BrainCenterNC AL OMPFC

Orbitomedial Prefrontal Cortex

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This page covers biological details of component group Orbitomedial Prefrontal Cortex. Component group is part of aHuman target integrated biological model.

• Top-down path to center: Cerebral Cortex -> Anterior Lobe (NC.LOBE.ANT) -> Prefrontal Cortex (NC.AL.PFC) -> Orbitomedial Prefrontal Cortex (NC.AL.OMPFC) (see Mind Maps)
• Function: High-level Motivational Functions

(generated)

Components

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Component items:

• Orbitofrontal Cortex (NC.AL.OPFC): Personality
  • Lateral Frontopolar Cortex (NDM.NC.AL.FPC): Emotion Regulation
  • Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFC): Prefrontal associational integration
    • Most Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCR): Integral conscious selection of novelty
    • Sulcal Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCS): Gustatory and auditory selection of novelty
    • Medial Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCM): Somatosensory selection of novelty
    • Lateral Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCL): Visual selection of novelty
• Medial Prefrontal Cortex (NC.AL.MPFC): Response Selection
  • Dorsomedial Prefrontal Cortex (NDM.NC.AL.DMPFC): Ongoing Extroverted Attention to Select Appropriate Response
  • Ventromedial Prefrontal Cortex (NDM.NC.AL.VMPFC): Ongoing Introverted Attention with Regard to Emotions and Feelings, Reward or Punishment

Connectivity

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Internal Regions Connections:

Source Region	Target Region	Reference
Lateral Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCL)	Most Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCR)	Regulation of Social Brain (MPFC -> OFC, abstract)
Medial Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCM)	Lateral Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCL)	Regulation of Social Brain (MPFC -> OFC, abstract)
	Most Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCR)	Regulation of Social Brain (MPFC -> OFC, abstract)
Sulcal Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCS)	Lateral Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCL)	Regulation of Social Brain (MPFC -> OFC, abstract)

External Connections:

External Inbound Center Connections:

Source Center	Sample Link	Reference
Central Extended Amygdala (FAM.FT.CEAM)	LMC.FT.NBM -> NDM.NC.AL.FPC	Physiology and pathophysiology of lower urinary tract (NBM -> MPFC, abstract)
Septal Nuclei (FAM.FT.SEP)	FAM.FT.SEP.DBB -> NDM.NC.AL.VMPFC	(unknown reference)
Hypothalamus (FD.HT)	LAC.FD.HT.LTN -> NDM.NC.AL.ROFCS	Bowels control brain: gut hormones and obesity (LHA -> OFC, abstract)
Cognitive Thalamus (FD.TH.CR)	NDM.FD.TH.MDM -> NDM.NC.AL.FPC	Amygdala and its network (MD -> MPFC, abstract)
Sensory Thalamus (FD.TH.SR)	NDM.FD.TH.SM -> NDM.NC.AL.DMPFC	Saccadic Vision (Thalamus -> FrontalCortex, abstract)
Hippocampal Formation (FMM.FT.HF)	FMM.FT.HC.CA1P -> NDM.NC.AL.DMPFC	Gating of medial prefrontal activity by the entorhinal cortex (HC -> MPFC, abstract)
Ventral Tegmental Area (LMC.MM.VTA)	LMC.MM.VTA -> NDM.NC.AL.FPC	Amygdala and its network (VTA -> MPFC, abstract)
Lateral Prefrontal Cortex (NC.AL.LPFC)	NDM.NC.AL.IPG -> NDM.NC.AL.DMPFC	(unknown reference)
Insular Cortex (NC.INS)	NCP.NC.INS.PPC -> NDM.NC.AL.FPC	Amygdalar disruption of prefrontal cortex (INS -> MPFC, abstract)
Medial Parietal Lobule (NC.MPL)	NCP.NC.MPL.RSC -> NDM.NC.AL.ROFCR	Prefrontal Cortex (PFC) in emotional behavior (PCA -> OPFC, abstract)
Parietal Operculum (NC.PO)	NCP.NC.PO.PCC -> NDM.NC.AL.ROFCS	Global visual system (ParietalCortex -> FrontalCortex, abstract)
Superior Parietal Lobule (NC.SPL)	NCP.NC.SPL.SA -> NDM.NC.AL.ROFCM	Cortico-Cortical Connectivity (SA -> PFC, abstract)

External Outbound Center Connections:

Target Center	Sample Link	Reference
Amygdala (FAM.FT.AM)	NDM.NC.AL.DMPFC -> FAM.FT.AM.ITC	(unknown reference)
Septal Nuclei (FAM.FT.SEP)	NDM.NC.AL.FPC -> FAM.FT.SEP.SH	(unknown reference)
Hypothalamus (FD.HT)	NDM.NC.AL.FPC -> LAC.FD.HT.RCH	Prefrontal Cortex (PFC) in emotional behavior (OPFC -> HT, abstract)
Cognitive Thalamus (FD.TH.CR)	NDM.NC.AL.ROFCR -> FMM.FD.TH.RE	(unknown reference)
Subthalamus Area (FEC.FD.STA)	NDM.NC.AL.ROFCR -> FEC.FD.STN.DL	Serotonin regulation of subthalamic neurons (CTX -> STN, abstract)
Basal Ganglia (FEC.FT.BG)	NDM.NC.AL.FPC -> FEC.FT.ACC.CORE	Affective basal ganglia circuit (OMPFC -> NACC, abstract)
Anterior Cingulate Area (NC.ACG)	NDM.NC.AL.DMPFC -> NDM.NC.AL.DACG	(unknown reference)
Lateral Prefrontal Cortex (NC.AL.LPFC)	NDM.NC.AL.FPC -> NDM.NC.AL.DLPFCR	Prefrontal Cortex (PFC) in emotional behavior (OPFC -> LPFC, abstract)