BrainRegionLAC FD HT MPO

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Median Preoptic Nucleus

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This page covers biological details of component Median Preoptic Nucleus. Region is part of aHuman target integrated biological model.

  • Top-down path to region: Forebrain Diencephalon -> Hypothalamus (FD.HT) -> Anterior Hypothalamus Area (LAC.FD.HT.AHT) -> Chiasmatic Area (LAC.FD.HT.CHS) -> Preoptic Nucleus (LAC.FD.HT.PO) -> Median Preoptic Nucleus (LAC.FD.HT.MPO) (see Mind Maps)
  • Type: nucleus
  • Brain area: Lower Brain - Autonomous Control Area
  • Role: processor.autonomic
  • Function: generates thirst
  • Notes to function: Drinking decreases noradrenaline release in median preoptic nucleus

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Components

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  • no child items defined

Connectivity

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LAC.FD.HT.MPO.dot.png

Inbound Region Connections:

Source Area Source Region Source Name Type Reference
FAM FAM.FT.AM.MPD Medial Posterior Dorsal Amygdaloid Nucleus inhibitory-gaba Role for serotonin in moral behavior (AMY -> HYP, abstract)
FMM FMM.FT.HC.CA1D Distal CA1 of Hippocampus excitatory-glu Feeling (HC -> HT, abstract)
LAC LAC.FD.HT.DM Dorsomedial Hypothalamic Nucleus excitatory-glu Eating and sleeping to survive (DMH -> MPO)
LAC.FD.HT.PRM Premammillary Nucleus excitatory-glu (unknown reference)
LAC.FD.HT.SCN Suprachiasmatic Nucleus excitatory-glu Intrahypothalamic connections important for neural control of food intake and energy balance (SCH -> MPOA)
LAC.HL.TGS.PE5 Peritrigeminal Nucleus excitatory-glu (unknown reference)
NDM NDM.FD.TH.PV Paraventricular Nucleus of Thalamus excitatory-glu (unknown reference)

Outbound Region Connections:

Target Area Target Region Target Name Type Reference
FAM FAM.FD.TH.PT Paratenial Nucleus of Thalamus excitatory-glu (unknown reference)
LAC LAC.FD.HT.AH Anterior Hypothalamic Nucleus excitatory-glu Intrahypothalamic connections important for neural control of food intake and energy balance (MPOA -> AH)
LAC.FD.HT.PV Paraventricular Nucleus excitatory-glu Intrahypothalamic connections important for neural control of food intake and energy balance (MPOA -> PA)
LAC.FD.HT.SO Supraoptic Nucleus excitatory-glu Intrahypothalamic connections important for neural control of food intake and energy balance (MPOA -> SON)
LMC LMC.HL.RP.OB Raphe Obscurus Nucleus excitatory-glu (unknown reference)

Thirdparty Circuits

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map: AH=Anterior Hypothalamic Nucleus,LAC.FD.HT.AH, ARC=Arcuate Nucleus of Hypothalamus,LAC.FD.HT.AR, DMN=Dorsomedial Hypothalamic Nucleus,LAC.FD.HT.DM, LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN, MPOA=Median Preoptic Nucleus,LAC.FD.HT.MPO, PA=Paraventricular Nucleus,LAC.FD.HT.PV, SCH=Suprachiasmatic Nucleus,LAC.FD.HT.SCN, SON=Supraoptic Nucleus,LAC.FD.HT.SO, VMN=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM unavailable

map: ARC=Arcuate Nucleus of Hypothalamus,LAC.FD.HT.AR, DMH=Dorsomedial Hypothalamic Nucleus,LAC.FD.HT.DM, LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN, MPO=Median Preoptic Nucleus,LAC.FD.HT.MPO, PVH=Paraventricular Nucleus,LAC.FD.HT.PV, SCN=Suprachiasmatic Nucleus,LAC.FD.HT.SCN, VLPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO, VMH=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM unavailable

map: CN=Caudate Nucleus,FEC.FT.CN (Caudate Nucleus Head (FEC.FT.CN.HD), Caudate Nucleus Body (FEC.FT.CN.BD), Caudate Nucleus Tail (FEC.FT.CN.TL)), DVM=Vagus Nucleus,LAC.HL.VGN, IMG=Inferior Mesenteric Ganglion,LAC.PN.SYM.IMG, IML=Intermediolateral Nucleus,LAC.SC.IZ.IML, LC=Locus Coeruleus,LMC.HT.LC, MPFC=Orbitofrontal Cortex,NC.AL.OPFC (Lateral Frontopolar Cortex (NDM.NC.AL.FPC), Most Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCR), Sulcal Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCS), Medial Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCM), Lateral Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCL)), MPOA=Median Preoptic Nucleus,LAC.FD.HT.MPO, NBM=Basal Nucleus of Meynert,LMC.FT.NBM, ONF=Onuf's Nucleus,LPC.SC.VH.ONF, PBN=Parabrachial Nucleus,LPC.HT.PRF.PB, PEL=Pelvic Peripheral Ganglion,LAC.PN.PSYM.PPG, PU=Dorsal Putamen Lateral,FEC.FT.PU.LT, PVN=Paraventricular Nucleus,LAC.FD.HT.PV, SNC=Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT, SPS=Sacral Parasympathetic Nucleus,LAC.SC.IZ.SPS, VTA=Ventral Tegmental Area,LMC.MM.VTA, ZI=Subthalamic Nucleus Caudal,BGA.FD.STN.ZI unavailable


References

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