View source for BrainRegionFMM NC PH LEC

<pre style="color: green">Lateral Entorhinal Cortex</pre>
@@[[Home]] -> [[BiologicalLifeResearch]] -> [[BrainAreaFMM]] -> [[BrainRegionFMM_NC_PH_LEC]]
----

This page covers biological details of component Lateral Entorhinal Cortex.
Region is part of aHuman target integrated biological model.

* '''Top-down path to region''': Cerebral Cortex -> Parahippocampal Lobe (NC.LOBE.PH) -> Anterior Parahippocampal Gyrus (FMM.NC.PHA) -> [[BrainCenterNC_PHA_RH|Rhinal Cortex]] (NC.PHA.RH) -> Entorhinal Cortex (FMM.NC.PH.ET) -> [[BrainRegionFMM_NC_PH_LEC|Lateral Entorhinal Cortex]] (FMM.NC.PH.LEC) (see [[OverallMindMaps|Mind Maps]])
* '''Type''': cortex
* '''Brain area''': [[BrainAreaFMM|Forebrain - Memory Management Area]]
* '''Brodmann ID''': 28
* '''Role''': processor.memory.complex
* '''Function''': Memory consolidation, emotional aspects
* '''Notes to function''': non-spatial input to HC; process information about individual items and locations based on a local frame of reference, primarily using external sensory input; it provides the hippocampus with information about content of experience
(generated)
= Components =
(generated)


* no child items defined

= Connectivity =
(generated)


http://ahuman.org/svn/ahwiki/images/dot/FMM.NC.PH.LEC.dot.png

'''Inbound Region Connections:'''

{| class=wikitable width=80%
| '''Source Area''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Reference'''
|-
| [[BrainAreaFAM|FAM]] || [[BrainRegionFAM_FD_TH_PT|FAM.FD.TH.PT]] || Paratenial Nucleus of Thalamus || excitatory-glu || [http://learnmem.cshlp.org/content/18/6/384/F1.expansion.html Contributions of Diencephalon to Recognition Memory (MID -> EC, abstract)]
|-
|  || [[BrainRegionFAM_FT_AM_BP|FAM.FT.AM.BP]] || Parvicellular Basal Amygdaloid Nucleus || excitatory-glu || [http://highered.mcgraw-hill.com/sites/dl/free/0071402357/156721/figure350_1.html Principal Connections of Hippocampus (AM -> EC, abstract)]
|-
| [[BrainAreaFMM|FMM]] || [[BrainRegionFMM_FT_HF_SUBD|FMM.FT.HF.SUBD]] || Distal Subiculum || excitatory-glu || [http://learnmem.cshlp.org/content/14/11/714/F1.expansion Attractor Network in Hippocampus (SUB -> EC, abstract)]
|-
|  || [[BrainRegionFMM_NC_PH_PER|FMM.NC.PH.PER]] || Perirhinal Cortex || feedforward-glu || [http://www.scholarpedia.org/article/Inferior_temporal_cortex Visual Path to Hippocampus (PRPH -> ER, abstract)]
|-
| [[BrainAreaLMC|LMC]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || Ventral Tegmental Area || modulatory-da || [http://www.impulsecontroldisorders.org/html/cravings.html Combining Novelty, Motivational Salience, and Reward to Control Attention and Learning (VTA -> EC, abstract)]
|-
| [[BrainAreaNDM|NDM]] || [[BrainRegionNDM_FD_TH_PV|NDM.FD.TH.PV]] || Paraventricular Nucleus of Thalamus || excitatory-glu || [http://learnmem.cshlp.org/content/18/6/384/F1.expansion.html Contributions of Diencephalon to Recognition Memory (MID -> EC, abstract)]
|-
| [[BrainAreaNSA|NSA]] || [[BrainRegionNSA_NC_IT_TE|NSA.NC.IT.TE]] || Inferotemporal Cortex || feedforward-glu || [http://www.nature.com/nrn/journal/v3/n2/fig_tab/nrn726_F3.html McNaughton Spatial Processing Network (ITCortex -> EnthCortex, abstract)]
|-
|  || [[BrainRegionNSA_NC_PH_PIR|NSA.NC.PH.PIR]] || Piriform Cortex || feedforward-glu || [http://www.sciencedirect.com/science/article/pii/S1571064507000243 KIV model of cortico-hippocampal formation with subcortical projections for motor actions (PC -> EC, abstract)]
|-
|  || [[BrainRegionNSA_NC_STG_A3|NSA.NC.STG.A3]] || Wernicke's area A3 || feedforward-glu || (unknown reference)
|-
|  || [[BrainRegionNSA_NC_STG_A4|NSA.NC.STG.A4]] || Wernicke's area A4 || feedforward-glu || (unknown reference)
|}

'''Outbound Region Connections:'''

{| class=wikitable width=80%
| '''Target Area''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Reference'''
|-
| [[BrainAreaFAM|FAM]] || [[BrainRegionFAM_FT_AM_AB|FAM.FT.AM.AB]] || Accessory Basal Amygdaloid Nucleus || excitatory-glu || [http://www.sciencedirect.com/science/article/pii/S030100820900183X Simplified model of hippocampal formation anatomy (EC -> Amyg, abstract)]
|-
|  || [[BrainRegionFAM_FT_AM_LAVM|FAM.FT.AM.LAVM]] || Ventromedial Amygdaloid Nucleus || excitatory-glu || [http://www.sciencedirect.com/science/article/pii/S030100820900183X Simplified model of hippocampal formation anatomy (EC -> Amyg, abstract)]
|-
| [[BrainAreaFEC|FEC]] || [[BrainRegionFEC_FT_ACC_CORE|FEC.FT.ACC.CORE]] || Nucleus Accumbens Core || excitatory-glu || [http://usvn.ahuman.org/svn/ahwiki/images/wiki/research/biomodel/nucleus-accumbens.jpg Nucleus Accumbens (EC -> NACC, abstract)]
|-
| [[BrainAreaFMM|FMM]] || [[BrainRegionFMM_FT_HC_CA1D|FMM.FT.HC.CA1D]] || Distal CA1 of Hippocampus || excitatory-glu || [http://journal.frontiersin.org/Journal/10.3389/fpsyt.2013.00061/full Neuronal projections in the hippocampus (ET -> CA1, abstract)]
|-
|  || [[BrainRegionFMM_FT_HC_CA2|FMM.FT.HC.CA2]] || Dorsolateral Cornu Ammonis of Hippocampus || excitatory-glu || [http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin Amygdala and its network (EC -> HC, abstract)]
|-
|  || [[BrainRegionFMM_FT_HC_CA3P|FMM.FT.HC.CA3P]] || Proximal CA3 of Hippocampus || excitatory-glu || [http://journal.frontiersin.org/Journal/10.3389/fpsyt.2013.00061/full Neuronal projections in the hippocampus (ET -> CA3, abstract)]
|-
|  || [[BrainRegionFMM_FT_HC_DG|FMM.FT.HC.DG]] || Dentate Gyrus || excitatory-glu || [http://journal.frontiersin.org/Journal/10.3389/fpsyt.2013.00061/full Neuronal projections in the hippocampus (ET -> DG, abstract)]
|-
|  || [[BrainRegionFMM_FT_HF_SUBP|FMM.FT.HF.SUBP]] || Proximal Subiculum || excitatory-glu || [http://www.scholarpedia.org/article/Inferior_temporal_cortex Visual Path to Hippocampus (ER -> H, abstract)]
|-
| [[BrainAreaNDM|NDM]] || [[BrainRegionNDM_FD_TH_MDM|NDM.FD.TH.MDM]] || Medial Mediodorsal Nucleus of Thalamus || excitatory-glu || [http://learnmem.cshlp.org/content/18/6/384/F1.expansion.html Contributions of Diencephalon to Recognition Memory (EC -> MDmc, abstract)]
|}

= Thirdparty Circuits =
(generated)

* [http://learnmem.cshlp.org/content/18/6/384/F1.large.jpg Contributions of Diencephalon to Recognition Memory] - see [http://learnmem.cshlp.org/content/18/6/384/F1.expansion.html Reference] (CT.RECOGNITION-MEMORY)

 AD=[[BrainRegionFMM_FD_TH_AD|Anterodorsal Nucleus,FMM.FD.TH.AD]]
 AM=[[BrainRegionNCP_FD_TH_AM|Anteromedial Nucleus,NCP.FD.TH.AM]]
 AN=Anterior Nucleus of Thalamus,FD.TH.AN (see [[BrainCenterFD_TH_CR|Cognitive Thalamus]])
 AV=[[BrainRegionFMM_FD_TH_AV|Anteroventral Nucleus,FMM.FD.TH.AV]]
 CM=[[BrainRegionFEC_FD_TH_CM|Centromedian Nucleus of Thalamus,FEC.FD.TH.CM]]
 DLPFC=Mid-Dorsolateral Prefrontal Cortex,NDM.NC.AL.DLPFC (see [[BrainCenterNC_AL_LPFC|Lateral Prefrontal Cortex]])
 EC=Entorhinal Cortex,FMM.NC.PH.ET (see [[BrainCenterNC_PHA_RH|Rhinal Cortex]])
 HC=Hippocampus,FMM.FT.HC (see [[BrainCenterFMM_FT_HF|Hippocampal Formation]])
 LD=[[BrainRegionFMM_FD_TH_LD|Lateral Dorsal Nucleus of Thalamus,FMM.FD.TH.LD]]
 MB=[[BrainRegionFMM_FD_MB_MMB|Medial Mammillary Nucleus,FMM.FD.MB.MMB]]
 MDmc=Mediodorsal Nucleus of Thalamus,FD.TH.MD (see [[BrainCenterFD_TH_CR|Cognitive Thalamus]])
 MID=Midline Nuclear Group of Thalamus,FD.TH.MTH (see [[BrainCenterFD_TH_CR|Cognitive Thalamus]])
 MPFC=Orbitofrontal Cortex,NC.AL.OPFC (see [[BrainCenterNC_AL_OMPFC|Orbitomedial Prefrontal Cortex]])
 OFC=Orbitofrontal Cortex,NC.AL.OPFC (see [[BrainCenterNC_AL_OMPFC|Orbitomedial Prefrontal Cortex]])
 Parasub=[[BrainRegionFMM_NC_PH_PAS|Parasubiculum,FMM.NC.PH.PAS]]
 Perirhinal=[[BrainRegionFMM_NC_PH_PER|Perirhinal Cortex,FMM.NC.PH.PER]]
 PostCingulate=[[BrainRegionNCP_NC_MPL_PSCG|Posterior Cingulate Cortex,NCP.NC.MPL.PSCG]]
 Presub=[[BrainRegionFMM_NC_PH_PRS|Presubiculum,FMM.NC.PH.PRS]]
 Sub=Subiculum,FMM.FT.HF.SUB (see [[BrainCenterFMM_FT_HF|Hippocampal Formation]])
 SubPrePara=Subiculum,FMM.FT.HF.SUB (see [[BrainCenterFMM_FT_HF|Hippocampal Formation]])
 mPULV=[[BrainRegionNPE_FD_TH_MPV|Medial Pulvinar,NPE.FD.TH.MPV]]
<img src="http://ahuman.org/svn/ahwiki/images/ext/e0a360130a8150912e9c8da5be134c54.jpg" alt=alt="unavailable" style="max-width: 100%;" height=600 width=600>

* [http://ars.els-cdn.com/content/image/1-s2.0-S030100820900183X-gr4.jpg Simplified model of hippocampal formation anatomy] - see [http://www.sciencedirect.com/science/article/pii/S030100820900183X Reference] (CT.OPERATING-MODEL)

 Amyg=[[BrainCenterFAM_FT_AM|Amygdala,FAM.FT.AM]]
 CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (see [[BrainCenterFMM_FT_HF|Hippocampal Formation]])
 CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (see [[BrainCenterFMM_FT_HF|Hippocampal Formation]])
 DG=[[BrainRegionFMM_FT_HC_DG|Dentate Gyrus,FMM.FT.HC.DG]]
 EC=Entorhinal Cortex,FMM.NC.PH.ET (see [[BrainCenterNC_PHA_RH|Rhinal Cortex]])
 NACC=Accumbens Nucleus,FEC.FT.ACC (see [[BrainCenterFEC_FT_BG|Basal Ganglia]])
 SUB=Subiculum,FMM.FT.HF.SUB (see [[BrainCenterFMM_FT_HF|Hippocampal Formation]])
 mPFC=Orbitofrontal Cortex,NC.AL.OPFC (see [[BrainCenterNC_AL_OMPFC|Orbitomedial Prefrontal Cortex]])
<img src="http://ahuman.org/svn/ahwiki/images/ext/dadb137a040ae8763cae16e277d660cc.jpg" alt=alt="unavailable" style="max-width: 100%;">

* [http://www.scholarpedia.org/w/images/thumb/f/f2/ITCortex_pathway.jpg/400px-ITCortex_pathway.jpg Visual Path to Hippocampus] - see [http://www.scholarpedia.org/article/Inferior_temporal_cortex Reference] (CP.VISUAL-PATH-TO-HC)

 A=[[BrainCenterFAM_FT_AM|Amygdala,FAM.FT.AM]]
 ER=Entorhinal Cortex,FMM.NC.PH.ET (see [[BrainCenterNC_PHA_RH|Rhinal Cortex]])
 H=[[BrainCenterFMM_FT_HF|Hippocampal Formation,FMM.FT.HF]]
 IT=[[BrainRegionNSA_NC_IT_TE|Inferotemporal Cortex,NSA.NC.IT.TE]]
 PRPH=[[BrainRegionFMM_NC_PH_PER|Perirhinal Cortex,FMM.NC.PH.PER]]
 TEO=[[BrainRegionNSA_NC_IT_TEO|Preoccipital Inferotemporal Area,NSA.NC.IT.TEO]]
 V1=[[BrainRegionNSA_NC_OCC_V1|Primary Visual Cortex,NSA.NC.OCC.V1]]
 V2=Secondary Visual Cortex,NSA.NC.OCC.V2 (see [[BrainCenterNC_LOBE_OCC|Occipital Lobe]])
 V4=Fusiform Gyrus,NSA.NC.OCC.V4 (see [[BrainCenterNC_LOBE_OCC|Occipital Lobe]])
<img src="http://ahuman.org/svn/ahwiki/images/ext/1ca19e4b768c66419c5fbbff8eddc51a.jpg" alt=alt="unavailable" style="max-width: 100%;">

* [http://usvn.ahuman.org/svn/ahwiki/images/wiki/research/biomodel/nucleus-accumbens.jpg Nucleus Accumbens] (unknown reference) (CF.NUCLEUUS-ACCUMBENS)

 CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (see [[BrainCenterFMM_FT_HF|Hippocampal Formation]])
 CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (see [[BrainCenterFMM_FT_HF|Hippocampal Formation]])
 EC=Entorhinal Cortex,FMM.NC.PH.ET (see [[BrainCenterNC_PHA_RH|Rhinal Cortex]])
 NACC=Accumbens Nucleus,FEC.FT.ACC (see [[BrainCenterFEC_FT_BG|Basal Ganglia]])
 PAS=[[BrainRegionFMM_NC_PH_PAS|Parasubiculum,FMM.NC.PH.PAS]]
 PRR=[[BrainRegionFMM_NC_PH_PER|Perirhinal Cortex,FMM.NC.PH.PER]]
 SUB=Subiculum,FMM.FT.HF.SUB (see [[BrainCenterFMM_FT_HF|Hippocampal Formation]])
<img src="http://ahuman.org/svn/ahwiki/images/ext/61315b42c434b6f82081632f705a444d.jpg" alt=alt="unavailable" style="max-width: 100%;">

* [http://sni.wpengine.com/wp-content/uploads/2015/05/3520/SNI-3-40-g001.png Amygdala and its network] - see [http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin Reference] (CF.AM-NET)

 BLN=[[BrainRegionFAM_FT_AM_BP|Parvicellular Basal Amygdaloid Nucleus,FAM.FT.AM.BP]]
 CEA=Central Amygdala,FAM.FT.AM.CEA (see [[BrainCenterFAM_FT_AM|Amygdala]])
 EC=Entorhinal Cortex,FMM.NC.PH.ET (see [[BrainCenterNC_PHA_RH|Rhinal Cortex]])
 HC=Hippocampus,FMM.FT.HC (see [[BrainCenterFMM_FT_HF|Hippocampal Formation]])
 HTS=[[BrainRegionLAC_FD_HT_LTN|Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN]]
 ITC=[[BrainRegionNSA_NC_IT_TE|Inferotemporal Cortex,NSA.NC.IT.TE]]
 LA=Lateral Amygdaloid Nucleus,FAM.FT.AM.LA (see [[BrainCenterFAM_FT_AM|Amygdala]])
 LHB=Lateral Habenula,FAM.FD.LHB (see [[BrainCenterFAM_FD_HB|Habenula]])
 MD=Mediodorsal Nucleus of Thalamus,FD.TH.MD (see [[BrainCenterFD_TH_CR|Cognitive Thalamus]])
 MPFC=[[BrainCenterNC_AL_OMPFC|Orbitomedial Prefrontal Cortex,NC.AL.OMPFC]]
 NACC=Accumbens Nucleus,FEC.FT.ACC (see [[BrainCenterFEC_FT_BG|Basal Ganglia]])
 PAG=[[BrainRegionLMC_MM_PAG|Periaqueductal Gray Matter,LMC.MM.PAG]]
 RMTG=[[BrainRegionFEC_HT_TG_RMTG|Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG]]
 STC=[[BrainRegionNSA_NC_STG_A3|Wernicke's area A3,NSA.NC.STG.A3]]
 VGDM=[[BrainRegionLAC_HL_VGN|Vagus Nucleus,LAC.HL.VGN]]
 VTA=[[BrainRegionLMC_MM_VTA|Ventral Tegmental Area,LMC.MM.VTA]]
<img src="http://ahuman.org/svn/ahwiki/images/ext/148ecc584cca86040df3ac88ecdbcba6.png" alt=alt="unavailable" style="max-width: 100%;">

* [http://www.frontiersin.org/files/Articles/46459/fpsyt-04-00061-HTML/image_m/fpsyt-04-00061-g002.jpg Neuronal projections in the hippocampus] - see [http://journal.frontiersin.org/Journal/10.3389/fpsyt.2013.00061/full Reference] (CF.AM-HC)

 BLA=Basolateral Nuclear Complex,FAM.FT.AM.BL (see [[BrainCenterFAM_FT_AM|Amygdala]])
 CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (see [[BrainCenterFMM_FT_HF|Hippocampal Formation]])
 CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (see [[BrainCenterFMM_FT_HF|Hippocampal Formation]])
 DG=[[BrainRegionFMM_FT_HC_DG|Dentate Gyrus,FMM.FT.HC.DG]]
 ET=Entorhinal Cortex,FMM.NC.PH.ET (see [[BrainCenterNC_PHA_RH|Rhinal Cortex]])
<img src="http://ahuman.org/svn/ahwiki/images/ext/6db5356f9304330012fda936b30e6d95.jpg" alt=alt="unavailable" style="max-width: 100%;">


= References =
(generated)

* http://learnmem.cshlp.org/content/18/6/384/F1.expansion.html
* http://www.sciencedirect.com/science/article/pii/S030100820900183X
* http://www.scholarpedia.org/article/Inferior_temporal_cortex
* http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin
* http://journal.frontiersin.org/Journal/10.3389/fpsyt.2013.00061/full