BrainRegionLMC HT LC

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Locus Coeruleus

@@Home -> BiologicalLifeResearch -> BrainAreaLMC -> BrainRegionLMC_HT_LC

This page covers biological details of component Locus Coeruleus. Region is part of aHuman target integrated biological model.

Top-down path to region: Hindbrain Metencephalon -> Locus Coeruleus (LMC.HT.LC) (see Mind Maps)
Type: nucleus
Brain area: Lower Brain - Modulatory Contol Area
Role: processor.autonomic
Function: Regulate the intensity of responses to salient stimuli
Notes to function: NE Source, enhance signal-to-noise ratio, suppressing irrelevant stimuli (lateral inhibition); inhibitory nucleus

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Contents

1 Components
2 Connectivity
3 Thirdparty Circuits
4 References

Components

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no child items defined

Connectivity

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LMC.HT.LC.dot.png

Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Reference
FAM	FAM.FT.AM.CEM	Medial Central Amygdaloid Nucleus	excitatory-glu	Amygdalar disruption of prefrontal cortex (AM -> LC, abstract)
	FAM.FT.BNST	Bed Nucleus of Stria Terminalis	excitatory-glu	(unknown reference)
LAC	LAC.FD.HT.DM	Dorsomedial Hypothalamic Nucleus	excitatory-glu	Effect of light on pupil diameter (DMH -> LC)
	LAC.FD.HT.TBM	Tuberomammillary Nucleus	excitatory-glu	(unknown reference)
LRC	LRC.HL.RF.MED	Central Medullary Reticular Nucleus	excitatory-glu	(unknown reference)
NDM	NDM.NC.AL.VACG	Ventral Anterior Cingulate Area	excitatory-glu	(unknown reference)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
FAM	FAM.FD.LHB.LT	Lateral Habenula Lateral Part	modulatory-ne	Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract)
	FAM.FD.LHB.MED	Lateral Habenula Medial Part	modulatory-ne	Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract)
	FAM.FD.MHB	Medial Habenula	modulatory-ne	Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> MHB)
	FAM.FT.SEP.DBB	Diagonal Band of Broca	modulatory-ne	(unknown reference)
FEC	FEC.FT.SNC.MED	Substantia Nigra Pars Compacta Medial	modulatory-ne	(unknown reference)
	FEC.HT.TG.IPD	Interpeduncular Nucleus	modulatory-ne	Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> IPN)
LAC	LAC.FD.HT.VLPO	Ventrolateral Preoptic Nucleus	modulatory-ne	Simplified NREM sleep-promoting pathway (LC -> VLPO)
	LAC.SC.IZ.CSC	Ciliospinal Center	modulatory-ne	Effect of light on pupil diameter (LC -> IML)
	LAC.SC.IZ.IML	Intermediolateral Nucleus	modulatory-ne	Physiology and pathophysiology of lower urinary tract (LC -> IML)

Thirdparty Circuits

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Effect of light on pupil diameter - see Reference

map: DMH=Dorsomedial Hypothalamic Nucleus,LAC.FD.HT.DM, EW=Edinger-Westphal Nucleus,LAC.MM.EWN, EYE=Eye,TARGET.TSA.EYE, GC=Ciliary Ganglion,LAC.PN.PSYM.CLG, IML=Ciliospinal Center,LAC.SC.IZ.CSC, LC=Locus Coeruleus,LMC.HT.LC, OPN=Pretectal Olivary Nucleus,LRC.MM.PT.PON, PVN=Paraventricular Nucleus,LAC.FD.HT.PV, RET=Retinal Nucleus,LPC.FD.RT, SCG=Superior Cervical Ganglion,LAC.PN.SYM.SCG, SCN=Suprachiasmatic Nucleus,LAC.FD.HT.SCN unavailable

Physiology and pathophysiology of lower urinary tract - see Reference

map: CN=Caudate Nucleus,FEC.FT.CN (Caudate Nucleus Head (FEC.FT.CN.HD), Caudate Nucleus Body (FEC.FT.CN.BD), Caudate Nucleus Tail (FEC.FT.CN.TL)), DVM=Vagus Nucleus,LAC.HL.VGN, IMG=Inferior Mesenteric Ganglion,LAC.PN.SYM.IMG, IML=Intermediolateral Nucleus,LAC.SC.IZ.IML, LC=Locus Coeruleus,LMC.HT.LC, MPFC=Orbitofrontal Cortex,NC.AL.OPFC (Lateral Frontopolar Cortex (NDM.NC.AL.FPC), Most Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCR), Sulcal Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCS), Medial Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCM), Lateral Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCL)), MPOA=Median Preoptic Nucleus,LAC.FD.HT.MPO, NBM=Basal Nucleus of Meynert,LMC.FT.NBM, ONF=Onuf's Nucleus,LPC.SC.VH.ONF, PBN=Parabrachial Nucleus,LPC.HT.PRF.PB, PEL=Pelvic Peripheral Ganglion,LAC.PN.PSYM.PPG, PU=Dorsal Putamen Lateral,FEC.FT.PU.LT, PVN=Paraventricular Nucleus,LAC.FD.HT.PV, SNC=Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT, SPS=Sacral Parasympathetic Nucleus,LAC.SC.IZ.SPS, VTA=Ventral Tegmental Area,LMC.MM.VTA, ZI=Subthalamic Nucleus Caudal,BGA.FD.STN.ZI unavailable

Contribution of nAChR subunits to nicotine withdrawal symptoms - see Reference

map: IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD, LC=Locus Coeruleus,LMC.HT.LC, LHB=Lateral Habenula,FAM.FD.LHB (Lateral Habenula Medial Part (FAM.FD.LHB.MED), Lateral Habenula Lateral Part (FAM.FD.LHB.LT)), MHB=Medial Habenula,FAM.FD.MHB unavailable

Simplified NREM sleep-promoting pathway - see Reference

map: LC=Locus Coeruleus,LMC.HT.LC, LDTg=Laterodorsal Tegmental Nucleus,LMC.HT.TG.LDT, TMN=Tuberomammillary Nucleus,LAC.FD.HT.TBM, VLPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO unavailable

Amygdalar disruption of prefrontal cortex - see Reference

map: ACG=Anterior Cingulate Cortex,NC.AL.ACG (Ventral Anterior Cingulate Area (NDM.NC.AL.VACG), Dorsal Anterior Cingulate Area (NDM.NC.AL.DACG), Subgenual Cingulate Cortex (NCP.NC.AL.SGCG)), AM=Amygdala,FAM.FT.AM, HC=Hippocampus,FMM.FT.HC (Dentate Gyrus (FMM.FT.HC.DG), Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D), Dorsolateral Cornu Ammonis of Hippocampus (FMM.FT.HC.CA2), Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P), Middle CA3 of Hippocampus (FMM.FT.HC.CA3M), Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)), HT.L=Lateral Hypothalamic Area,LAC.FD.HT.LT (Lateral Hypothalamic Nucleus (LAC.FD.HT.LTN), Supramammillary Nucleus (LAC.FD.HT.SUM), Tuberomammillary Nucleus (LAC.FD.HT.TBM), Premammillary Nucleus (LAC.FD.HT.PRM)), HT.PV=Paraventricular Nucleus,LAC.FD.HT.PV, INS=Insular Cortex,NC.INS, LC=Locus Coeruleus,LMC.HT.LC, MPFC=Orbitofrontal Cortex,NC.AL.OPFC (Lateral Frontopolar Cortex (NDM.NC.AL.FPC), Most Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCR), Sulcal Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCS), Medial Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCM), Lateral Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCL)), PAG=Periaqueductal Gray Matter,LMC.MM.PAG, PB=Parabrachial Nucleus,LPC.HT.PRF.PB, PUT=Endocrine Glands,TARGET.TEA.ENDOCRINE, SOL=Solitary Nucleus,LPC.HL.SOL, TH=Thalamus,FD.TH (Lateral Geniculate Nucleus (NSA.FD.LGN), Medial Geniculate Body (NSA.FD.TH.MGB), Ventral Posteroinferior Nucleus (NCP.FD.TH.VPI), Ventral Posterolateral Nucleus (NCP.FD.TH.VPL), Ventral Posteromedial Nucleus (NCP.FD.TH.VPM), Inferior Pulvinar (NSA.FD.TH.IPV), Lateral Pulvinar (NSA.FD.TH.LPV), Medial Pulvinar (NPE.FD.TH.MPV), Oral Pulvinar (NPE.FD.TH.OPV), Limitans Nucleus of Thalamus (NCP.FD.TH.LI), Suprageniculate Nucleus of Thalamus (NSA.FD.TH.SG), Submedial Nucleus of Thalamus (NDM.FD.TH.SM), Ventral Anterior Nucleus (NMA.FD.TH.VA), Ventral Lateral Nucleus (NMA.FD.TH.VL), Lateral Dorsal Nucleus of Thalamus (FMM.FD.TH.LD), Lateral Posterior Nucleus of Thalamus (NPE.FD.TH.LP), Medial Mediodorsal Nucleus of Thalamus (NDM.FD.TH.MDM), Central Mediodorsal Nucleus of Thalamus (NCP.FD.TH.MDC), Lateral Mediodorsal Nucleus of Thalamus (NMA.FD.TH.MDL), Anteromedial Nucleus (NCP.FD.TH.AM), Anteroventral Nucleus (FMM.FD.TH.AV), Anterodorsal Nucleus (FMM.FD.TH.AD), Rostral Intralaminar Nuclear Group of Thalamus (NCP.FD.TH.RIL), Centromedian Nucleus of Thalamus (FEC.FD.TH.CM), Parafascicular Nucleus of Thalamus (FEC.FD.TH.PF), Paratenial Nucleus of Thalamus (FAM.FD.TH.PT), Paraventricular Nucleus of Thalamus (NDM.FD.TH.PV), Reuniens Nucleus of Thalamus (FMM.FD.TH.RE), Rhomboidal Nucleus of Thalamus (FMM.FD.TH.RH), Subfascicular Nucleus of Thalamus (LLC.FD.TH.SF)) unavailable

References

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