Medial Septal Nucleus

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This page covers biological details of component Medial Septal Nucleus. Region is part of aHuman target integrated biological model.

Top-down path to region: Forebrain Telencephalon -> Extended Amygdala (FAM.FT.EXTAM) -> Septal Nuclei (FAM.FT.SEP) -> Dorsal Septal Nucleus (FAM.FT.SEP.DS) -> Medial Septal Group (FAM.FT.SEP.MG) -> Medial Septal Nucleus (FAM.FT.SEP.MED) (see Mind Maps)
Type: nucleus
Brain area: Forebrain - Affective Motivations Area
Role: relay
Function: affect HC for spatial learning, generation of theta waves
Notes to function: output nucleus; projections from AM and HC overlap; control theta rythm and exprolatory behavior; from/to MFB to fornix fimbria

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Components

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Connectivity

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FAM.FT.SEP.MED.dot.png

Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Reference
LAC	LAC.FD.HT.SUM	Supramammillary Nucleus	excitatory-glu	Medial mammillary nucleus and theta rhythm (SupraMM -> SEP, abstract)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
FAM	FAM.FD.MHB	Medial Habenula	modulatory-ach	Both LHb and MHb control the dopaminergic and serotonergic systems (MS -> MHb)
FEC	FEC.FD.TH.PF	Parafascicular Nucleus of Thalamus	modulatory-ach	(unknown reference)
FMM	FMM.FD.MB.LMB	Lateral Mammillary Nucleus	modulatory-ach	Cingulate Gyrus (SEP -> HT, abstract)
	FMM.FD.MB.MMB	Medial Mammillary Nucleus	inhibitory-gaba	Cingulate Gyrus (SEP -> HT, abstract)
NCP	NCP.NC.MPL.RSC	Retrosplenial Cortex	modulatory-ach	Medial mammillary nucleus and theta rhythm (SEP -> RSP, abstract)
NDM	NDM.FD.TH.MDM	Medial Mediodorsal Nucleus of Thalamus	modulatory-ach	Thalamocortical relationships (s1MD -> MD, abstract)