Proximal CA1 of Hippocampus

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This page covers biological details of component Proximal CA1 of Hippocampus. Region is part of aHuman target integrated biological model.

Top-down path to region: Forebrain Telencephalon -> Hippocampal Formation (FMM.FT.HF) -> Hippocampus (FMM.FT.HC) -> Ventrolateral Cornu Ammonis of Hippocampus (FMM.FT.HC.CA1) -> Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P) (see Mind Maps)
Type: cortex
Brain area: Forebrain - Memory Management Area
Role: processor.memory.ca1
Function: Long-term memory, spatial

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Components

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Connectivity

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FMM.FT.HC.CA1P.dot.png

Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Reference
FAM	FAM.FT.AM.AB	Accessory Basal Amygdaloid Nucleus	excitatory-glu	Detailed amygdalohippocampal projections (ABmg -> CA1P)
FMM	FMM.FD.TH.AV	Anteroventral Nucleus	excitatory-glu	Contributions of Diencephalon to Recognition Memory (AN -> HC, abstract)
	FMM.FD.TH.LD	Lateral Dorsal Nucleus of Thalamus	excitatory-glu	Contributions of Diencephalon to Recognition Memory (LD -> HC, abstract)
	FMM.FT.HC.CA2	Dorsolateral Cornu Ammonis of Hippocampus	excitatory-glu	Flow of impulses in hippocampal region (CA2 -> CA1, abstract)
	FMM.FT.HC.CA3D	Distal CA3 of Hippocampus	excitatory-glu	Neuronal projections in the hippocampus (CA3 -> CA1, abstract)
	FMM.NC.PH.MEC	Medial Entorhinal Cortex	excitatory-glu	Neuronal projections in the hippocampus (ET -> CA1, abstract)
NCP	NCP.NC.MPL.PSCG	Posterior Cingulate Cortex	excitatory-glu	Feeling (CG -> HC, abstract)
	NCP.NC.MPL.RSC	Retrosplenial Cortex	excitatory-glu	Prefrontal Cortex (PFC) in emotional behavior (PCA -> HCA, abstract)
NPE	NPE.NC.IPL.MST	Medial Superior Temporal Area	excitatory-glu	Contribution of hippocampal region CA3 to consciousness (IPL -> CA1, abstract)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
FMM	FMM.FD.MB.MMB	Medial Mammillary Nucleus	excitatory-glu	Feeling (HC -> HT, abstract)
	FMM.FT.HF.SUBD	Distal Subiculum	excitatory-glu	Attractor Network in Hippocampus (CA1 -> SUB, abstract)
	FMM.NC.PH.PAS	Parasubiculum	excitatory-glu	(unknown reference)
	FMM.NC.PH.POR	Postrhinal Cortex	excitatory-glu	Entorhinal Cortex Inputs and Outputs (CA1 -> TFTH, abstract)
NDM	NDM.NC.AL.DMPFC	Dorsomedial Prefrontal Cortex	excitatory-glu	Gating of medial prefrontal activity by the entorhinal cortex (HC -> MPFC, abstract)

Thirdparty Circuits

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Medial mammillary nucleus and theta rhythm - see Reference

map: AVTH=Anteroventral Nucleus,FMM.FD.TH.AV, HF=Hippocampal Formation,FMM.FT.HF, MMB=Medial Mammillary Nucleus,FMM.FD.MB.MMB, RSP=Retrosplenial Cortex,NCP.NC.MPL.RSC, SEP=Septal Nuclei,FAM.FT.SEP, SupraMM=Supramammillary Nucleus,LAC.FD.HT.SUM, VTN=Ventral Tegmental Area,LMC.MM.VTA unavailable

Head Direction Cell Circuit - see Reference

map: AD=Anterodorsal Nucleus,FMM.FD.TH.AD, DTN=Laterodorsal Tegmental Nucleus,LMC.HT.TG.DTG, EC=Entorhinal Cortex,FMM.NC.PH.ET (Lateral Entorhinal Cortex (FMM.NC.PH.LEC), Medial Entorhinal Cortex (FMM.NC.PH.MEC)), HC=Hippocampus,FMM.FT.HC (Dentate Gyrus (FMM.FT.HC.DG), Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D), Dorsolateral Cornu Ammonis of Hippocampus (FMM.FT.HC.CA2), Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P), Middle CA3 of Hippocampus (FMM.FT.HC.CA3M), Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)), IPD=Interpeduncular Nucleus,FEC.HT.TG.IPD, LD=Lateral Dorsal Nucleus of Thalamus,FMM.FD.TH.LD, LHAB=Habenula,FAM.FD.HB, LMB=Lateral Mammillary Nucleus,FMM.FD.MB.LMB, MVSN=Medial Vestibular Nucleus,LPC.HT.MVBN, NPRP=Prepositus Nucleus,LRC.HL.NPH, PC=Parietal Lobe,NC.LOBE.PAR (Medial Superior Temporal Area (NPE.NC.IPL.MST), Supramarginal Wernike Cortex (NPE.NC.IPL.SMW), Retrosplenial Cortex (NCP.NC.MPL.RSC), Posterior Cingulate Cortex (NCP.NC.MPL.PSCG), Subgenual Cingulate Cortex (NCP.NC.MPL.SGCG), Precentral Cortex (NCP.NC.PO.PCC), Primary Somatosensory Cortex (NCP.NC.PG.S1), Secondary Somatosensory Cortex (NCP.NC.PG.S2), Parietal Ventral Cortex (NCP.NC.PG.PV), Somatosensory Association Cortex (NCP.NC.SPL.SA), Rostral Precuneus (NPE.NC.SPL.PF), Caudal Precuneus (NPE.NC.SPL.PG), Medial Intraparietal Sulcus (NPE.NC.IPS.MIP), Lateral Intraparietal Sulcus (NPE.NC.IPS.LIP), Ventral Intraparietal Sulcus (NSA.NC.IPS.VIP), Anterior Intraparietal Sulcus (NSA.NC.IPS.AIP)), PRHC=Postrhinal Cortex,FMM.NC.PH.POR, PSUB=Postsubiculum,FMM.NC.PH.POS, RSP=Retrosplenial Cortex,NCP.NC.MPL.RSC, SUPGEN=Suprageniculate Nucleus of Thalamus,NSA.FD.TH.SG, VC=Occipital Lobe,NC.LOBE.OCC unavailable

Entorhinal Cortex Inputs and Outputs - see Reference

map: CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D)), EC=Entorhinal Cortex,FMM.NC.PH.ET (Lateral Entorhinal Cortex (FMM.NC.PH.LEC), Medial Entorhinal Cortex (FMM.NC.PH.MEC)), TFTH=Postrhinal Cortex,FMM.NC.PH.POR unavailable