Difference between revisions of "BrainRegionLMC MM VTA"
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* '''Type''': nucleus | * '''Type''': nucleus | ||
* '''Quality''': L0 | * '''Quality''': L0 | ||
| − | * '''Brain area''': [[BrainAreaLMC|Lower Brain - Modulatory Contol Area]] | + | * '''Brain area''': [[BrainAreaLMC|Lower Brain - Modulatory Contol Area]] (LMC) |
| + | * '''Area circuit''': Dopamine - Reward-Motivated Behavior, Cognitive Alertness (DA) | ||
* '''Role''': processor.autonomic | * '''Role''': processor.autonomic | ||
* '''Function''': Respond to novel stimuli, unexpected rewards, and reward predictive sensory cues | * '''Function''': Respond to novel stimuli, unexpected rewards, and reward predictive sensory cues | ||
Revision as of 12:03, 14 April 2019
Ventral Tegmental Area
@@Home -> BiologicalLifeResearch -> BrainAreaLMC -> BrainRegionLMC_MM_VTA
This page covers biological details of component Ventral Tegmental Area. Region is part of aHuman target integrated biological model.
- Top-down path to region: Midbrain Mesencephalon -> Ventral Tegmental Area (LMC.MM.VTA) (see Mind Maps)
- Type: nucleus
- Quality: L0
- Brain area: Lower Brain - Modulatory Contol Area (LMC)
- Area circuit: Dopamine - Reward-Motivated Behavior, Cognitive Alertness (DA)
- Role: processor.autonomic
- Function: Respond to novel stimuli, unexpected rewards, and reward predictive sensory cues
(generated)
Components
(generated)
Component items:
- Ventral Tegmental Nucleus (LMC.MM.VTG): moderates hippocampal-driven rhythmic firing frequency in medial mammillary
- Parabrachial Pigmented Area
- Paranigral Nucleus
- Parafasciculus Retroflexus Area
Connectivity
(generated)
Inbound Region Connections:
| Source Area | Source Region | Source Name | Type | Reference |
| FAM | FAM.FD.LHB.MED | Lateral Habenula Medial Part | excitatory-glu | Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> VTA) |
| FAM.FT.BNST | Bed Nucleus of Stria Terminalis | excitatory-glu | (unknown reference) | |
| FEC | FEC.FT.ACC.CORE | Nucleus Accumbens Core | inhibitory-gaba | Reward circuit of human brain (NACC -> VTA, abstract) |
| FEC.FT.VP.VM | Ventral Pallidum Ventromedial | inhibitory-gaba | Craving (VPAL -> VTA, abstract) | |
| FEC.HT.TG.IPD | Interpeduncular Nucleus | modulatory-ach | Both LHb and MHb control the dopaminergic and serotonergic systems (IPN -> VTA) | |
| FEC.HT.TG.RMTG | Rostromedial Tegmental Nucleus | inhibitory-gaba | Amygdala and its network (RMTG -> VTA) | |
| LPC | LPC.HL.SOL | Solitary Nucleus | excitatory-glu | Bowels control brain: gut hormones and obesity (NTS -> VTA) |
Outbound Region Connections:
Thirdparty Circuits
(generated)
- Regulation of Social Brain - see Reference (CT.SOCIAL-BRAIN)
AMG=Amygdala,FAM.FT.AM Caud=Caudate Nucleus,FEC.FT.CN (see Basal Ganglia) DACC=Dorsal Anterior Cingulate Area,NDM.NC.AL.DACG DLPFC=Mid-Dorsolateral Prefrontal Cortex,NDM.NC.AL.DLPFC (see Lateral Prefrontal Cortex) Hipp=Hippocampus,FMM.FT.HC (see Hippocampal Formation) IFG=Inferior Prefrontal Gyrus,NDM.NC.AL.IPG LSN=Lateral Spinal Nucleus,LAC.SC.LH.LSN MPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex) NACC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia) OFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex) PhippG=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex) Put=Dorsal Putamen,FEC.FT.DPU (see Basal Ganglia) SGC=Subgenual Cingulate Cortex,NCP.NC.AL.SGCG SN=Substantia Nigra,FEC.FT.SN (see Basal Ganglia) VACC=Ventral Anterior Cingulate Area,NDM.NC.AL.VACG VTA=Ventral Tegmental Area,LMC.MM.VTA VentPal=Ventral Pallidum,FEC.FT.VP (see Basal Ganglia)
- Mammillary bodies: two memory systems in one - see Reference (CT.MB-MEMORY)
ADTH=Anterodorsal Nucleus,FMM.FD.TH.AD AMTH=Anteromedial Nucleus,NCP.FD.TH.AM AVTH=Anteroventral Nucleus,FMM.FD.TH.AV DTN=Laterodorsal Tegmental Nucleus,LMC.HT.TG.LDT LMB=Lateral Mammillary Nucleus,FMM.FD.MB.LMB MMB=Medial Mammillary Nucleus,FMM.FD.MB.MMB MedialEC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex) PAS=Parasubiculum,FMM.NC.PH.PAS POS=Postsubiculum,FMM.NC.PH.POS PRS=Presubiculum,FMM.NC.PH.PRS SEP=Septal Nuclei,FAM.FT.SEP SUB=Subiculum,FMM.FT.HF.SUB (see Hippocampal Formation) SupraMM=Supramammillary Nucleus,LAC.FD.HT.SUM TuberoMM=Lateral Tuberal Nuclei,LAC.FD.HT.LTUB (see Hypothalamus) VTN=Ventral Tegmental Area,LMC.MM.VTA
- Combining Novelty, Motivational Salience, and Reward to Control Attention and Learning - see Reference (CT.LONG-TERM-MEMORY-VTA)
ACC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia) CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (see Hippocampal Formation) CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (see Hippocampal Formation) DG=Dentate Gyrus,FMM.FT.HC.DG EC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex) PFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex) PPTG=Pedunculopontine Tegmental Nuclei,LMC.HT.TG.PPN SUB=Subiculum,FMM.FT.HF.SUB (see Hippocampal Formation) VPAL=Ventral Pallidum,FEC.FT.VP (see Basal Ganglia) VTA=Ventral Tegmental Area,LMC.MM.VTA
- Bowels control brain: gut hormones and obesity - see Reference (CP.BOWELS)
AMY=Amygdala,FAM.FT.AM ARC=Arcuate Nucleus of Hypothalamus,LAC.FD.HT.AR DS=Dorsal Striatum,FEC.FT.DST (see Basal Ganglia) LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN ME=Endocrine Glands,TARGET.TEA.ENDOCRINE NAc=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia) NTS=Solitary Nucleus,LPC.HL.SOL OFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex) PBN=Parabrachial Nucleus,LPC.HT.PRF.PB PVN=Paraventricular Nucleus,LAC.FD.HT.PV VMN=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM VTA=Ventral Tegmental Area,LMC.MM.VTA
- Physiology and pathophysiology of lower urinary tract - see Reference (CM.ONUF)
CN=Caudate Nucleus,FEC.FT.CN (see Basal Ganglia) DVM=Vagus Nucleus,LAC.HL.VGN IMG=Inferior Mesenteric Ganglion,LAC.PN.SYM.IMG IML=Intermediolateral Nucleus,LAC.SC.IZ.IML LC=Locus Coeruleus,LMC.HT.LC MPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex) MPOA=Median Preoptic Nucleus,LAC.FD.HT.MPO NBM=Basal Nucleus of Meynert,LMC.FT.NBM ONF=Onuf's Nucleus,LPC.SC.VH.ONF PBN=Parabrachial Nucleus,LPC.HT.PRF.PB PEL=Pelvic Peripheral Ganglion,LAC.PN.PSYM.PPG PU=Dorsal Putamen Lateral,FEC.FT.PU.LT PVN=Paraventricular Nucleus,LAC.FD.HT.PV SNC=Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT SPS=Sacral Parasympathetic Nucleus,LAC.SC.IZ.SPS VTA=Ventral Tegmental Area,LMC.MM.VTA ZI=Subthalamic Nucleus Caudal,BGA.FD.STN.ZI
- Reward circuit of human brain - see Reference (CF.REWARD-CIRCUIT)
AM=Amygdala,FAM.FT.AM HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation) NACC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia) PFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex) VPAL=Ventral Pallidum,FEC.FT.VP (see Basal Ganglia) VTA=Ventral Tegmental Area,LMC.MM.VTA
NACC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia) OMPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex) SNr=Substantia Nigra Pars Reticulata Medial,FEC.FT.SNR.MED VPAL=Ventral Pallidum,FEC.FT.VP (see Basal Ganglia) VTA=Ventral Tegmental Area,LMC.MM.VTA
- Amygdala and its network - see Reference (CF.AM-NET)
BLN=Parvicellular Basal Amygdaloid Nucleus,FAM.FT.AM.BP CEA=Central Amygdala,FAM.FT.AM.CEA (see Amygdala) EC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex) HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation) HTS=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN ITC=Inferotemporal Cortex,NSA.NC.IT.TE LA=Lateral Amygdaloid Nucleus,FAM.FT.AM.LA (see Amygdala) LHB=Lateral Habenula,FAM.FD.LHB (see Habenula) MD=Mediodorsal Nucleus of Thalamus,FD.TH.MD (see Cognitive Thalamus) MPFC=Orbitomedial Prefrontal Cortex,NC.AL.OMPFC NACC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia) PAG=Periaqueductal Gray Matter,LMC.MM.PAG RMTG=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG STC=Wernicke's area A3,NSA.NC.STG.A3 VGDM=Vagus Nucleus,LAC.HL.VGN VTA=Ventral Tegmental Area,LMC.MM.VTA
- Medial mammillary nucleus and theta rhythm - see Reference (CT.MMB-THETA)
AVTH=Anteroventral Nucleus,FMM.FD.TH.AV HF=Hippocampal Formation,FMM.FT.HF MMB=Medial Mammillary Nucleus,FMM.FD.MB.MMB RSP=Retrosplenial Cortex,NCP.NC.MPL.RSC SEP=Septal Nuclei,FAM.FT.SEP SupraMM=Supramammillary Nucleus,LAC.FD.HT.SUM VTN=Ventral Tegmental Area,LMC.MM.VTA
- Oculomotor decision-making - see Reference (CP.OCULOMOTOR-DECISION-MAKING)
AMYG=Amygdala,FAM.FT.AM CGa=Anterior Cingulate Cortex,NC.AL.ACG (see Anterior Cingulate Area) CGp=Posterior Cingulate Cortex,NCP.NC.MPL.PSCG Caudate=Caudate Nucleus,FEC.FT.CN (see Basal Ganglia) FEF=Frontal Eye Field,NMA.NC.PMC.FEF (see Premotor Cortex) LIP=Lateral Intraparietal Sulcus,NPE.NC.IPS.LIP NAC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia) OFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex) PFC=Mid-Dorsolateral Prefrontal Cortex,NDM.NC.AL.DLPFC (see Lateral Prefrontal Cortex) SC=Superior Colliculus,MM.SC (see Reflexes Nuclei of Midbrain Mesencephalon) SEF=Supplementary Eye Field,NPE.NC.SMC.SEF SNc=Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT SNr=Substantia Nigra Pars Reticulata Dorsolateral,FEC.FT.SNR.DL Thalamus=Thalamus,FD.TH VTA=Ventral Tegmental Area,LMC.MM.VTA
- Regulation of the rapid eye movement (REM) sleep by habenular projection - see Reference (CF.REM-HB)
DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB DTG=Laterodorsal Tegmental Nucleus,LMC.HT.TG.DTG EPN=Endopiriform Nucleus,FAM.FT.EPF GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia) LHT=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN LHbL=Lateral Habenula Lateral Part,FAM.FD.LHB.LT LHbM=Lateral Habenula Medial Part,FAM.FD.LHB.MED NI=Incertus Nucleus,FAM.HT.TG.NI RMTg=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation) SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia) VTA=Ventral Tegmental Area,LMC.MM.VTA VTG=Ventral Tegmental Area,LMC.MM.VTG
- Both LHb and MHb control the dopaminergic and serotonergic systems - see Reference (CF.HB-DA5HT)
DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB DRN=Dorsal Raphe Nucleus,LMC.MM.RP.DRN GPb=Dorsal Pallidum,FEC.FT.DP (see Basal Ganglia) IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN LHbL=Lateral Habenula Lateral Part,FAM.FD.LHB.LT LHbM=Lateral Habenula Medial Part,FAM.FD.LHB.MED LPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO LS=Lateral Septal Nucleus,FAM.FT.SEP.LT MHb=Medial Habenula,FAM.FD.MHB MRN=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation) MS=Medial Septal Nucleus,FAM.FT.SEP.MED PS=Posterior Septal Group,FAM.FT.SEP.PG (see Septal Nuclei) RMTg=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia) VP=Ventral Pallidum,FEC.FT.VP (see Basal Ganglia) VTA=Ventral Tegmental Area,LMC.MM.VTA
- Habenula Connections - see Reference (CF.HB-CONNECTIONS)
CPu=Striatum,FEC.FT.ST (see Basal Ganglia) DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB DR=Dorsal Raphe Nucleus,LMC.MM.RP.DRN GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia) IP=Interpeduncular Nucleus,FEC.HT.TG.IPD LH=Lateral Hypothalamic Area,LAC.FD.HT.LT (see Hypothalamus) LHb=Lateral Habenula,FAM.FD.LHB (see Habenula) LPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO MHb=Medial Habenula,FAM.FD.MHB MR=Superior Central Raphe Nucleus,LMC.MM.RP.SUC PB=Endocrine Glands,TARGET.TEA.ENDOCRINE S=Septal Nuclei,FAM.FT.SEP SNc=Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT VTA=Ventral Tegmental Area,LMC.MM.VTA
- Connectivity map of the habenula - see Reference (CF.HB-CONN)
CPu=Striatum,FEC.FT.ST (see Basal Ganglia) EP=Endopiriform Nucleus,FAM.FT.EPF Hippo=Hippocampus,FMM.FT.HC (see Hippocampal Formation) IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD L=Lateral Habenula,FAM.FD.LHB (see Habenula) LH=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN M=Medial Habenula,FAM.FD.MHB NAc=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia) PAG=Periaqueductal Gray Matter,LMC.MM.PAG Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation) SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia) Septum=Septal Nuclei,FAM.FT.SEP VTA=Ventral Tegmental Area,LMC.MM.VTA
References
(generated)
- http://brmlab.cz/project/brain_hacking/tdcs/pfc
- http://www.nature.com/nrn/journal/v5/n1/fig_tab/nrn1299_F2.html
- http://www.impulsecontroldisorders.org/html/cravings.html
- http://www.nature.com/nrendo/journal/v6/n8/fig_tab/nrendo.2010.93_F1.html
- http://www.intechopen.com/books/computational-intelligence-in-electromyography-analysis-a-perspective-on-current-applications-and-future-challenges/sphincter-emg-for-diagnosing-multiple-system-atrophy-and-related-disorders
- http://neurowiki2012.wikispaces.com/Presynaptic+Mechanisms+of+Synaptic+Plasticity
- http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin
- http://www.nature.com/nrn/journal/v5/n1/fig_tab/nrn1299_F4.html
- http://www.springerimages.com/Images/LifeSciences/1-10.1007_s00359-004-0565-9-0
- http://journal.frontiersin.org/article/10.3389/fnhum.2013.00826/full
- http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html
- http://www.scholarpedia.org/article/Habenula
- http://jn.physiology.org/content/107/10/2633
