Periaqueductal Gray Matter

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This page covers biological details of component Periaqueductal Gray Matter. Region is part of aHuman target integrated biological model.

Top-down path to region: Midbrain Mesencephalon -> Periaqueductal Gray Matter (LMC.MM.PAG) (see Mind Maps)
Type: nucleus
Brain area: Lower Brain - Modulatory Contol Area
Role: relay
Function: Descending modulation of pain and in defensive behaviour
Notes to function: if there is a lesion in the PAG, then consciousness is lost; electrical stimulation of the PAG results in immediate and profound analgesia; modulatory nucleus

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Components

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Connectivity

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LMC.MM.PAG.dot.png

Inbound Region Connections:*

|| Source Area || Source Region || Source Name || Type || Reference || || FAM || FAM.FT.AM.CEM || Medial Central Amygdaloid Nucleus || excitatory-glu || [disruption of prefrontal cortex (AM -> PAG, abstract)] || || LAC || LAC.FD.HT.VM || Ventromedial Hypothalamic Nucleus || excitatory-glu || (unknown reference) || || NCP || NCP.NC.AL.SGCG || Subgenual Cingulate Cortex || excitatory-glu || (unknown reference) ||

Outbound Region Connections:*

|| Target Area || Target Region || Target Name || Type || Reference || || LAC || LAC.HP.BR || Barrington's Nucleus || modulatory-enk || [overview of spinobulbospinal micturition reflex pathway (PAG -> BAR)] || || LLC || LLC.FD.TH.SF || Subfascicular Nucleus of Thalamus || modulatory-enk || (unknown reference) || || LMC || LMC.HM.RP.MG || Raphe Magnus Nucleus || modulatory-enk || (unknown reference) || || || LMC.HM.RP.PL || Raphe Pallidus Nucleus || modulatory-enk || (unknown reference) || || LPC || LPC.FD.TH.PV || Paraventricular Nucleus of Thalamus || modulatory-enk || (unknown reference) || || || LPC.HM.AMB || Ambiguus Nucleus || modulatory-enk || (unknown reference) || || LRC || LRC.HM.RA || Retroambigualis Nucleus || modulatory-enk || (unknown reference) || || || LRC.HP.PN.SC || Nucleus Subceruleus || modulatory-enk || (unknown reference) ||