Parabrachial Nucleus

@@Home -> BiologicalLifeResearch -> BrainAreaLPC -> BrainRegionLPC_HT_PRF_PB

This page covers biological details of component Parabrachial Nucleus. Region is part of aHuman target integrated biological model.

Top-down path to region: Hindbrain Metencephalon -> Pontine Reticular Formation (HT.RF) -> Pontine Reticular Formation, Lateral Column (HT.RF.LAT) -> Parabrachial Nucleus (LPC.HT.PRF.PB) (see Mind Maps)
Type: nucleus
Brain area: Lower Brain - Peripheral Control Area
Role: processor.affective
Function: Source of short-latency nociceptive input; sense of physiological condition of body well-being or interoception
Notes to function: major relay site for visceral afferents ascending through ventrobasal thalamus and terminating in insular cortex

(generated)

Components

(generated)

Component items:

Connectivity

(generated)

LPC.HT.PRF.PB.dot.png

Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Reference
FAM	FAM.FT.IPAC.MED	Medial Interstitial Anterior Commissural Nucleus	excitatory-glu	(unknown reference)
LPC	LPC.HL.SOL	Solitary Nucleus	excitatory-glu	Amygdalar disruption of prefrontal cortex (SOL -> PB)
NCP	NCP.NC.AL.SGCG	Subgenual Cingulate Cortex	excitatory-glu	Motor neurons control (CTX -> PRF, abstract)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
FAM	FAM.FT.AM.CEL	Central Amygdaloid Nucleus, lateral subdivision	excitatory-glu	Amygdalar disruption of prefrontal cortex (PB -> AM, abstract)
FEC	FEC.FT.ACC.SH	Nucleus Accumbens Shell	excitatory-glu	Bowels control brain: gut hormones and obesity (PBN -> NAc, abstract)
	FEC.FT.PU.LT	Dorsal Putamen Lateral	excitatory-glu	Bowels control brain: gut hormones and obesity (PBN -> DS, abstract)
	FEC.FT.PU.MED	Dorsal Putamen Medial	excitatory-glu	Bowels control brain: gut hormones and obesity (PBN -> DS, abstract)
LAC	LAC.FD.HT.DM	Dorsomedial Hypothalamic Nucleus	excitatory-glu	Food-entrainable circadian oscillator (PBN -> DMH)
	LAC.HL.VGN	Vagus Nucleus	excitatory-glu	Physiology and pathophysiology of lower urinary tract (PBN -> DVM)
NCP	NCP.NC.INS.PIC	Posterior Insular Cortex	excitatory-glu	Gustatory sensory system of rat and macaque (PB -> Gud, abstract)
NSA	NSA.FD.TH.VPI	Ventral Posteroinferior Nucleus	excitatory-glu	(unknown reference)
	NSA.FD.TH.VPM	Ventral Posteromedial Nucleus	excitatory-glu	Gustatory sensory system of rat and macaque (PB -> VPMpc)