BrainRegionFMM NC PH LEC

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Lateral Entorhinal Cortex

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This page covers biological details of component Lateral Entorhinal Cortex. Region is part of aHuman target integrated biological model.

  • Top-down path to region: Cerebral Cortex -> Parahippocampal Lobe (NC.LOBE.PH) -> Anterior Parahippocampal Gyrus (FMM.NC.PHA) -> Rhinal Cortex (NC.PHA.RH) -> Entorhinal Cortex (FMM.NC.PH.ET) -> Lateral Entorhinal Cortex (FMM.NC.PH.LEC) (see Mind Maps)
  • Type: cortex
  • Quality: L0
  • Brain area: Forebrain - Memory Management Area (FMM)
  • Area circuit: Emotional Sensory Input to Hippocampus (MMASENSE)
  • Brodmann ID: 28
  • Role: processor.memory.complex
  • Function: Memory consolidation, emotional aspects
  • Notes to function:
    • non-spatial input to HC
    • process information about individual items and locations based on a local frame of reference, primarily using external sensory input
    • it provides the hippocampus with information about content of experience

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Components

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  • no child items defined

Connectivity

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FMM.NC.PH.LEC.dot.png

Inbound Region Connections:

Source Area Source Region Source Name Type Role Reference
FAM FAM.FD.TH.PT Paratenial Nucleus of Thalamus excitatory-glu uncertain Contributions of Diencephalon to Recognition Memory (MID -> EC, abstract)
FAM.FT.AM.BP Parvicellular Basal Amygdaloid Nucleus excitatory-glu uncertain Principal Connections of Hippocampus (AM -> EC, abstract)
FMM FMM.FT.HF.SUBD Distal Subiculum excitatory-glu uncertain Attractor Network in Hippocampus (SUB -> EC, abstract)
FMM.NC.PH.PER Perirhinal Cortex feedforward-glu uncertain Visual Path to Hippocampus (PRPH -> ER, abstract)
LMC LMC.MM.VTA Ventral Tegmental Area modulatory-da uncertain Combining Novelty, Motivational Salience, and Reward to Control Attention and Learning (VTA -> EC, abstract)
NDM NDM.FD.TH.PV Paraventricular Nucleus of Thalamus excitatory-glu uncertain Contributions of Diencephalon to Recognition Memory (MID -> EC, abstract)
NSA NSA.NC.IT.TE Inferotemporal Cortex feedforward-glu uncertain McNaughton Spatial Processing Network (ITCortex -> EnthCortex, abstract)
NSA.NC.PH.PIR Piriform Cortex feedforward-glu uncertain KIV model of cortico-hippocampal formation with subcortical projections for motor actions (PC -> EC, abstract)
NSA.NC.STG.A3 Wernicke's area A3 feedforward-glu uncertain (unknown reference)
NSA.NC.STG.A4 Wernicke's area A4 feedforward-glu uncertain (unknown reference)

Outbound Region Connections:

Target Area Target Region Target Name Type Role Reference
FAM FAM.FT.AM.AB Accessory Basal Amygdaloid Nucleus excitatory-glu uncertain Simplified model of hippocampal formation anatomy (EC -> Amyg, abstract)
FAM.FT.AM.LAVM Ventromedial Amygdaloid Nucleus excitatory-glu uncertain Simplified model of hippocampal formation anatomy (EC -> Amyg, abstract)
FEC FEC.FT.ACC.CORE Nucleus Accumbens Core excitatory-glu uncertain Nucleus Accumbens (EC -> NACC, abstract)
FMM FMM.FT.HC.CA1D Distal CA1 of Hippocampus excitatory-glu uncertain Neuronal projections in the hippocampus (ET -> CA1, abstract)
FMM.FT.HC.CA2 Dorsolateral Cornu Ammonis of Hippocampus excitatory-glu uncertain Amygdala and its network (EC -> HC, abstract)
FMM.FT.HC.CA3P Proximal CA3 of Hippocampus excitatory-glu uncertain Neuronal projections in the hippocampus (ET -> CA3, abstract)
FMM.FT.HC.DG Dentate Gyrus excitatory-glu uncertain Neuronal projections in the hippocampus (ET -> DG, abstract)
FMM.FT.HF.SUBP Proximal Subiculum excitatory-glu uncertain Visual Path to Hippocampus (ER -> H, abstract)
NDM NDM.FD.TH.MDM Medial Mediodorsal Nucleus of Thalamus excitatory-glu uncertain Contributions of Diencephalon to Recognition Memory (EC -> MDmc, abstract)

Thirdparty Circuits

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AD=Anterodorsal Nucleus,FMM.FD.TH.AD
AM=Anteromedial Nucleus,NCP.FD.TH.AM
AN=Anterior Nucleus of Thalamus,FD.TH.AN (see Cognitive Thalamus)
AV=Anteroventral Nucleus,FMM.FD.TH.AV
CM=Centromedian Nucleus of Thalamus,FEC.FD.TH.CM
DLPFC=Mid-Dorsolateral Prefrontal Cortex,NDM.NC.AL.DLPFC (see Lateral Prefrontal Cortex)
EC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)
HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
LD=Lateral Dorsal Nucleus of Thalamus,FMM.FD.TH.LD
MB=Medial Mammillary Nucleus,FMM.FD.MB.MMB
MDmc=Mediodorsal Nucleus of Thalamus,FD.TH.MD (see Cognitive Thalamus)
MID=Midline Nuclear Group of Thalamus,FD.TH.MTH (see Cognitive Thalamus)
MPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
OFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
Parasub=Parasubiculum,FMM.NC.PH.PAS
Perirhinal=Perirhinal Cortex,FMM.NC.PH.PER
PostCingulate=Posterior Cingulate Cortex,NCP.NC.MPL.PSCG
Presub=Presubiculum,FMM.NC.PH.PRS
Sub=Subiculum,FMM.FT.HF.SUB (see Hippocampal Formation)
SubPrePara=Subiculum,FMM.FT.HF.SUB (see Hippocampal Formation)
mPULV=Medial Pulvinar,NPE.FD.TH.MPV


Amyg=Amygdala,FAM.FT.AM
CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (see Hippocampal Formation)
CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (see Hippocampal Formation)
DG=Dentate Gyrus,FMM.FT.HC.DG
EC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)
NACC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia)
SUB=Subiculum,FMM.FT.HF.SUB (see Hippocampal Formation)
mPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)


A=Amygdala,FAM.FT.AM
ER=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)
H=Hippocampal Formation,FMM.FT.HF
IT=Inferotemporal Cortex,NSA.NC.IT.TE
PRPH=Perirhinal Cortex,FMM.NC.PH.PER
TEO=Preoccipital Inferotemporal Area,NSA.NC.IT.TEO
V1=Primary Visual Cortex,NSA.NC.OCC.V1
V2=Secondary Visual Cortex,NSA.NC.OCC.V2 (see Occipital Lobe)
V4=Fusiform Gyrus,NSA.NC.OCC.V4 (see Occipital Lobe)


CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (see Hippocampal Formation)
CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (see Hippocampal Formation)
EC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)
NACC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia)
PAS=Parasubiculum,FMM.NC.PH.PAS
PRR=Perirhinal Cortex,FMM.NC.PH.PER
SUB=Subiculum,FMM.FT.HF.SUB (see Hippocampal Formation)


BLN=Parvicellular Basal Amygdaloid Nucleus,FAM.FT.AM.BP
CEA=Central Amygdala,FAM.FT.AM.CEA (see Amygdala)
EC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)
HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
HTS=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
ITC=Inferotemporal Cortex,NSA.NC.IT.TE
LA=Lateral Amygdaloid Nucleus,FAM.FT.AM.LA (see Amygdala)
LHB=Lateral Habenula,FAM.FD.LHB (see Habenula)
MD=Mediodorsal Nucleus of Thalamus,FD.TH.MD (see Cognitive Thalamus)
MPFC=Orbitomedial Prefrontal Cortex,NC.AL.OMPFC
NACC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia)
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
RMTG=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG
STC=Wernicke's area A3,NSA.NC.STG.A3
VGDM=Vagus Nucleus,LAC.HL.VGN
VTA=Ventral Tegmental Area,LMC.MM.VTA


BLA=Basolateral Nuclear Complex,FAM.FT.AM.BL (see Amygdala)
CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (see Hippocampal Formation)
CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (see Hippocampal Formation)
DG=Dentate Gyrus,FMM.FT.HC.DG
ET=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)


References

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