Difference between revisions of "BrainRegionFMM NC PH MEC"
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* '''Role''': processor.memory.complex | * '''Role''': processor.memory.complex | ||
* '''Function''': Memory consolidation, basic, view independent position | * '''Function''': Memory consolidation, basic, view independent position | ||
| − | * '''Notes to function''': spatial input to HC | + | * '''Notes to function''': |
| + | ** spatial input to HC | ||
| + | ** grid cells | ||
| + | ** path integration computations based on a global frame of reference, primarily using internally generated, self-motion cues and external input about environmental boundaries and scenes | ||
| + | ** provides hippocampus with coordinate system that underlies spatial context of experience | ||
(generated) | (generated) | ||
= Components = | = Components = | ||
Revision as of 20:29, 24 March 2019
Medial Entorhinal Cortex
@@Home -> BiologicalLifeResearch -> BrainAreaFMM -> BrainRegionFMM_NC_PH_MEC
This page covers biological details of component Medial Entorhinal Cortex. Region is part of aHuman target integrated biological model.
- Top-down path to region: Cerebral Cortex -> Parahippocampal Lobe (NC.LOBE.PH) -> Anterior Parahippocampal Gyrus (FMM.NC.PHA) -> Rhinal Cortex (NC.PHA.RH) -> Entorhinal Cortex (FMM.NC.PH.ET) -> Medial Entorhinal Cortex (FMM.NC.PH.MEC) (see Mind Maps)
- Type: cortex
- Brain area: Forebrain - Memory Management Area
- Brodmann ID: 28
- Role: processor.memory.complex
- Function: Memory consolidation, basic, view independent position
- Notes to function:
- spatial input to HC
- grid cells
- path integration computations based on a global frame of reference, primarily using internally generated, self-motion cues and external input about environmental boundaries and scenes
- provides hippocampus with coordinate system that underlies spatial context of experience
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Components
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- no child items defined
Connectivity
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Inbound Region Connections:
| Source Area | Source Region | Source Name | Type | Reference |
| FMM | FMM.FT.HF.SUBD | Distal Subiculum | excitatory-glu | Attractor Network in Hippocampus (SUB -> EC, abstract) |
| FMM.NC.PH.PAS | Parasubiculum | feedforward-glu | (unknown reference) | |
| FMM.NC.PH.POR | Postrhinal Cortex | feedforward-glu | Entorhinal Cortex Inputs and Outputs (TFTH -> EC, abstract) | |
| FMM.NC.PH.POS | Postsubiculum | feedforward-glu | Head Direction Cell Circuit (PSUB -> EC, abstract) | |
| FMM.NC.PH.PRS | Presubiculum | feedforward-glu | Attractor Network in Hippocampus (PRESUB -> EC, abstract) | |
| NCP | NCP.NC.MPL.PSCG | Posterior Cingulate Cortex | feedforward-glu | McNaughton Spatial Processing Network (PCGRSP -> EnthCortex, abstract) |
| NCP.NC.MPL.RSC | Retrosplenial Cortex | feedforward-glu | McNaughton Spatial Processing Network (PCGRSP -> EnthCortex, abstract) |
Outbound Region Connections:
| Target Area | Target Region | Target Name | Type | Reference |
| FMM | FMM.FD.MB.MMB | Medial Mammillary Nucleus | excitatory-glu | Mammillary bodies: two memory systems in one (MedialEC -> MMB, abstract) |
| FMM.FD.TH.AV | Anteroventral Nucleus | excitatory-glu | Contributions of Diencephalon to Recognition Memory (EC -> AN, abstract) | |
| FMM.FD.TH.LD | Lateral Dorsal Nucleus of Thalamus | excitatory-glu | Contributions of Diencephalon to Recognition Memory (EC -> LD, abstract) | |
| FMM.FT.HC.CA1P | Proximal CA1 of Hippocampus | excitatory-glu | Neuronal projections in the hippocampus (ET -> CA1, abstract) | |
| FMM.FT.HC.CA2 | Dorsolateral Cornu Ammonis of Hippocampus | excitatory-glu | Amygdala and its network (EC -> HC, abstract) | |
| FMM.FT.HC.CA3D | Distal CA3 of Hippocampus | excitatory-glu | Neuronal projections in the hippocampus (ET -> CA3, abstract) | |
| FMM.FT.HC.DG | Dentate Gyrus | excitatory-glu | Neuronal projections in the hippocampus (ET -> DG, abstract) |
Thirdparty Circuits
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- Contributions of Diencephalon to Recognition Memory - see Reference (CT.RECOGNITION-MEMORY)
AD=Anterodorsal Nucleus,FMM.FD.TH.AD AM=Anteromedial Nucleus,NCP.FD.TH.AM AN=Anterior Nucleus of Thalamus,FD.TH.AN (see Cognitive Thalamus) AV=Anteroventral Nucleus,FMM.FD.TH.AV CM=Centromedian Nucleus of Thalamus,FEC.FD.TH.CM DLPFC=Mid-Dorsolateral Prefrontal Cortex,NDM.NC.AL.DLPFC (see Lateral Prefrontal Cortex) EC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex) HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation) LD=Lateral Dorsal Nucleus of Thalamus,FMM.FD.TH.LD MB=Medial Mammillary Nucleus,FMM.FD.MB.MMB MDmc=Mediodorsal Nucleus of Thalamus,FD.TH.MD (see Cognitive Thalamus) MID=Midline Nuclear Group of Thalamus,FD.TH.MTH (see Cognitive Thalamus) MPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex) OFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex) Parasub=Parasubiculum,FMM.NC.PH.PAS Perirhinal=Perirhinal Cortex,FMM.NC.PH.PER PostCingulate=Posterior Cingulate Cortex,NCP.NC.MPL.PSCG Presub=Presubiculum,FMM.NC.PH.PRS Sub=Subiculum,FMM.FT.HF.SUB (see Hippocampal Formation) SubPrePara=Subiculum,FMM.FT.HF.SUB (see Hippocampal Formation) mPULV=Medial Pulvinar,NPE.FD.TH.MPV
- Mammillary bodies: two memory systems in one - see Reference (CT.MB-MEMORY)
ADTH=Anterodorsal Nucleus,FMM.FD.TH.AD AMTH=Anteromedial Nucleus,NCP.FD.TH.AM AVTH=Anteroventral Nucleus,FMM.FD.TH.AV DTN=Laterodorsal Tegmental Nucleus,LMC.HT.TG.LDT LMB=Lateral Mammillary Nucleus,FMM.FD.MB.LMB MMB=Medial Mammillary Nucleus,FMM.FD.MB.MMB MedialEC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex) PAS=Parasubiculum,FMM.NC.PH.PAS POS=Postsubiculum,FMM.NC.PH.POS PRS=Presubiculum,FMM.NC.PH.PRS SEP=Septal Nuclei,FAM.FT.SEP SUB=Subiculum,FMM.FT.HF.SUB (see Hippocampal Formation) SupraMM=Supramammillary Nucleus,LAC.FD.HT.SUM TuberoMM=Lateral Tuberal Nuclei,LAC.FD.HT.LTUB (see Hypothalamus) VTN=Ventral Tegmental Area,LMC.MM.VTA
- Head Direction Cell Circuit - see Reference (CT.HEAD-DIRECTION)
AD=Anterodorsal Nucleus,FMM.FD.TH.AD DTN=Laterodorsal Tegmental Nucleus,LMC.HT.TG.DTG EC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex) HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation) IPD=Interpeduncular Nucleus,FEC.HT.TG.IPD LD=Lateral Dorsal Nucleus of Thalamus,FMM.FD.TH.LD LHAB=Habenula,FAM.FD.HB LMB=Lateral Mammillary Nucleus,FMM.FD.MB.LMB MVSN=Medial Vestibular Nucleus,LPC.HT.MVBN NPRP=Prepositus Nucleus,LRC.HL.NPH PC=Parietal Lobe,NC.LOBE.PAR PRHC=Postrhinal Cortex,FMM.NC.PH.POR PSUB=Postsubiculum,FMM.NC.PH.POS RSP=Retrosplenial Cortex,NCP.NC.MPL.RSC SUPGEN=Suprageniculate Nucleus of Thalamus,NSA.FD.TH.SG VC=Occipital Lobe,NC.LOBE.OCC
- McNaughton Spatial Processing Network - see Reference (CP.VISUAL-SPATIAL-PROCESSING)
EnthCortex=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex) HF=Hippocampal Formation,FMM.FT.HF ITCortex=Inferotemporal Area,NSA.NC.IT PCGRSP=Medial Parietal Lobule,NC.MPL ParInsVestCortex=Ventral Intraparietal Sulcus,NSA.NC.IPS.VIP PosteriorParietalCortex=Caudal Precuneus,NPE.NC.SPL.PG SUB=Subiculum,FMM.FT.HF.SUB (see Hippocampal Formation) SomSensCortex=Primary Somatosensory Cortex,NCP.NC.PG.S1 VisualCortex=Occipital Lobe,NC.LOBE.OCC
- Visual Path to Hippocampus - see Reference (CP.VISUAL-PATH-TO-HC)
A=Amygdala,FAM.FT.AM ER=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex) H=Hippocampal Formation,FMM.FT.HF IT=Inferotemporal Cortex,NSA.NC.IT.TE PRPH=Perirhinal Cortex,FMM.NC.PH.PER TEO=Preoccipital Inferotemporal Area,NSA.NC.IT.TEO V1=Primary Visual Cortex,NSA.NC.OCC.V1 V2=Secondary Visual Cortex,NSA.NC.OCC.V2 (see Occipital Lobe) V4=Fusiform Gyrus,NSA.NC.OCC.V4 (see Occipital Lobe)
- Amygdala and its network - see Reference (CF.AM-NET)
BLN=Parvicellular Basal Amygdaloid Nucleus,FAM.FT.AM.BP CEA=Central Amygdala,FAM.FT.AM.CEA (see Amygdala) EC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex) HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation) HTS=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN ITC=Inferotemporal Cortex,NSA.NC.IT.TE LA=Lateral Amygdaloid Nucleus,FAM.FT.AM.LA (see Amygdala) LHB=Lateral Habenula,FAM.FD.LHB (see Habenula) MD=Mediodorsal Nucleus of Thalamus,FD.TH.MD (see Cognitive Thalamus) MPFC=Orbitomedial Prefrontal Cortex,NC.AL.OMPFC NACC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia) PAG=Periaqueductal Gray Matter,LMC.MM.PAG RMTG=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG STC=Wernicke's area A3,NSA.NC.STG.A3 VGDM=Vagus Nucleus,LAC.HL.VGN VTA=Ventral Tegmental Area,LMC.MM.VTA
- Neuronal projections in the hippocampus - see Reference (CF.AM-HC)
BLA=Basolateral Nuclear Complex,FAM.FT.AM.BL (see Amygdala) CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (see Hippocampal Formation) CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (see Hippocampal Formation) DG=Dentate Gyrus,FMM.FT.HC.DG ET=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)
References
(generated)
- http://learnmem.cshlp.org/content/18/6/384/F1.expansion.html
- http://www.nature.com/nrn/journal/v5/n1/fig_tab/nrn1299_F2.html
- http://www.scholarpedia.org/article/Head_direction_cells
- http://www.nature.com/nrn/journal/v3/n2/fig_tab/nrn726_F3.html
- http://www.scholarpedia.org/article/Inferior_temporal_cortex
- http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin
- http://journal.frontiersin.org/Journal/10.3389/fpsyt.2013.00061/full
