BrainRegionFEC FT ACC CORE

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Nucleus Accumbens Core

@@Home -> BiologicalLifeResearch -> BrainAreaFEC -> BrainRegionFEC_FT_ACC_CORE

This page covers biological details of component Nucleus Accumbens Core. Region is part of aHuman target integrated biological model.

Top-down path to region: Forebrain Telencephalon -> Basal Ganglia (FEC.FT.BG) -> Striatum (FEC.FT.ST) -> Ventral Striatum (FEC.FT.VST) -> Accumbens Nucleus (FEC.FT.ACC) -> Nucleus Accumbens Core (FEC.FT.ACC.CORE) (see Mind Maps)
Type: nucleus
Brain area: Forebrain - Execution Control Area
Role: basal.ganglia.striatum
Function: cognitive processing of motor function related to reward and reinforcement; encodes new motor programs which facilitate acquisition of given reward in future

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Contents

1 Components
2 Connectivity
3 Thirdparty Circuits
4 References

Components

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no child items defined

Connectivity

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FEC.FT.ACC.CORE.dot.png

Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Reference
FAM	FAM.FD.TH.PT	Paratenial Nucleus of Thalamus	excitatory-glu	(unknown reference)
	FAM.FT.AM.BP	Parvicellular Basal Amygdaloid Nucleus	excitatory-glu	Amygdala and its network (BLN -> NACC, abstract)
FMM	FMM.FD.TH.RH	Rhomboidal Nucleus of Thalamus	excitatory-glu	(unknown reference)
	FMM.FT.HC.CA1D	Distal CA1 of Hippocampus	excitatory-glu	Nucleus Accumbens (CA1 -> NACC, abstract)
	FMM.FT.HF.SUBD	Distal Subiculum	excitatory-glu	Nucleus Accumbens (SUB -> NACC, abstract)
	FMM.FT.HF.SUBP	Proximal Subiculum	excitatory-glu	Nucleus Accumbens (SUB -> NACC, abstract)
	FMM.NC.PH.LEC	Lateral Entorhinal Cortex	excitatory-glu	Nucleus Accumbens (EC -> NACC, abstract)
	FMM.NC.PH.PAS	Parasubiculum	excitatory-glu	Nucleus Accumbens (PAS -> NACC, abstract)
	FMM.NC.PH.PER	Perirhinal Cortex	excitatory-glu	Nucleus Accumbens (PRR -> NACC, abstract)
NDM	NDM.FD.TH.PV	Paraventricular Nucleus of Thalamus	excitatory-glu	(unknown reference)
	NDM.NC.AL.FPC	Lateral Frontopolar Cortex	excitatory-glu	Affective basal ganglia circuit (OMPFC -> NACC, abstract)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
FAM	FAM.FD.LHB.LT	Lateral Habenula Lateral Part	inhibitory-gaba	Connectivity map of the habenula (NAc -> L, abstract)
FEC	FEC.FT.SNC.MED	Substantia Nigra Pars Compacta Medial	inhibitory-gaba	(unknown reference)
	FEC.FT.SNR.MED	Substantia Nigra Pars Reticulata Medial	inhibitory-gaba	Craving (NACC -> SNr, abstract)
	FEC.FT.VP.DL	Ventral Pallidum Dorsolateral	inhibitory-gaba	Craving (NACC -> VPAL, abstract)
LMC	LMC.MM.VTA	Ventral Tegmental Area	inhibitory-gaba	Reward circuit of human brain (NACC -> VTA, abstract)

Thirdparty Circuits

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Saccadic Vision - see Reference

map: BG=Basal Ganglia,FEC.FT.BG, CN=Caudate Nucleus,FEC.FT.CN (Caudate Nucleus Head (FEC.FT.CN.HD), Caudate Nucleus Body (FEC.FT.CN.BD), Caudate Nucleus Tail (FEC.FT.CN.TL)), CR=Cerebellum,LLC.HT.CR (Cerebellar Flocconodular Lobe (LRC.HT.CR.FN), Cerebellar Lateral Lobe (LLC.HT.CR.CC), Cerebellar Paravermis (LLC.HT.CR.PV), Cerebellar Vermis (LRC.HT.CR.VM)), FrontalCortex=Anterior Lobe,NC.LOBE.ANT (Rostral Mid-Dorsolateral Prefrontal Cortex (NDM.NC.AL.DLPFCR), Lateral Mid-Dorsolateral Prefrontal Cortex (NDM.NC.AL.DLPFCL), Inferior Prefrontal Gyrus (NDM.NC.AL.IPG), Broca's Area Pars Opercularis (NPE.NC.BRA.PO), Broca's Area Pars Triangularis (NPE.NC.BRA.PT), Lateral Frontopolar Cortex (NDM.NC.AL.FPC), Most Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCR), Sulcal Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCS), Medial Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCM), Lateral Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCL), Dorsomedial Prefrontal Cortex (NDM.NC.AL.DMPFC), Ventromedial Prefrontal Cortex (NDM.NC.AL.VMPFC), Ventral Anterior Cingulate Area (NDM.NC.AL.VACG), Dorsal Anterior Cingulate Area (NDM.NC.AL.DACG), Subgenual Cingulate Cortex (NCP.NC.AL.SGCG), Ventral Medial Cingulate Area (NDM.NC.AL.VMCG), Dorsal Medial Cingulate Area (NDM.NC.AL.DMCG), Pregenual Cingulate Cortex (NDM.NC.AL.PGCG), Motor Cortex (NMA.NC.MC), Caudal Frontal Eye Field (NPE.NC.PMC.CFEF), Anterior Frontal Eye Field (NPE.NC.PMC.AFEF), Dorsal Caudal Premotor Cortex (NMA.NC.PMC.F2), Dorsal Rostral Premotor Cortex (NMA.NC.PMC.F7), Ventral Caudal Premotor Cortex (NMA.NC.PMC.F4), Ventral Rostral Premotor Cortex (NMA.NC.PMC.F5), Supplementary Eye Field (NPE.NC.SMC.SEF), Pre-Supplementary Motor Area (NMA.NC.SMC.F6), Supplementary Motor Area (NMA.NC.SMC.F3)), GPe=Globus Pallidus External,FEC.FT.GPE (Globus Pallidus External Lateral (FEC.FT.GPE.LT), Globus Pallidus External Medial (FEC.FT.GPE.MED), Globus Pallidus External Dorsal (FEC.FT.GPE.DS), Globus Pallidus External Rostromedial (FEC.FT.GPE.RM), Globus Pallidus External Dorsolateral (FEC.FT.GPE.DL)), LGN=Lateral Geniculate Nucleus,NSA.FD.LGN, LIP=Lateral Intraparietal Sulcus,NPE.NC.IPS.LIP, RF=Pontine Reticular Formation,HT.RF, Retina=Retinal Nucleus,LPC.FD.RT, SCi=Superior Colliculus,MM.SC (Superficial Superior Colliculus (LRC.MM.SC.SUP), Intermediate Superior Colliculus (LRC.MM.SC.INT), Deep Superior Colliculus (LRC.MM.SC.DEEP)), SCs=Superior Colliculus,MM.SC (Superficial Superior Colliculus (LRC.MM.SC.SUP), Intermediate Superior Colliculus (LRC.MM.SC.INT), Deep Superior Colliculus (LRC.MM.SC.DEEP)), SNpr=Substantia Nigra Pars Reticulata Dorsolateral,FEC.FT.SNR.DL, STN=Subthalamic Nucleus,FEC.FD.STN (Subthalamic Nucleus Caudal (FEC.FD.STN.CD), Subthalamic Nucleus Internal Caudal (FEC.FD.STN.ICD), Subthalamic Nucleus Dorsolateral (FEC.FD.STN.DL), Subthalamic Nucleus Lateral (FEC.FD.STN.LT), Subthalamic Nucleus Medial (FEC.FD.STN.MED)), Thalamus=Thalamus,FD.TH (Lateral Geniculate Nucleus (NSA.FD.LGN), Medial Geniculate Body (NSA.FD.TH.MGB), Ventral Posteroinferior Nucleus (NCP.FD.TH.VPI), Ventral Posterolateral Nucleus (NCP.FD.TH.VPL), Ventral Posteromedial Nucleus (NCP.FD.TH.VPM), Inferior Pulvinar (NSA.FD.TH.IPV), Lateral Pulvinar (NSA.FD.TH.LPV), Medial Pulvinar (NPE.FD.TH.MPV), Oral Pulvinar (NPE.FD.TH.OPV), Limitans Nucleus of Thalamus (NCP.FD.TH.LI), Suprageniculate Nucleus of Thalamus (NSA.FD.TH.SG), Submedial Nucleus of Thalamus (NDM.FD.TH.SM), Ventral Anterior Nucleus (NMA.FD.TH.VA), Ventral Lateral Nucleus (NMA.FD.TH.VL), Lateral Dorsal Nucleus of Thalamus (FMM.FD.TH.LD), Lateral Posterior Nucleus of Thalamus (NPE.FD.TH.LP), Medial Mediodorsal Nucleus of Thalamus (NDM.FD.TH.MDM), Central Mediodorsal Nucleus of Thalamus (NCP.FD.TH.MDC), Lateral Mediodorsal Nucleus of Thalamus (NMA.FD.TH.MDL), Anteromedial Nucleus (NCP.FD.TH.AM), Anteroventral Nucleus (FMM.FD.TH.AV), Anterodorsal Nucleus (FMM.FD.TH.AD), Rostral Intralaminar Nuclear Group of Thalamus (NCP.FD.TH.RIL), Centromedian Nucleus of Thalamus (FEC.FD.TH.CM), Parafascicular Nucleus of Thalamus (FEC.FD.TH.PF), Paratenial Nucleus of Thalamus (FAM.FD.TH.PT), Paraventricular Nucleus of Thalamus (NDM.FD.TH.PV), Reuniens Nucleus of Thalamus (FMM.FD.TH.RE), Rhomboidal Nucleus of Thalamus (FMM.FD.TH.RH), Subfascicular Nucleus of Thalamus (LLC.FD.TH.SF)), VisualCortex=Occipital Lobe,NC.LOBE.OCC unavailable

Bowels control brain: gut hormones and obesity - see Reference

map: AMY=Amygdala,FAM.FT.AM, ARC=Arcuate Nucleus of Hypothalamus,LAC.FD.HT.AR, DS=Dorsal Striatum,FEC.FT.DST (Caudate Nucleus Head (FEC.FT.CN.HD), Caudate Nucleus Body (FEC.FT.CN.BD), Caudate Nucleus Tail (FEC.FT.CN.TL), Dorsal Putamen Lateral (FEC.FT.PU.LT), Dorsal Putamen Medial (FEC.FT.PU.MED)), LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN, ME=Endocrine Glands,TARGET.TEA.ENDOCRINE, NAc=Accumbens Nucleus,FEC.FT.ACC (Nucleus Accumbens Core (FEC.FT.ACC.CORE), Nucleus Accumbens Shell (FEC.FT.ACC.SH)), NTS=Solitary Nucleus,LPC.HL.SOL, OFC=Orbitofrontal Cortex,NC.AL.OPFC (Lateral Frontopolar Cortex (NDM.NC.AL.FPC), Most Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCR), Sulcal Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCS), Medial Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCM), Lateral Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCL)), PBN=Parabrachial Nucleus,LPC.HT.PRF.PB, PVN=Paraventricular Nucleus,LAC.FD.HT.PV, VMN=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM, VTA=Ventral Tegmental Area,LMC.MM.VTA unavailable

Reward circuit of human brain - see Reference

map: AM=Amygdala,FAM.FT.AM, HC=Hippocampus,FMM.FT.HC (Dentate Gyrus (FMM.FT.HC.DG), Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D), Dorsolateral Cornu Ammonis of Hippocampus (FMM.FT.HC.CA2), Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P), Middle CA3 of Hippocampus (FMM.FT.HC.CA3M), Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)), NACC=Accumbens Nucleus,FEC.FT.ACC (Nucleus Accumbens Core (FEC.FT.ACC.CORE), Nucleus Accumbens Shell (FEC.FT.ACC.SH)), PFC=Orbitofrontal Cortex,NC.AL.OPFC (Lateral Frontopolar Cortex (NDM.NC.AL.FPC), Most Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCR), Sulcal Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCS), Medial Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCM), Lateral Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCL)), VPAL=Ventral Pallidum,FEC.FT.VP (Ventral Pallidum Dorsolateral (FEC.FT.VP.DL), Ventral Pallidum Ventromedial (FEC.FT.VP.VM)), VTA=Ventral Tegmental Area,LMC.MM.VTA unavailable

Connectivity map of the habenula - see Reference

map: CPu=Striatum,FEC.FT.ST (Nucleus Accumbens Core (FEC.FT.ACC.CORE), Nucleus Accumbens Shell (FEC.FT.ACC.SH), Ventral Putamen (FEC.FT.PU.VT), Caudate Nucleus Head (FEC.FT.CN.HD), Caudate Nucleus Body (FEC.FT.CN.BD), Caudate Nucleus Tail (FEC.FT.CN.TL), Dorsal Putamen Lateral (FEC.FT.PU.LT), Dorsal Putamen Medial (FEC.FT.PU.MED)), EP=Endopiriform Nucleus,FAM.FT.EPF, Hippo=Hippocampus,FMM.FT.HC (Dentate Gyrus (FMM.FT.HC.DG), Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D), Dorsolateral Cornu Ammonis of Hippocampus (FMM.FT.HC.CA2), Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P), Middle CA3 of Hippocampus (FMM.FT.HC.CA3M), Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)), IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD, L=Lateral Habenula,FAM.FD.LHB (Lateral Habenula Medial Part (FAM.FD.LHB.MED), Lateral Habenula Lateral Part (FAM.FD.LHB.LT)), LH=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN, M=Medial Habenula,FAM.FD.MHB, NAc=Accumbens Nucleus,FEC.FT.ACC (Nucleus Accumbens Core (FEC.FT.ACC.CORE), Nucleus Accumbens Shell (FEC.FT.ACC.SH)), PAG=Periaqueductal Gray Matter,LMC.MM.PAG, Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (Raphe Pallidus Nucleus (LMC.HL.RP.PL), Raphe Obscurus Nucleus (LMC.HL.RP.OB), Raphe Magnus Nucleus (LMC.HL.RP.MG)), SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (Substantia Nigra Pars Compacta Lateral (FEC.FT.SNC.LT), Substantia Nigra Pars Compacta Medial (FEC.FT.SNC.MED)), Septum=Septal Nuclei,FAM.FT.SEP, VTA=Ventral Tegmental Area,LMC.MM.VTA unavailable

Craving - see Reference

map: NACC=Accumbens Nucleus,FEC.FT.ACC (Nucleus Accumbens Core (FEC.FT.ACC.CORE), Nucleus Accumbens Shell (FEC.FT.ACC.SH)), OMPFC=Orbitofrontal Cortex,NC.AL.OPFC (Lateral Frontopolar Cortex (NDM.NC.AL.FPC), Most Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCR), Sulcal Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCS), Medial Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCM), Lateral Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCL)), SNr=Substantia Nigra Pars Reticulata Medial,FEC.FT.SNR.MED, VPAL=Ventral Pallidum,FEC.FT.VP (Ventral Pallidum Dorsolateral (FEC.FT.VP.DL), Ventral Pallidum Ventromedial (FEC.FT.VP.VM)), VTA=Ventral Tegmental Area,LMC.MM.VTA unavailable

References

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