Premotor Cortex

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This page covers biological details of component group Premotor Cortex. Component group is part of aHuman target integrated biological model.

Top-down path to center: Cerebral Cortex -> Anterior Lobe (NC.LOBE.ANT) -> Premotor Cortex (NC.PMC) (see Mind Maps)
Function: Selection of appropriate motor plans for voluntary movements

(generated)

Components

(generated)

Component items:

Frontal Eye Field (NMA.NC.PMC.FEF): Initiation of eye movements
- Caudal Frontal Eye Field (NPE.NC.PMC.CFEF): Head and eye movements toward visual stimuli
- Anterior Frontal Eye Field (NPE.NC.PMC.AFEF): Head and eye movements toward auditory stimuli
Dorsal Premotor Cortex (MCA.NC.DPMC)
- Dorsal Caudal Premotor Cortex (NMA.NC.PMC.F2): Guiding reaching
- Dorsal Rostral Premotor Cortex (NMA.NC.PMC.F7): Associate arbitrary sensory stimuli with specific eye movements
Ventral Premotor Cortex (MCA.NC.VPMC)
- Ventral Caudal Premotor Cortex (NMA.NC.PMC.F4): Sensory guidance of movement
- Ventral Rostral Premotor Cortex (NMA.NC.PMC.F5): Shaping hand during grasping

Connectivity

(generated)

Internal Regions Connections:

unavailable

Source Region	Target Region	Reference
Ventral Caudal Premotor Cortex (NMA.NC.PMC.F4)	Dorsal Caudal Premotor Cortex (NMA.NC.PMC.F2)	(unknown reference)
Ventral Rostral Premotor Cortex (NMA.NC.PMC.F5)	Dorsal Caudal Premotor Cortex (NMA.NC.PMC.F2)	(unknown reference)
Dorsal Rostral Premotor Cortex (NMA.NC.PMC.F7)	Dorsal Caudal Premotor Cortex (NMA.NC.PMC.F2)	(unknown reference)
Anterior Frontal Eye Field (NPE.NC.PMC.AFEF)	Ventral Rostral Premotor Cortex (NMA.NC.PMC.F5)	Cortical Auditory System (PMC8 -> PMC6, abstract)
	Dorsal Rostral Premotor Cortex (NMA.NC.PMC.F7)	(unknown reference)
Caudal Frontal Eye Field (NPE.NC.PMC.CFEF)	Ventral Rostral Premotor Cortex (NMA.NC.PMC.F5)	(unknown reference)
	Anterior Frontal Eye Field (NPE.NC.PMC.AFEF)	(unknown reference)

External Connections:

unavailable

External Inbound Center Connections:

Source Center	Sample Link	Reference
Cognitive Thalamus (FD.TH.CR)	NMA.FD.TH.MDL -> NPE.NC.PMC.AFEF	Oculomotor decision-making (Thalamus -> FEF, abstract)
Motor Thalamus (FD.TH.MR)	NMA.FD.TH.VA -> NMA.NC.PMC.F2	Prefrontal Cortex (PFC) in motor behavior (TH -> PMC, abstract)
Anterior Cingulate Area (NC.ACG)	NDM.NC.AL.VACG -> NMA.NC.PMC.F2	(unknown reference)
Lateral Prefrontal Cortex (NC.AL.LPFC)	NDM.NC.AL.DLPFCL -> NMA.NC.PMC.F5	Prefrontal Cortex (PFC) in motor behavior (LPFC -> PMC, abstract)
Inferior Parietal Lobule (NC.IPL)	NPE.NC.IPL.SMW -> NMA.NC.PMC.F2	Dual Auditory Processing (PPC -> DLPFC, abstract)
Anterior Parietal Cortex (NC.PG.APC)	NCP.NC.PG.S1 -> NMA.NC.PMC.F2	Global visual system (ParietalCortex -> FrontalCortex, abstract)
Superior Parietal Lobule (NC.SPL)	NCP.NC.SPL.SA -> NMA.NC.PMC.F2	3 Visual Cortex Paths (SPL -> dPM, abstract)
Superior Temporal Gyrus (NC.STG)	NSA.NC.STG.A3 -> NMA.NC.PMC.F4	Dual Auditory Processing (ST -> VLPFC, abstract)
Supplementary Motor Cortex (NMA.NC.SMC)	NMA.NC.SMC.F3 -> NMA.NC.PMC.F2	3 Visual Cortex Paths (pre-SMA -> dPM, abstract)
Intraparietal Sulcus (NSA.NC.IPS)	NSA.NC.IPS.AIP -> NMA.NC.PMC.F4	Primate Control of Grasping (AIP -> F4)
Inferotemporal Area (NSA.NC.IT)	NSA.NC.IT.TE -> NPE.NC.PMC.CFEF	Saccades and smooth movements (TEF -> FEF, abstract)
Transverse Temporal Gyrus (NSA.NC.TTG)	NSA.NC.TTG.A1 -> NMA.NC.PMC.F7	Dual Auditory Processing (A1 -> DLPFC, abstract)

External Outbound Center Connections:

Target Center	Sample Link	Reference
Subthalamus Area (FEC.FD.STA)	NPE.NC.PMC.AFEF -> FEC.FD.STN.MED	Functional subdivisions of the subthalamic nucleus (FEF -> STN, abstract)
Basal Ganglia (FEC.FT.BG)	NMA.NC.PMC.F2 -> FEC.FT.PU.MED	Global visual system (FrontalCortex -> BGA, abstract)
Medullary Reticular Formation (HL.RF)	NPE.NC.PMC.AFEF -> LRC.HL.PRF.GCR	Motor neurons control (CTX -> MRF, abstract)
Pontine Reticular Formation (HT.RF)	NPE.NC.PMC.AFEF -> LRC.HT.PRF.RPO	Motor neurons control (CTX -> PRF, abstract)
Reflexes Nuclei of Midbrain Mesencephalon (MM.REF)	NPE.NC.PMC.AFEF -> LRC.MM.CJ	Summary of eye movement control (FEF -> riMLF, abstract)
Lateral Prefrontal Cortex (NC.AL.LPFC)	NMA.NC.PMC.F4 -> NDM.NC.AL.DLPFCL	Cortico-Cortical Connectivity (MA -> PFC, abstract)
Motor Cortex (NMA.NC.MC)	NMA.NC.PMC.F2 -> NMA.NC.MC	Prefrontal Cortex (PFC) in motor behavior (PMC -> MC, abstract)
Supplementary Motor Cortex (NMA.NC.SMC)	NMA.NC.PMC.F4 -> NMA.NC.SMC.F3	(unknown reference)