BrainCenterFAM FT SEP
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Septal Nuclei
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This page covers biological details of component group Septal Nuclei. Component group is part of aHuman target integrated biological model.
- Top-down path to center: Forebrain Telencephalon -> Extended Amygdala (FAM.FT.EXTAM) -> Septal Nuclei (FAM.FT.SEP) (see Mind Maps)
- Function: Inhibition of fear and expression of pleasurable responses
(generated)
Components
(generated)
Component items:
- Dorsal Septal Nucleus (FAM.FT.SEP.DS)
- Lateral Septal Group (FAM.FT.SEP.LG)
- Lateral Septal Nucleus (FAM.FT.SEP.LT): promote active stress coping behavior
- Septohippocampal Nucleus (FAM.FT.SEP.SH): participate in solving conflict between two or more competing goals, defensive circuit
- Medial Septal Group (FAM.FT.SEP.MG)
- Medial Septal Nucleus (FAM.FT.SEP.MED): affect HC for spatial learning, generation of theta waves
- Diagonal Band of Broca (FAM.FT.SEP.DBB): involved in generation of theta waves in hippocampus
- Lateral Septal Group (FAM.FT.SEP.LG)
- Posterior Septal Group (FAM.FT.SEP.PG)
- Bed Nucleus of Anterior Commissure (FAM.FT.SEP.BAC): projection to contralateral HC
- Septofimbrial Nucleus (FAM.FT.SEP.SF): afferent to medial habenula, primary input to indirect encoding negative feedback
- Triangular Septal Nucleus (FAM.FT.SEP.TR): afferent to medial habenula, interpeduncular nucleus
Connectivity
(generated)
Internal Regions Connections:
- no connections
External Connections:
External Inbound Center Connections:
| Source Center | Sample Link | Reference |
| Amygdala (FAM.FT.AM) | FAM.FT.AM.MPV -> FAM.FT.SEP.LT | (unknown reference) |
| Central Extended Amygdala (FAM.FT.CEAM) | FAM.FT.BNST -> FAM.FT.SEP.BAC | (unknown reference) |
| Hypothalamus (FD.HT) | LAC.FD.HT.SUM -> FAM.FT.SEP.DBB | Medial mammillary nucleus and theta rhythm (SupraMM -> SEP, abstract) |
| Hippocampal Formation (FMM.FT.HF) | FMM.FT.HC.CA1D -> FAM.FT.SEP.LT | Connectivity map of the habenula (Hippo -> Septum, abstract) |
| Pontine Tegmental Nuclei (HT.TG) | FAM.HT.TG.NI -> FAM.FT.SEP.SF | (unknown reference) |
| Locus Coeruleus (LMC.HT.LC) | LMC.HT.LC -> FAM.FT.SEP.DBB | (unknown reference) |
| Mesencephalic Reticular Formation (MM.RF) | LMC.MM.RP.SUC -> FAM.FT.SEP.LT | (unknown reference) |
| Orbitomedial Prefrontal Cortex (NC.AL.OMPFC) | NDM.NC.AL.FPC -> FAM.FT.SEP.SH | (unknown reference) |
External Outbound Center Connections:
| Target Center | Sample Link | Reference |
| Habenula (FAM.FD.HB) | FAM.FT.SEP.BAC -> FAM.FD.MHB | Connectivity map of the habenula (Septum -> M, abstract) |
| Hypothalamus (FD.HT) | FAM.FT.SEP.DBB -> FMM.FD.MB.MMB | Cingulate Gyrus (SEP -> HT, abstract) |
| Cognitive Thalamus (FD.TH.CR) | FAM.FT.SEP.LT -> NDM.FD.TH.PV | (unknown reference) |
| Hippocampal Formation (FMM.FT.HF) | FAM.FT.SEP.BAC -> FMM.FT.HF.SUBP | Medial mammillary nucleus and theta rhythm (SEP -> HF, abstract) |
| Orbitomedial Prefrontal Cortex (NC.AL.OMPFC) | FAM.FT.SEP.DBB -> NDM.NC.AL.VMPFC | (unknown reference) |
| Medial Parietal Lobule (NC.MPL) | FAM.FT.SEP.MED -> NCP.NC.MPL.RSC | Medial mammillary nucleus and theta rhythm (SEP -> RSP, abstract) |
