BrainRegionLAC FD HT VLPO
Ventrolateral Preoptic Nucleus
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This page covers biological details of component Ventrolateral Preoptic Nucleus. Region is part of aHuman target integrated biological model.
- Top-down path to region: Forebrain Diencephalon -> Hypothalamus (FD.HT) -> Anterior Hypothalamus Area (LAC.FD.HT.AHT) -> Chiasmatic Area (LAC.FD.HT.CHS) -> Preoptic Nucleus (LAC.FD.HT.PO) -> Ventrolateral Preoptic Nucleus (LAC.FD.HT.VLPO) (see Mind Maps)
- Type: nucleus
- Brain area: Lower Brain - Autonomous Control Area
- Role: processor.autonomic
- Function: mediates non-REM sleep onset
- Notes to function: lesions in VLPO result in insomnia
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Components
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- no child items defined
Connectivity
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Inbound Region Connections:
| Source Area | Source Region | Source Name | Type | Reference |
| FAM | FAM.FT.AM.MEA | Medial Anterior Amygdaloid Nucleus | excitatory-glu | Role for serotonin in moral behavior (AMY -> HYP, abstract) |
| FAM.FT.SEP.LT | Lateral Septal Nucleus | inhibitory-gaba | Cingulate Gyrus (SEP -> HT, abstract) | |
| FEC | FEC.HT.TG.RMTG | Rostromedial Tegmental Nucleus | inhibitory-gaba | (unknown reference) |
| LAC | LAC.FD.HT.DM | Dorsomedial Hypothalamic Nucleus | excitatory-glu | Eating and sleeping to survive (DMH -> VLPO) |
| LAC.FD.HT.SCN | Suprachiasmatic Nucleus | excitatory-glu | (unknown reference) | |
| LAC.FD.HT.TBM | Tuberomammillary Nucleus | excitatory-glu | Simplified NREM sleep-promoting pathway (TMN -> VLPO) | |
| LAC.FD.HT.VM | Ventromedial Hypothalamic Nucleus | excitatory-glu | (unknown reference) | |
| LMC | LMC.HT.LC | Locus Coeruleus | modulatory-ne | Simplified NREM sleep-promoting pathway (LC -> VLPO) |
| NSA | NSA.NC.PH.PRP | Prepyriform Cortex | excitatory-glu | (unknown reference) |
Outbound Region Connections:
| Target Area | Target Region | Target Name | Type | Reference |
| FAM | FAM.FD.LHB.LT | Lateral Habenula Lateral Part | excitatory-glu | Habenula Connections (LPO -> LHb, abstract) |
| FAM.FD.LHB.MED | Lateral Habenula Medial Part | excitatory-glu | Both LHb and MHb control the dopaminergic and serotonergic systems (LPO -> LHbM) | |
| LAC | LAC.FD.HT.SUM | Supramammillary Nucleus | excitatory-glu | (unknown reference) |
| LMC | LMC.HT.TG.LDT | Laterodorsal Tegmental Nucleus | excitatory-glu | Simplified NREM sleep-promoting pathway (VLPO -> LDTg) |
Thirdparty Circuits
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map: LC=Locus Coeruleus,LMC.HT.LC, LDTg=Laterodorsal Tegmental Nucleus,LMC.HT.TG.LDT, TMN=Tuberomammillary Nucleus,LAC.FD.HT.TBM, VLPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO
map: DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB, DRN=Dorsal Raphe Nucleus,LMC.MM.RP.DRN, GPb=Dorsal Pallidum,FEC.FT.DP (Globus Pallidus External Lateral (FEC.FT.GPE.LT), Globus Pallidus External Medial (FEC.FT.GPE.MED), Globus Pallidus External Dorsal (FEC.FT.GPE.DS), Globus Pallidus External Rostromedial (FEC.FT.GPE.RM), Globus Pallidus External Dorsolateral (FEC.FT.GPE.DL), Globus Pallidus Internal Lateral (FEC.FT.GPI.LT), Globus Pallidus Internal Medial (FEC.FT.GPI.MED), Globus Pallidus Internal Dorsal (FEC.FT.GPI.DS), Globus Pallidus Internal Rostromedial (FEC.FT.GPI.RM), Globus Pallidus Internal Dorsolateral (FEC.FT.GPI.DL)), IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD, LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN, LHbL=Lateral Habenula Lateral Part,FAM.FD.LHB.LT, LHbM=Lateral Habenula Medial Part,FAM.FD.LHB.MED, LPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO, LS=Lateral Septal Nucleus,FAM.FT.SEP.LT, MHb=Medial Habenula,FAM.FD.MHB, MRN=Raphe Nuclei of Medulla,LMC.HL.RP (Raphe Pallidus Nucleus (LMC.HL.RP.PL), Raphe Obscurus Nucleus (LMC.HL.RP.OB), Raphe Magnus Nucleus (LMC.HL.RP.MG)), MS=Medial Septal Nucleus,FAM.FT.SEP.MED, PS=Posterior Septal Group,FAM.FT.SEP.PG (Bed Nucleus of Anterior Commissure (FAM.FT.SEP.BAC), Septofimbrial Nucleus (FAM.FT.SEP.SF), Triangular Septal Nucleus (FAM.FT.SEP.TR)), RMTg=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG, SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (Substantia Nigra Pars Compacta Lateral (FEC.FT.SNC.LT), Substantia Nigra Pars Compacta Medial (FEC.FT.SNC.MED)), VP=Ventral Pallidum,FEC.FT.VP (Ventral Pallidum Dorsolateral (FEC.FT.VP.DL), Ventral Pallidum Ventromedial (FEC.FT.VP.VM)), VTA=Ventral Tegmental Area,LMC.MM.VTA
map: CPu=Striatum,FEC.FT.ST (Nucleus Accumbens Core (FEC.FT.ACC.CORE), Nucleus Accumbens Shell (FEC.FT.ACC.SH), Ventral Putamen (FEC.FT.PU.VT), Caudate Nucleus Head (FEC.FT.CN.HD), Caudate Nucleus Body (FEC.FT.CN.BD), Caudate Nucleus Tail (FEC.FT.CN.TL), Dorsal Putamen Lateral (FEC.FT.PU.LT), Dorsal Putamen Medial (FEC.FT.PU.MED)), DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB, DR=Dorsal Raphe Nucleus,LMC.MM.RP.DRN, GPi=Globus Pallidus Internal,FEC.FT.GPI (Globus Pallidus Internal Lateral (FEC.FT.GPI.LT), Globus Pallidus Internal Medial (FEC.FT.GPI.MED), Globus Pallidus Internal Dorsal (FEC.FT.GPI.DS), Globus Pallidus Internal Rostromedial (FEC.FT.GPI.RM), Globus Pallidus Internal Dorsolateral (FEC.FT.GPI.DL)), IP=Interpeduncular Nucleus,FEC.HT.TG.IPD, LH=Lateral Hypothalamic Area,LAC.FD.HT.LT (Lateral Hypothalamic Nucleus (LAC.FD.HT.LTN), Supramammillary Nucleus (LAC.FD.HT.SUM), Tuberomammillary Nucleus (LAC.FD.HT.TBM), Premammillary Nucleus (LAC.FD.HT.PRM)), LHb=Lateral Habenula,FAM.FD.LHB (Lateral Habenula Medial Part (FAM.FD.LHB.MED), Lateral Habenula Lateral Part (FAM.FD.LHB.LT)), LPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO, MHb=Medial Habenula,FAM.FD.MHB, MR=Superior Central Raphe Nucleus,LMC.MM.RP.SUC, PB=Endocrine Glands,TARGET.TEA.ENDOCRINE, S=Septal Nuclei,FAM.FT.SEP, SNc=Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT, VTA=Ventral Tegmental Area,LMC.MM.VTA
map: ARC=Arcuate Nucleus of Hypothalamus,LAC.FD.HT.AR, DMH=Dorsomedial Hypothalamic Nucleus,LAC.FD.HT.DM, LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN, MPO=Median Preoptic Nucleus,LAC.FD.HT.MPO, PVH=Paraventricular Nucleus,LAC.FD.HT.PV, SCN=Suprachiasmatic Nucleus,LAC.FD.HT.SCN, VLPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO, VMH=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM
References
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