BrainAreaFMM

Forebrain Memory Management Area

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Local Circuits

(generated)

ID	Name	Regions
MMAHCE	Emotional Hippocampus	FMM.FD.TH.RH, FMM.FT.HC.CA1D, FMM.FT.HC.CA3P, FMM.FT.HF.SUBP
MMAHCF	Creating Fields	FMM.FT.HC.CA2, FMM.FT.HC.DG
MMAHCS	Spatial Hippocampus	FMM.FT.HC.CA1P, FMM.FT.HC.CA3D, FMM.FT.HF.SUBD
MMAHCT	Thalamic Hippocampus	FMM.FD.TH.RE, FMM.FT.HC.CA1M, FMM.FT.HC.CA3M, FMM.FT.HF.SUBM
MMAORIENT	Orienting Control	FMM.FD.MB.LMB, FMM.FD.TH.AD, FMM.NC.PH.POS
MMASENSE	Emotional Sensory Input to Hippocampus	FMM.NC.PH.LEC, FMM.NC.PH.PER
MMASENSS	Spatial Sensory Input to Hippocampus	FMM.NC.PH.MEC, FMM.NC.PH.POR
MMATHETA	Theta Waves Control	FMM.FD.MB.MMB, FMM.FD.TH.AV, FMM.FD.TH.LD, FMM.NC.PH.PAS, FMM.NC.PH.PRS

Emotional Hippocampus

Component ID	Component Name	Type	Service	Function	Comments
FMM.FD.TH.RH	Rhomboidal Nucleus of Thalamus	nucleus	FMU	Communication of information across memory delays to guide memory responses	like RE, return projection from PFC to HC, spatial working memory
FMM.FT.HC.CA1D	Distal CA1 of Hippocampus	cortex	FMU	Long-term memory, motivational
FMM.FT.HC.CA3P	Proximal CA3 of Hippocampus	cortex	FMU	Representing sequences of episodic memory, spatial
FMM.FT.HF.SUBP	Proximal Subiculum	cortex	FMU	Controlling hypothalamic-pituitary-adrenal (HPA) axis

Internal Region Connections:

Source Region	Target Region	Type	Reference
FMM.FD.TH.RH	FMM.FT.HF.SUBP	nucleus-allocortex	Contributions of Diencephalon to Recognition Memory (MID -> SubPrePara, abstract)
FMM.FT.HC.CA1D	FMM.FT.HF.SUBP	allocortex-allocortex	Attractor Network in Hippocampus (CA1 -> SUB, abstract)
FMM.FT.HC.CA3P	FMM.FT.HC.CA1D	allocortex-allocortex	Neuronal projections in the hippocampus (CA3 -> CA1, abstract)

External Inbound Region Connections:

Source Area	Local Region	Source Region	Source Name	Type	Reference
Cortical
NDM	FMM.FD.TH.RH	NDM.NC.AL.ROFCR	Most Rostral Orbitofrontal Cortex	neocortex-nucleus	(unknown reference)
Subcortical
FAM	FMM.FT.HC.CA1D	FAM.FT.AM.BP	Parvicellular Basal Amygdaloid Nucleus	nucleus-allocortex	Detailed amygdalohippocampal projections (Bpc -> CA1D)
	FMM.FT.HF.SUBP	FAM.FT.SEP.BAC	Bed Nucleus of Anterior Commissure	nucleus-allocortex	Medial mammillary nucleus and theta rhythm (SEP -> HF, abstract)
FEC	FMM.FT.HC.CA3P	FEC.HT.TG.IPD	Interpeduncular Nucleus	nucleus-allocortex-ACh	Connectivity map of the habenula (IPN -> Hippo, abstract)
FMM	FMM.FT.HC.CA1D	FMM.FT.HC.CA2	Dorsolateral Cornu Ammonis of Hippocampus	allocortex-allocortex	Flow of impulses in hippocampal region (CA2 -> CA1, abstract)
		FMM.NC.PH.LEC	Lateral Entorhinal Cortex	neocortex-allocortex	Neuronal projections in the hippocampus (ET -> CA1, abstract)
	FMM.FT.HC.CA3P	FMM.FT.HC.DG	Dentate Gyrus	allocortex-allocortex	Neuronal projections in the hippocampus (DG -> CA3, abstract)
		FMM.NC.PH.LEC	Lateral Entorhinal Cortex	neocortex-allocortex	Neuronal projections in the hippocampus (ET -> CA3, abstract)
	FMM.FT.HF.SUBP	FMM.NC.PH.LEC	Lateral Entorhinal Cortex	neocortex-allocortex	Visual Path to Hippocampus (ER -> H, abstract)
		FMM.NC.PH.PER	Perirhinal Cortex	neocortex-allocortex	Gustatory sensory system of rat and macaque (PrC -> HF, abstract)
LAC	FMM.FT.HC.CA3P	LAC.FD.HT.PN	Posterior Hypothalamic Nucleus	nucleus-allocortex	(unknown reference)
		LAC.FD.HT.SUM	Supramammillary Nucleus	nucleus-allocortex	Medial mammillary nucleus and theta rhythm (SupraMM -> HF, abstract)
LMC	FMM.FT.HC.CA1D	LMC.MM.VTA	Ventral Tegmental Area	nucleus-allocortex-DA	Reward circuit of human brain (VTA -> HC, abstract)

External Outbound Region Connections:

Target Area	Local Region	Target Region	Target Name	Type	Reference
Cortical
NDM	FMM.FT.HC.CA1D	NDM.NC.AL.ROFCR	Most Rostral Orbitofrontal Cortex	allocortex-neocortex	Simplified model of hippocampal formation anatomy (CA1 -> mPFC, abstract)
		NDM.NC.AL.VMPFC	Ventromedial Prefrontal Cortex	allocortex-neocortex	Gating of medial prefrontal activity by the entorhinal cortex (HC -> MPFC, abstract)
Subcortical
FAM	FMM.FT.HC.CA1D	FAM.FT.AM.LAVM	Ventromedial Amygdaloid Nucleus	allocortex-nucleus	Fear regulation (Hippocampus -> LA, abstract)
		FAM.FT.SEP.LT	Lateral Septal Nucleus	allocortex-nucleus	Connectivity map of the habenula (Hippo -> Septum, abstract)
	FMM.FT.HF.SUBP	FAM.FT.AM.AB	Accessory Basal Amygdaloid Nucleus	allocortex-nucleus	Simplified model of hippocampal formation anatomy (SUB -> Amyg, abstract)
FEC	FMM.FD.TH.RH	FEC.FT.ACC.CORE	Nucleus Accumbens Core	nucleus-nucleus	(unknown reference)
	FMM.FT.HC.CA1D	FEC.FT.ACC.CORE	Nucleus Accumbens Core	allocortex-nucleus	Nucleus Accumbens (CA1 -> NACC, abstract)
	FMM.FT.HF.SUBP	FEC.FT.ACC.CORE	Nucleus Accumbens Core	allocortex-nucleus	Nucleus Accumbens (SUB -> NACC, abstract)
FMM	FMM.FT.HC.CA3P	FMM.FT.HC.CA2	Dorsolateral Cornu Ammonis of Hippocampus	allocortex-allocortex-gaba	KIV model of cortico-hippocampal formation with subcortical projections for motor actions (CA3 -> CA2, abstract)
	FMM.FT.HF.SUBP	FMM.FD.MB.MMB	Medial Mammillary Nucleus	allocortex-nucleus	Principal Connections of Hippocampus (HC -> MB, abstract)
LAC	FMM.FT.HC.CA1D	LAC.FD.HT.MPO	Median Preoptic Nucleus	allocortex-nucleus	Feeling (HC -> HT, abstract)
	FMM.FT.HF.SUBP	LAC.FD.HT.AH	Anterior Hypothalamic Nucleus	allocortex-nucleus	(unknown reference)
		LAC.FD.HT.VM	Ventromedial Hypothalamic Nucleus	allocortex-nucleus	(unknown reference)

Creating Fields

Component ID	Component Name	Type	Service	Function	Comments
FMM.FT.HC.CA2	Dorsolateral Cornu Ammonis of Hippocampus	cortex	FMU	Gate controlled by the activity of the supramammillary nucleus to control signal propagation between HC lamines	Hippocampus. Receives theta rithm input from Septum Nucleus; the only SUM projection in rat, the only converge from ET L2 and L3; social memory
FMM.FT.HC.DG	Dentate Gyrus	cortex	FMU	Distinguishing multiple instances of similar events

Internal Region Connections:

• no connections

External Inbound Region Connections:

Source Area	Local Region	Source Region	Source Name	Type	Reference
Subcortical
FAM	FMM.FT.HC.CA2	FAM.FT.SEP.DBB	Diagonal Band of Broca	nucleus-allocortex-gaba	Medial mammillary nucleus and theta rhythm (SEP -> HF, abstract)
FMM	FMM.FT.HC.CA2	FMM.FT.HC.CA3D	Distal CA3 of Hippocampus	allocortex-allocortex-gaba	KIV model of cortico-hippocampal formation with subcortical projections for motor actions (CA3 -> CA2, abstract)
		FMM.FT.HC.CA3M	Middle CA3 of Hippocampus	allocortex-allocortex-gaba	KIV model of cortico-hippocampal formation with subcortical projections for motor actions (CA3 -> CA2, abstract)
		FMM.FT.HC.CA3P	Proximal CA3 of Hippocampus	allocortex-allocortex-gaba	KIV model of cortico-hippocampal formation with subcortical projections for motor actions (CA3 -> CA2, abstract)
		FMM.NC.PH.LEC	Lateral Entorhinal Cortex	neocortex-allocortex	Amygdala and its network (EC -> HC, abstract)
		FMM.NC.PH.MEC	Medial Entorhinal Cortex	neocortex-allocortex	Amygdala and its network (EC -> HC, abstract)
	FMM.FT.HC.DG	FMM.NC.PH.LEC	Lateral Entorhinal Cortex	neocortex-allocortex	Neuronal projections in the hippocampus (ET -> DG, abstract)
		FMM.NC.PH.MEC	Medial Entorhinal Cortex	neocortex-allocortex	Neuronal projections in the hippocampus (ET -> DG, abstract)
		FMM.NC.PH.PER	Perirhinal Cortex	neocortex-allocortex	Gustatory sensory system of rat and macaque (PrC -> HF, abstract)
LAC	FMM.FT.HC.CA2	LAC.FD.HT.SUM	Supramammillary Nucleus	nucleus-allocortex	Medial mammillary nucleus and theta rhythm (SupraMM -> HF, abstract)
	FMM.FT.HC.DG	LAC.FD.HT.PN	Posterior Hypothalamic Nucleus	nucleus-allocortex	(unknown reference)
		LAC.FD.HT.SUM	Supramammillary Nucleus	nucleus-allocortex	Medial mammillary nucleus and theta rhythm (SupraMM -> HF, abstract)
LRC	FMM.FT.HC.DG	LRC.HT.NSC	Nucleus Subceruleus	nucleus-allocortex	(unknown reference)

External Outbound Region Connections:

Target Area	Local Region	Target Region	Target Name	Type	Reference
Subcortical
FMM	FMM.FT.HC.CA2	FMM.FT.HC.CA1D	Distal CA1 of Hippocampus	allocortex-allocortex	Flow of impulses in hippocampal region (CA2 -> CA1, abstract)
		FMM.FT.HC.CA1M	Middle CA1 of Hippocampus	allocortex-allocortex	Flow of impulses in hippocampal region (CA2 -> CA1, abstract)
		FMM.FT.HC.CA1P	Proximal CA1 of Hippocampus	allocortex-allocortex	Flow of impulses in hippocampal region (CA2 -> CA1, abstract)
	FMM.FT.HC.DG	FMM.FT.HC.CA3D	Distal CA3 of Hippocampus	allocortex-allocortex	Neuronal projections in the hippocampus (DG -> CA3, abstract)
		FMM.FT.HC.CA3M	Middle CA3 of Hippocampus	allocortex-allocortex	Neuronal projections in the hippocampus (DG -> CA3, abstract)
		FMM.FT.HC.CA3P	Proximal CA3 of Hippocampus	allocortex-allocortex	Neuronal projections in the hippocampus (DG -> CA3, abstract)

Spatial Hippocampus

Component ID	Component Name	Type	Service	Function	Comments
FMM.FT.HC.CA1P	Proximal CA1 of Hippocampus	cortex	FMU	Long-term memory, spatial
FMM.FT.HC.CA3D	Distal CA3 of Hippocampus	cortex	FMU	Representing sequences of episodic memory, motivational
FMM.FT.HF.SUBD	Distal Subiculum	cortex	FMU	Providing coarse representation of space

Internal Region Connections:

Source Region	Target Region	Type	Reference
FMM.FT.HC.CA1P	FMM.FT.HF.SUBD	allocortex-allocortex	Attractor Network in Hippocampus (CA1 -> SUB, abstract)
FMM.FT.HC.CA3D	FMM.FT.HC.CA1P	allocortex-allocortex	Neuronal projections in the hippocampus (CA3 -> CA1, abstract)

External Inbound Region Connections:

Source Area	Local Region	Source Region	Source Name	Type	Reference
Cortical
NCP	FMM.FT.HC.CA1P	NCP.NC.MPL.PSCG	Posterior Cingulate Cortex	neocortex-allocortex	Feeling (CG -> HC, abstract)
		NCP.NC.MPL.RSC	Retrosplenial Cortex	neocortex-allocortex	Prefrontal Cortex (PFC) in emotional behavior (PCA -> HCA, abstract)
NPE	FMM.FT.HC.CA1P	NPE.NC.IPL.MST	Medial Superior Temporal Area	neocortex-allocortex	Contribution of hippocampal region CA3 to consciousness (IPL -> CA1, abstract)
	FMM.FT.HC.CA3D	NPE.NC.IPL.MST	Medial Superior Temporal Area	neocortex-allocortex	(unknown reference)
Subcortical
FAM	FMM.FT.HC.CA1P	FAM.FT.AM.AB	Accessory Basal Amygdaloid Nucleus	nucleus-allocortex	Detailed amygdalohippocampal projections (ABmg -> CA1P)
FMM	FMM.FT.HC.CA1P	FMM.FD.TH.AV	Anteroventral Nucleus	nucleus-allocortex	Contributions of Diencephalon to Recognition Memory (AN -> HC, abstract)
		FMM.FD.TH.LD	Lateral Dorsal Nucleus of Thalamus	nucleus-allocortex	Contributions of Diencephalon to Recognition Memory (LD -> HC, abstract)
		FMM.FT.HC.CA2	Dorsolateral Cornu Ammonis of Hippocampus	allocortex-allocortex	Flow of impulses in hippocampal region (CA2 -> CA1, abstract)
		FMM.NC.PH.MEC	Medial Entorhinal Cortex	neocortex-allocortex	Neuronal projections in the hippocampus (ET -> CA1, abstract)
	FMM.FT.HC.CA3D	FMM.FT.HC.DG	Dentate Gyrus	allocortex-allocortex	Neuronal projections in the hippocampus (DG -> CA3, abstract)
		FMM.NC.PH.MEC	Medial Entorhinal Cortex	neocortex-allocortex	Neuronal projections in the hippocampus (ET -> CA3, abstract)
	FMM.FT.HF.SUBD	FMM.NC.PH.POR	Postrhinal Cortex	neocortex-allocortex	(unknown reference)

External Outbound Region Connections:

Target Area	Local Region	Target Region	Target Name	Type	Reference
Cortical
NCP	FMM.FT.HF.SUBD	NCP.NC.MPL.RSC	Retrosplenial Cortex	allocortex-neocortex	McNaughton Spatial Processing Network (SUB -> PCGRSP, abstract)
NDM	FMM.FT.HC.CA1P	NDM.NC.AL.DMPFC	Dorsomedial Prefrontal Cortex	allocortex-neocortex	Gating of medial prefrontal activity by the entorhinal cortex (HC -> MPFC, abstract)
	FMM.FT.HF.SUBD	NDM.NC.AL.ROFCR	Most Rostral Orbitofrontal Cortex	allocortex-neocortex	Simplified model of hippocampal formation anatomy (SUB -> mPFC, abstract)
Subcortical
FAM	FMM.FT.HC.CA3D	FAM.FT.SEP.SF	Septofimbrial Nucleus	allocortex-nucleus	Connectivity map of the habenula (Hippo -> Septum, abstract)
	FMM.FT.HF.SUBD	FAM.FT.AM.AB	Accessory Basal Amygdaloid Nucleus	allocortex-nucleus	Simplified model of hippocampal formation anatomy (SUB -> Amyg, abstract)
		FAM.FT.SEP.TR	Triangular Septal Nucleus	allocortex-nucleus	Principal Connections of Hippocampus (HC -> SEP, abstract)
FEC	FMM.FT.HF.SUBD	FEC.FT.ACC.CORE	Nucleus Accumbens Core	allocortex-nucleus	Nucleus Accumbens (SUB -> NACC, abstract)
FMM	FMM.FT.HC.CA1P	FMM.FD.MB.MMB	Medial Mammillary Nucleus	allocortex-nucleus	Feeling (HC -> HT, abstract)
		FMM.NC.PH.PAS	Parasubiculum	allocortex-neocortex	(unknown reference)
		FMM.NC.PH.POR	Postrhinal Cortex	allocortex-neocortex	Entorhinal Cortex Inputs and Outputs (CA1 -> TFTH, abstract)
	FMM.FT.HC.CA3D	FMM.FT.HC.CA2	Dorsolateral Cornu Ammonis of Hippocampus	allocortex-allocortex-gaba	KIV model of cortico-hippocampal formation with subcortical projections for motor actions (CA3 -> CA2, abstract)
	FMM.FT.HF.SUBD	FMM.FD.MB.MMB	Medial Mammillary Nucleus	allocortex-nucleus	Principal Connections of Hippocampus (HC -> MB, abstract)
		FMM.FD.TH.AV	Anteroventral Nucleus	allocortex-nucleus	Thalamocortical relationships (s1A -> A, abstract)
		FMM.FD.TH.LD	Lateral Dorsal Nucleus of Thalamus	allocortex-nucleus	Contributions of Diencephalon to Recognition Memory (Sub -> LD, abstract)
		FMM.NC.PH.LEC	Lateral Entorhinal Cortex	allocortex-neocortex	Attractor Network in Hippocampus (SUB -> EC, abstract)
		FMM.NC.PH.MEC	Medial Entorhinal Cortex	allocortex-neocortex	Attractor Network in Hippocampus (SUB -> EC, abstract)
		FMM.NC.PH.POS	Postsubiculum	allocortex-neocortex	Hippocampal Formation (Sub -> PoS, abstract)
		FMM.NC.PH.PRS	Presubiculum	allocortex-neocortex	Attractor Network in Hippocampus (SUB -> PRESUB, abstract)
LAC	FMM.FT.HF.SUBD	LAC.FD.HT.PV	Paraventricular Nucleus	allocortex-nucleus	(unknown reference)

Thalamic Hippocampus

Component ID	Component Name	Type	Service	Function	Comments
FMM.FD.TH.RE	Reuniens Nucleus of Thalamus	nucleus	FMU	Gate information between OMPFC and HC dependent upon attentive/arousal states	Regulate amount of neural traffic with changes in attentiveness
FMM.FT.HC.CA1M	Middle CA1 of Hippocampus	cortex	FMU	Long-term memory, synchronize
FMM.FT.HC.CA3M	Middle CA3 of Hippocampus	cortex	FMU	Representing sequences of episodic memory, synchronize
FMM.FT.HF.SUBM	Middle Subiculum	cortex	FMU	Dynamic bridging of temporal intervals

Internal Region Connections:

Source Region	Target Region	Type	Reference
FMM.FD.TH.RE	FMM.FT.HC.CA1M	nucleus-allocortex	Contributions of Diencephalon to Recognition Memory (MID -> HC, abstract)
FMM.FT.HC.CA1M	FMM.FT.HF.SUBM	allocortex-allocortex	Attractor Network in Hippocampus (CA1 -> SUB, abstract)
FMM.FT.HC.CA3M	FMM.FT.HC.CA1M	allocortex-allocortex	Neuronal projections in the hippocampus (CA3 -> CA1, abstract)
FMM.FT.HF.SUBM	FMM.FD.TH.RE	allocortex-nucleus	Contributions of Diencephalon to Recognition Memory (Sub -> MID, abstract)

External Inbound Region Connections:

Source Area	Local Region	Source Region	Source Name	Type	Reference
Cortical
NDM	FMM.FD.TH.RE	NDM.NC.AL.ROFCR	Most Rostral Orbitofrontal Cortex	neocortex-nucleus	(unknown reference)
Subcortical
FAM	FMM.FD.TH.RE	FAM.FT.AM.MPV	Medial Posterior Ventral Amygdaloid Nucleus	nucleus-nucleus-gaba	Oculomotor decision-making (AMYG -> Thalamus, abstract)
FMM	FMM.FT.HC.CA1M	FMM.FT.HC.CA2	Dorsolateral Cornu Ammonis of Hippocampus	allocortex-allocortex	Flow of impulses in hippocampal region (CA2 -> CA1, abstract)
	FMM.FT.HC.CA3M	FMM.FT.HC.DG	Dentate Gyrus	allocortex-allocortex	Neuronal projections in the hippocampus (DG -> CA3, abstract)

External Outbound Region Connections:

Target Area	Local Region	Target Region	Target Name	Type	Reference
Cortical
NCP	FMM.FT.HF.SUBM	NCP.FD.TH.AM	Anteromedial Nucleus	allocortex-nucleus	Thalamocortical relationships (s1A -> A, abstract)
Subcortical
FMM	FMM.FT.HC.CA3M	FMM.FT.HC.CA2	Dorsolateral Cornu Ammonis of Hippocampus	allocortex-allocortex-gaba	KIV model of cortico-hippocampal formation with subcortical projections for motor actions (CA3 -> CA2, abstract)

Orienting Control

Component ID	Component Name	Type	Service	Function	Comments
FMM.FD.MB.LMB	Lateral Mammillary Nucleus	nucleus	FMU	Generate theta rythm and relay to HC	Memory, recognition, spatial awareness, and interpreting the context of events
FMM.FD.TH.AD	Anterodorsal Nucleus	nucleus	NPU	head direction, spatial learning and memory
FMM.NC.PH.POS	Postsubiculum	cortex, BA 48	FMU	Visual association	Detached dorsal part of presubiculum; Integrate visual landmarks with internal representations of environments

Internal Region Connections:

Source Region	Target Region	Type	Reference
FMM.FD.MB.LMB	FMM.FD.TH.AD	nucleus-nucleus	Head Direction Cell Circuit (LMB -> AD)
FMM.FD.TH.AD	FMM.NC.PH.POS	nucleus-neocortex	Head Direction Cell Circuit (AD -> PSUB)
FMM.NC.PH.POS	FMM.FD.MB.LMB	neocortex-nucleus	Head Direction Cell Circuit (PSUB -> LMB)

External Inbound Region Connections:

Source Area	Local Region	Source Region	Source Name	Type	Reference
Cortical
NCP	FMM.FD.TH.AD	NCP.NC.MPL.RSC	Retrosplenial Cortex	neocortex-nucleus	Head Direction Cell Circuit (RSP -> AD)
	FMM.NC.PH.POS	NCP.NC.MPL.RSC	Retrosplenial Cortex	neocortex-neocortex	Head Direction Cell Circuit (RSP -> PSUB)
NSA	FMM.NC.PH.POS	NSA.NC.OCC.V2TK	Secondary Visual Cortex, Thick Stripe	neocortex-neocortex	Head Direction Cell Circuit (VC -> PSUB, abstract)
Subcortical
FAM	FMM.FD.MB.LMB	FAM.FT.SEP.MED	Medial Septal Nucleus	nucleus-nucleus-ACh	Cingulate Gyrus (SEP -> HT, abstract)
FMM	FMM.FD.MB.LMB	FMM.NC.PH.PAS	Parasubiculum	neocortex-nucleus	Mammillary bodies: two memory systems in one (PAS -> LMB)
		FMM.NC.PH.PRS	Presubiculum	neocortex-nucleus	Mammillary bodies: two memory systems in one (PRS -> LMB)
	FMM.NC.PH.POS	FMM.FD.TH.LD	Lateral Dorsal Nucleus of Thalamus	nucleus-neocortex	Head Direction Cell Circuit (LD -> PSUB)
		FMM.FT.HF.SUBD	Distal Subiculum	allocortex-neocortex	Hippocampal Formation (Sub -> PoS, abstract)
LAC	FMM.FD.MB.LMB	LAC.FD.HT.SUM	Supramammillary Nucleus	nucleus-nucleus	Mammillary bodies: two memory systems in one (SupraMM -> LMB)
LMC	FMM.FD.MB.LMB	LMC.HT.TG.DTG	Dorsal Tegmental Nucleus	nucleus-nucleus-ACh	(unknown reference)
LRC	FMM.FD.TH.AD	LRC.MM.SC.INT	Intermediate Superior Colliculus	nucleus-nucleus	Global visual system (SCi -> ATH, abstract)

External Outbound Region Connections:

Target Area	Local Region	Target Region	Target Name	Type	Reference
Subcortical
FMM	FMM.NC.PH.POS	FMM.NC.PH.MEC	Medial Entorhinal Cortex	neocortex-neocortex	Head Direction Cell Circuit (PSUB -> EC, abstract)
LLC	FMM.FD.MB.LMB	LLC.HT.PRF.RTMG	Pontine Reticulotegmental Nucleus	nucleus-nucleus	Mammillary Body (LMB -> RTG)
LMC	FMM.FD.MB.LMB	LMC.HT.TG.LDT	Laterodorsal Tegmental Nucleus	nucleus-nucleus	Hippocampal Formation (LMam -> DTN)

Emotional Sensory Input to Hippocampus

Component ID	Component Name	Type	Service	Function	Comments
FMM.NC.PH.LEC	Lateral Entorhinal Cortex	cortex, BA 28	FMU	Memory consolidation, emotional aspects	non-spatial input to HC; process information about individual items and locations based on a local frame of reference, primarily using external sensory input; it provides the hippocampus with information about content of experience
FMM.NC.PH.PER	Perirhinal Cortex	cortex, BA 35,36	FMU	Associate different visual views of objects and their various nonvisual attributes	35 - transentorhinal cortex (agranular), 36 - actorhinal cortex (agranular)

Internal Region Connections:

Source Region	Target Region	Type	Reference
FMM.NC.PH.PER	FMM.NC.PH.LEC	neocortex-neocortex	Visual Path to Hippocampus (PRPH -> ER, abstract)

External Inbound Region Connections:

Source Area	Local Region	Source Region	Source Name	Type	Reference
Cortical
NCP	FMM.NC.PH.PER	NCP.NC.INS.AIC	Anterior Insular Cortex	neocortex-neocortex	Gustatory sensory system of rat and macaque (Iav -> PrC, abstract)
		NCP.NC.INS.HR	Anterior Temporal Lobe	neocortex-neocortex	Contribution of hippocampal region CA3 to consciousness (AnteriorTemporal -> PRCortex)
		NCP.NC.PG.PV	Parietal Ventral Cortex	neocortex-neocortex	(unknown reference)
NDM	FMM.NC.PH.LEC	NDM.FD.TH.PV	Paraventricular Nucleus of Thalamus	nucleus-neocortex	Contributions of Diencephalon to Recognition Memory (MID -> EC, abstract)
	FMM.NC.PH.PER	NDM.FD.TH.PV	Paraventricular Nucleus of Thalamus	nucleus-neocortex	Contributions of Diencephalon to Recognition Memory (MID -> Perirhinal, abstract)
NSA	FMM.NC.PH.LEC	NSA.NC.IT.TE	Inferotemporal Cortex	neocortex-neocortex	McNaughton Spatial Processing Network (ITCortex -> EnthCortex, abstract)
		NSA.NC.PH.PIR	Piriform Cortex	neocortex-neocortex	KIV model of cortico-hippocampal formation with subcortical projections for motor actions (PC -> EC, abstract)
		NSA.NC.STG.A3	Wernicke's area A3	neocortex-neocortex	(unknown reference)
		NSA.NC.STG.A4	Wernicke's area A4	neocortex-neocortex	(unknown reference)
	FMM.NC.PH.PER	NSA.NC.IT.TE	Inferotemporal Cortex	neocortex-neocortex	Visual Path to Hippocampus (IT -> PRPH)
Subcortical
FAM	FMM.NC.PH.LEC	FAM.FD.TH.PT	Paratenial Nucleus of Thalamus	nucleus-neocortex	Contributions of Diencephalon to Recognition Memory (MID -> EC, abstract)
		FAM.FT.AM.BP	Parvicellular Basal Amygdaloid Nucleus	nucleus-neocortex	Principal Connections of Hippocampus (AM -> EC, abstract)
	FMM.NC.PH.PER	FAM.HT.TG.NI	Incertus Nucleus	nucleus-neocortex-gaba	(unknown reference)
FMM	FMM.NC.PH.LEC	FMM.FT.HF.SUBD	Distal Subiculum	allocortex-neocortex	Attractor Network in Hippocampus (SUB -> EC, abstract)
LMC	FMM.NC.PH.LEC	LMC.MM.VTA	Ventral Tegmental Area	nucleus-neocortex-DA	Combining Novelty, Motivational Salience, and Reward to Control Attention and Learning (VTA -> EC, abstract)

External Outbound Region Connections:

Target Area	Local Region	Target Region	Target Name	Type	Reference
Cortical
NDM	FMM.NC.PH.LEC	NDM.FD.TH.MDM	Medial Mediodorsal Nucleus of Thalamus	neocortex-nucleus	Contributions of Diencephalon to Recognition Memory (EC -> MDmc, abstract)
	FMM.NC.PH.PER	NDM.FD.TH.MDM	Medial Mediodorsal Nucleus of Thalamus	neocortex-nucleus	Contributions of Diencephalon to Recognition Memory (Perirhinal -> MDmc, abstract)
NPE	FMM.NC.PH.PER	NPE.FD.TH.MPV	Medial Pulvinar	neocortex-nucleus	Contributions of Diencephalon to Recognition Memory (Perirhinal -> mPULV)
Subcortical
FAM	FMM.NC.PH.LEC	FAM.FT.AM.AB	Accessory Basal Amygdaloid Nucleus	neocortex-nucleus	Simplified model of hippocampal formation anatomy (EC -> Amyg, abstract)
		FAM.FT.AM.LAVM	Ventromedial Amygdaloid Nucleus	neocortex-nucleus	Simplified model of hippocampal formation anatomy (EC -> Amyg, abstract)
FEC	FMM.NC.PH.LEC	FEC.FT.ACC.CORE	Nucleus Accumbens Core	neocortex-nucleus	Nucleus Accumbens (EC -> NACC, abstract)
	FMM.NC.PH.PER	FEC.FT.ACC.CORE	Nucleus Accumbens Core	neocortex-nucleus	Nucleus Accumbens (PRR -> NACC, abstract)
FMM	FMM.NC.PH.LEC	FMM.FT.HC.CA1D	Distal CA1 of Hippocampus	neocortex-allocortex	Neuronal projections in the hippocampus (ET -> CA1, abstract)
		FMM.FT.HC.CA2	Dorsolateral Cornu Ammonis of Hippocampus	neocortex-allocortex	Amygdala and its network (EC -> HC, abstract)
		FMM.FT.HC.CA3P	Proximal CA3 of Hippocampus	neocortex-allocortex	Neuronal projections in the hippocampus (ET -> CA3, abstract)
		FMM.FT.HC.DG	Dentate Gyrus	neocortex-allocortex	Neuronal projections in the hippocampus (ET -> DG, abstract)
		FMM.FT.HF.SUBP	Proximal Subiculum	neocortex-allocortex	Visual Path to Hippocampus (ER -> H, abstract)
	FMM.NC.PH.PER	FMM.FT.HC.DG	Dentate Gyrus	neocortex-allocortex	Gustatory sensory system of rat and macaque (PrC -> HF, abstract)
		FMM.FT.HF.SUBP	Proximal Subiculum	neocortex-allocortex	Gustatory sensory system of rat and macaque (PrC -> HF, abstract)

Spatial Sensory Input to Hippocampus

Component ID	Component Name	Type	Service	Function	Comments
FMM.NC.PH.MEC	Medial Entorhinal Cortex	cortex, BA 28	FMU	Memory consolidation, basic, view independent position	spatial input to HC; grid cells; path integration computations based on a global frame of reference, primarily using internally generated, self-motion cues and external input about environmental boundaries and scenes; provides hippocampus with coordinate system that underlies spatial context of experience
FMM.NC.PH.POR	Postrhinal Cortex	cortex	FMU	Spatial declarative memory	do not have brodmann numbers, referred to as TF, TH; postrhinal in rodents, parahippocampal in primates

Internal Region Connections:

Source Region	Target Region	Type	Reference
FMM.NC.PH.POR	FMM.NC.PH.MEC	neocortex-neocortex	Entorhinal Cortex Inputs and Outputs (TFTH -> EC, abstract)

External Inbound Region Connections:

Source Area	Local Region	Source Region	Source Name	Type	Reference
Cortical
NCP	FMM.NC.PH.MEC	NCP.NC.MPL.PSCG	Posterior Cingulate Cortex	neocortex-neocortex	McNaughton Spatial Processing Network (PCGRSP -> EnthCortex, abstract)
		NCP.NC.MPL.RSC	Retrosplenial Cortex	neocortex-neocortex	McNaughton Spatial Processing Network (PCGRSP -> EnthCortex, abstract)
NPE	FMM.NC.PH.POR	NPE.NC.IPL.MST	Medial Superior Temporal Area	neocortex-neocortex	Head Direction Cell Circuit (PC -> PRHC, abstract)
Subcortical
FMM	FMM.NC.PH.MEC	FMM.FT.HF.SUBD	Distal Subiculum	allocortex-neocortex	Attractor Network in Hippocampus (SUB -> EC, abstract)
		FMM.NC.PH.PAS	Parasubiculum	neocortex-neocortex	(unknown reference)
		FMM.NC.PH.POS	Postsubiculum	neocortex-neocortex	Head Direction Cell Circuit (PSUB -> EC, abstract)
		FMM.NC.PH.PRS	Presubiculum	neocortex-neocortex	Attractor Network in Hippocampus (PRESUB -> EC, abstract)
	FMM.NC.PH.POR	FMM.FT.HC.CA1P	Proximal CA1 of Hippocampus	allocortex-neocortex	Entorhinal Cortex Inputs and Outputs (CA1 -> TFTH, abstract)

External Outbound Region Connections:

Target Area	Local Region	Target Region	Target Name	Type	Reference
Subcortical
FMM	FMM.NC.PH.MEC	FMM.FD.MB.MMB	Medial Mammillary Nucleus	neocortex-nucleus	Mammillary bodies: two memory systems in one (MedialEC -> MMB, abstract)
		FMM.FD.TH.AV	Anteroventral Nucleus	neocortex-nucleus	Contributions of Diencephalon to Recognition Memory (EC -> AN, abstract)
		FMM.FD.TH.LD	Lateral Dorsal Nucleus of Thalamus	neocortex-nucleus	Contributions of Diencephalon to Recognition Memory (EC -> LD, abstract)
		FMM.FT.HC.CA1P	Proximal CA1 of Hippocampus	neocortex-allocortex	Neuronal projections in the hippocampus (ET -> CA1, abstract)
		FMM.FT.HC.CA2	Dorsolateral Cornu Ammonis of Hippocampus	neocortex-allocortex	Amygdala and its network (EC -> HC, abstract)
		FMM.FT.HC.CA3D	Distal CA3 of Hippocampus	neocortex-allocortex	Neuronal projections in the hippocampus (ET -> CA3, abstract)
		FMM.FT.HC.DG	Dentate Gyrus	neocortex-allocortex	Neuronal projections in the hippocampus (ET -> DG, abstract)
	FMM.NC.PH.POR	FMM.FT.HF.SUBD	Distal Subiculum	neocortex-allocortex	(unknown reference)

Theta Waves Control

Component ID	Component Name	Type	Service	Function	Comments
FMM.FD.MB.MMB	Medial Mammillary Nucleus	nucleus	FMU	Relay for impulses coming from AM and HC	Memory, recognition, spatial awareness, and interpreting the context of events
FMM.FD.TH.AV	Anteroventral Nucleus	nucleus	NPU	return loop to convey theta to HF, attentional processes
FMM.FD.TH.LD	Lateral Dorsal Nucleus of Thalamus	nucleus	NPU	Head direction, spatial learning	From RSP L5,6 BA17,18, RT, LGN
FMM.NC.PH.PAS	Parasubiculum	cortex, BA 49	FMU	Spatial navigation and the integration of head-directional information	Major projects to ET, from CA1,AM
FMM.NC.PH.PRS	Presubiculum	cortex, BA 27	FMU	Path integration, head direction	Major projects to ET, from TH.LD

Internal Region Connections:

Source Region	Target Region	Type	Reference
FMM.FD.MB.MMB	FMM.FD.TH.AV	nucleus-nucleus	Mammillary bodies: two memory systems in one (MMB -> AVTH)
FMM.FD.TH.AV	FMM.NC.PH.PAS	nucleus-neocortex	(unknown reference)
	FMM.NC.PH.PRS	nucleus-neocortex	(unknown reference)
FMM.NC.PH.PAS	FMM.FD.TH.LD	neocortex-nucleus	Contributions of Diencephalon to Recognition Memory (Parasub -> LD)
FMM.NC.PH.PRS	FMM.FD.MB.MMB	neocortex-nucleus	Attractor Network in Hippocampus (PRESUB -> MBIN)
	FMM.FD.TH.LD	neocortex-nucleus	Contributions of Diencephalon to Recognition Memory (Presub -> LD)

External Inbound Region Connections:

Source Area	Local Region	Source Region	Source Name	Type	Reference
Cortical
NCP	FMM.FD.TH.AV	NCP.NC.MPL.RSC	Retrosplenial Cortex	neocortex-nucleus	Medial mammillary nucleus and theta rhythm (RSP -> AVTH)
	FMM.FD.TH.LD	NCP.NC.MPL.RSC	Retrosplenial Cortex	neocortex-nucleus	Head Direction Cell Circuit (RSP -> LD)
	FMM.NC.PH.PRS	NCP.NC.INS.PPC	Peripaleocortical Claustral	neocortex-neocortex	(unknown reference)
NPE	FMM.FD.TH.LD	NPE.NC.SPL.PF	Rostral Precuneus	neocortex-nucleus	Thalamocortical relationships (sLD -> LD, abstract)
Subcortical
FAM	FMM.FD.MB.MMB	FAM.FT.SEP.DBB	Diagonal Band of Broca	nucleus-nucleus-gaba	Cingulate Gyrus (SEP -> HT, abstract)
		FAM.FT.SEP.MED	Medial Septal Nucleus	nucleus-nucleus-gaba	Cingulate Gyrus (SEP -> HT, abstract)
	FMM.NC.PH.PAS	FAM.FT.AM.BP	Parvicellular Basal Amygdaloid Nucleus	nucleus-neocortex	Detailed amygdalohippocampal projections (Bpc -> PaS)
		FAM.FT.AM.LAVL	Ventrolateral Amygdaloid Nucleus	nucleus-neocortex	Detailed amygdalohippocampal projections (L -> PaS, abstract)
	FMM.NC.PH.PRS	FAM.FT.AM.BP	Parvicellular Basal Amygdaloid Nucleus	nucleus-neocortex	Detailed amygdalohippocampal projections (Bpc -> PrS)
FMM	FMM.FD.MB.MMB	FMM.FT.HC.CA1P	Proximal CA1 of Hippocampus	allocortex-nucleus	Feeling (HC -> HT, abstract)
		FMM.FT.HF.SUBD	Distal Subiculum	allocortex-nucleus	Principal Connections of Hippocampus (HC -> MB, abstract)
		FMM.FT.HF.SUBP	Proximal Subiculum	allocortex-nucleus	Principal Connections of Hippocampus (HC -> MB, abstract)
		FMM.NC.PH.MEC	Medial Entorhinal Cortex	neocortex-nucleus	Mammillary bodies: two memory systems in one (MedialEC -> MMB, abstract)
	FMM.FD.TH.AV	FMM.FT.HF.SUBD	Distal Subiculum	allocortex-nucleus	Thalamocortical relationships (s1A -> A, abstract)
		FMM.NC.PH.MEC	Medial Entorhinal Cortex	neocortex-nucleus	Contributions of Diencephalon to Recognition Memory (EC -> AN, abstract)
	FMM.FD.TH.LD	FMM.FT.HF.SUBD	Distal Subiculum	allocortex-nucleus	Contributions of Diencephalon to Recognition Memory (Sub -> LD, abstract)
		FMM.NC.PH.MEC	Medial Entorhinal Cortex	neocortex-nucleus	Contributions of Diencephalon to Recognition Memory (EC -> LD, abstract)
	FMM.NC.PH.PAS	FMM.FT.HC.CA1P	Proximal CA1 of Hippocampus	allocortex-neocortex	(unknown reference)
	FMM.NC.PH.PRS	FMM.FT.HF.SUBD	Distal Subiculum	allocortex-neocortex	Attractor Network in Hippocampus (SUB -> PRESUB, abstract)
LAC	FMM.FD.MB.MMB	LAC.FD.HT.TBM	Tuberomammillary Nucleus	nucleus-nucleus	Mammillary bodies: two memory systems in one (TuberoMM -> MMB, abstract)
LMC	FMM.FD.MB.MMB	LMC.MM.RP.SUC	Superior Central Raphe Nucleus	nucleus-nucleus-5HT	(unknown reference)
		LMC.MM.VTA	Ventral Tegmental Area	nucleus-nucleus-DA	Mammillary bodies: two memory systems in one (VTN -> MMB)

External Outbound Region Connections:

Target Area	Local Region	Target Region	Target Name	Type	Reference
Cortical
NCP	FMM.FD.MB.MMB	NCP.FD.TH.AM	Anteromedial Nucleus	nucleus-nucleus	Mammillary bodies: two memory systems in one (MMB -> AMTH)
	FMM.FD.TH.AV	NCP.NC.MPL.PSCG	Posterior Cingulate Cortex	nucleus-neocortex	Contribution of hippocampal region CA3 to consciousness (TH.AV -> PosteriorCingulate)
NDM	FMM.FD.TH.LD	NDM.NC.AL.DACG	Dorsal Anterior Cingulate Area	nucleus-neocortex	Thalamocortical relationships (LD -> pLD, abstract)
NPE	FMM.NC.PH.PRS	NPE.FD.TH.MPV	Medial Pulvinar	neocortex-nucleus	Contributions of Diencephalon to Recognition Memory (Presub -> mPULV)
Subcortical
FEC	FMM.NC.PH.PAS	FEC.FT.ACC.CORE	Nucleus Accumbens Core	neocortex-nucleus	Nucleus Accumbens (PAS -> NACC, abstract)
FMM	FMM.FD.TH.AV	FMM.FT.HC.CA1P	Proximal CA1 of Hippocampus	nucleus-allocortex	Contributions of Diencephalon to Recognition Memory (AN -> HC, abstract)
	FMM.FD.TH.LD	FMM.FT.HC.CA1P	Proximal CA1 of Hippocampus	nucleus-allocortex	Contributions of Diencephalon to Recognition Memory (LD -> HC, abstract)
		FMM.NC.PH.POS	Postsubiculum	nucleus-neocortex	Head Direction Cell Circuit (LD -> PSUB)
	FMM.NC.PH.PAS	FMM.FD.MB.LMB	Lateral Mammillary Nucleus	neocortex-nucleus	Mammillary bodies: two memory systems in one (PAS -> LMB)
		FMM.NC.PH.MEC	Medial Entorhinal Cortex	neocortex-neocortex	(unknown reference)
	FMM.NC.PH.PRS	FMM.FD.MB.LMB	Lateral Mammillary Nucleus	neocortex-nucleus	Mammillary bodies: two memory systems in one (PRS -> LMB)
		FMM.NC.PH.MEC	Medial Entorhinal Cortex	neocortex-neocortex	Attractor Network in Hippocampus (PRESUB -> EC, abstract)
LLC	FMM.FD.MB.MMB	LLC.HT.PN.RSP	Rostral Pontine Nucleus	nucleus-nucleus	Prefrontal Cortex (PFC) in emotional behavior (HT -> PN, abstract)
		LLC.HT.PRF.RTMG	Pontine Reticulotegmental Nucleus	nucleus-nucleus	Mammillary Body (MMB -> RTG)

Thirdparty Circuits

(generated)

• Contributions of Diencephalon to Recognition Memory - see Reference

• Mammillary bodies: two memory systems in one - see Reference

• Head Direction Cell Circuit - see Reference

• Attractor Network in Hippocampus - see Reference

• Detailed amygdalohippocampal projections - see Reference

• Hippocampal Formation - see Reference

• Flow of impulses in hippocampal region - see Reference

• Contribution of hippocampal region CA3 to consciousness - see Reference

• Nucleus Accumbens (unknown reference)

• KIV model of cortico-hippocampal formation with subcortical projections for motor actions - see Reference

• Hippocampus in Detail - see Reference

• Principal Connections of Hippocampus - see Reference

• Medial mammillary nucleus and theta rhythm - see Reference

• Mammillary Body (unknown reference)

• Entorhinal Cortex Inputs and Outputs - see Reference

• Visual Path to Hippocampus - see Reference

• Gustatory sensory system of rat and macaque - see Reference

• Basal Nucleus of Meynert - see Reference

• Simplified model of hippocampal formation anatomy - see Reference

• Combining Novelty, Motivational Salience, and Reward to Control Attention and Learning - see Reference

• Neuronal projections in the hippocampus - see Reference

• Thalamocortical relationships - see Reference

• Hippocampus and Septal Area - see Reference

References

(generated)

• http://learnmem.cshlp.org/content/18/6/384/F1.expansion.html
• http://www.nature.com/nrn/journal/v5/n1/fig_tab/nrn1299_F2.html
• http://www.scholarpedia.org/article/Head_direction_cells
• http://learnmem.cshlp.org/content/14/11/714/F1.expansion
• https://books.google.ru/books?id=P3fSBwAAQBAJ
• article:2009-Hippocampus-Thesis.pdf
• http://www.sciencedirect.com/science/article/pii/S030645220600755X
• http://www.sciencedirect.com/science/article/pii/S0149763409002061
• http://www.sciencedirect.com/science/article/pii/S1571064507000243
• http://what-when-how.com/neuroscience/the-limbic-system-integrative-systems-part-1/
• http://highered.mcgraw-hill.com/sites/dl/free/0071402357/156721/figure350_1.html
• http://www.nature.com/nrn/journal/v5/n1/fig_tab/nrn1299_F4.html
• http://www.sciencedirect.com/science/article/pii/S0149763411001722
• http://www.scholarpedia.org/article/Inferior_temporal_cortex
• http://www.sciencedirect.com/science/article/pii/S0149763401000215
• article:Biological/2005-The-Human-Nervous-System.pdf
• http://www.sciencedirect.com/science/article/pii/S030100820900183X
• http://www.impulsecontroldisorders.org/html/cravings.html
• http://journal.frontiersin.org/Journal/10.3389/fpsyt.2013.00061/full
• http://what-when-how.com/neuroscience/the-thalamus-and-cerebral-cortex-integrative-systems-part-2/
• http://neurondevelopment.org/hippocampal-development