BrainRegionFEC FT SNC MED
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Substantia Nigra Pars Compacta Medial
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This page covers biological details of component Substantia Nigra Pars Compacta Medial. Region is part of aHuman target integrated biological model.
- Top-down path to region: Forebrain Telencephalon -> Basal Ganglia (FEC.FT.BG) -> Substantia Nigra (FEC.FT.SN) -> Substantia Nigra Pars Compacta (FEC.FT.SNC) -> Substantia Nigra Pars Compacta Medial (FEC.FT.SNC.MED) (see Mind Maps)
- Type: nucleus
- Quality: L0
- Brain area: Forebrain - Execution Control Area (FEC)
- Area circuit: Motor Motivational Salience (FECLM)
- Role: basal.ganglia.nigracompacta
- Function: motivational loop
- Notes to function:
- VP, ventral circuits
(generated)
Components
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- no child items defined
Connectivity
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Inbound Region Connections:
| Source Area | Source Region | Source Name | Type | Role | Reference |
| FAM | FAM.FT.BNST | Bed Nucleus of Stria Terminalis | excitatory-glu | uncertain | (unknown reference) |
| FEC | FEC.FT.ACC.CORE | Nucleus Accumbens Core | inhibitory-gaba | uncertain | (unknown reference) |
| FEC.FT.GPI.RM | Globus Pallidus Internal Rostromedial | inhibitory-gaba | uncertain | Prefrontal Cortex (PFC) in motor behavior (GP -> SN, abstract) | |
| FEC.FT.SNR.MED | Substantia Nigra Pars Reticulata Medial | inhibitory-gaba | uncertain | (unknown reference) | |
| FEC.HT.TG.RMTG | Rostromedial Tegmental Nucleus | inhibitory-gaba | uncertain | Both LHb and MHb control the dopaminergic and serotonergic systems (RMTg -> SNc, abstract) | |
| LMC | LMC.HT.LC | Locus Coeruleus | modulatory-ne | uncertain | (unknown reference) |
Outbound Region Connections:
| Target Area | Target Region | Target Name | Type | Role | Reference |
| FAM | FAM.FT.AM.CEM | Medial Central Amygdaloid Nucleus | modulatory-da | uncertain | (unknown reference) |
| FEC | FEC.FT.ACC.SH | Nucleus Accumbens Shell | modulatory-da | uncertain | Connectivity map of the habenula (SNc -> CPu, abstract) |
| LAC | LAC.FD.HT.SUM | Supramammillary Nucleus | modulatory-da | uncertain | (unknown reference) |
| LRC | LRC.HT.PRF.PVR | Parvocellular Reticular Nucleus | modulatory-da | uncertain | (unknown reference) |
Thirdparty Circuits
(generated)
- Summary of the organization of the substantia nigra pars reticulata and pedunculopontine nucleus in lamprey - see Reference (CM.SN-PPN)
GPe=Globus Pallidus External,FEC.FT.GPE (see Basal Ganglia) GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia) PPN=Pedunculopontine Tegmental Nuclei,LMC.HT.TG.PPN SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia) SNr=Substantia Nigra Pars Reticulata,FEC.FT.SNR (see Basal Ganglia) STN=Subthalamic Nucleus,FEC.FD.STN (see Subthalamus Area)
- Connectivity map of the habenula - see Reference (CF.HB-CONN)
CPu=Striatum,FEC.FT.ST (see Basal Ganglia) EP=Endopiriform Nucleus,FAM.FT.EPF Hippo=Hippocampus,FMM.FT.HC (see Hippocampal Formation) IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD L=Lateral Habenula,FAM.FD.LHB (see Habenula) LH=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN M=Medial Habenula,FAM.FD.MHB NAc=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia) PAG=Periaqueductal Gray Matter,LMC.MM.PAG Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation) SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia) Septum=Septal Nuclei,FAM.FT.SEP VTA=Ventral Tegmental Area,LMC.MM.VTA
References
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