BrainRegionNMA NC MC

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Motor Cortex

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This page covers biological details of component Motor Cortex. Region is part of aHuman target integrated biological model.

  • Top-down path to region: Cerebral Cortex -> Anterior Lobe (NC.LOBE.ANT) -> Motor Cortex (NMA.NC.MC) (see Mind Maps)
  • Type: cortex
  • Quality: L0
  • Brain area: Neocortical Brain - Motor Aggregation Area (NMA)
  • Area circuit: Flexor Motor (FLM)
  • Brodmann ID: 04
  • Role: cortex.motor.flexor
  • Function: Execution of required voluntary movements
  • Notes to function:
    • F1
    • Encode individual movements

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Components

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  • no child items defined

Connectivity

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NMA.NC.MC.dot.png

Inbound Region Connections:

Source Area Source Region Source Name Type Role Reference
NCP NCP.NC.PG.PV Parietal Ventral Cortex feedforward-glu uncertain Global visual system (ParietalCortex -> FrontalCortex, abstract)
NCP.NC.PG.S1 Primary Somatosensory Cortex feedforward-glu uncertain Cortico-Cortical Connectivity (S1 -> M1)
NCP.NC.PG.S2 Secondary Somatosensory Cortex feedforward-glu uncertain Global visual system (ParietalCortex -> FrontalCortex, abstract)
NMA NMA.FD.TH.VL Ventral Lateral Nucleus excitatory-glu uncertain Thalamocortical relationships (VL -> pVL)
NMA.NC.PMC.F2 Dorsal Caudal Premotor Cortex feedforward-glu uncertain Prefrontal Cortex (PFC) in motor behavior (PMC -> MC, abstract)
NMA.NC.PMC.F5 Ventral Rostral Premotor Cortex feedforward-glu uncertain Primate Control of Grasping (F5 -> F1)

Outbound Region Connections:

Target Area Target Region Target Name Type Role Reference
FEC FEC.FD.STN.LT Subthalamic Nucleus Lateral excitatory-glu uncertain Functional subdivisions of the subthalamic nucleus (MC -> STN, abstract)
FEC.FT.PU.LT Dorsal Putamen Lateral excitatory-glu uncertain Basal Ganglia Activity (M1 -> PU, abstract)
LLC LLC.HT.BPN Basilar Pontine Nuclei excitatory-glu uncertain Cerebellum functional divisions (CTX -> PNN, abstract)
LLC.HT.PN.PBB Pontobulbar Body excitatory-glu uncertain Prefrontal Cortex (PFC) in motor behavior (MC -> PN, abstract)
LLC.HT.PRF.RTMG Pontine Reticulotegmental Nucleus excitatory-glu uncertain Motor neurons control (CTX -> PRF, abstract)
LPC LPC.HL.AMB Ambiguus Nucleus excitatory-glu uncertain (unknown reference)
LPC.SC.VH.ONF Onuf's Nucleus excitatory-glu uncertain Cerebellum functional divisions (CTX -> SCM, abstract)
LPC.SC.VH.PL Posterolateral Nucleus excitatory-glu uncertain Cerebellum functional divisions (CTX -> SCM, abstract)
LPC.SC.VH.PM Posteromedial Nucleus excitatory-glu uncertain Cerebellum functional divisions (CTX -> SCM, abstract)
LPC.SC.VH.RPL Retroposterolateral Nucleus excitatory-glu uncertain Cerebellum functional divisions (CTX -> SCM, abstract)
LRC LRC.HT.PRF.CRF Caudal Pontine Reticular Nucleus excitatory-glu uncertain Motor neurons control (CTX -> PRF, abstract)

Thirdparty Circuits

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ATH=Anterior Nucleus of Thalamus,FD.TH.AN (see Cognitive Thalamus)
BGA=Basal Ganglia,FEC.FT.BG
FrontalCortex=Anterior Lobe,NC.LOBE.ANT
LGN=Lateral Geniculate Nucleus,NSA.FD.LGN
OPN=Oculomotor Nucleus,LPC.MM.OCN
ParietalCortex=Parietal Lobe,NC.LOBE.PAR
Pulvinar=Pulvinar,FD.PV (see Sensory Thalamus)
RF=Pontine Reticular Formation,HT.RF
Retina=Retinal Nucleus,LPC.FD.RT
SCi=Superior Colliculus,MM.SC (see Reflexes Nuclei of Midbrain Mesencephalon)
SCs=Superior Colliculus,MM.SC (see Reflexes Nuclei of Midbrain Mesencephalon)
SNc=Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT
SNr=Substantia Nigra Pars Reticulata Dorsolateral,FEC.FT.SNR.DL
SpinalCord=Lamina IX,SC.VH.L9 (see Anterior/Ventral Horn)
Striatum=Striatum,FEC.FT.ST (see Basal Ganglia)
VisualCortex=Occipital Lobe,NC.LOBE.OCC


ACG=Anterior Cingulate Cortex,NC.AL.ACG (see Anterior Cingulate Area)
FEF=Frontal Eye Field,NMA.NC.PMC.FEF (see Premotor Cortex)
GPe=Globus Pallidus External,FEC.FT.GPE (see Basal Ganglia)
GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia)
MC=Motor Cortex,NMA.NC.MC
SNr=Substantia Nigra Pars Reticulata,FEC.FT.SNR (see Basal Ganglia)
STN=Subthalamic Nucleus,FEC.FD.STN (see Subthalamus Area)
VP=Ventral Pallidum,FEC.FT.VP (see Basal Ganglia)


CN.PU=Striatum,FEC.FT.ST (see Basal Ganglia)
CR=Cerebellar Complex,LLC.HT.CRC
GP=Globus Pallidus,FEC.FT.GP (see Basal Ganglia)
LPFC=Mid-Dorsolateral Prefrontal Cortex,NDM.NC.AL.DLPFC (see Lateral Prefrontal Cortex)
MC=Motor Cortex,NMA.NC.MC
PMC=Premotor Cortex,NC.PMC
PN=Pontine Nuclear Complex,HT.PN (see Metencephalic Sensory Nuclei)
SN=Substantia Nigra,FEC.FT.SN (see Basal Ganglia)
TH=Ventral Thalamus,FD.TH.VTH (see Motor Thalamus)


CR=Cerebellum,LLC.HT.CR (see Cerebellar Complex)
CTX=Anterior Lobe,NC.LOBE.ANT
EAMN=Anterior/Ventral Horn,SC.VH
EGMN=Anterior/Ventral Horn,SC.VH
FAMN=Anterior/Ventral Horn,SC.VH
FG=Fastigual Nucleus,LRC.HT.CR.FG
IP=Interposed Nucleus,LLC.HT.CR.IP (see Cerebellar Complex)
LT=Dentate Nucleus,LLC.HT.CR.DN
MRF=Medullary Reticular Formation,HL.RF
PRF=Pontine Reticular Formation,HT.RF
RD=Red Nucleus,LLC.MM.RD
VB=Vestibular Nuclei,LPC.HT.VBN


CCV=Central Cervical Nucleus,LPC.SC.IZ.CCV
CRP=Cerebellar Lateral Lobe,LLC.HT.CR.CC
CRS=Cerebellar Paravermis,LLC.HT.CR.PV
CRV=Cerebellar Vermis,LRC.HT.CR.VM
CTX=Anterior Lobe,NC.LOBE.ANT
DN=Dentate Nucleus,LLC.HT.CR.DN
FG=Fastigual Nucleus,LRC.HT.CR.FG
IO=Inferior Olivary Nucleus,LLC.HL.IO
IP=Interposed Nucleus,LLC.HT.CR.IP (see Cerebellar Complex)
LT=Dentate Nucleus,LLC.HT.CR.DN
PNN=Basilar Pontine Nuclei,LLC.HT.BPN
RD=Red Nucleus,LLC.MM.RD
RF=Pontine Reticular Formation,HT.RF
SCM=Anterior/Ventral Horn,SC.VH
SCS=Proprius Nucleus,LPC.SC.PH.NP
SCSD=Clarke Nucleus,LPC.SC.PH.CL
VB=Vestibular Nuclei,LPC.HT.VBN
VBG=Vestibular Ganglion,LPC.PN.SG.VB
VL=Ventral Lateral Nucleus,NMA.FD.TH.VL


GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia)
GPo=Globus Pallidus External,FEC.FT.GPE (see Basal Ganglia)
M1=Motor Cortex,NMA.NC.MC
PMC=Premotor Cortex,NC.PMC
PU=Dorsal Putamen,FEC.FT.DPU (see Basal Ganglia)
S1=Primary Somatosensory Cortex,NCP.NC.PG.S1
SMC=Supplementary Motor Cortex,NMA.NC.SMC
SN=Substantia Nigra,FEC.FT.SN (see Basal Ganglia)
STN=Subthalamic Nucleus,FEC.FD.STN (see Subthalamus Area)
VLo=Ventral Lateral Nucleus,NMA.FD.TH.VL


A1=Primary Auditory Cortex,NSA.NC.TTG.A1
AA=Wernicke's area A3,NSA.NC.STG.A3
M1=Motor Cortex,NMA.NC.MC
MA=Premotor Cortex,NC.PMC
PFC=Prefrontal Cortex,NC.AL.PFC
PTHA=Inferior Parietal Lobule,NC.IPL
S1=Primary Somatosensory Cortex,NCP.NC.PG.S1
SA=Somatosensory Association Cortex,NCP.NC.SPL.SA
V1=Primary Visual Cortex,NSA.NC.OCC.V1
VA=Secondary Visual Cortex,NSA.NC.OCC.V2 (see Occipital Lobe)


DLPFC=Mid-Dorsolateral Prefrontal Cortex,NDM.NC.AL.DLPFC (see Lateral Prefrontal Cortex)
IT=Inferotemporal Area,NSA.NC.IT
M1=Motor Cortex,NMA.NC.MC
PC=Parietal Lobe,NC.LOBE.PAR
PM=Premotor Cortex,NC.PMC
V1=Occipital Lobe,NC.LOBE.OCC
VLPFC=Mid-Dorsolateral Prefrontal Cortex,NDM.NC.AL.DLPFC (see Lateral Prefrontal Cortex)


IPL=Inferior Parietal Lobule,NC.IPL
IPS=Intraparietal Sulcus,NSA.NC.IPS
IT=Inferotemporal Area,NSA.NC.IT
LPC=Mid-Dorsolateral Prefrontal Cortex,NDM.NC.AL.DLPFC (see Lateral Prefrontal Cortex)
MI=Motor Cortex,NMA.NC.MC
OCC=Occipital Lobe,NC.LOBE.OCC
SPL=Superior Parietal Lobule,NC.SPL
dPM=Dorsal Premotor Cortex,MCA.NC.DPMC (see Premotor Cortex)
pre-SMA=Supplementary Motor Cortex,NMA.NC.SMC
vPM=Ventral Premotor Cortex,MCA.NC.VPMC (see Premotor Cortex)


MC=Motor Cortex,NMA.NC.MC


MC=Motor Cortex,NMA.NC.MC


M1=Motor Cortex,NMA.NC.MC


M1=Motor Cortex,NMA.NC.MC


46=Mid-Dorsolateral Prefrontal Cortex,NDM.NC.AL.DLPFC (see Lateral Prefrontal Cortex)
AIP=Anterior Intraparietal Sulcus,NSA.NC.IPS.AIP
BG=Basal Ganglia,FEC.FT.BG
BTH=Ventral Anterior Nucleus,NMA.FD.TH.VA
F1=Motor Cortex,NMA.NC.MC
F2=Dorsal Caudal Premotor Cortex,NMA.NC.PMC.F2
F4=Ventral Caudal Premotor Cortex,NMA.NC.PMC.F4
F5=Ventral Rostral Premotor Cortex,NMA.NC.PMC.F5
F6=Pre-Supplementary Motor Area,NMA.NC.SMC.F6
IT=Inferotemporal Area,NSA.NC.IT
PIP=Posterior Eye Field,NPE.NC.IPS.PEF (see Intraparietal Sulcus)
S1=Primary Somatosensory Cortex,NCP.NC.PG.S1
S2=Primary Somatosensory Cortex,NCP.NC.PG.S1
VC=Occipital Lobe,NC.LOBE.OCC
VIP=Ventral Intraparietal Sulcus,NSA.NC.IPS.VIP


M1=Motor Cortex,NMA.NC.MC


A=Anterior Nucleus of Thalamus,FD.TH.AN (see Cognitive Thalamus)
CM=Centromedian Nucleus of Thalamus,FEC.FD.TH.CM
LD=Lateral Dorsal Nucleus of Thalamus,FMM.FD.TH.LD
LGN=Lateral Geniculate Nucleus,NSA.FD.LGN
LP=Lateral Posterior Nucleus of Thalamus,NPE.FD.TH.LP
MD=Mediodorsal Nucleus of Thalamus,FD.TH.MD (see Cognitive Thalamus)
MGN=Medial Geniculate Body,NSA.FD.TH.MGB
P=Ventral Posterior Nuclei,NSA.FD.TH.VP (see Sensory Thalamus)
VA=Ventral Anterior Nucleus,NMA.FD.TH.VA
VL=Ventral Lateral Nucleus,NMA.FD.TH.VL
VPL=Ventral Posterolateral Nucleus,NCP.FD.TH.VPL
VPM=Ventral Posteromedial Nucleus,NCP.FD.TH.VPM
pA=Posterior Cingulate Cortex,NCP.NC.MPL.PSCG
pCM=Dorsal Putamen,FEC.FT.DPU (see Basal Ganglia)
pLD=Anterior Cingulate Cortex,NC.AL.ACG (see Anterior Cingulate Area)
pLGN=Primary Visual Cortex,NSA.NC.OCC.V1
pLP=Superior Parietal Lobule,NC.SPL
pMD=Prefrontal Cortex,NC.AL.PFC
pMGN=Primary Auditory Cortex,NSA.NC.TTG.A1
pP=Insular Cortex,NC.INS
pVA=Supplementary Motor Cortex,NMA.NC.SMC
pVL=Motor Cortex,NMA.NC.MC
pVPL=Primary Somatosensory Cortex,NCP.NC.PG.S1
pVPM=Precentral Cortex,NCP.NC.PO.PCC
s1A=Subiculum,FMM.FT.HF.SUB (see Hippocampal Formation)
s1MD=Septal Nuclei,FAM.FT.SEP
s1P=Central Cervical Nucleus,LPC.SC.IZ.CCV
s1VL=Dentate Nucleus,LLC.HT.CR.DN
s2A=Mammillary Body,FD.MB (see Hypothalamus)
s2MD=Piriform Cortex,NSA.NC.PH.PIR
s2P=Principal Trigeminal Nucleus,LPC.HT.PN.PTR
s2VL=Basal Ganglia,FEC.FT.BG
s3MD=Prefrontal Cortex,NC.AL.PFC
sCM=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia)
sLD=Superior Parietal Lobule,NC.SPL
sLP=Superior Colliculus,MM.SC (see Reflexes Nuclei of Midbrain Mesencephalon)
sVA=Basal Ganglia,FEC.FT.BG
sVPL=Marginal Nucleus,LPC.SC.PH.MG (see Posterior/Dorsal Horn)
sVPM=Solitary Nucleus,LPC.HL.SOL


References

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