BrainRegionLMC MM PAG

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Periaqueductal Gray Matter

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This page covers biological details of component Periaqueductal Gray Matter. Region is part of aHuman target integrated biological model.

  • Top-down path to region: Midbrain Mesencephalon -> Periaqueductal Gray Matter (LMC.MM.PAG) (see Mind Maps)
  • Type: nucleus
  • Quality: L0
  • Brain area: Lower Brain - Modulatory Contol Area (LMC)
  • Area circuit: Enkephalin - Regulating Nociception in Body (ENK)
  • Role: processor.autonomic
  • Function: Descending modulation of pain and in defensive behaviour
  • Notes to function:
    • if there is a lesion in the PAG, then consciousness is lost
    • electrical stimulation of the PAG results in immediate and profound analgesia
    • modulatory nucleus

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Components

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  • no child items defined

Connectivity

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LMC.MM.PAG.dot.png

Inbound Region Connections:

Source Area Source Region Source Name Type Role Reference
FAM FAM.FT.AM.CEM Medial Central Amygdaloid Nucleus excitatory-glu uncertain Amygdalar disruption of prefrontal cortex (AM -> PAG, abstract)
FEC FEC.HT.TG.IPD Interpeduncular Nucleus modulatory-ach uncertain Connectivity map of the habenula (IPN -> PAG)
NCP NCP.NC.AL.SGCG Subgenual Cingulate Cortex excitatory-glu uncertain (unknown reference)

Outbound Region Connections:

Target Area Target Region Target Name Type Role Reference
LAC LAC.HT.BR Barrington's Nucleus modulatory-enk uncertain Schematic overview of spinobulbospinal micturition reflex pathway (PAG -> BAR)
LLC LLC.FD.TH.SF Subfascicular Nucleus of Thalamus modulatory-enk uncertain (unknown reference)
LMC LMC.HL.RP.MG Raphe Magnus Nucleus modulatory-enk uncertain Connectivity map of the habenula (PAG -> Raphe, abstract)
LMC.HL.RP.PL Raphe Pallidus Nucleus modulatory-enk uncertain Connectivity map of the habenula (PAG -> Raphe, abstract)
LPC LPC.HL.AMB Ambiguus Nucleus modulatory-enk uncertain (unknown reference)
LRC LRC.HL.RA Retroambigualis Nucleus modulatory-enk uncertain (unknown reference)
LRC.HT.NSC Nucleus Subceruleus modulatory-enk uncertain (unknown reference)
NDM NDM.FD.TH.PV Paraventricular Nucleus of Thalamus modulatory-enk uncertain (unknown reference)

Thirdparty Circuits

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BAR=Barrington's Nucleus,LAC.HT.BR
IMG=Inferior Mesenteric Ganglion,LAC.PN.SYM.IMG
IML=Intermediolateral Nucleus,LAC.SC.IZ.IML
ONF=Onuf's Nucleus,LPC.SC.VH.ONF
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
PEL=Pelvic Peripheral Ganglion,LAC.PN.PSYM.PPG
SPS=Sacral Parasympathetic Nucleus,LAC.SC.IZ.SPS


CPu=Striatum,FEC.FT.ST (see Basal Ganglia)
EP=Endopiriform Nucleus,FAM.FT.EPF
Hippo=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD
L=Lateral Habenula,FAM.FD.LHB (see Habenula)
LH=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
M=Medial Habenula,FAM.FD.MHB
NAc=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia)
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation)
SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia)
Septum=Septal Nuclei,FAM.FT.SEP
VTA=Ventral Tegmental Area,LMC.MM.VTA


PAG=Periaqueductal Gray Matter,LMC.MM.PAG
VMH=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM


ACC=Anterior Cingulate Cortex,NC.AL.ACG (see Anterior Cingulate Area)
AMY=Amygdala,FAM.FT.AM
BG=Basal Ganglia,FEC.FT.BG
Cerebellum=Cerebellar Complex,LLC.HT.CRC
Insula=Insular Cortex,NC.INS
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
PB=Parabrachial Nucleus,LPC.HT.PRF.PB
PFC=Prefrontal Cortex,NC.AL.PFC
S1=Primary Somatosensory Cortex,NCP.NC.PG.S1
S2=Secondary Somatosensory Cortex,NCP.NC.PG.S2
SC=Posterior/Dorsal Horn,BMA.SC.PH
Thalamus=Sensory Thalamus,FD.TH.SR


ACC=Anterior Cingulate Cortex,NC.AL.ACG (see Anterior Cingulate Area)
AM=Amygdala,FAM.FT.AM
INS=Insular Cortex,NC.INS
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
PFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
PPC=Superior Parietal Lobule,NC.SPL
S1=Primary Somatosensory Cortex,NCP.NC.PG.S1
SMA=Supplementary Motor Cortex,NMA.NC.SMC
TH=Thalamus,FD.TH


BLN=Parvicellular Basal Amygdaloid Nucleus,FAM.FT.AM.BP
CEA=Central Amygdala,FAM.FT.AM.CEA (see Amygdala)
EC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)
HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
HTS=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
ITC=Inferotemporal Cortex,NSA.NC.IT.TE
LA=Lateral Amygdaloid Nucleus,FAM.FT.AM.LA (see Amygdala)
LHB=Lateral Habenula,FAM.FD.LHB (see Habenula)
MD=Mediodorsal Nucleus of Thalamus,FD.TH.MD (see Cognitive Thalamus)
MPFC=Orbitomedial Prefrontal Cortex,NC.AL.OMPFC
NACC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia)
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
RMTG=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG
STC=Wernicke's area A3,NSA.NC.STG.A3
VGDM=Vagus Nucleus,LAC.HL.VGN
VTA=Ventral Tegmental Area,LMC.MM.VTA


ACG=Anterior Cingulate Cortex,NC.AL.ACG (see Anterior Cingulate Area)
AM=Amygdala,FAM.FT.AM
HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
HT.L=Lateral Hypothalamic Area,LAC.FD.HT.LT (see Hypothalamus)
HT.PV=Paraventricular Nucleus,LAC.FD.HT.PV
INS=Insular Cortex,NC.INS
LC=Locus Coeruleus,LMC.HT.LC
MPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
PB=Parabrachial Nucleus,LPC.HT.PRF.PB
PUT=Endocrine Glands,TARGET.TEA.ENDOCRINE
SOL=Solitary Nucleus,LPC.HL.SOL
TH=Thalamus,FD.TH


References

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