Difference between revisions of "BrainRegionLMC MM PAG"

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<pre style="color: green">Periaqueductal Gray Matter</pre>
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<pre style="color: green">Periaqueductal Gray Matter
+
−
</pre>
+
 
@@[[Home]] -> [[BiologicalLifeResearch]] -> [[BrainAreaLMC]] -> [[BrainRegionLMC_MM_PAG]]
 
@@[[Home]] -> [[BiologicalLifeResearch]] -> [[BrainAreaLMC]] -> [[BrainRegionLMC_MM_PAG]]
 
----
 
----
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Region is part of aHuman target integrated biological model.
 
Region is part of aHuman target integrated biological model.
  
−
* *Top-down path to region*: Midbrain Mesencephalon -> Periaqueductal Gray Matter (LMC.MM.PAG) (see [[OverallMindMaps|Mind Maps]])
+
* '''Top-down path to region''': Midbrain Mesencephalon -> [[BrainRegionLMC_MM_PAG|Periaqueductal Gray Matter]] (LMC.MM.PAG) (see [[OverallMindMaps|Mind Maps]])
−
* *Type*: nucleus
+
* '''Type''': nucleus
−
* *Brain area*: [[BrainAreaLMC|Lower Brain - Modulatory Contol Area]]
+
* '''Quality''': L0
−
* *Role*: relay
+
* '''Brain area''': [[BrainAreaLMC|Lower Brain - Modulatory Contol Area]] (LMC)
−
* *Function*: Descending modulation of pain and in defensive behaviour
+
* '''Area circuit''': Enkephalin -  Regulating Nociception in Body (ENK)
−
* *Notes to function*: if there is a lesion in the PAG, then consciousness is lost; electrical stimulation of the PAG results in immediate and profound analgesia; modulatory nucleus
+
* '''Role''': processor.autonomic
 +
* '''Function''': Descending modulation of pain and in defensive behaviour
 +
* '''Notes to function''':  
 +
** if there is a lesion in the PAG, then consciousness is lost
 +
**  electrical stimulation of the PAG results in immediate and profound analgesia
 +
**  modulatory nucleus
 
(generated)
 
(generated)
 
= Components =
 
= Components =
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−
http://ahuman.googlecode.com/svn/images/dot/aHuman/LMC.MM.PAG.dot.png
+
http://ahuman.org/svn/ahwiki/images/dot/LMC.MM.PAG.dot.png
  
−
*Inbound Region Connections:*
+
'''Inbound Region Connections:'''
  
−
|| *Source Area* || *Source Region* || *Source Name* || *Type* || *Reference* ||
+
{| class=wikitable width=80%
−
|| [[BrainAreaFAM|FAM]] || [[BrainRegionFAM_FT_AM_CEM FAM.FT.AM.CEM]] || Medial Central Amygdaloid Nucleus || excitatory-glu || [[http://neuropolitics.org/defaultmay10.asp Amygdalar disruption of prefrontal cortex (AM -> PAG, abstract)]] ||
+
| '''Source Area''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Role''' || '''Reference'''
−
|| [[BrainAreaLAC|LAC]] || [[BrainRegionLAC_FD_HT_VM LAC.FD.HT.VM]] || Ventromedial Hypothalamic Nucleus || excitatory-glu || (unknown reference) ||
+
|-
−
|| [[BrainAreaNCP|NCP]] || [[BrainRegionNCP_NC_AL_SGCG NCP.NC.AL.SGCG]] || Subgenual Cingulate Cortex || excitatory-glu || (unknown reference) ||
+
| [[BrainAreaFAM|FAM]] || [[BrainRegionFAM_FT_AM_CEM|FAM.FT.AM.CEM]] || Medial Central Amygdaloid Nucleus || excitatory-glu || uncertain ||[http://neuropolitics.org/defaultmay10.asp Amygdalar disruption of prefrontal cortex (AM -> PAG, abstract)]
 +
|-
 +
| [[BrainAreaFEC|FEC]] || [[BrainRegionFEC_HT_TG_IPD|FEC.HT.TG.IPD]] || Interpeduncular Nucleus || modulatory-ach || uncertain ||[http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (IPN -> PAG)]
 +
|-
 +
| [[BrainAreaNCP|NCP]] || [[BrainRegionNCP_NC_AL_SGCG|NCP.NC.AL.SGCG]] || Subgenual Cingulate Cortex || excitatory-glu || uncertain ||(unknown reference)
 +
|}
  
−
*Outbound Region Connections:*
+
'''Outbound Region Connections:'''
  
−
|| *Target Area* || *Target Region* || *Target Name* || *Type* || *Reference* ||
+
{| class=wikitable width=80%
−
|| [[BrainAreaLAC|LAC]] || [[BrainRegionLAC_HP_BR LAC.HP.BR]] || Barrington's Nucleus || modulatory-enk || [[http://jp.physoc.org/content/557/1/287/F9.expansion.html Schematic overview of spinobulbospinal micturition reflex pathway (PAG -> BAR)]] ||
+
| '''Target Area''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Role''' || '''Reference'''
−
|| [[BrainAreaLLC|LLC]] || [[BrainRegionLLC_FD_TH_SF LLC.FD.TH.SF]] || Subfascicular Nucleus of Thalamus || modulatory-enk || (unknown reference) ||
+
|-
−
|| [[BrainAreaLMC|LMC]] || [[BrainRegionLMC_HM_RP_MG LMC.HM.RP.MG]] || Raphe Magnus Nucleus || modulatory-enk || (unknown reference) ||
+
| [[BrainAreaLAC|LAC]] || [[BrainRegionLAC_HT_BR|LAC.HT.BR]] || Barrington's Nucleus || modulatory-enk || uncertain || [http://jp.physoc.org/content/557/1/287/F9.expansion.html Schematic overview of spinobulbospinal micturition reflex pathway (PAG -> BAR)]
−
||  || [[BrainRegionLMC_HM_RP_PL|LMC.HM.RP.PL]] || Raphe Pallidus Nucleus || modulatory-enk || (unknown reference) ||
+
|-
−
|| [[BrainAreaLPC|LPC]] || [[BrainRegionLPC_FD_TH_PV LPC.FD.TH.PV]] || Paraventricular Nucleus of Thalamus || modulatory-enk || (unknown reference) ||
+
| [[BrainAreaLLC|LLC]] || [[BrainRegionLLC_FD_TH_SF|LLC.FD.TH.SF]] || Subfascicular Nucleus of Thalamus || modulatory-enk || uncertain || (unknown reference)
−
|| || [[BrainRegionLPC_HM_AMB|LPC.HM.AMB]] || Ambiguus Nucleus || modulatory-enk || (unknown reference) ||
+
|-
−
|| [[BrainAreaLRC|LRC]] || [[BrainRegionLRC_HM_RA LRC.HM.RA]] || Retroambigualis Nucleus || modulatory-enk || (unknown reference) ||
+
| [[BrainAreaLMC|LMC]] || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || Raphe Magnus Nucleus || modulatory-enk || uncertain || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (PAG -> Raphe, abstract)]
−
|| || [[BrainRegionLRC_HP_PN_SC|LRC.HP.PN.SC]] || Nucleus Subceruleus || modulatory-enk || (unknown reference) ||
+
|-
 +
|  || [[BrainRegionLMC_HL_RP_PL|LMC.HL.RP.PL]] || Raphe Pallidus Nucleus || modulatory-enk || uncertain || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (PAG -> Raphe, abstract)]
 +
|-
 +
| [[BrainAreaLPC|LPC]] || [[BrainRegionLPC_HL_AMB|LPC.HL.AMB]] || Ambiguus Nucleus || modulatory-enk || uncertain || (unknown reference)
 +
|-
 +
| [[BrainAreaLRC|LRC]] || [[BrainRegionLRC_HL_RA|LRC.HL.RA]] || Retroambigualis Nucleus || modulatory-enk || uncertain || (unknown reference)
 +
|-
 +
|  || [[BrainRegionLRC_HT_NSC|LRC.HT.NSC]] || Nucleus Subceruleus || modulatory-enk || uncertain || (unknown reference)
 +
|-
 +
| [[BrainAreaNDM|NDM]] || [[BrainRegionNDM_FD_TH_PV|NDM.FD.TH.PV]] || Paraventricular Nucleus of Thalamus || modulatory-enk || uncertain || (unknown reference)
 +
|}
  
 
= Thirdparty Circuits =
 
= Thirdparty Circuits =
 
(generated)
 
(generated)
  
−
* [[http://jp.physoc.org/content/557/1/287/F9.large.jpg|Schematic overview of spinobulbospinal micturition reflex pathway]] - see [[http://jp.physoc.org/content/557/1/287/F9.expansion.html Reference]]
+
* [http://jp.physoc.org/content/557/1/287/F9.large.jpg Schematic overview of spinobulbospinal micturition reflex pathway] - see [http://jp.physoc.org/content/557/1/287/F9.expansion.html Reference] (CM.BARRINGTON)
 +
 
 +
BAR=[[BrainRegionLAC_HT_BR|Barrington's Nucleus,LAC.HT.BR]]
 +
IMG=[[BrainRegionLAC_PN_SYM_IMG|Inferior Mesenteric Ganglion,LAC.PN.SYM.IMG]]
 +
IML=[[BrainRegionLAC_SC_IZ_IML|Intermediolateral Nucleus,LAC.SC.IZ.IML]]
 +
ONF=[[BrainRegionLPC_SC_VH_ONF|Onuf's Nucleus,LPC.SC.VH.ONF]]
 +
PAG=[[BrainRegionLMC_MM_PAG|Periaqueductal Gray Matter,LMC.MM.PAG]]
 +
PEL=[[BrainRegionLAC_PN_PSYM_PPG|Pelvic Peripheral Ganglion,LAC.PN.PSYM.PPG]]
 +
SPS=[[BrainRegionLAC_SC_IZ_SPS|Sacral Parasympathetic Nucleus,LAC.SC.IZ.SPS]]
 +
<img src="http://ahuman.org/svn/ahwiki/images/ext/d3a94cb64cd1a44f5a636efab549880c.jpg" alt=alt="unavailable" style="max-width: 100%;">
 +
 
 +
* [http://d2avczb82rh8fa.cloudfront.net/content/jn/107/10/2633/F1.large.jpg Connectivity map of the habenula] - see [http://jn.physiology.org/content/107/10/2633 Reference] (CF.HB-CONN)
 +
 
 +
CPu=Striatum,FEC.FT.ST (see [[BrainCenterFEC_FT_BG|Basal Ganglia]])
 +
EP=[[BrainRegionFAM_FT_EPF|Endopiriform Nucleus,FAM.FT.EPF]]
 +
Hippo=Hippocampus,FMM.FT.HC (see [[BrainCenterFMM_FT_HF|Hippocampal Formation]])
 +
IPN=[[BrainRegionFEC_HT_TG_IPD|Interpeduncular Nucleus,FEC.HT.TG.IPD]]
 +
L=Lateral Habenula,FAM.FD.LHB (see [[BrainCenterFAM_FD_HB|Habenula]])
 +
LH=[[BrainRegionLAC_FD_HT_LTN|Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN]]
 +
M=[[BrainRegionFAM_FD_MHB|Medial Habenula,FAM.FD.MHB]]
 +
NAc=Accumbens Nucleus,FEC.FT.ACC (see [[BrainCenterFEC_FT_BG|Basal Ganglia]])
 +
PAG=[[BrainRegionLMC_MM_PAG|Periaqueductal Gray Matter,LMC.MM.PAG]]
 +
Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (see [[BrainCenterHL_RF|Medullary Reticular Formation]])
 +
SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see [[BrainCenterFEC_FT_BG|Basal Ganglia]])
 +
Septum=[[BrainCenterFAM_FT_SEP|Septal Nuclei,FAM.FT.SEP]]
 +
VTA=[[BrainRegionLMC_MM_VTA|Ventral Tegmental Area,LMC.MM.VTA]]
 +
<img src="http://ahuman.org/svn/ahwiki/images/ext/213e030f063f9640f8ace79244e622d1.jpg" alt=alt="unavailable" style="max-width: 100%;">
 +
 
 +
* [http://www.jneurosci.org/content/20/4/1589/F9.medium.gif Spine induction on short primary dendrites in the ventrolateral VMH] - see [http://www.jneurosci.org/content/20/4/1589/F9.expansion Reference] (CL.VMH-PAG)
 +
 
 +
PAG=[[BrainRegionLMC_MM_PAG|Periaqueductal Gray Matter,LMC.MM.PAG]]
 +
VMH=[[BrainRegionLAC_FD_HT_VM|Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM]]
 +
<img src="http://ahuman.org/svn/ahwiki/images/ext/90584ffc3db5a30b720beea518e6e181.gif" alt=alt="unavailable" style="max-width: 100%;">
 +
 
 +
* [http://www.nature.com/nrn/journal/v14/n7/images/nrn3516-f2.jpg Afferent pain pathways] - see [http://www.nature.com/nrn/journal/v14/n7/fig_tab/nrn3516_F2.html Reference] (CF.PAIN-PATH)
  
−
<img src="http://jp.physoc.org/content/557/1/287/F9.large.jpg" alt="unavailable">
+
ACC=Anterior Cingulate Cortex,NC.AL.ACG (see [[BrainCenterNC_ACG|Anterior Cingulate Area]])
 +
AMY=[[BrainCenterFAM_FT_AM|Amygdala,FAM.FT.AM]]
 +
BG=[[BrainCenterFEC_FT_BG|Basal Ganglia,FEC.FT.BG]]
 +
Cerebellum=[[BrainCenterLLC_HT_CRC|Cerebellar Complex,LLC.HT.CRC]]
 +
Insula=[[BrainCenterNC_INS|Insular Cortex,NC.INS]]
 +
PAG=[[BrainRegionLMC_MM_PAG|Periaqueductal Gray Matter,LMC.MM.PAG]]
 +
PB=[[BrainRegionLPC_HT_PRF_PB|Parabrachial Nucleus,LPC.HT.PRF.PB]]
 +
PFC=Prefrontal Cortex,NC.AL.PFC
 +
S1=[[BrainRegionNCP_NC_PG_S1|Primary Somatosensory Cortex,NCP.NC.PG.S1]]
 +
S2=[[BrainRegionNCP_NC_PG_S2|Secondary Somatosensory Cortex,NCP.NC.PG.S2]]
 +
SC=[[BrainCenterBMA_SC_PH|Posterior/Dorsal Horn,BMA.SC.PH]]
 +
Thalamus=[[BrainCenterFD_TH_SR|Sensory Thalamus,FD.TH.SR]]
 +
<img src="http://ahuman.org/svn/ahwiki/images/ext/efdfc437211a8a58c0e2fdfb40cbfe3c.jpg" alt=alt="unavailable" style="max-width: 100%;">
  
−
* [[http://www.springerimages.com/img/Images/Springer/JOU=10194/VOL=2006.7/ISU=4/ART=2006_307/MediaObjects/MEDIUM_10194_2006_Article_307_Fig1.jpg|Pain matrix]] - see [[http://www.springerimages.com/Images/MedicineAndPublicHealth/1-10.1007_s10194-006-0307-1-0 Reference]]
+
* [http://www.springerimages.com/img/Images/Springer/JOU=10194/VOL=2006.7/ISU=4/ART=2006_307/MediaObjects/MEDIUM_10194_2006_Article_307_Fig1.jpg Pain matrix] - see [http://www.springerimages.com/Images/MedicineAndPublicHealth/1-10.1007_s10194-006-0307-1-0 Reference] (CF.PAIN-MATRIX)
  
−
<img src="http://www.springerimages.com/img/Images/Springer/JOU=10194/VOL=2006.7/ISU=4/ART=2006_307/MediaObjects/MEDIUM_10194_2006_Article_307_Fig1.jpg" alt="unavailable">
+
ACC=Anterior Cingulate Cortex,NC.AL.ACG (see [[BrainCenterNC_ACG|Anterior Cingulate Area]])
 +
AM=[[BrainCenterFAM_FT_AM|Amygdala,FAM.FT.AM]]
 +
INS=[[BrainCenterNC_INS|Insular Cortex,NC.INS]]
 +
PAG=[[BrainRegionLMC_MM_PAG|Periaqueductal Gray Matter,LMC.MM.PAG]]
 +
PFC=Orbitofrontal Cortex,NC.AL.OPFC (see [[BrainCenterNC_AL_OMPFC|Orbitomedial Prefrontal Cortex]])
 +
PPC=[[BrainCenterNC_SPL|Superior Parietal Lobule,NC.SPL]]
 +
S1=[[BrainRegionNCP_NC_PG_S1|Primary Somatosensory Cortex,NCP.NC.PG.S1]]
 +
SMA=[[BrainCenterNMA_NC_SMC|Supplementary Motor Cortex,NMA.NC.SMC]]
 +
TH=Thalamus,FD.TH
 +
<img src="http://ahuman.org/svn/ahwiki/images/ext/da9ef60331d8479a33db1fd60894d275.jpg" alt=alt="unavailable" style="max-width: 100%;">
  
−
* [[http://www.surgicalneurologyint.com/articles/2012/3/2/images/SurgNeurolInt_2012_3_2_40_91609_u1.jpg|Amygdala and its network]] - see [[http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin Reference]]
+
* [http://sni.wpengine.com/wp-content/uploads/2015/05/3520/SNI-3-40-g001.png Amygdala and its network] - see [http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin Reference] (CF.AM-NET)
  
−
<img src="http://www.surgicalneurologyint.com/articles/2012/3/2/images/SurgNeurolInt_2012_3_2_40_91609_u1.jpg" alt="unavailable">
+
BLN=[[BrainRegionFAM_FT_AM_BP|Parvicellular Basal Amygdaloid Nucleus,FAM.FT.AM.BP]]
 +
CEA=Central Amygdala,FAM.FT.AM.CEA (see [[BrainCenterFAM_FT_AM|Amygdala]])
 +
EC=Entorhinal Cortex,FMM.NC.PH.ET (see [[BrainCenterNC_PHA_RH|Rhinal Cortex]])
 +
HC=Hippocampus,FMM.FT.HC (see [[BrainCenterFMM_FT_HF|Hippocampal Formation]])
 +
HTS=[[BrainRegionLAC_FD_HT_LTN|Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN]]
 +
ITC=[[BrainRegionNSA_NC_IT_TE|Inferotemporal Cortex,NSA.NC.IT.TE]]
 +
LA=Lateral Amygdaloid Nucleus,FAM.FT.AM.LA (see [[BrainCenterFAM_FT_AM|Amygdala]])
 +
LHB=Lateral Habenula,FAM.FD.LHB (see [[BrainCenterFAM_FD_HB|Habenula]])
 +
MD=Mediodorsal Nucleus of Thalamus,FD.TH.MD (see [[BrainCenterFD_TH_CR|Cognitive Thalamus]])
 +
MPFC=[[BrainCenterNC_AL_OMPFC|Orbitomedial Prefrontal Cortex,NC.AL.OMPFC]]
 +
NACC=Accumbens Nucleus,FEC.FT.ACC (see [[BrainCenterFEC_FT_BG|Basal Ganglia]])
 +
PAG=[[BrainRegionLMC_MM_PAG|Periaqueductal Gray Matter,LMC.MM.PAG]]
 +
RMTG=[[BrainRegionFEC_HT_TG_RMTG|Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG]]
 +
STC=[[BrainRegionNSA_NC_STG_A3|Wernicke's area A3,NSA.NC.STG.A3]]
 +
VGDM=[[BrainRegionLAC_HL_VGN|Vagus Nucleus,LAC.HL.VGN]]
 +
VTA=[[BrainRegionLMC_MM_VTA|Ventral Tegmental Area,LMC.MM.VTA]]
 +
<img src="http://ahuman.org/svn/ahwiki/images/ext/148ecc584cca86040df3ac88ecdbcba6.png" alt=alt="unavailable" style="max-width: 100%;">
  
−
* [[http://neuropolitics.org/connect-amygdala.jpg|Amygdalar disruption of prefrontal cortex]] - see [[http://neuropolitics.org/defaultmay10.asp Reference]]
+
* [http://neuropolitics.org/connect-amygdala.jpg Amygdalar disruption of prefrontal cortex] - see [http://neuropolitics.org/defaultmay10.asp Reference] (CF.AM-DISRUPTION)
  
−
<img src="http://neuropolitics.org/connect-amygdala.jpg" alt="unavailable">
+
ACG=Anterior Cingulate Cortex,NC.AL.ACG (see [[BrainCenterNC_ACG|Anterior Cingulate Area]])
 +
AM=[[BrainCenterFAM_FT_AM|Amygdala,FAM.FT.AM]]
 +
HC=Hippocampus,FMM.FT.HC (see [[BrainCenterFMM_FT_HF|Hippocampal Formation]])
 +
HT.L=Lateral Hypothalamic Area,LAC.FD.HT.LT (see [[BrainCenterFD_HT|Hypothalamus]])
 +
HT.PV=[[BrainRegionLAC_FD_HT_PV|Paraventricular Nucleus,LAC.FD.HT.PV]]
 +
INS=[[BrainCenterNC_INS|Insular Cortex,NC.INS]]
 +
LC=[[BrainRegionLMC_HT_LC|Locus Coeruleus,LMC.HT.LC]]
 +
MPFC=Orbitofrontal Cortex,NC.AL.OPFC (see [[BrainCenterNC_AL_OMPFC|Orbitomedial Prefrontal Cortex]])
 +
PAG=[[BrainRegionLMC_MM_PAG|Periaqueductal Gray Matter,LMC.MM.PAG]]
 +
PB=[[BrainRegionLPC_HT_PRF_PB|Parabrachial Nucleus,LPC.HT.PRF.PB]]
 +
PUT=[[BrainRegionTARGET_TEA_ENDOCRINE|Endocrine Glands,TARGET.TEA.ENDOCRINE]]
 +
SOL=[[BrainRegionLPC_HL_SOL|Solitary Nucleus,LPC.HL.SOL]]
 +
TH=Thalamus,FD.TH
 +
<img src="http://ahuman.org/svn/ahwiki/images/ext/e212b5f27aa77f69673ce0cb4ce84428.jpg" alt=alt="unavailable" style="max-width: 100%;">
  
  
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* http://jp.physoc.org/content/557/1/287/F9.expansion.html
 
* http://jp.physoc.org/content/557/1/287/F9.expansion.html
 +
* http://jn.physiology.org/content/107/10/2633
 +
* http://www.jneurosci.org/content/20/4/1589/F9.expansion
 +
* http://www.nature.com/nrn/journal/v14/n7/fig_tab/nrn3516_F2.html
 
* http://www.springerimages.com/Images/MedicineAndPublicHealth/1-10.1007_s10194-006-0307-1-0
 
* http://www.springerimages.com/Images/MedicineAndPublicHealth/1-10.1007_s10194-006-0307-1-0
 
* http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin
 
* http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin
 
* http://neuropolitics.org/defaultmay10.asp
 
* http://neuropolitics.org/defaultmay10.asp

Latest revision as of 18:29, 28 April 2019

Periaqueductal Gray Matter

@@Home -> BiologicalLifeResearch -> BrainAreaLMC -> BrainRegionLMC_MM_PAG

This page covers biological details of component Periaqueductal Gray Matter. Region is part of aHuman target integrated biological model.

  • Top-down path to region: Midbrain Mesencephalon -> Periaqueductal Gray Matter (LMC.MM.PAG) (see Mind Maps)
  • Type: nucleus
  • Quality: L0
  • Brain area: Lower Brain - Modulatory Contol Area (LMC)
  • Area circuit: Enkephalin - Regulating Nociception in Body (ENK)
  • Role: processor.autonomic
  • Function: Descending modulation of pain and in defensive behaviour
  • Notes to function:
    • if there is a lesion in the PAG, then consciousness is lost
    • electrical stimulation of the PAG results in immediate and profound analgesia
    • modulatory nucleus

(generated)

Components

(generated)


  • no child items defined

Connectivity

(generated)


LMC.MM.PAG.dot.png

Inbound Region Connections:

Source Area Source Region Source Name Type Role Reference
FAM FAM.FT.AM.CEM Medial Central Amygdaloid Nucleus excitatory-glu uncertain Amygdalar disruption of prefrontal cortex (AM -> PAG, abstract)
FEC FEC.HT.TG.IPD Interpeduncular Nucleus modulatory-ach uncertain Connectivity map of the habenula (IPN -> PAG)
NCP NCP.NC.AL.SGCG Subgenual Cingulate Cortex excitatory-glu uncertain (unknown reference)

Outbound Region Connections:

Target Area Target Region Target Name Type Role Reference
LAC LAC.HT.BR Barrington's Nucleus modulatory-enk uncertain Schematic overview of spinobulbospinal micturition reflex pathway (PAG -> BAR)
LLC LLC.FD.TH.SF Subfascicular Nucleus of Thalamus modulatory-enk uncertain (unknown reference)
LMC LMC.HL.RP.MG Raphe Magnus Nucleus modulatory-enk uncertain Connectivity map of the habenula (PAG -> Raphe, abstract)
LMC.HL.RP.PL Raphe Pallidus Nucleus modulatory-enk uncertain Connectivity map of the habenula (PAG -> Raphe, abstract)
LPC LPC.HL.AMB Ambiguus Nucleus modulatory-enk uncertain (unknown reference)
LRC LRC.HL.RA Retroambigualis Nucleus modulatory-enk uncertain (unknown reference)
LRC.HT.NSC Nucleus Subceruleus modulatory-enk uncertain (unknown reference)
NDM NDM.FD.TH.PV Paraventricular Nucleus of Thalamus modulatory-enk uncertain (unknown reference)

Thirdparty Circuits

(generated) 

BAR=Barrington's Nucleus,LAC.HT.BR
IMG=Inferior Mesenteric Ganglion,LAC.PN.SYM.IMG
IML=Intermediolateral Nucleus,LAC.SC.IZ.IML
ONF=Onuf's Nucleus,LPC.SC.VH.ONF
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
PEL=Pelvic Peripheral Ganglion,LAC.PN.PSYM.PPG
SPS=Sacral Parasympathetic Nucleus,LAC.SC.IZ.SPS


CPu=Striatum,FEC.FT.ST (see Basal Ganglia)
EP=Endopiriform Nucleus,FAM.FT.EPF
Hippo=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD
L=Lateral Habenula,FAM.FD.LHB (see Habenula)
LH=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
M=Medial Habenula,FAM.FD.MHB
NAc=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia)
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation)
SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia)
Septum=Septal Nuclei,FAM.FT.SEP
VTA=Ventral Tegmental Area,LMC.MM.VTA


PAG=Periaqueductal Gray Matter,LMC.MM.PAG
VMH=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM


ACC=Anterior Cingulate Cortex,NC.AL.ACG (see Anterior Cingulate Area)
AMY=Amygdala,FAM.FT.AM
BG=Basal Ganglia,FEC.FT.BG
Cerebellum=Cerebellar Complex,LLC.HT.CRC
Insula=Insular Cortex,NC.INS
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
PB=Parabrachial Nucleus,LPC.HT.PRF.PB
PFC=Prefrontal Cortex,NC.AL.PFC
S1=Primary Somatosensory Cortex,NCP.NC.PG.S1
S2=Secondary Somatosensory Cortex,NCP.NC.PG.S2
SC=Posterior/Dorsal Horn,BMA.SC.PH
Thalamus=Sensory Thalamus,FD.TH.SR


ACC=Anterior Cingulate Cortex,NC.AL.ACG (see Anterior Cingulate Area)
AM=Amygdala,FAM.FT.AM
INS=Insular Cortex,NC.INS
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
PFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
PPC=Superior Parietal Lobule,NC.SPL
S1=Primary Somatosensory Cortex,NCP.NC.PG.S1
SMA=Supplementary Motor Cortex,NMA.NC.SMC
TH=Thalamus,FD.TH


BLN=Parvicellular Basal Amygdaloid Nucleus,FAM.FT.AM.BP
CEA=Central Amygdala,FAM.FT.AM.CEA (see Amygdala)
EC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)
HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
HTS=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
ITC=Inferotemporal Cortex,NSA.NC.IT.TE
LA=Lateral Amygdaloid Nucleus,FAM.FT.AM.LA (see Amygdala)
LHB=Lateral Habenula,FAM.FD.LHB (see Habenula)
MD=Mediodorsal Nucleus of Thalamus,FD.TH.MD (see Cognitive Thalamus)
MPFC=Orbitomedial Prefrontal Cortex,NC.AL.OMPFC
NACC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia)
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
RMTG=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG
STC=Wernicke's area A3,NSA.NC.STG.A3
VGDM=Vagus Nucleus,LAC.HL.VGN
VTA=Ventral Tegmental Area,LMC.MM.VTA


ACG=Anterior Cingulate Cortex,NC.AL.ACG (see Anterior Cingulate Area)
AM=Amygdala,FAM.FT.AM
HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
HT.L=Lateral Hypothalamic Area,LAC.FD.HT.LT (see Hypothalamus)
HT.PV=Paraventricular Nucleus,LAC.FD.HT.PV
INS=Insular Cortex,NC.INS
LC=Locus Coeruleus,LMC.HT.LC
MPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
PB=Parabrachial Nucleus,LPC.HT.PRF.PB
PUT=Endocrine Glands,TARGET.TEA.ENDOCRINE
SOL=Solitary Nucleus,LPC.HL.SOL
TH=Thalamus,FD.TH


References

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