BrainRegionLAC FD HT AR
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Arcuate Nucleus of Hypothalamus
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This page covers biological details of component Arcuate Nucleus of Hypothalamus. Region is part of aHuman target integrated biological model.
- Top-down path to region: Forebrain Diencephalon -> Hypothalamus (FD.HT) -> Anterior Hypothalamus Area (LAC.FD.HT.AHT) -> Tuberal Area (LAC.FD.HT.TUB) -> Arcuate Nucleus of Hypothalamus (LAC.FD.HT.AR) (see Mind Maps)
- Type: nucleus
- Brain area: Lower Brain - Autonomous Control Area
- Role: processor.autonomic
- Function: Regulation of growth, appetite and body weight
- Notes to function: lateral of tuberlulum, TIDA - releases dopamine to regulate secretion of prolactin hormone, GHRH - stimulate growth hormone secretion (ventrolateral)
(generated)
Components
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- no child items defined
Connectivity
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Inbound Region Connections:
- no connections
Outbound Region Connections:
| Target Area | Target Region | Target Name | Type | Reference |
| LAC | LAC.FD.HT.DM | Dorsomedial Hypothalamic Nucleus | excitatory-glu | Intrahypothalamic connections important for neural control of food intake and energy balance (ARC -> DMN) |
| LAC.FD.HT.LTN | Lateral Hypothalamic Nucleus | excitatory-glu | Intrahypothalamic connections important for neural control of food intake and energy balance (ARC -> LHA) | |
| LAC.FD.HT.PV | Paraventricular Nucleus | excitatory-glu | Intrahypothalamic connections important for neural control of food intake and energy balance (ARC -> PA) | |
| LAC.FD.HT.VM | Ventromedial Hypothalamic Nucleus | excitatory-glu | Schematic of hypothalamic circuitry underlying satiety (ARC -> VMH) | |
| TEA | TARGET.TEA.ENDOCRINE | Endocrine Glands | endocrine-adenohypophysis | (unknown reference) |
Thirdparty Circuits
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- Intrahypothalamic connections important for neural control of food intake and energy balance - see Reference (CL.INTRAHYPOTHALAMIC)
AH=Anterior Hypothalamic Nucleus,LAC.FD.HT.AH ARC=Arcuate Nucleus of Hypothalamus,LAC.FD.HT.AR DMN=Dorsomedial Hypothalamic Nucleus,LAC.FD.HT.DM LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN MPOA=Median Preoptic Nucleus,LAC.FD.HT.MPO PA=Paraventricular Nucleus,LAC.FD.HT.PV SCH=Suprachiasmatic Nucleus,LAC.FD.HT.SCN SON=Supraoptic Nucleus,LAC.FD.HT.SO VMN=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM
- Schematic of hypothalamic circuitry underlying satiety - see Reference (CP.SATIETY)
ARC=Arcuate Nucleus of Hypothalamus,LAC.FD.HT.AR DMH=Dorsomedial Hypothalamic Nucleus,LAC.FD.HT.DM LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN NTS=Solitary Nucleus,LPC.HL.SOL PVN=Paraventricular Nucleus,LAC.FD.HT.PV VMH=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM
- Glucose-sensing neural network - see Reference (CP.GLUCOSE)
ARC=Arcuate Nucleus of Hypothalamus,LAC.FD.HT.AR DMN=Dorsomedial Hypothalamic Nucleus,LAC.FD.HT.DM LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN PVH=Paraventricular Nucleus,LAC.FD.HT.PV VMH=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM
- Eating and sleeping to survive - see Reference (CP.DMH-CYCLES)
ARC=Arcuate Nucleus of Hypothalamus,LAC.FD.HT.AR DMH=Dorsomedial Hypothalamic Nucleus,LAC.FD.HT.DM LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN MPO=Median Preoptic Nucleus,LAC.FD.HT.MPO PVH=Paraventricular Nucleus,LAC.FD.HT.PV SCN=Suprachiasmatic Nucleus,LAC.FD.HT.SCN VLPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO VMH=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM
- Bowels control brain: gut hormones and obesity - see Reference (CP.BOWELS)
AMY=Amygdala,FAM.FT.AM ARC=Arcuate Nucleus of Hypothalamus,LAC.FD.HT.AR DS=Dorsal Striatum,FEC.FT.DST (see Basal Ganglia) LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN ME=Endocrine Glands,TARGET.TEA.ENDOCRINE NAc=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia) NTS=Solitary Nucleus,LPC.HL.SOL OFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex) PBN=Parabrachial Nucleus,LPC.HT.PRF.PB PVN=Paraventricular Nucleus,LAC.FD.HT.PV VMN=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM VTA=Ventral Tegmental Area,LMC.MM.VTA
References
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- http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.122.2314rep=rep1type=pdf
- http://neuroscience.uth.tmc.edu/s4/chapter04.html
- http://ajpregu.physiology.org/content/302/2/R215
- http://www.dana.org/Publications/ReportDetails.aspx?id=44217
- http://www.nature.com/nrendo/journal/v6/n8/fig_tab/nrendo.2010.93_F1.html
