BrainRegionFMM NC PH MEC

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Medial Entorhinal Cortex

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This page covers biological details of component Medial Entorhinal Cortex. Region is part of aHuman target integrated biological model.

  • Top-down path to region: Cerebral Cortex -> Parahippocampal Lobe (NC.LOBE.PH) -> Anterior Parahippocampal Gyrus (FMM.NC.PHA) -> Rhinal Cortex (NC.PHA.RH) -> Entorhinal Cortex (FMM.NC.PH.ET) -> Medial Entorhinal Cortex (FMM.NC.PH.MEC) (see Mind Maps)
  • Type: cortex
  • Quality: L0
  • Brain area: Forebrain - Memory Management Area (FMM)
  • Area circuit: Spatial Sensory Input to Hippocampus (MMASENSS)
  • Brodmann ID: 28
  • Role: processor.memory.complex
  • Function: Memory consolidation, basic, view independent position
  • Notes to function:
    • spatial input to HC
    • grid cells
    • path integration computations based on a global frame of reference, primarily using internally generated, self-motion cues and external input about environmental boundaries and scenes
    • provides hippocampus with coordinate system that underlies spatial context of experience

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Components

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  • no child items defined

Connectivity

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FMM.NC.PH.MEC.dot.png

Inbound Region Connections:

Source Area Source Region Source Name Type Role Reference
FMM FMM.FT.HF.SUBD Distal Subiculum excitatory-glu uncertain Attractor Network in Hippocampus (SUB -> EC, abstract)
FMM.NC.PH.PAS Parasubiculum feedforward-glu uncertain (unknown reference)
FMM.NC.PH.POR Postrhinal Cortex feedforward-glu uncertain Entorhinal Cortex Inputs and Outputs (TFTH -> EC, abstract)
FMM.NC.PH.POS Postsubiculum feedforward-glu uncertain Head Direction Cell Circuit (PSUB -> EC, abstract)
FMM.NC.PH.PRS Presubiculum feedforward-glu uncertain Attractor Network in Hippocampus (PRESUB -> EC, abstract)
NCP NCP.NC.MPL.PSCG Posterior Cingulate Cortex feedforward-glu uncertain McNaughton Spatial Processing Network (PCGRSP -> EnthCortex, abstract)
NCP.NC.MPL.RSC Retrosplenial Cortex feedforward-glu uncertain McNaughton Spatial Processing Network (PCGRSP -> EnthCortex, abstract)

Outbound Region Connections:

Target Area Target Region Target Name Type Role Reference
FMM FMM.FD.MB.MMB Medial Mammillary Nucleus excitatory-glu uncertain Mammillary bodies: two memory systems in one (MedialEC -> MMB, abstract)
FMM.FD.TH.AV Anteroventral Nucleus excitatory-glu uncertain Contributions of Diencephalon to Recognition Memory (EC -> AN, abstract)
FMM.FD.TH.LD Lateral Dorsal Nucleus of Thalamus excitatory-glu uncertain Contributions of Diencephalon to Recognition Memory (EC -> LD, abstract)
FMM.FT.HC.CA1P Proximal CA1 of Hippocampus excitatory-glu uncertain Neuronal projections in the hippocampus (ET -> CA1, abstract)
FMM.FT.HC.CA2 Dorsolateral Cornu Ammonis of Hippocampus excitatory-glu uncertain Amygdala and its network (EC -> HC, abstract)
FMM.FT.HC.CA3D Distal CA3 of Hippocampus excitatory-glu uncertain Neuronal projections in the hippocampus (ET -> CA3, abstract)
FMM.FT.HC.DG Dentate Gyrus excitatory-glu uncertain Neuronal projections in the hippocampus (ET -> DG, abstract)

Thirdparty Circuits

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AD=Anterodorsal Nucleus,FMM.FD.TH.AD
AM=Anteromedial Nucleus,NCP.FD.TH.AM
AN=Anterior Nucleus of Thalamus,FD.TH.AN (see Cognitive Thalamus)
AV=Anteroventral Nucleus,FMM.FD.TH.AV
CM=Centromedian Nucleus of Thalamus,FEC.FD.TH.CM
DLPFC=Mid-Dorsolateral Prefrontal Cortex,NDM.NC.AL.DLPFC (see Lateral Prefrontal Cortex)
EC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)
HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
LD=Lateral Dorsal Nucleus of Thalamus,FMM.FD.TH.LD
MB=Medial Mammillary Nucleus,FMM.FD.MB.MMB
MDmc=Mediodorsal Nucleus of Thalamus,FD.TH.MD (see Cognitive Thalamus)
MID=Midline Nuclear Group of Thalamus,FD.TH.MTH (see Cognitive Thalamus)
MPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
OFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
Parasub=Parasubiculum,FMM.NC.PH.PAS
Perirhinal=Perirhinal Cortex,FMM.NC.PH.PER
PostCingulate=Posterior Cingulate Cortex,NCP.NC.MPL.PSCG
Presub=Presubiculum,FMM.NC.PH.PRS
Sub=Subiculum,FMM.FT.HF.SUB (see Hippocampal Formation)
SubPrePara=Subiculum,FMM.FT.HF.SUB (see Hippocampal Formation)
mPULV=Medial Pulvinar,NPE.FD.TH.MPV


ADTH=Anterodorsal Nucleus,FMM.FD.TH.AD
AMTH=Anteromedial Nucleus,NCP.FD.TH.AM
AVTH=Anteroventral Nucleus,FMM.FD.TH.AV
DTN=Laterodorsal Tegmental Nucleus,LMC.HT.TG.LDT
LMB=Lateral Mammillary Nucleus,FMM.FD.MB.LMB
MMB=Medial Mammillary Nucleus,FMM.FD.MB.MMB
MedialEC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)
PAS=Parasubiculum,FMM.NC.PH.PAS
POS=Postsubiculum,FMM.NC.PH.POS
PRS=Presubiculum,FMM.NC.PH.PRS
SEP=Septal Nuclei,FAM.FT.SEP
SUB=Subiculum,FMM.FT.HF.SUB (see Hippocampal Formation)
SupraMM=Supramammillary Nucleus,LAC.FD.HT.SUM
TuberoMM=Lateral Tuberal Nuclei,LAC.FD.HT.LTUB (see Hypothalamus)
VTN=Ventral Tegmental Area,LMC.MM.VTA


AD=Anterodorsal Nucleus,FMM.FD.TH.AD
DTN=Laterodorsal Tegmental Nucleus,LMC.HT.TG.DTG
EC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)
HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
IPD=Interpeduncular Nucleus,FEC.HT.TG.IPD
LD=Lateral Dorsal Nucleus of Thalamus,FMM.FD.TH.LD
LHAB=Habenula,FAM.FD.HB
LMB=Lateral Mammillary Nucleus,FMM.FD.MB.LMB
MVSN=Medial Vestibular Nucleus,LPC.HT.MVBN
NPRP=Prepositus Nucleus,LRC.HL.NPH
PC=Parietal Lobe,NC.LOBE.PAR
PRHC=Postrhinal Cortex,FMM.NC.PH.POR
PSUB=Postsubiculum,FMM.NC.PH.POS
RSP=Retrosplenial Cortex,NCP.NC.MPL.RSC
SUPGEN=Suprageniculate Nucleus of Thalamus,NSA.FD.TH.SG
VC=Occipital Lobe,NC.LOBE.OCC


EnthCortex=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)
HF=Hippocampal Formation,FMM.FT.HF
ITCortex=Inferotemporal Area,NSA.NC.IT
PCGRSP=Medial Parietal Lobule,NC.MPL
ParInsVestCortex=Ventral Intraparietal Sulcus,NSA.NC.IPS.VIP
PosteriorParietalCortex=Caudal Precuneus,NPE.NC.SPL.PG
SUB=Subiculum,FMM.FT.HF.SUB (see Hippocampal Formation)
SomSensCortex=Primary Somatosensory Cortex,NCP.NC.PG.S1
VisualCortex=Occipital Lobe,NC.LOBE.OCC


A=Amygdala,FAM.FT.AM
ER=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)
H=Hippocampal Formation,FMM.FT.HF
IT=Inferotemporal Cortex,NSA.NC.IT.TE
PRPH=Perirhinal Cortex,FMM.NC.PH.PER
TEO=Preoccipital Inferotemporal Area,NSA.NC.IT.TEO
V1=Primary Visual Cortex,NSA.NC.OCC.V1
V2=Secondary Visual Cortex,NSA.NC.OCC.V2 (see Occipital Lobe)
V4=Fusiform Gyrus,NSA.NC.OCC.V4 (see Occipital Lobe)


BLN=Parvicellular Basal Amygdaloid Nucleus,FAM.FT.AM.BP
CEA=Central Amygdala,FAM.FT.AM.CEA (see Amygdala)
EC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)
HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
HTS=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
ITC=Inferotemporal Cortex,NSA.NC.IT.TE
LA=Lateral Amygdaloid Nucleus,FAM.FT.AM.LA (see Amygdala)
LHB=Lateral Habenula,FAM.FD.LHB (see Habenula)
MD=Mediodorsal Nucleus of Thalamus,FD.TH.MD (see Cognitive Thalamus)
MPFC=Orbitomedial Prefrontal Cortex,NC.AL.OMPFC
NACC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia)
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
RMTG=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG
STC=Wernicke's area A3,NSA.NC.STG.A3
VGDM=Vagus Nucleus,LAC.HL.VGN
VTA=Ventral Tegmental Area,LMC.MM.VTA


BLA=Basolateral Nuclear Complex,FAM.FT.AM.BL (see Amygdala)
CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (see Hippocampal Formation)
CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (see Hippocampal Formation)
DG=Dentate Gyrus,FMM.FT.HC.DG
ET=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)


References

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