BrainCenterFMM FT HF

Hippocampal Formation

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This page covers biological details of component group Hippocampal Formation. Component group is part of aHuman target integrated biological model.

• Top-down path to center: Forebrain Telencephalon -> Hippocampal Formation (FMM.FT.HF) (see Mind Maps)
• Function: Attention and short-term to long-term memory conversion
• Notes to function: allocortex

(generated)

Components

(generated)

Component items:

• Hippocampus (FMM.FT.HC)
  • Dentate Gyrus (FMM.FT.HC.DG): Distinguishing multiple instances of similar events
  • Ventrolateral Cornu Ammonis of Hippocampus (FMM.FT.HC.CA1): Representing sequences of episodic memory - long-term
    • Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P): Long-term memory, spatial
    • Middle CA1 of Hippocampus (FMM.FT.HC.CA1M): Long-term memory, synchronize
    • Distal CA1 of Hippocampus (FMM.FT.HC.CA1D): Long-term memory, motivational
  • Dorsolateral Cornu Ammonis of Hippocampus (FMM.FT.HC.CA2): Gate controlled by the activity of the supramammillary nucleus to control signal propagation between HC lamines
  • Dorsomedial Cornu Ammonis of Hippocampus (FMM.FT.HC.CA3): Representing sequences of episodic memory - short-term
    • Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P): Representing sequences of episodic memory, spatial
    • Middle CA3 of Hippocampus (FMM.FT.HC.CA3M): Representing sequences of episodic memory, synchronize
    • Distal CA3 of Hippocampus (FMM.FT.HC.CA3D): Representing sequences of episodic memory, motivational
• Subiculum (FMM.FT.HF.SUB): Spatial navigation and mnemonic processing
  • Proximal Subiculum (FMM.FT.HF.SUBP): Controlling hypothalamic-pituitary-adrenal (HPA) axis
  • Middle Subiculum (FMM.FT.HF.SUBM): Dynamic bridging of temporal intervals
  • Distal Subiculum (FMM.FT.HF.SUBD): Providing coarse representation of space

Connectivity

(generated)

Internal Regions Connections:

Source Region	Target Region	Reference
Distal CA1 of Hippocampus (FMM.FT.HC.CA1D)	Proximal Subiculum (FMM.FT.HF.SUBP)	Attractor Network in Hippocampus (CA1 -> SUB, abstract)
Middle CA1 of Hippocampus (FMM.FT.HC.CA1M)	Middle Subiculum (FMM.FT.HF.SUBM)	Attractor Network in Hippocampus (CA1 -> SUB, abstract)
Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P)	Distal Subiculum (FMM.FT.HF.SUBD)	Attractor Network in Hippocampus (CA1 -> SUB, abstract)
Dorsolateral Cornu Ammonis of Hippocampus (FMM.FT.HC.CA2)	Distal CA1 of Hippocampus (FMM.FT.HC.CA1D)	Flow of impulses in hippocampal region (CA2 -> CA1, abstract)
	Middle CA1 of Hippocampus (FMM.FT.HC.CA1M)	Flow of impulses in hippocampal region (CA2 -> CA1, abstract)
	Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P)	Flow of impulses in hippocampal region (CA2 -> CA1, abstract)
Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)	Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P)	Neuronal projections in the hippocampus (CA3 -> CA1, abstract)
	Dorsolateral Cornu Ammonis of Hippocampus (FMM.FT.HC.CA2)	KIV model of cortico-hippocampal formation with subcortical projections for motor actions (CA3 -> CA2, abstract)
Middle CA3 of Hippocampus (FMM.FT.HC.CA3M)	Middle CA1 of Hippocampus (FMM.FT.HC.CA1M)	Neuronal projections in the hippocampus (CA3 -> CA1, abstract)
	Dorsolateral Cornu Ammonis of Hippocampus (FMM.FT.HC.CA2)	KIV model of cortico-hippocampal formation with subcortical projections for motor actions (CA3 -> CA2, abstract)
Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P)	Distal CA1 of Hippocampus (FMM.FT.HC.CA1D)	Neuronal projections in the hippocampus (CA3 -> CA1, abstract)
	Dorsolateral Cornu Ammonis of Hippocampus (FMM.FT.HC.CA2)	KIV model of cortico-hippocampal formation with subcortical projections for motor actions (CA3 -> CA2, abstract)
Dentate Gyrus (FMM.FT.HC.DG)	Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)	Neuronal projections in the hippocampus (DG -> CA3, abstract)
	Middle CA3 of Hippocampus (FMM.FT.HC.CA3M)	Neuronal projections in the hippocampus (DG -> CA3, abstract)
	Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P)	Neuronal projections in the hippocampus (DG -> CA3, abstract)

External Connections:

External Inbound Center Connections:

Source Center	Reference
Amygdala (FAM.FT.AM)	Detailed amygdalohippocampal projections (Bpc -> CA1D)
Septal Nuclei (FAM.FT.SEP)	Medial mammillary nucleus and theta rhythm (SEP -> HF, abstract)
Hypothalamus (FD.HT)	Medial mammillary nucleus and theta rhythm (SupraMM -> HF, abstract)
Cognitive Thalamus (FD.TH.CR)	Contributions of Diencephalon to Recognition Memory (MID -> HC, abstract)
Motor Thalamus (FD.TH.MR)	Contributions of Diencephalon to Recognition Memory (LD -> HC, abstract)
Posterior Parahippocampal Gyrus (FMM.NC.PHP)	(unknown reference)
Metencephalic Motor Nuclei (HT.MN)	(unknown reference)
Pontine Tegmental Nuclei (HT.TG)	Connectivity map of the habenula (IPN -> Hippo, abstract)
Ventral Tegmental Area (LMC.MM.VTA)	Reward circuit of human brain (VTA -> HC, abstract)
Inferior Parietal Lobule (NC.IPL)	Contribution of hippocampal region CA3 to consciousness (IPL -> CA1, abstract)
Medial Parietal Lobule (NC.MPL)	Feeling (CG -> HC, abstract)
Rhinal Cortex (NC.PHA.RH)	Neuronal projections in the hippocampus (ET -> CA1, abstract)

External Outbound Center Connections:

Target Center	Reference
Amygdala (FAM.FT.AM)	Fear regulation (Hippocampus -> LA, abstract)
Septal Nuclei (FAM.FT.SEP)	Connectivity map of the habenula (Hippo -> Septum, abstract)
Hypothalamus (FD.HT)	Feeling (HC -> HT, abstract)
Cognitive Thalamus (FD.TH.CR)	Thalamocortical relationships (s1A -> A, abstract)
Motor Thalamus (FD.TH.MR)	Contributions of Diencephalon to Recognition Memory (Sub -> LD, abstract)
Basal Ganglia (FEC.FT.BG)	Nucleus Accumbens (CA1 -> NACC, abstract)
Retrosubicular Area (FMM.NC.PHA.RS)	(unknown reference)
Posterior Parahippocampal Gyrus (FMM.NC.PHP)	Entorhinal Cortex Inputs and Outputs (CA1 -> TFTH, abstract)
Orbitomedial Prefrontal Cortex (NC.AL.OMPFC)	Simplified model of hippocampal formation anatomy (CA1 -> mPFC, abstract)
Medial Parietal Lobule (NC.MPL)	McNaughton Spatial Processing Network (SUB -> PCGRSP, abstract)
Rhinal Cortex (NC.PHA.RH)	Attractor Network in Hippocampus (SUB -> EC, abstract)