BrainRegionLAC FD HT VLPO
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Ventrolateral Preoptic Nucleus
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This page covers biological details of component Ventrolateral Preoptic Nucleus. Region is part of aHuman target integrated biological model.
- Top-down path to region: Forebrain Diencephalon -> Hypothalamus (FD.HT) -> Anterior Hypothalamus Area (LAC.FD.HT.AHT) -> Chiasmatic Area (LAC.FD.HT.CHS) -> Preoptic Nucleus (LAC.FD.HT.PO) -> Ventrolateral Preoptic Nucleus (LAC.FD.HT.VLPO) (see Mind Maps)
- Type: nucleus
- Brain area: Lower Brain - Autonomous Control Area
- Role: processor.autonomic
- Function: mediates non-REM sleep onset
- Notes to function: lesions in VLPO result in insomnia
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Components
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- no child items defined
Connectivity
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Inbound Region Connections:
| Source Area | Source Region | Source Name | Type | Reference |
| FAM | FAM.FT.AM.MEA | Medial Anterior Amygdaloid Nucleus | excitatory-glu | Role for serotonin in moral behavior (AMY -> HYP, abstract) |
| FAM.FT.SEP.LT | Lateral Septal Nucleus | inhibitory-gaba | Cingulate Gyrus (SEP -> HT, abstract) | |
| FEC | FEC.HT.PPN.RMTG | Rostromedial Tegmental Nucleus | inhibitory-gaba | (unknown reference) |
| LAC | LAC.FD.HT.DM | Dorsomedial Hypothalamic Nucleus | excitatory-glu | Eating and sleeping to survive (DMH -> VLPO) |
| LAC.FD.HT.SCN | Suprachiasmatic Nucleus | excitatory-glu | (unknown reference) | |
| LAC.FD.HT.TBM | Tuberomammillary Nucleus | excitatory-glu | Simplified NREM sleep-promoting pathway (TMN -> VLPO) | |
| LAC.FD.HT.VM | Ventromedial Hypothalamic Nucleus | excitatory-glu | (unknown reference) | |
| LMC | LMC.HT.LC | Locus Coeruleus | modulatory-ne | Simplified NREM sleep-promoting pathway (LC -> VLPO) |
| NSA | NSA.NC.PH.PRP | Prepyriform Cortex | excitatory-glu | (unknown reference) |
Outbound Region Connections:
| Target Area | Target Region | Target Name | Type | Reference |
| FAM | FAM.FD.LHB.LT | Lateral Habenula Lateral Part | excitatory-glu | Habenula Connections (LPO -> LHb, abstract) |
| FAM.FD.LHB.MED | Lateral Habenula Medial Part | excitatory-glu | Both LHb and MHb control the dopaminergic and serotonergic systems (LPO -> LHbM) | |
| LAC | LAC.FD.HT.SUM | Supramammillary Nucleus | excitatory-glu | (unknown reference) |
| LMC | LMC.HT.TG.LDT | Laterodorsal Tegmental Nucleus | excitatory-glu | Simplified NREM sleep-promoting pathway (VLPO -> LDTg) |
Thirdparty Circuits
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References
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