BrainRegionFAM HT TG NI

Incertus Nucleus

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This page covers biological details of component Incertus Nucleus. Region is part of aHuman target integrated biological model.

• Top-down path to region: Hindbrain Metencephalon -> Pontine Tegmental Nuclei (HT.TG) -> Incertus Nucleus (FAM.HT.TG.NI) (see Mind Maps)
• Type: nucleus
• Brain area: Forebrain - Affective Motivations Area
• Role: processor.affective
• Function: Behavioural activation and the response to stress
• Notes to function:
  • Modulating influences on prefrontal and hippocampal cortical activity, midline behavior control
  • modulatory nucleus
  • relay from reticularis pontis oralis nucleus to septo-hippocampal system

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Components

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• no child items defined

Connectivity

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Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Reference
FAM	FAM.FD.LHB.MED	Lateral Habenula Medial Part	excitatory-glu	Regulation of the rapid eye movement (REM) sleep by habenular projection (LHbM -> NI)
LRC	LRC.HT.PRF.RPO	Oral Pontine Reticular Nucleus	excitatory-glu	(unknown reference)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
FAM	FAM.FT.EPF	Endopiriform Nucleus	inhibitory-gaba	(unknown reference)
	FAM.FT.SEP.SF	Septofimbrial Nucleus	inhibitory-gaba	(unknown reference)
	FAM.FT.SEP.TR	Triangular Septal Nucleus	inhibitory-gaba	(unknown reference)
FMM	FMM.NC.PH.PER	Perirhinal Cortex	inhibitory-gaba	(unknown reference)

Thirdparty Circuits

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• Regulation of the rapid eye movement (REM) sleep by habenular projection - see Reference (CF.REM-HB)

DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB
DTG=Laterodorsal Tegmental Nucleus,LMC.HT.TG.DTG
EPN=Endopiriform Nucleus,FAM.FT.EPF
GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia)
LHT=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
LHbL=Lateral Habenula Lateral Part,FAM.FD.LHB.LT
LHbM=Lateral Habenula Medial Part,FAM.FD.LHB.MED
NI=Incertus Nucleus,FAM.HT.TG.NI
RMTg=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG
Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation)
SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia)
VTA=Ventral Tegmental Area,LMC.MM.VTA
VTG=Ventral Tegmental Area,LMC.MM.VTG

References

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• http://journal.frontiersin.org/article/10.3389/fnhum.2013.00826/full