Revision as of 16:57, 27 November 2018

Dentate Gyrus

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This page covers biological details of component Dentate Gyrus. Region is part of aHuman target integrated biological model.

• Top-down path to region: Forebrain Telencephalon -> Hippocampal Formation (FMM.FT.HF) -> Hippocampus (FMM.FT.HC) -> Dentate Gyrus (FMM.FT.HC.DG) (see Mind Maps)
• Type: cortex
• Brain area: Forebrain - Memory Management Area
• Role: processor.memory.dg
• Function: Distinguishing multiple instances of similar events

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Components

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• no child items defined

Connectivity

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Inbound Region Connections:

Outbound Region Connections:

Thirdparty Circuits

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• Head Direction Cell Circuit - see Reference

map: AD=Anterodorsal Nucleus,FMM.FD.TH.AD, DTN=Laterodorsal Tegmental Nucleus,LMC.HT.TG.DTG, EC=Entorhinal Cortex,FMM.NC.PH.ET (Lateral Entorhinal Cortex (FMM.NC.PH.LEC), Medial Entorhinal Cortex (FMM.NC.PH.MEC)), HC=Hippocampus,FMM.FT.HC (Dentate Gyrus (FMM.FT.HC.DG), Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D), Dorsolateral Cornu Ammonis of Hippocampus (FMM.FT.HC.CA2), Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P), Middle CA3 of Hippocampus (FMM.FT.HC.CA3M), Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)), IPD=Interpeduncular Nucleus,FEC.HT.TG.IPD, LD=Lateral Dorsal Nucleus of Thalamus,FMM.FD.TH.LD, LHAB=Habenula,FAM.FD.HB, LMB=Lateral Mammillary Nucleus,FMM.FD.MB.LMB, MVSN=Medial Vestibular Nucleus,LPC.HT.MVBN, NPRP=Prepositus Nucleus,LRC.HL.NPH, PC=Parietal Lobe,NC.LOBE.PAR (Medial Superior Temporal Area (NPE.NC.IPL.MST), Supramarginal Wernike Cortex (NPE.NC.IPL.SMW), Retrosplenial Cortex (NCP.NC.MPL.RSC), Posterior Cingulate Cortex (NCP.NC.MPL.PSCG), Subgenual Cingulate Cortex (NCP.NC.MPL.SGCG), Precentral Cortex (NCP.NC.PO.PCC), Primary Somatosensory Cortex (NCP.NC.PG.S1), Secondary Somatosensory Cortex (NCP.NC.PG.S2), Parietal Ventral Cortex (NCP.NC.PG.PV), Somatosensory Association Cortex (NCP.NC.SPL.SA), Rostral Precuneus (NPE.NC.SPL.PF), Caudal Precuneus (NPE.NC.SPL.PG), Medial Intraparietal Sulcus (NPE.NC.IPS.MIP), Lateral Intraparietal Sulcus (NPE.NC.IPS.LIP), Ventral Intraparietal Sulcus (NSA.NC.IPS.VIP), Anterior Intraparietal Sulcus (NSA.NC.IPS.AIP)), PRHC=Postrhinal Cortex,FMM.NC.PH.POR, PSUB=Postsubiculum,FMM.NC.PH.POS, RSP=Retrosplenial Cortex,NCP.NC.MPL.RSC, SUPGEN=Suprageniculate Nucleus of Thalamus,NSA.FD.TH.SG, VC=Occipital Lobe,NC.LOBE.OCC

• Feeling - see Reference

map: AN=Anterior Nucleus of Thalamus,FD.TH.AN (Anteromedial Nucleus (NCP.FD.TH.AM), Anteroventral Nucleus (FMM.FD.TH.AV), Anterodorsal Nucleus (FMM.FD.TH.AD)), CG=Posterior Cingulate Cortex,NCP.NC.MPL.PSCG, HC=Hippocampus,FMM.FT.HC (Dentate Gyrus (FMM.FT.HC.DG), Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D), Dorsolateral Cornu Ammonis of Hippocampus (FMM.FT.HC.CA2), Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P), Middle CA3 of Hippocampus (FMM.FT.HC.CA3M), Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)), HT=Hypothalamus,FD.HT

• Neuronal projections in the hippocampus - see Reference

map: BLA=Basolateral Nuclear Complex,FAM.FT.AM.BL (Dorsolateral Amygdaloid Nucleus (FAM.FT.AM.LADL), Ventrolateral Amygdaloid Nucleus (FAM.FT.AM.LAVL), Ventromedial Amygdaloid Nucleus (FAM.FT.AM.LAVM), Parvicellular Basal Amygdaloid Nucleus (FAM.FT.AM.BP), Magnocellular Basal Amygdaloid Nucleus (FAM.FT.AM.BM), Accessory Basal Amygdaloid Nucleus (FAM.FT.AM.AB)), CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D)), CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P), Middle CA3 of Hippocampus (FMM.FT.HC.CA3M), Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)), DG=Dentate Gyrus,FMM.FT.HC.DG, ET=Entorhinal Cortex,FMM.NC.PH.ET (Lateral Entorhinal Cortex (FMM.NC.PH.LEC), Medial Entorhinal Cortex (FMM.NC.PH.MEC))

• Simplified model of hippocampal formation anatomy - see Reference

map: Amyg=Amygdala,FAM.FT.AM, CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D)), CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P), Middle CA3 of Hippocampus (FMM.FT.HC.CA3M), Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)), DG=Dentate Gyrus,FMM.FT.HC.DG, EC=Entorhinal Cortex,FMM.NC.PH.ET (Lateral Entorhinal Cortex (FMM.NC.PH.LEC), Medial Entorhinal Cortex (FMM.NC.PH.MEC)), NACC=Accumbens Nucleus,FEC.FT.ACC (Nucleus Accumbens Core (FEC.FT.ACC.CORE), Nucleus Accumbens Shell (FEC.FT.ACC.SH)), SUB=Subiculum,FMM.FT.HF.SUB (Proximal Subiculum (FMM.FT.HF.SUBP), Middle Subiculum (FMM.FT.HF.SUBM), Distal Subiculum (FMM.FT.HF.SUBD)), mPFC=Orbitofrontal Cortex,NC.AL.OPFC (Lateral Frontopolar Cortex (NDM.NC.AL.FPC), Most Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCR), Sulcal Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCS), Medial Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCM), Lateral Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCL))

• Combining Novelty, Motivational Salience, and Reward to Control Attention and Learning - see Reference

map: ACC=Accumbens Nucleus,FEC.FT.ACC (Nucleus Accumbens Core (FEC.FT.ACC.CORE), Nucleus Accumbens Shell (FEC.FT.ACC.SH)), CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D)), CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P), Middle CA3 of Hippocampus (FMM.FT.HC.CA3M), Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)), DG=Dentate Gyrus,FMM.FT.HC.DG, EC=Entorhinal Cortex,FMM.NC.PH.ET (Lateral Entorhinal Cortex (FMM.NC.PH.LEC), Medial Entorhinal Cortex (FMM.NC.PH.MEC)), PFC=Orbitofrontal Cortex,NC.AL.OPFC (Lateral Frontopolar Cortex (NDM.NC.AL.FPC), Most Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCR), Sulcal Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCS), Medial Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCM), Lateral Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCL)), PPTG=Pedunculopontine Tegmental Nuclei,LMC.HT.TG.PPN, SUB=Subiculum,FMM.FT.HF.SUB (Proximal Subiculum (FMM.FT.HF.SUBP), Middle Subiculum (FMM.FT.HF.SUBM), Distal Subiculum (FMM.FT.HF.SUBD)), VPAL=Ventral Pallidum,FEC.FT.VP (Ventral Pallidum Dorsolateral (FEC.FT.VP.DL), Ventral Pallidum Ventromedial (FEC.FT.VP.VM)), VTA=Ventral Tegmental Area,LMC.MM.VTA

• KIV model of cortico-hippocampal formation with subcortical projections for motor actions - see Reference

map: AON=Anterior Olfactory Nucleus,LPC.FT.AON, CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D)), CA2=Dorsolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA2, CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P), Middle CA3 of Hippocampus (FMM.FT.HC.CA3M), Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)), DG=Dentate Gyrus,FMM.FT.HC.DG, EC=Entorhinal Cortex,FMM.NC.PH.ET (Lateral Entorhinal Cortex (FMM.NC.PH.LEC), Medial Entorhinal Cortex (FMM.NC.PH.MEC)), PC=Piriform Cortex,NSA.NC.PH.PIR

• Hippocampal Formation - see Reference

map: ATN=Anterior Nucleus of Thalamus,FD.TH.AN (Anteromedial Nucleus (NCP.FD.TH.AM), Anteroventral Nucleus (FMM.FD.TH.AV), Anterodorsal Nucleus (FMM.FD.TH.AD)), CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D)), CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P), Middle CA3 of Hippocampus (FMM.FT.HC.CA3M), Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)), DG=Dentate Gyrus,FMM.FT.HC.DG, DTN=Laterodorsal Tegmental Nucleus,LMC.HT.TG.LDT, EC=Entorhinal Cortex,FMM.NC.PH.ET (Lateral Entorhinal Cortex (FMM.NC.PH.LEC), Medial Entorhinal Cortex (FMM.NC.PH.MEC)), LDN=Lateral Dorsal Nucleus of Thalamus,FMM.FD.TH.LD, LMam=Lateral Mammillary Nucleus,FMM.FD.MB.LMB, PoS=Postsubiculum,FMM.NC.PH.POS, Rsp=Retrosplenial Cortex,NCP.NC.MPL.RSC, Sub=Subiculum,FMM.FT.HF.SUB (Proximal Subiculum (FMM.FT.HF.SUBP), Middle Subiculum (FMM.FT.HF.SUBM), Distal Subiculum (FMM.FT.HF.SUBD))

• Hippocampus in Detail - see Reference

map: CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D)), CA2=Dorsolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA2, CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P), Middle CA3 of Hippocampus (FMM.FT.HC.CA3M), Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)), CA4=Dentate Gyrus,FMM.FT.HC.DG

• Principal Connections of Hippocampus - see Reference

map: AM=Amygdala,FAM.FT.AM, AN=Anterior Nucleus of Thalamus,FD.TH.AN (Anteromedial Nucleus (NCP.FD.TH.AM), Anteroventral Nucleus (FMM.FD.TH.AV), Anterodorsal Nucleus (FMM.FD.TH.AD)), DG=Dentate Gyrus,FMM.FT.HC.DG, DorsalCingulate=Dorsal Anterior Cingulate Area,NDM.NC.AL.DACG, EC=Entorhinal Cortex,FMM.NC.PH.ET (Lateral Entorhinal Cortex (FMM.NC.PH.LEC), Medial Entorhinal Cortex (FMM.NC.PH.MEC)), HC=Subiculum,FMM.FT.HF.SUB (Proximal Subiculum (FMM.FT.HF.SUBP), Middle Subiculum (FMM.FT.HF.SUBM), Distal Subiculum (FMM.FT.HF.SUBD)), MB=Medial Mammillary Nucleus,FMM.FD.MB.MMB, PosteriorCingulate=Posterior Cingulate Cortex,NCP.NC.MPL.PSCG, SEP=Septal Nuclei,FAM.FT.SEP, SUB=Subiculum,FMM.FT.HF.SUB (Proximal Subiculum (FMM.FT.HF.SUBP), Middle Subiculum (FMM.FT.HF.SUBM), Distal Subiculum (FMM.FT.HF.SUBD)), VentralCingulate=Ventral Anterior Cingulate Area,NDM.NC.AL.VACG

• Flow of impulses in hippocampal region - see Reference

map: CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D)), CA2=Dorsolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA2, CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P), Middle CA3 of Hippocampus (FMM.FT.HC.CA3M), Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)), DG=Dentate Gyrus,FMM.FT.HC.DG, ENT=Entorhinal Cortex,FMM.NC.PH.ET (Lateral Entorhinal Cortex (FMM.NC.PH.LEC), Medial Entorhinal Cortex (FMM.NC.PH.MEC)), PRES=Presubiculum,FMM.NC.PH.PRS, SUB=Subiculum,FMM.FT.HF.SUB (Proximal Subiculum (FMM.FT.HF.SUBP), Middle Subiculum (FMM.FT.HF.SUBM), Distal Subiculum (FMM.FT.HF.SUBD))

• Attractor Network in Hippocampus - see Reference

map: AN=Anterior Nucleus of Thalamus,FD.TH.AN (Anteromedial Nucleus (NCP.FD.TH.AM), Anteroventral Nucleus (FMM.FD.TH.AV), Anterodorsal Nucleus (FMM.FD.TH.AD)), CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D)), CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P), Middle CA3 of Hippocampus (FMM.FT.HC.CA3M), Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)), DG=Dentate Gyrus,FMM.FT.HC.DG, EC=Entorhinal Cortex,FMM.NC.PH.ET (Lateral Entorhinal Cortex (FMM.NC.PH.LEC), Medial Entorhinal Cortex (FMM.NC.PH.MEC)), MBIN=Medial Mammillary Nucleus,FMM.FD.MB.MMB, MBOUT=Lateral Mammillary Nucleus,FMM.FD.MB.LMB, NACC=Accumbens Nucleus,FEC.FT.ACC (Nucleus Accumbens Core (FEC.FT.ACC.CORE), Nucleus Accumbens Shell (FEC.FT.ACC.SH)), PERI=Perirhinal Cortex,FMM.NC.PH.PER, PRESUB=Presubiculum,FMM.NC.PH.PRS, SEP=Septal Nuclei,FAM.FT.SEP, SUB=Subiculum,FMM.FT.HF.SUB (Proximal Subiculum (FMM.FT.HF.SUBP), Middle Subiculum (FMM.FT.HF.SUBM), Distal Subiculum (FMM.FT.HF.SUBD))

References

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• http://www.scholarpedia.org/article/Head_direction_cells
• http://www.nature.com/nrn/journal/v5/n7
• http://journal.frontiersin.org/Journal/10.3389/fpsyt.2013.00061/full
• http://www.sciencedirect.com/science/article/pii/S030100820900183X
• http://www.impulsecontroldisorders.org/html/cravings.html
• http://www.sciencedirect.com/science/article/pii/S1571064507000243
• article:2009-Hippocampus-Thesis.pdf
• http://what-when-how.com/neuroscience/the-limbic-system-integrative-systems-part-1/
• http://highered.mcgraw-hill.com/sites/dl/free/0071402357/156721/figure350_1.html
• http://www.sciencedirect.com/science/article/pii/S030645220600755X
• http://learnmem.cshlp.org/content/14/11/714/F1.expansion