Medial Entorhinal Cortex

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This page covers biological details of component Medial Entorhinal Cortex. Region is part of aHuman target integrated biological model.

Top-down path to region: Cerebral Cortex -> Parahippocampal Lobe (NC.LOBE.PH) -> Anterior Parahippocampal Gyrus (FMM.NC.PHA) -> Rhinal Cortex (NC.PHA.RH) -> Entorhinal Cortex (FMM.NC.PH.ET) -> Medial Entorhinal Cortex (FMM.NC.PH.MEC) (see Mind Maps)
Type: cortex
Brain area: Forebrain - Memory Management Area
Brodmann ID: 28
Role: processor
Function: Memory consolidation, basic, view inpedepdent position
Notes to function: spatial input to HC; grid cells; path integration computations based on a global frame of reference, primarily using internally generated, self-motion cues and external input about environmental boundaries and scenes; provides hippocampus with coordinate system that underlies spatial context of experience

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Components

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Connectivity

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FMM.NC.PH.MEC.dot.png

Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Reference
FMM	FMM.FT.HF.SUBD	Distal Subiculum	excitatory-glu	Attractor Network in Hippocampus (SUB -> EC, abstract)
	FMM.NC.PH.PAS	Parasubiculum	feedforward-glu	(unknown reference)
	FMM.NC.PH.POR	Postrhinal Cortex	feedforward-glu	Entorhinal Cortex Inputs and Outputs (TFTH -> EC, abstract)
	FMM.NC.PH.POS	Postsubiculum	feedforward-glu	Head Direction Cell Circuit (PSUB -> EC, abstract)
	FMM.NC.PH.PRS	Presubiculum	feedforward-glu	Attractor Network in Hippocampus (PRESUB -> EC, abstract)
NCP	NCP.NC.MPL.PSCG	Posterior Cingulate Cortex	feedforward-glu	McNaughton Spatial Processing Network (PCGRSP -> EnthCortex, abstract)
	NCP.NC.MPL.RSC	Retrosplenial Cortex	feedforward-glu	McNaughton Spatial Processing Network (PCGRSP -> EnthCortex, abstract)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
FMM	FMM.FD.MB.MMB	Medial Mammillary Nucleus	excitatory-glu	Mammillary bodies: two memory systems in one (MedialEC -> MMB, abstract)
	FMM.FD.TH.LD	Lateral Dorsal Nucleus of Thalamus	excitatory-glu	Contributions of Diencephalon to Recognition Memory (EC -> LD, abstract)
	FMM.FT.HC.CA1P	Proximal CA1 of Hippocampus	excitatory-glu	Neuronal projections in the hippocampus (ET -> CA1, abstract)
	FMM.FT.HC.CA2	Dorsolateral Cornu Ammonis of Hippocampus	excitatory-glu	Amygdala and its network (EC -> HC, abstract)
	FMM.FT.HC.CA3D	Distal CA3 of Hippocampus	excitatory-glu	Neuronal projections in the hippocampus (ET -> CA3, abstract)
	FMM.FT.HC.DG	Dentate Gyrus	excitatory-glu	Neuronal projections in the hippocampus (ET -> DG, abstract)