BrainRegionNMA NC SMC F6
Pre-Supplementary Motor Area
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This page covers biological details of component Pre-Supplementary Motor Area. Region is part of aHuman target integrated biological model.
- Top-down path to region: Cerebral Cortex -> Anterior Lobe (NC.LOBE.ANT) -> Supplementary Motor Cortex (NMA.NC.SMC) -> Pre-Supplementary Motor Area (NMA.NC.SMC.F6) (see Mind Maps)
- Type: cortex
- Brain area: Neocortical Brain - Motor Aggregation Area
- Brodmann ID: 06
- Role: cortex.generic
- Function: High level motor functions; Numerical and verbal mental-operation tasks
- Notes to function: from TH/VLpc, MD from caudate, CR; F5/24c/46; no connections with F1
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Components
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- no child items defined
Connectivity
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Inbound Region Connections:
| Source Area | Source Region | Source Name | Type | Reference |
| NDM | NDM.NC.AL.DLPFCR | Rostral Mid-Dorsolateral Prefrontal Cortex | feedforward-glu | Primate Control of Grasping (46 -> F6, abstract) |
| NMA | NMA.FD.TH.VA | Ventral Anterior Nucleus | excitatory-glu | Primate Control of Grasping (BTH -> F6) |
| NMA.FD.TH.VL | Ventral Lateral Nucleus | excitatory-glu | Basal Ganglia Activity (VLo -> SMC, abstract) |
Outbound Region Connections:
| Target Area | Target Region | Target Name | Type | Reference |
| FEC | FEC.FD.STN.MED | Subthalamic Nucleus Medial | excitatory-glu | Serotonin regulation of subthalamic neurons (CTX -> STN, abstract) |
| FEC.FT.PU.MED | Dorsal Putamen Medial | excitatory-glu | Primate Control of Grasping (F6 -> BG, abstract) | |
| NMA | NMA.NC.PMC.F4 | Ventral Caudal Premotor Cortex | feedforward-glu | Primate Control of Grasping (F6 -> F4) |
| NMA.NC.PMC.F5 | Ventral Rostral Premotor Cortex | feedforward-glu | Primate Control of Grasping (F6 -> F5) |
Thirdparty Circuits
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map: CTX=Anterior Lobe,NC.LOBE.ANT (Rostral Mid-Dorsolateral Prefrontal Cortex (NDM.NC.AL.DLPFCR), Lateral Mid-Dorsolateral Prefrontal Cortex (NDM.NC.AL.DLPFCL), Inferior Prefrontal Gyrus (NDM.NC.AL.IPG), Broca's Area Pars Opercularis (NPE.NC.BRA.PO), Broca's Area Pars Triangularis (NPE.NC.BRA.PT), Lateral Frontopolar Cortex (NDM.NC.AL.FPC), Most Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCR), Sulcal Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCS), Medial Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCM), Lateral Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCL), Dorsomedial Prefrontal Cortex (NDM.NC.AL.DMPFC), Ventromedial Prefrontal Cortex (NDM.NC.AL.VMPFC), Ventral Anterior Cingulate Area (NDM.NC.AL.VACG), Dorsal Anterior Cingulate Area (NDM.NC.AL.DACG), Subgenual Cingulate Cortex (NCP.NC.AL.SGCG), Ventral Medial Cingulate Area (NDM.NC.AL.VMCG), Dorsal Medial Cingulate Area (NDM.NC.AL.DMCG), Pregenual Cingulate Cortex (NDM.NC.AL.PGCG), Motor Cortex (NMA.NC.MC), Caudal Frontal Eye Field (NPE.NC.PMC.CFEF), Anterior Frontal Eye Field (NPE.NC.PMC.AFEF), Dorsal Caudal Premotor Cortex (NMA.NC.PMC.F2), Dorsal Rostral Premotor Cortex (NMA.NC.PMC.F7), Ventral Caudal Premotor Cortex (NMA.NC.PMC.F4), Ventral Rostral Premotor Cortex (NMA.NC.PMC.F5), Supplementary Eye Field (NPE.NC.SMC.SEF), Pre-Supplementary Motor Area (NMA.NC.SMC.F6), Supplementary Motor Area (NMA.NC.SMC.F3)), GPe=Globus Pallidus External,FEC.FT.GPE (Globus Pallidus External Lateral (FEC.FT.GPE.LT), Globus Pallidus External Medial (FEC.FT.GPE.MED), Globus Pallidus External Dorsal (FEC.FT.GPE.DS), Globus Pallidus External Rostromedial (FEC.FT.GPE.RM), Globus Pallidus External Dorsolateral (FEC.FT.GPE.DL)), GPi=Globus Pallidus Internal,FEC.FT.GPI (Globus Pallidus Internal Lateral (FEC.FT.GPI.LT), Globus Pallidus Internal Medial (FEC.FT.GPI.MED), Globus Pallidus Internal Dorsal (FEC.FT.GPI.DS), Globus Pallidus Internal Rostromedial (FEC.FT.GPI.RM), Globus Pallidus Internal Dorsolateral (FEC.FT.GPI.DL)), PPN=Pedunculopontine Tegmental Nuclei,LMC.HT.TG.PPN, SNr=Substantia Nigra Pars Reticulata,FEC.FT.SNR (Substantia Nigra Pars Reticulata Dorsolateral (FEC.FT.SNR.DL), Substantia Nigra Pars Reticulata Rostromedial (FEC.FT.SNR.RM), Substantia Nigra Pars Reticulata Ventrolateral (FEC.FT.SNR.VL), Substantia Nigra Pars Reticulata Medial (FEC.FT.SNR.MED)), STN=Subthalamic Nucleus,FEC.FD.STN (Subthalamic Nucleus Caudal (FEC.FD.STN.CD), Subthalamic Nucleus Internal Caudal (FEC.FD.STN.ICD), Subthalamic Nucleus Dorsolateral (FEC.FD.STN.DL), Subthalamic Nucleus Lateral (FEC.FD.STN.LT), Subthalamic Nucleus Medial (FEC.FD.STN.MED))
map: 46=Mid-Dorsolateral Prefrontal Cortex,NDM.NC.AL.DLPFC (Rostral Mid-Dorsolateral Prefrontal Cortex (NDM.NC.AL.DLPFCR), Lateral Mid-Dorsolateral Prefrontal Cortex (NDM.NC.AL.DLPFCL)), AIP=Anterior Intraparietal Sulcus,NSA.NC.IPS.AIP, BG=Basal Ganglia,FEC.FT.BG, BTH=Ventral Anterior Nucleus,NMA.FD.TH.VA, F1=Motor Cortex,NMA.NC.MC, F2=Dorsal Caudal Premotor Cortex,NMA.NC.PMC.F2, F4=Ventral Caudal Premotor Cortex,NMA.NC.PMC.F4, F5=Ventral Rostral Premotor Cortex,NMA.NC.PMC.F5, F6=Pre-Supplementary Motor Area,NMA.NC.SMC.F6, IT=Inferotemporal Area,NSA.NC.IT, PIP=Posterior Eye Field,NPE.NC.IPS.PEF (Medial Intraparietal Sulcus (NPE.NC.IPS.MIP), Lateral Intraparietal Sulcus (NPE.NC.IPS.LIP)), S1=Primary Somatosensory Cortex,NCP.NC.PG.S1, S2=Primary Somatosensory Cortex,NCP.NC.PG.S1, VC=Occipital Lobe,NC.LOBE.OCC, VIP=Ventral Intraparietal Sulcus,NSA.NC.IPS.VIP
References
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