Medial Mammillary Nucleus

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This page covers biological details of component Medial Mammillary Nucleus. Region is part of aHuman target integrated biological model.

Top-down path to region: Forebrain Diencephalon -> Hypothalamus (FD.HT) -> Mammillary Body (FD.MB) -> Medial Mammillary Nucleus (FMM.FD.MB.MMB) (see Mind Maps)
Type: nucleus
Brain area: Forebrain - Memory Management Area
Role: processor.memory.space
Function: Relay for impulses coming from AM and HC
Notes to function: Memory, recognition, spatial awareness, and interpreting the context of events

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Components

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Component items:

Mediolateral Mammillary Nucleus
Medial Part of Medial Mammillary Nucleus

Connectivity

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FMM.FD.MB.MMB.dot.png

Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Reference
FAM	FAM.FT.SEP.DBB	Diagonal Band of Broca	inhibitory-gaba	Cingulate Gyrus (SEP -> HT, abstract)
	FAM.FT.SEP.MED	Medial Septal Nucleus	inhibitory-gaba	Cingulate Gyrus (SEP -> HT, abstract)
FMM	FMM.FT.HC.CA1P	Proximal CA1 of Hippocampus	excitatory-glu	Feeling (HC -> HT, abstract)
	FMM.FT.HF.SUBD	Distal Subiculum	excitatory-glu	Principal Connections of Hippocampus (HC -> MB, abstract)
	FMM.FT.HF.SUBP	Proximal Subiculum	excitatory-glu	Principal Connections of Hippocampus (HC -> MB, abstract)
	FMM.NC.PH.MEC	Medial Entorhinal Cortex	excitatory-glu	Mammillary bodies: two memory systems in one (MedialEC -> MMB, abstract)
	FMM.NC.PH.PRS	Presubiculum	excitatory-glu	Attractor Network in Hippocampus (PRESUB -> MBIN)
LAC	LAC.FD.HT.TBM	Tuberomammillary Nucleus	excitatory-glu	Mammillary bodies: two memory systems in one (TuberoMM -> MMB, abstract)
LMC	LMC.MM.RP.SUC	Superior Central Raphe Nucleus	modulatory-5ht	(unknown reference)
	LMC.MM.VTA	Ventral Tegmental Area	modulatory-da	Mammillary bodies: two memory systems in one (VTN -> MMB)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
FMM	FMM.FD.TH.AV	Anteroventral Nucleus	excitatory-glu	Mammillary bodies: two memory systems in one (MMB -> AVTH)
LLC	LLC.HT.PN.RSP	Rostral Pontine Nucleus	excitatory-glu	Prefrontal Cortex (PFC) in emotional behavior (HT -> PN, abstract)
	LLC.HT.PRF.RTMG	Pontine Reticulotegmental Nucleus	excitatory-glu	Mammillary Body (MMB -> RTG)
NCP	NCP.FD.TH.AM	Anteromedial Nucleus	excitatory-glu	Mammillary bodies: two memory systems in one (MMB -> AMTH)

Thirdparty Circuits

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Medial mammillary nucleus and theta rhythm - see Reference

map: AVTH=Anteroventral Nucleus,FMM.FD.TH.AV, HF=Hippocampal Formation,FMM.FT.HF, MMB=Medial Mammillary Nucleus,FMM.FD.MB.MMB, RSP=Retrosplenial Cortex,NCP.NC.MPL.RSC, SEP=Septal Nuclei,FAM.FT.SEP, SupraMM=Supramammillary Nucleus,LAC.FD.HT.SUM, VTN=Ventral Tegmental Area,LMC.MM.VTA unavailable

Mammillary bodies: two memory systems in one - see Reference

map: ADTH=Anterodorsal Nucleus,FMM.FD.TH.AD, AMTH=Anteromedial Nucleus,NCP.FD.TH.AM, AVTH=Anteroventral Nucleus,FMM.FD.TH.AV, DTN=Laterodorsal Tegmental Nucleus,LMC.HT.TG.LDT, LMB=Lateral Mammillary Nucleus,FMM.FD.MB.LMB, MMB=Medial Mammillary Nucleus,FMM.FD.MB.MMB, MedialEC=Entorhinal Cortex,FMM.NC.PH.ET (Lateral Entorhinal Cortex (FMM.NC.PH.LEC), Medial Entorhinal Cortex (FMM.NC.PH.MEC)), PAS=Parasubiculum,FMM.NC.PH.PAS, POS=Postsubiculum,FMM.NC.PH.POS, PRS=Presubiculum,FMM.NC.PH.PRS, SEP=Septal Nuclei,FAM.FT.SEP, SUB=Subiculum,FMM.FT.HF.SUB (Proximal Subiculum (FMM.FT.HF.SUBP), Middle Subiculum (FMM.FT.HF.SUBM), Distal Subiculum (FMM.FT.HF.SUBD)), SupraMM=Supramammillary Nucleus,LAC.FD.HT.SUM, TuberoMM=Lateral Tuberal Nuclei,LAC.FD.HT.LTUB (Supramammillary Nucleus (LAC.FD.HT.SUM), Tuberomammillary Nucleus (LAC.FD.HT.TBM), Premammillary Nucleus (LAC.FD.HT.PRM)), VTN=Ventral Tegmental Area,LMC.MM.VTA unavailable

Mammillary Body (unknown reference)

map: LMB=Lateral Mammillary Nucleus,FMM.FD.MB.LMB, MMB=Medial Mammillary Nucleus,FMM.FD.MB.MMB, RTG=Pontine Reticulotegmental Nucleus,LLC.HT.PRF.RTMG unavailable

Prefrontal Cortex (PFC) in emotional behavior - see Reference

map: ACG=Anterior Cingulate Cortex,NC.AL.ACG (Ventral Anterior Cingulate Area (NDM.NC.AL.VACG), Dorsal Anterior Cingulate Area (NDM.NC.AL.DACG), Subgenual Cingulate Cortex (NCP.NC.AL.SGCG)), AM=Amygdala,FAM.FT.AM, HCA=Hippocampus,FMM.FT.HC (Dentate Gyrus (FMM.FT.HC.DG), Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D), Dorsolateral Cornu Ammonis of Hippocampus (FMM.FT.HC.CA2), Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P), Middle CA3 of Hippocampus (FMM.FT.HC.CA3M), Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)), HT=Hypothalamus,FD.HT, LPFC=Mid-Dorsolateral Prefrontal Cortex,NDM.NC.AL.DLPFC (Rostral Mid-Dorsolateral Prefrontal Cortex (NDM.NC.AL.DLPFCR), Lateral Mid-Dorsolateral Prefrontal Cortex (NDM.NC.AL.DLPFCL)), OPFC=Orbitofrontal Cortex,NC.AL.OPFC (Lateral Frontopolar Cortex (NDM.NC.AL.FPC), Most Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCR), Sulcal Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCS), Medial Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCM), Lateral Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCL)), PCA=Medial Parietal Lobule,NC.MPL, PN=Pontine Nuclear Complex,HT.PN (Principal Trigeminal Nucleus (LPC.HT.PN.PTR), Pontobulbar Body (LLC.HT.PN.PBB), Rostral Pontine Nucleus (LLC.HT.PN.RSP), Nuclei of Lateral Lemniscus (LPC.HT.PN.LL)), TH=Mediodorsal Nucleus of Thalamus,FD.TH.MD (Medial Mediodorsal Nucleus of Thalamus (NDM.FD.TH.MDM), Central Mediodorsal Nucleus of Thalamus (NCP.FD.TH.MDC), Lateral Mediodorsal Nucleus of Thalamus (NMA.FD.TH.MDL)) unavailable

Contributions of Diencephalon to Recognition Memory - see Reference

Hippocampus and Septal Area - see Reference

map: CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D)), LateralSeptal=Septal Nuclei,FAM.FT.SEP, MB=Medial Mammillary Nucleus,FMM.FD.MB.MMB unavailable