BrainCenterFAM FD HB

Habenula

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This page covers biological details of component group Habenula. Component group is part of aHuman target integrated biological model.

• Top-down path to center: Forebrain Diencephalon -> Habenula (FAM.FD.HB) (see Mind Maps)
• Function: Encoding negative feedback

(generated)

Components

(generated)

Component items:

• Lateral Habenula (FAM.FD.LHB): Encoding negative feedback, direct; motivational control of behavior; pain processing, reward, motivation, and learning
  • Lateral Habenula Medial Part (FAM.FD.LHB.MED): Encoding negative feedback, direct, Septal
  • Lateral Habenula Lateral Part (FAM.FD.LHB.LT): Encoding negative feedback, direct, Pallidal
• Medial Habenula (FAM.FD.MHB): Encoding negative feedback, indirect

Connectivity

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Internal Regions Connections:

Source Region	Target Region	Reference
Medial Habenula (FAM.FD.MHB)	Lateral Habenula Medial Part (FAM.FD.LHB.MED)	Connectivity map of the habenula (M -> L, abstract)

External Connections:

External Inbound Center Connections:

Source Center	Sample Link	Reference
Central Extended Amygdala (FAM.FT.CEAM)	FAM.FT.EPF -> FAM.FD.LHB.LT	Regulation of the rapid eye movement (REM) sleep by habenular projection (EPN -> LHbL)
Septal Nuclei (FAM.FT.SEP)	FAM.FT.SEP.LT -> FAM.FD.LHB.MED	Both LHb and MHb control the dopaminergic and serotonergic systems (LS -> LHbM)
Hypothalamus (FD.HT)	LAC.FD.HT.PO -> FAM.FD.LHB.LT	Habenula Connections (LPO -> LHb, abstract)
Basal Ganglia (FEC.FT.BG)	FEC.FT.GPI.DS -> FAM.FD.LHB.LT	Habenula Connections (GPi -> LHb, abstract)
Locus Coeruleus (LMC.HT.LC)	LMC.HT.LC -> FAM.FD.MHB	(unknown reference)
Mesencephalic Reticular Formation (MM.RF)	LMC.MM.RF.SUC -> FAM.FD.LHB.LT	(unknown reference)

External Outbound Center Connections:

Target Center	Sample Link	Reference
Basal Ganglia (FEC.FT.BG)	FAM.FD.LHB.MED -> FEC.FT.SNC.LT	Habenula Connections (LHb -> SNc, abstract)
Medullary Reticular Formation (HL.RF)	FAM.FD.LHB.MED -> LMC.HL.RP.MG	Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> MRN, abstract)
Pontine Tegmental Nuclei (HT.TG)	FAM.FD.LHB.LT -> FEC.HT.PPN.RMTG	Both LHb and MHb control the dopaminergic and serotonergic systems (LHbL -> RMTg)
Ventral Tegmental Area (LMC.MM.VTA)	FAM.FD.LHB.MED -> LMC.MM.VTA	Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> VTA)
Mesencephalic Reticular Formation (MM.RF)	FAM.FD.LHB.MED -> LMC.MM.RF.SUC	Habenula Connections (LHb -> MR, abstract)
Endocrine Glands (TARGET.TEA.ENDOCRINE)	FAM.FD.MHB -> TARGET.TEA.ENDOCRINE	Habenula Connections (MHb -> PB)