Decision Making Area

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Local Circuits

(generated)

ID	Name	Regions
HLC	High-Level Control	NDM.FD.TH.MDM, NDM.NC.AL.FPC
HLNM	High-Level Novelty Attention	NDM.NC.AL.ROFCL, NDM.NC.AL.ROFCM, NDM.NC.AL.ROFCR, NDM.NC.AL.ROFCS
HWM	Working Memory	NDM.NC.AL.DLPFCL, NDM.NC.AL.DLPFCR
MAS	Motivatory Associations	NDM.FD.TH.SM, NDM.NC.AL.DMPFC, NDM.NC.AL.IPG, NDM.NC.AL.VMPFC
MRS	Motivational Responses	NDM.NC.AL.DMCG, NDM.NC.AL.PGCG, NDM.NC.AL.VMCG
UMC	Unimodal Control	NDM.NC.AL.DACG, NDM.NC.AL.VACG

High-Level Control

unavailable

Component ID	Component Name	Type	Service	Function	Comments
NDM.FD.TH.MDM	Medial Mediodorsal Nucleus of Thalamus	nucleus	NPU	relay emotional attention to orbitofrontal cortex	orbitofrontal cortex (BA12,13) defined by MDm projection; relay AM-Bp to OFC; OFCm - subjective pleasantness, OFCl - subjective unpleasantness
NDM.NC.AL.FPC	Lateral Frontopolar Cortex	cortex, BA 10	NPU	Emotion Regulation	Frontopolar area, contains ILC - infralimbic cortex

Internal Region Connections:

Source Region	Target Region	Type	Reference
NDM.FD.TH.MDM	NDM.NC.AL.FPC	nucleus-neocortex	[relationships (MD -> pMD, abstract)]

External Inbound Region Connections:

Source Area	Local Region	Source Region	Source Name	Type	Reference
Cortical
NCP	NDM.NC.AL.FPC	NCP.NC.INS.PPC	Peripaleocortical Claustral	neocortex-neocortex	[disruption of prefrontal cortex (INS -> MPFC, abstract)]
Subcortical
FAM	NDM.FD.TH.MDM	FAM.FT.AM.AB	Accessory Basal Amygdaloid Nucleus	nucleus-nucleus	[Cortex (PFC) in emotional behavior (AM -> TH, abstract)]
		FAM.FT.SEP.MED	Medial Septal Nucleus	nucleus-nucleus-ACh	[relationships (s1MD -> MD, abstract)]
FEC	NDM.FD.TH.MDM	FEC.FT.GPI.RM	Globus Pallidus Internal Rostromedial	nucleus-nucleus-gaba	[Vision (BG -> Thalamus, abstract)]
FMM	NDM.FD.TH.MDM	FMM.NC.PH.LEC	Lateral Entorhinal Cortex	neocortex-nucleus	[of Diencephalon to Recognition Memory (EC -> MDmc, abstract)]
		FMM.NC.PH.PER	Perirhinal Cortex	neocortex-nucleus	[of Diencephalon to Recognition Memory (Perirhinal -> MDmc, abstract)]
LMC	NDM.NC.AL.FPC	LMC.FT.NBM	Basal Nucleus of Meynert	nucleus-neocortex-ACh	[and pathophysiology of lower urinary tract (NBM -> MPFC, abstract)]
		LMC.MM.VTA	Ventral Tegmental Area	nucleus-neocortex-DA	[circuit of human brain (VTA -> PFC, abstract)]

External Outbound Region Connections:

Target Area	Local Region	Target Region	Target Name	Type	Reference
Cortical
NDM	NDM.FD.TH.MDM	NDM.NC.AL.DLPFCR	Rostral Mid-Dorsolateral Prefrontal Cortex	nucleus-neocortex	[Cortex (PFC) in emotional behavior (TH -> LPFC, abstract)]
	NDM.NC.AL.FPC	NDM.NC.AL.DLPFCR	Rostral Mid-Dorsolateral Prefrontal Cortex	neocortex-neocortex	[Cortex (PFC) in emotional behavior (OPFC -> LPFC, abstract)]
		NDM.NC.AL.VACG	Ventral Anterior Cingulate Area	neocortex-neocortex	[for serotonin in moral behavior (OMPFC -> ACG, abstract)]
Subcortical
FAM	NDM.NC.AL.FPC	FAM.FT.AM.BM	Magnocellular Basal Amygdaloid Nucleus	neocortex-nucleus	(unknown reference)
		FAM.FT.AM.BP	Parvicellular Basal Amygdaloid Nucleus	neocortex-nucleus	(unknown reference)
		FAM.FT.SEP.SH	Septohippocampal Nucleus	neocortex-nucleus	(unknown reference)
FEC	NDM.NC.AL.FPC	FEC.FT.ACC.CORE	Nucleus Accumbens Core	neocortex-nucleus	[basal ganglia circuit (OMPFC -> NACC, abstract)]
		FEC.FT.SNR.MED	Substantia Nigra Pars Reticulata Medial	neocortex-nucleus	[visual system (FrontalCortex -> BGA, abstract)]
LAC	NDM.NC.AL.FPC	LAC.FD.HT.RCH	Retrochiasmatic Nucleus	neocortex-nucleus	[Cortex (PFC) in emotional behavior (OPFC -> HT, abstract)]

High-Level Novelty Attention

unavailable

Component ID	Component Name	Type	Service	Function	Comments
NDM.NC.AL.ROFCL	Lateral Rostral Orbitofrontal Cortex	cortex, BA 12	NPU	Visual selection of novelty	12L
NDM.NC.AL.ROFCM	Medial Rostral Orbitofrontal Cortex	cortex, BA 12	NPU	Somatosensory selection of novelty	12M
NDM.NC.AL.ROFCR	Most Rostral Orbitofrontal Cortex	cortex, BA 12	NPU	Integral conscious selection of novelty	12R
NDM.NC.AL.ROFCS	Sulcal Rostral Orbitofrontal Cortex	cortex, BA 12	NPU	Gustatory and auditory selection of novelty	12S

Internal Region Connections:

Source Region	Target Region	Type	Reference
NDM.NC.AL.ROFCL	NDM.NC.AL.ROFCR	neocortex-neocortex	[of Social Brain (MPFC -> OFC, abstract)]
NDM.NC.AL.ROFCM	NDM.NC.AL.ROFCL	neocortex-neocortex	[of Social Brain (MPFC -> OFC, abstract)]
	NDM.NC.AL.ROFCR	neocortex-neocortex	[of Social Brain (MPFC -> OFC, abstract)]
NDM.NC.AL.ROFCS	NDM.NC.AL.ROFCL	neocortex-neocortex	[of Social Brain (MPFC -> OFC, abstract)]

External Inbound Region Connections:

Source Area	Local Region	Source Region	Source Name	Type	Reference
Cortical
NCP	NDM.NC.AL.ROFCR	NCP.NC.MPL.RSC	Retrosplenial Cortex	neocortex-neocortex	[Cortex (PFC) in emotional behavior (PCA -> OPFC, abstract)]
NPE	NDM.NC.AL.ROFCL	NPE.FD.TH.MPV	Medial Pulvinar	nucleus-neocortex	[Vision (Thalamus -> FrontalCortex, abstract)]
	NDM.NC.AL.ROFCM	NPE.NC.SPL.SA	Somatosensory Association Cortex	neocortex-neocortex	[Connectivity (SA -> PFC, abstract)]
NSA	NDM.NC.AL.ROFCS	NSA.NC.PO.PCC	Precentral Cortex	neocortex-neocortex	[visual system (ParietalCortex -> FrontalCortex, abstract)]
Subcortical
FAM	NDM.NC.AL.ROFCR	FAM.FD.TH.PT	Paratenial Nucleus of Thalamus	nucleus-neocortex	[Vision (Thalamus -> FrontalCortex, abstract)]
FMM	NDM.NC.AL.ROFCR	FMM.FT.HC.CA1D	Distal CA1 of Hippocampus	allocortex-neocortex	[model of hippocampal formation anatomy (CA1 -> mPFC, abstract)]
		FMM.FT.HF.SUBD	Distal Subiculum	allocortex-neocortex	[model of hippocampal formation anatomy (SUB -> mPFC, abstract)]

External Outbound Region Connections:

Target Area	Local Region	Target Region	Target Name	Type	Reference
Cortical
NDM	NDM.NC.AL.ROFCR	NDM.NC.AL.DACG	Dorsal Anterior Cingulate Area	neocortex-neocortex	[for serotonin in moral behavior (OMPFC -> ACG, abstract)]
		NDM.NC.AL.IPG	Inferior Prefrontal Gyrus	neocortex-neocortex	[of Social Brain (OFC -> IFG, abstract)]
Subcortical
FEC	NDM.NC.AL.ROFCR	FEC.FD.STN.DL	Subthalamic Nucleus Dorsolateral	neocortex-nucleus	(unknown reference)
		FEC.FD.TH.RH	Rhomboidal Nucleus of Thalamus	neocortex-nucleus	(unknown reference)
		FEC.FT.CN.TL	Caudate Nucleus Tail	neocortex-nucleus	[visual system (FrontalCortex -> BGA, abstract)]
FMM	NDM.NC.AL.ROFCR	FMM.FD.TH.RE	Reuniens Nucleus of Thalamus	neocortex-nucleus	(unknown reference)

Working Memory

unavailable

Component ID	Component Name	Type	Service	Function	Comments
NDM.NC.AL.DLPFCL	Lateral Mid-Dorsolateral Prefrontal Cortex	cortex, BA 46	NPU	Cognitive control related to stimulus processing and selection of relevant information for behavior
NDM.NC.AL.DLPFCR	Rostral Mid-Dorsolateral Prefrontal Cortex	cortex, BA 46	NPU	Cognitive control and monitoring to resolve conflict in information processing and competing response plans

Internal Region Connections:

no connections

External Inbound Region Connections:

Source Area	Local Region	Source Region	Source Name	Type	Reference
Cortical
NCP	NDM.NC.AL.DLPFCR	NCP.NC.MPL.RSC	Retrosplenial Cortex	neocortex-neocortex	[Cortex (PFC) in emotional behavior (PCA -> LPFC, abstract)]
NDM	NDM.NC.AL.DLPFCL	NDM.NC.AL.IPG	Inferior Prefrontal Gyrus	neocortex-neocortex	[Effort Network (fPole -> DLPFC, abstract)]
	NDM.NC.AL.DLPFCR	NDM.FD.TH.MDM	Medial Mediodorsal Nucleus of Thalamus	nucleus-neocortex	[Cortex (PFC) in emotional behavior (TH -> LPFC, abstract)]
		NDM.NC.AL.FPC	Lateral Frontopolar Cortex	neocortex-neocortex	[Cortex (PFC) in emotional behavior (OPFC -> LPFC, abstract)]
NMA	NDM.NC.AL.DLPFCL	NMA.NC.PMC.F4	Ventral Caudal Premotor Cortex	neocortex-neocortex	[Connectivity (MA -> PFC, abstract)]
NPE	NDM.NC.AL.DLPFCL	NPE.FD.TH.MPV	Medial Pulvinar	nucleus-neocortex	[Vision (Thalamus -> FrontalCortex, abstract)]
	NDM.NC.AL.DLPFCR	NPE.NC.IPL.MST	Medial Superior Temporal Area	neocortex-neocortex	[Connectivity (PTHA -> PFC, abstract)]
NSA	NDM.NC.AL.DLPFCL	NSA.NC.IT.TE	Inferotemporal Cortex	neocortex-neocortex	[Visual Cortex Paths (IT -> LPC, abstract)]
		NSA.NC.OCC.V2TN	Secondary Visual Cortex, Thin Stripe	neocortex-neocortex	[Connectivity (VA -> PFC, abstract)]
Subcortical
LLC	NDM.NC.AL.DLPFCL	LLC.HP.CR.DN	Dentate Nucleus	nucleus-neocortex	[Cortex (PFC) in motor behavior (CR -> LPFC, abstract)]

External Outbound Region Connections:

Target Area	Local Region	Target Region	Target Name	Type	Reference
Cortical
NDM	NDM.NC.AL.DLPFCR	NDM.NC.AL.DACG	Dorsal Anterior Cingulate Area	neocortex-neocortex	[Cortex (PFC) in emotional behavior (LPFC -> ACG, abstract)]
NMA	NDM.NC.AL.DLPFCL	NMA.FD.TH.VA	Ventral Anterior Nucleus	neocortex-nucleus	[Cortex (PFC) in motor behavior (LPFC -> TH, abstract)]
		NMA.NC.PMC.AFEF	Anterior Frontal Eye Field	neocortex-neocortex	[Cortex (PFC) in motor behavior (LPFC -> PMC, abstract)]
		NMA.NC.PMC.F5	Ventral Rostral Premotor Cortex	neocortex-neocortex	[Cortex (PFC) in motor behavior (LPFC -> PMC, abstract)]
	NDM.NC.AL.DLPFCR	NMA.NC.PMC.F7	Dorsal Rostral Premotor Cortex	neocortex-neocortex	[Cortex (PFC) in motor behavior (LPFC -> PMC, abstract)]
		NMA.NC.SMC.SEF	Supplementary Eye Field	neocortex-neocortex	[Visual Cortex Paths (LPC -> pre-SMA, abstract)]
Subcortical
FEC	NDM.NC.AL.DLPFCL	FEC.FT.CN.HD	Caudate Nucleus Head	neocortex-nucleus	[visual system (FrontalCortex -> BGA, abstract)]

Motivatory Associations

unavailable

Component ID	Component Name	Type	Service	Function	Comments
NDM.FD.TH.SM	Submedial Nucleus of Thalamus	nucleus	NPU	Pain center	Projections from SC Lamina I, trigeminal nucleus to ACC
NDM.NC.AL.DMPFC	Dorsomedial Prefrontal Cortex	cortex, BA 09	NPU	Ongoing Extroverted Attention to Select Appropriate Response	upper MPFC, primary connections to the cingulate and the motor and premotor cortices
NDM.NC.AL.IPG	Inferior Prefrontal Gyrus	cortex, BA 47	NPU	Processing of syntax in oral and sign languages	Personality, endurance
NDM.NC.AL.VMPFC	Ventromedial Prefrontal Cortex	cortex, BA 11	NPU	Ongoing Introverted Attention with Regard to Emotions and Feelings, Reward or Punishment	lower MPFC, primary connections to limbic and sensory cortices; Reward mediated behaviours

Internal Region Connections:

Source Region	Target Region	Type	Reference
NDM.FD.TH.SM	NDM.NC.AL.DMPFC	nucleus-neocortex	[Vision (Thalamus -> FrontalCortex, abstract)]
NDM.NC.AL.IPG	NDM.NC.AL.DMPFC	neocortex-neocortex	(unknown reference)

External Inbound Region Connections:

Source Area	Local Region	Source Region	Source Name	Type	Reference
Cortical
NCP	NDM.NC.AL.IPG	NCP.NC.INS.AIC	Anterior Insular Cortex	neocortex-neocortex	[Effort Network (Insula -> fPole, abstract)]
		NCP.NC.TPC	Temporopolar Cortex	neocortex-neocortex	[Regions (TC -> vIFC)]
NDM	NDM.NC.AL.IPG	NDM.NC.AL.ROFCR	Most Rostral Orbitofrontal Cortex	neocortex-neocortex	[of Social Brain (OFC -> IFG, abstract)]
Subcortical
FAM	NDM.NC.AL.VMPFC	FAM.FT.SEP.DBB	Diagonal Band of Broca	nucleus-neocortex-gaba	(unknown reference)
LPC	NDM.FD.TH.SM	LPC.SC.PH.LMG	Lower Marginal Nucleus	nucleus-nucleus	(unknown reference)
		LPC.SC.PH.UMG	Upper Marginal Nucleus	nucleus-nucleus	(unknown reference)
	NDM.NC.AL.VMPFC	LPC.FD.TH.PV	Paraventricular Nucleus of Thalamus	nucleus-neocortex	[Vision (Thalamus -> FrontalCortex, abstract)]

External Outbound Region Connections:

Target Area	Local Region	Target Region	Target Name	Type	Reference
Cortical
NDM	NDM.NC.AL.DMPFC	NDM.NC.AL.DACG	Dorsal Anterior Cingulate Area	neocortex-neocortex	(unknown reference)
	NDM.NC.AL.IPG	NDM.NC.AL.DLPFCL	Lateral Mid-Dorsolateral Prefrontal Cortex	neocortex-neocortex	[Effort Network (fPole -> DLPFC, abstract)]
		NDM.NC.AL.VACG	Ventral Anterior Cingulate Area	neocortex-neocortex	[Effort Network (fPole -> vACC)]
Subcortical
FAM	NDM.NC.AL.DMPFC	FAM.FT.AM.ITC	Intercalated Amygdaloid Nuclei	neocortex-nucleus	(unknown reference)

Motivational Responses

unavailable

Component ID	Component Name	Type	Service	Function	Comments
NDM.NC.AL.DMCG	Dorsal Anterior Cingulate Area	cortex, BA 32	NPU	Rational Thought Processes	Anticipate and detect targets, indicate novelty, influence motor responses, encode reward values, and signal errors, motor, attentional and cognitive functions; BA32-caudal
NDM.NC.AL.PGCG	Pregenual Cingulate Cortex	cortex, BA 33	NPU	Sensation of Emotion	Storage of emotional memory, emotions, mood and autonomic functions
NDM.NC.AL.VMCG	Ventral Anterior Cingulate Area	cortex, BA 24	NPU	Response Selection	BA24-caudal

Internal Region Connections:

no connections

External Inbound Region Connections:

no connections

External Outbound Region Connections:

no connections

Unimodal Control

unavailable

Component ID	Component Name	Type	Service	Function	Comments
NDM.NC.AL.DACG	Dorsal Anterior Cingulate Area	cortex, BA 32	NPU	Rational Thought Processes	Anticipate and detect targets, indicate novelty, influence motor responses, encode reward values, and signal errors, motor, attentional and cognitive functions; BA32-rostral
NDM.NC.AL.VACG	Ventral Anterior Cingulate Area	cortex, BA 24	NPU	Seat of Free Will	motor, attentional and cognitive functions; BA24-rostral

Internal Region Connections:

Source Region	Target Region	Type	Reference
NDM.NC.AL.DACG	NDM.NC.AL.VACG	neocortex-neocortex	[Connections of Hippocampus (DorsalCingulate -> VentralCingulate)]

External Inbound Region Connections:

Source Area	Local Region	Source Region	Source Name	Type	Reference
Cortical
NCP	NDM.NC.AL.DACG	NCP.NC.INS.PPC	Peripaleocortical Claustral	neocortex-neocortex	[disruption of prefrontal cortex (INS -> ACG, abstract)]
	NDM.NC.AL.VACG	NCP.FD.TH.AM	Anteromedial Nucleus	nucleus-neocortex	[Vision (Thalamus -> FrontalCortex, abstract)]
		NCP.NC.INS.AIC	Anterior Insular Cortex	neocortex-neocortex	[disruption of prefrontal cortex (INS -> ACG, abstract)]
NDM	NDM.NC.AL.DACG	NDM.NC.AL.DLPFCR	Rostral Mid-Dorsolateral Prefrontal Cortex	neocortex-neocortex	[Cortex (PFC) in emotional behavior (LPFC -> ACG, abstract)]
		NDM.NC.AL.DMPFC	Dorsomedial Prefrontal Cortex	neocortex-neocortex	(unknown reference)
		NDM.NC.AL.ROFCR	Most Rostral Orbitofrontal Cortex	neocortex-neocortex	[for serotonin in moral behavior (OMPFC -> ACG, abstract)]
	NDM.NC.AL.VACG	NDM.NC.AL.FPC	Lateral Frontopolar Cortex	neocortex-neocortex	[for serotonin in moral behavior (OMPFC -> ACG, abstract)]
		NDM.NC.AL.IPG	Inferior Prefrontal Gyrus	neocortex-neocortex	[Effort Network (fPole -> vACC)]
NMA	NDM.NC.AL.DACG	NMA.FD.TH.MDL	Lateral Mediodorsal Nucleus of Thalamus	nucleus-neocortex	[Vision (Thalamus -> FrontalCortex, abstract)]
NPE	NDM.NC.AL.DACG	NPE.NC.IPL.MST	Medial Superior Temporal Area	neocortex-neocortex	[visual system (ParietalCortex -> FrontalCortex, abstract)]
		NPE.NC.SPL.PF	Rostral Precuneus	neocortex-neocortex	[visual system (ParietalCortex -> FrontalCortex, abstract)]
NSA	NDM.NC.AL.DACG	NSA.NC.TTG.A2	Auditory Association Area	neocortex-neocortex	[Effort Network (ACA -> dACC)]
Subcortical
FAM	NDM.NC.AL.DACG	FAM.FT.AM.AB	Accessory Basal Amygdaloid Nucleus	nucleus-neocortex	[disruption of prefrontal cortex (AM -> ACG, abstract)]
	NDM.NC.AL.VACG	FAM.FT.AM.AB	Accessory Basal Amygdaloid Nucleus	nucleus-neocortex	[disruption of prefrontal cortex (AM -> ACG, abstract)]
FEC	NDM.NC.AL.DACG	FEC.FD.TH.LI	Limitans Nucleus of Thalamus	nucleus-neocortex	[Vision (Thalamus -> FrontalCortex, abstract)]
LMC	NDM.NC.AL.DACG	LMC.MM.VTA	Ventral Tegmental Area	nucleus-neocortex-DA	(unknown reference)

External Outbound Region Connections:

Target Area	Local Region	Target Region	Target Name	Type	Reference
Cortical
NCP	NDM.NC.AL.DACG	NCP.NC.MPL.PSCG	Posterior Cingulate Cortex	neocortex-neocortex	[visual system (FrontalCortex -> ParietalCortex, abstract)]
	NDM.NC.AL.VACG	NCP.NC.MPL.PSCG	Posterior Cingulate Cortex	neocortex-neocortex	[Connections of Hippocampus (VentralCingulate -> PosteriorCingulate)]
NMA	NDM.NC.AL.DACG	NMA.NC.PMC.F7	Dorsal Rostral Premotor Cortex	neocortex-neocortex	(unknown reference)
	NDM.NC.AL.VACG	NMA.NC.PMC.F2	Dorsal Caudal Premotor Cortex	neocortex-neocortex	(unknown reference)
Subcortical
FAM	NDM.NC.AL.DACG	FAM.FT.AM.BP	Parvicellular Basal Amygdaloid Nucleus	neocortex-nucleus	[for serotonin in moral behavior (ACG -> AMY, abstract)]
	NDM.NC.AL.VACG	FAM.FT.AM.BP	Parvicellular Basal Amygdaloid Nucleus	neocortex-nucleus	[for serotonin in moral behavior (ACG -> AMY, abstract)]
FEC	NDM.NC.AL.DACG	FEC.FD.STN.CD	Subthalamic Nucleus Caudal	neocortex-nucleus	(unknown reference)
		FEC.FT.CN.HD	Caudate Nucleus Head	neocortex-nucleus	[visual system (FrontalCortex -> BGA, abstract)]
	NDM.NC.AL.VACG	FEC.FT.ACC.SH	Nucleus Accumbens Shell	neocortex-nucleus	[visual system (FrontalCortex -> BGA, abstract)]
		FEC.FT.CN.BD	Caudate Nucleus Body	neocortex-nucleus	[visual system (FrontalCortex -> BGA, abstract)]
		FEC.FT.PU.VT	Ventral Putamen	neocortex-nucleus	[visual system (FrontalCortex -> BGA, abstract)]
LLC	NDM.NC.AL.VACG	LLC.HP.PRF.PDT	Pontine Reticulotegmental Nucleus	neocortex-nucleus	[Control (Premotor24 -> RF, abstract)]
		LLC.MM.RD	Red Nucleus	neocortex-nucleus	(unknown reference)
LMC	NDM.NC.AL.VACG	LMC.HP.LC	Locus Coeruleus	neocortex-nucleus	[Control (Premotor24 -> RF, abstract)]