegmental Area,LMC.MM.VTA
- Connectivity map of the habenula - see Reference (CF.HB-CONN)
CPu=Striatum,FEC.FT.ST (see Basal Ganglia) EP=Endopiriform Nucleus,FAM.FT.EPF Hippo=Hippocampus,FMM.FT.HC (see Hippocampal Formation) IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD L=Lateral Habenula,FAM.FD.LHB (see Habenula) LH=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN M=Medial Habenula,FAM.FD.MHB NAc=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia) PAG=Periaqueductal Gray Matter,LMC.MM.PAG Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation) SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia) Septum=Septal Nuclei,FAM.FT.SEP VTA=Ventral Tegmental Area,LMC.MM.VTA
NACC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia) OMPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex) SNr=Substantia Nigra Pars Reticulata Medial,FEC.FT.SNR.MED VPAL=Ventral Pallidum,FEC.FT.VP (see Basal Ganglia) VTA=Ventral Tegmental Area,LMC.MM.VTA
- Affective basal ganglia circuit - see Reference (CF.AFFECTIVE-BG)
NACC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia) OMPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex) nBM=Basal Nucleus of Meynert,LMC.FT.NBM
References
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