BrainRegionFEC FT SNR MED

Substantia Nigra Pars Reticulata Medial

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This page covers biological details of component Substantia Nigra Pars Reticulata Medial. Region is part of aHuman target integrated biological model.

• Top-down path to region: Forebrain Telencephalon -> Basal Ganglia (BGA.FT.BG) -> Substantia Nigra (BGA.FT.SN) -> Substantia Nigra Pars Reticulata (LMC.FT.SNR) -> Substantia Nigra Pars Reticulata Medial (FEC.FT.SNR.MED) (see Mind Maps)
• Type: nucleus
• Brain area: Forebrain - Execution Control Area
• Role: relay
• Function: Motivational loop

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Components

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• no child items defined

Connectivity

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Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Reference
FEC	FEC.FD.STN.DL	Subthalamic Nucleus Dorsolateral	excitatory-glu	(unknown reference)
	FEC.FT.ACC.CORE	Nucleus Accumbens Core	inhibitory-gaba	Craving (NACC -> SNr, abstract)
	FEC.FT.CN.TL	Caudate Nucleus Tail	inhibitory-gaba	Saccades and smooth movements (CN -> SN, abstract)
	FEC.FT.GPE.RM	Globus Pallidus External Rostromedial	inhibitory-gaba	Prefrontal Cortex (PFC) in motor behavior (GP -> SN, abstract)
	FEC.FT.PU.VT	Ventral Putamen	inhibitory-gaba	(unknown reference)
	FEC.FT.VP.DL	Ventral Pallidum Dorsolateral	inhibitory-gaba	Craving (VPAL -> SNr, abstract)
NDM	NDM.NC.AL.FPC	Lateral Frontopolar Cortex	excitatory-glu	Global visual system (FrontalCortex -> BGA, abstract)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
FEC	FEC.FT.SNC.MED	Substantia Nigra Pars Compacta Medial	inhibitory-gaba	(unknown reference)
	FEC.HT.PPN.IPD	Interpeduncular Nucleus	inhibitory-gaba	(unknown reference)
NMA	NMA.FD.TH.MDL	Lateral Mediodorsal Nucleus of Thalamus	inhibitory-gaba	Saccadic Vision (BG -> Thalamus, abstract)

Thirdparty Circuits

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• Saccadic Vision - see Reference

• Craving - see Reference

References

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• http://www.nature.com/nrn/journal/v5/n3/box/nrn1345_BX1.html
• http://www.impulsecontroldisorders.org/html/cravings.html