BrainRegionLAC FD HT LTN

Lateral Hypothalamic Nucleus

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This page covers biological details of component Lateral Hypothalamic Nucleus. Region is part of aHuman target integrated biological model.

• Top-down path to region: Forebrain Diencephalon -> Hypothalamus (FD.HT) -> Lateral Hypothalamic Area (LAC.FD.HT.LT) -> Lateral Hypothalamic Nucleus (LAC.FD.HT.LTN) (see Mind Maps)
• Type: nucleus
• Brain area: Lower Brain - Autonomous Control Area
• Role: relay
• Function: feeding center
• Notes to function: lesions - lack of appetite

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Components

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• no child items defined

Connectivity

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Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Reference
FAM	FAM.FT.AM.BP	Parvicellular Basal Amygdaloid Nucleus	excitatory-glu	Amygdala and its network (BLN -> HTS)
	FAM.FT.AM.CEM	Medial Central Amygdaloid Nucleus	excitatory-glu	Amygdalar disruption of prefrontal cortex (AM -> HT.L, abstract)
	FAM.FT.SEP.SH	Septohippocampal Nucleus	excitatory-glu	Cingulate Gyrus (SEP -> HT, abstract)
FEC	FEC.FT.ACC.SH	Nucleus Accumbens Shell	inhibitory-gaba	(unknown reference)
LAC	LAC.FD.HT.AR	Arcuate Nucleus of Hypothalamus	excitatory-glu	Intrahypothalamic connections important for neural control of food intake and energy balance (ARC -> LHA)
	LAC.FD.HT.DM	Dorsomedial Hypothalamic Nucleus	excitatory-glu	Eating and sleeping to survive (DMH -> LHA)
	LAC.FD.HT.VM	Ventromedial Hypothalamic Nucleus	excitatory-glu	Glucose-sensing neural network (VMH -> LHA)
LPC	LPC.HL.SOL	Solitary Nucleus	excitatory-glu	Schematic of hypothalamic circuitry underlying satiety (NTS -> LHA)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
FAM	FAM.FD.LHB.LT	Lateral Habenula Lateral Part	excitatory-glu	Regulation of the rapid eye movement (REM) sleep by habenular projection (LHT -> LHbL)
	FAM.FD.LHB.MED	Lateral Habenula Medial Part	excitatory-glu	Both LHb and MHb control the dopaminergic and serotonergic systems (LHA -> LHbM)
LAC	LAC.FD.HT.PV	Paraventricular Nucleus	excitatory-glu	Schematic of hypothalamic circuitry underlying satiety (LHA -> PVN)
LMC	LMC.HL.RP.MG	Raphe Magnus Nucleus	excitatory-glu	(unknown reference)
NDM	NDM.NC.AL.ROFCS	Sulcal Rostral Orbitofrontal Cortex	excitatory-glu	Bowels control brain: gut hormones and obesity (LHA -> OFC, abstract)

Thirdparty Circuits

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• Schematic of hypothalamic circuitry underlying satiety - see Reference

• Bowels control brain: gut hormones and obesity - see Reference

• Regulation of the rapid eye movement (REM) sleep by habenular projection - see Reference

• Both LHb and MHb control the dopaminergic and serotonergic systems - see Reference

• Fear regulation - see Reference

• Glucose-sensing neural network - see Reference

• Food-entrainable circadian oscillator - see Reference

• Eating and sleeping to survive - see Reference

• Intrahypothalamic connections important for neural control of food intake and energy balance - see Reference

• Connectivity map of the habenula - see Reference

• Amygdala and its network - see Reference

References

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• http://neuroscience.uth.tmc.edu/s4/chapter04.html
• http://www.nature.com/nrendo/journal/v6/n8/fig_tab/nrendo.2010.93_F1.html
• http://journal.frontiersin.org/article/10.3389/fnhum.2013.00826/full
• http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html
• https://brmlab.cz/project/brain_hacking/tdcs/pfc
• http://ajpregu.physiology.org/content/302/2/R215
• http://www.pnas.org/content/103/32/12150/F7.expansion.html
• http://www.dana.org/Publications/ReportDetails.aspx?id=44217
• http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.122.2314rep=rep1type=pdf
• http://jn.physiology.org/content/107/10/2633
• http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin