Lateral Entorhinal Cortex

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This page covers biological details of component Lateral Entorhinal Cortex. Region is part of aHuman target integrated biological model.

Top-down path to region: Cerebral Cortex -> Parahippocampal Lobe (NC.LOBE.PH) -> Anterior Parahippocampal Gyrus (FMM.NC.PHA) -> Rhinal Cortex (NC.PHA.RH) -> Entorhinal Cortex (FMM.NC.PH.ET) -> Lateral Entorhinal Cortex (FMM.NC.PH.LEC) (see Mind Maps)
Type: cortex
Brain area: Forebrain - Memory Management Area
Brodmann ID: 28
Role: processor.memory.complex
Function: Memory consolidation, emotional aspects
Notes to function: non-spatial input to HC; process information about individual items and locations based on a local frame of reference, primarily using external sensory input; it provides the hippocampus with information about content of experience

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Components

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Connectivity

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FMM.NC.PH.LEC.dot.png

Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Reference
FAM	FAM.FD.TH.PT	Paratenial Nucleus of Thalamus	excitatory-glu	Contributions of Diencephalon to Recognition Memory (MID -> EC, abstract)
	FAM.FT.AM.BP	Parvicellular Basal Amygdaloid Nucleus	excitatory-glu	Principal Connections of Hippocampus (AM -> EC, abstract)
FMM	FMM.FT.HF.SUBD	Distal Subiculum	excitatory-glu	Attractor Network in Hippocampus (SUB -> EC, abstract)
	FMM.NC.PH.PER	Perirhinal Cortex	feedforward-glu	Visual Path to Hippocampus (PRPH -> ER, abstract)
LMC	LMC.MM.VTA	Ventral Tegmental Area	modulatory-da	Combining Novelty, Motivational Salience, and Reward to Control Attention and Learning (VTA -> EC, abstract)
NDM	NDM.FD.TH.PV	Paraventricular Nucleus of Thalamus	excitatory-glu	Contributions of Diencephalon to Recognition Memory (MID -> EC, abstract)
NSA	NSA.NC.IT.TE	Inferotemporal Cortex	feedforward-glu	McNaughton Spatial Processing Network (ITCortex -> EnthCortex, abstract)
	NSA.NC.PH.PIR	Piriform Cortex	feedforward-glu	KIV model of cortico-hippocampal formation with subcortical projections for motor actions (PC -> EC, abstract)
	NSA.NC.STG.A3	Wernicke's area A3	feedforward-glu	(unknown reference)
	NSA.NC.STG.A4	Wernicke's area A4	feedforward-glu	(unknown reference)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
FAM	FAM.FT.AM.AB	Accessory Basal Amygdaloid Nucleus	excitatory-glu	Simplified model of hippocampal formation anatomy (EC -> Amyg, abstract)
	FAM.FT.AM.LAVM	Ventromedial Amygdaloid Nucleus	excitatory-glu	Simplified model of hippocampal formation anatomy (EC -> Amyg, abstract)
FEC	FEC.FT.ACC.CORE	Nucleus Accumbens Core	excitatory-glu	Nucleus Accumbens (EC -> NACC, abstract)
FMM	FMM.FT.HC.CA1D	Distal CA1 of Hippocampus	excitatory-glu	Neuronal projections in the hippocampus (ET -> CA1, abstract)
	FMM.FT.HC.CA2	Dorsolateral Cornu Ammonis of Hippocampus	excitatory-glu	Amygdala and its network (EC -> HC, abstract)
	FMM.FT.HC.CA3P	Proximal CA3 of Hippocampus	excitatory-glu	Neuronal projections in the hippocampus (ET -> CA3, abstract)
	FMM.FT.HC.DG	Dentate Gyrus	excitatory-glu	Neuronal projections in the hippocampus (ET -> DG, abstract)
	FMM.FT.HF.SUBP	Proximal Subiculum	excitatory-glu	Visual Path to Hippocampus (ER -> H, abstract)
NDM	NDM.FD.TH.MDM	Medial Mediodorsal Nucleus of Thalamus	excitatory-glu	Contributions of Diencephalon to Recognition Memory (EC -> MDmc, abstract)

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map: Amyg=Amygdala,FAM.FT.AM, CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D)), CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P), Middle CA3 of Hippocampus (FMM.FT.HC.CA3M), Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)), DG=Dentate Gyrus,FMM.FT.HC.DG, EC=Entorhinal Cortex,FMM.NC.PH.ET (Lateral Entorhinal Cortex (FMM.NC.PH.LEC), Medial Entorhinal Cortex (FMM.NC.PH.MEC)), NACC=Accumbens Nucleus,FEC.FT.ACC (Nucleus Accumbens Core (FEC.FT.ACC.CORE), Nucleus Accumbens Shell (FEC.FT.ACC.SH)), SUB=Subiculum,FMM.FT.HF.SUB (Proximal Subiculum (FMM.FT.HF.SUBP), Middle Subiculum (FMM.FT.HF.SUBM), Distal Subiculum (FMM.FT.HF.SUBD)), mPFC=Orbitofrontal Cortex,NC.AL.OPFC (Lateral Frontopolar Cortex (NDM.NC.AL.FPC), Most Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCR), Sulcal Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCS), Medial Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCM), Lateral Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCL)) unavailable

map: CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D)), CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P), Middle CA3 of Hippocampus (FMM.FT.HC.CA3M), Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)), EC=Entorhinal Cortex,FMM.NC.PH.ET (Lateral Entorhinal Cortex (FMM.NC.PH.LEC), Medial Entorhinal Cortex (FMM.NC.PH.MEC)), NACC=Accumbens Nucleus,FEC.FT.ACC (Nucleus Accumbens Core (FEC.FT.ACC.CORE), Nucleus Accumbens Shell (FEC.FT.ACC.SH)), PAS=Parasubiculum,FMM.NC.PH.PAS, PRR=Perirhinal Cortex,FMM.NC.PH.PER, SUB=Subiculum,FMM.FT.HF.SUB (Proximal Subiculum (FMM.FT.HF.SUBP), Middle Subiculum (FMM.FT.HF.SUBM), Distal Subiculum (FMM.FT.HF.SUBD)) unavailable