Revision as of 01:47, 24 January 2016

Lateral Entorhinal Cortex

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This page covers biological details of component Lateral Entorhinal Cortex. Region is part of aHuman target integrated biological model.

Top-down path to region: Cerebral Cortex -> Parahippocampal Lobe (NC.LOBE.PH) -> Anterior Parahippocampal Gyrus (FMM.NC.PHA) -> Rhinal Cortex (NC.PHA.RH) -> Entorhinal Cortex (FMM.NC.PH.ET) -> Lateral Entorhinal Cortex (FMM.NC.PH.LEC) (see Mind Maps)
Type: cortex
Brain area: Forebrain - Memory Management Area
Brodmann ID: 28
Role: processor.memory.complex
Function: Memory consolidation, emotional aspects
Notes to function: non-spatial input to HC; process information about individual items and locations based on a local frame of reference, primarily using external sensory input; it provides the hippocampus with information about content of experience

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Components

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FMM.NC.PH.LEC.dot.png

Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Reference
FAM	FAM.FD.TH.PT	Paratenial Nucleus of Thalamus	excitatory-glu	Contributions of Diencephalon to Recognition Memory (MID -> EC, abstract)
	FAM.FT.AM.BP	Parvicellular Basal Amygdaloid Nucleus	excitatory-glu	Principal Connections of Hippocampus (AM -> EC, abstract)
FMM	FMM.FT.HF.SUBD	Distal Subiculum	excitatory-glu	Attractor Network in Hippocampus (SUB -> EC, abstract)
	FMM.NC.PH.PER	Perirhinal Cortex	feedforward-glu	Visual Path to Hippocampus (PRPH -> ER, abstract)
LMC	LMC.MM.VTA	Ventral Tegmental Area	modulatory-da	Combining Novelty, Motivational Salience, and Reward to Control Attention and Learning (VTA -> EC, abstract)
NDM	NDM.FD.TH.PV	Paraventricular Nucleus of Thalamus	excitatory-glu	Contributions of Diencephalon to Recognition Memory (MID -> EC, abstract)
NSA	NSA.NC.IT.TE	Inferotemporal Cortex	feedforward-glu	McNaughton Spatial Processing Network (ITCortex -> EnthCortex, abstract)
	NSA.NC.PH.PIR	Piriform Cortex	feedforward-glu	KIV model of cortico-hippocampal formation with subcortical projections for motor actions (PC -> EC, abstract)
	NSA.NC.STG.A3	Wernicke's area A3	feedforward-glu	(unknown reference)
	NSA.NC.STG.A4	Wernicke's area A4	feedforward-glu	(unknown reference)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
FAM	FAM.FT.AM.AB	Accessory Basal Amygdaloid Nucleus	excitatory-glu	Simplified model of hippocampal formation anatomy (EC -> Amyg, abstract)
	FAM.FT.AM.LAVM	Ventromedial Amygdaloid Nucleus	excitatory-glu	Simplified model of hippocampal formation anatomy (EC -> Amyg, abstract)
FEC	FEC.FT.ACC.CORE	Nucleus Accumbens Core	excitatory-glu	Nucleus Accumbens (EC -> NACC, abstract)
FMM	FMM.FT.HC.CA1D	Distal CA1 of Hippocampus	excitatory-glu	Neuronal projections in the hippocampus (ET -> CA1, abstract)
	FMM.FT.HC.CA2	Dorsolateral Cornu Ammonis of Hippocampus	excitatory-glu	Amygdala and its network (EC -> HC, abstract)
	FMM.FT.HC.CA3P	Proximal CA3 of Hippocampus	excitatory-glu	Neuronal projections in the hippocampus (ET -> CA3, abstract)
	FMM.FT.HC.DG	Dentate Gyrus	excitatory-glu	Neuronal projections in the hippocampus (ET -> DG, abstract)
	FMM.FT.HF.SUBP	Proximal Subiculum	excitatory-glu	Visual Path to Hippocampus (ER -> H, abstract)
NDM	NDM.FD.TH.MDM	Medial Mediodorsal Nucleus of Thalamus	excitatory-glu	Contributions of Diencephalon to Recognition Memory (EC -> MDmc, abstract)

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 | [[BrainAreaLMC|LMC]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || Ventral Tegmental Area || modulatory-da || [http://www.impulsecontroldisorders.org/html/cravings.html Combining Novelty, Motivational Salience, and Reward to Control Attention and Learning (VTA -> EC, abstract)]
 |-
-| [[BrainAreaLPC|LPC]] || [[BrainRegionLPC_FD_TH_PV|LPC.FD.TH.PV]] || Paraventricular Nucleus of Thalamus || excitatory-glu || [http://learnmem.cshlp.org/content/18/6/384/F1.expansion.html Contributions of Diencephalon to Recognition Memory (MID -> EC, abstract)]
+| [[BrainAreaNDM|NDM]] || [[BrainRegionNDM_FD_TH_PV|NDM.FD.TH.PV]] || Paraventricular Nucleus of Thalamus || excitatory-glu || [http://learnmem.cshlp.org/content/18/6/384/F1.expansion.html Contributions of Diencephalon to Recognition Memory (MID -> EC, abstract)]
 |-
 | [[BrainAreaNSA|NSA]] || [[BrainRegionNSA_NC_IT_TE|NSA.NC.IT.TE]] || Inferotemporal Cortex || feedforward-glu || [http://www.nature.com/nrn/journal/v3/n2/fig_tab/nrn726_F3.html McNaughton Spatial Processing Network (ITCortex -> EnthCortex, abstract)]