BrainRegionLAC FD HT TBM

Tuberomammillary Nucleus

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This page covers biological details of component Tuberomammillary Nucleus. Region is part of aHuman target integrated biological model.

• Top-down path to region: Forebrain Diencephalon -> Hypothalamus (FD.HT) -> Lateral Hypothalamic Area (LAC.FD.HT.LT) -> Lateral Tuberal Nuclei (LAC.FD.HT.LTUB) -> Tuberomammillary Nucleus (LAC.FD.HT.TBM) (see Mind Maps)
• Type: nucleus
• Brain area: Lower Brain - Autonomous Control Area
• Role: relay
• Function: sole source of histamine in the brain
• Notes to function: regulate sleep, helps produce responses to sexual stimuli, and helps body respond to stressful situations

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Components

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Component items:

• Dorsal Tuberomammillary Nucleus
• Ventral Tuberomammillary Nucleus

Connectivity

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Inbound Region Connections:

• no connections

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
FAM	FAM.FT.SEP.LT	Lateral Septal Nucleus	excitatory-glu	(unknown reference)
FMM	FMM.FD.MB.MMB	Medial Mammillary Nucleus	excitatory-glu	Mammillary bodies: two memory systems in one (TuberoMM -> MMB, abstract)
LAC	LAC.FD.HT.PO	Preoptic Nucleus	excitatory-glu	Simplified NREM sleep-promoting pathway (TMN -> VLPO)
LMC	LMC.HT.LC	Locus Coeruleus	excitatory-glu	(unknown reference)
LPC	LPC.FT.MOB	Main Olfactory Bulb	excitatory-glu	(unknown reference)

Thirdparty Circuits

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• Mammillary bodies: two memory systems in one - see Reference

• Simplified NREM sleep-promoting pathway - see Reference

References

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• http://www.nature.com/nrn/journal/v5/n1/fig_tab/nrn1299_F2.html
• http://www.nature.com/neuro/journal/v5/n10/fig_tab/nn913_F1.html