BrainRegionFAM FT SEP LT
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Lateral Septal Nucleus
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This page covers biological details of component Lateral Septal Nucleus. Region is part of aHuman target integrated biological model.
- Top-down path to region: Forebrain Telencephalon -> Extended Amygdala (FAM.FT.EXTAM) -> Septal Nuclei (FAM.FT.SEP) -> Dorsal Septal Nucleus (FAM.FT.SEP.DS) -> Lateral Septal Group (FAM.FT.SEP.LG) -> Lateral Septal Nucleus (FAM.FT.SEP.LT) (see Mind Maps)
- Type: nucleus
- Quality: L0
- Brain area: Forebrain - Affective Motivations Area (FAM)
- Area circuit: Solving Fight-Flight Dilemma (FAMXFFD)
- Role: processor.affective
- Function: promote active stress coping behavior
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Components
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- no child items defined
Connectivity
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Inbound Region Connections:
| Source Area | Source Region | Source Name | Type | Role | Reference |
| FAM | FAM.FT.AM.CEM | Medial Central Amygdaloid Nucleus | excitatory-glu | uncertain | (unknown reference) |
| FAM.FT.AM.MPV | Medial Posterior Ventral Amygdaloid Nucleus | inhibitory-gaba | uncertain | (unknown reference) | |
| FMM | FMM.FT.HC.CA1D | Distal CA1 of Hippocampus | excitatory-glu | uncertain | Connectivity map of the habenula (Hippo -> Septum, abstract) |
| LAC | LAC.FD.HT.PN | Posterior Hypothalamic Nucleus | excitatory-glu | uncertain | (unknown reference) |
| LAC.FD.HT.TBM | Tuberomammillary Nucleus | excitatory-glu | uncertain | (unknown reference) | |
| LMC | LMC.MM.RP.SUC | Superior Central Raphe Nucleus | modulatory-5ht | uncertain | (unknown reference) |
Outbound Region Connections:
| Target Area | Target Region | Target Name | Type | Role | Reference |
| FAM | FAM.FD.LHB.MED | Lateral Habenula Medial Part | inhibitory-gaba | uncertain | Both LHb and MHb control the dopaminergic and serotonergic systems (LS -> LHbM) |
| LAC | LAC.FD.HT.VLPO | Ventrolateral Preoptic Nucleus | inhibitory-gaba | uncertain | Cingulate Gyrus (SEP -> HT, abstract) |
| NDM | NDM.FD.TH.PV | Paraventricular Nucleus of Thalamus | inhibitory-gaba | uncertain | (unknown reference) |
Thirdparty Circuits
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- Medial mammillary nucleus and theta rhythm - see Reference (CT.MMB-THETA)
AVTH=Anteroventral Nucleus,FMM.FD.TH.AV HF=Hippocampal Formation,FMM.FT.HF MMB=Medial Mammillary Nucleus,FMM.FD.MB.MMB RSP=Retrosplenial Cortex,NCP.NC.MPL.RSC SEP=Septal Nuclei,FAM.FT.SEP SupraMM=Supramammillary Nucleus,LAC.FD.HT.SUM VTN=Ventral Tegmental Area,LMC.MM.VTA
- Cingulate Gyrus - see Reference (CT.CINGULATE-CORTEX)
CG=Posterior Cingulate Cortex,NCP.NC.MPL.PSCG ET=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex) HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation) HT=Hypothalamus,FD.HT MB=Mammillary Body,FD.MB (see Hypothalamus) SEP=Septal Nuclei,FAM.FT.SEP TH=Anterior Nucleus of Thalamus,FD.TH.AN (see Cognitive Thalamus)
- Both LHb and MHb control the dopaminergic and serotonergic systems - see Reference (CF.HB-DA5HT)
DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB DRN=Dorsal Raphe Nucleus,LMC.MM.RP.DRN GPb=Dorsal Pallidum,FEC.FT.DP (see Basal Ganglia) IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN LHbL=Lateral Habenula Lateral Part,FAM.FD.LHB.LT LHbM=Lateral Habenula Medial Part,FAM.FD.LHB.MED LPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO LS=Lateral Septal Nucleus,FAM.FT.SEP.LT MHb=Medial Habenula,FAM.FD.MHB MRN=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation) MS=Medial Septal Nucleus,FAM.FT.SEP.MED PS=Posterior Septal Group,FAM.FT.SEP.PG (see Septal Nuclei) RMTg=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia) VP=Ventral Pallidum,FEC.FT.VP (see Basal Ganglia) VTA=Ventral Tegmental Area,LMC.MM.VTA
References
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