#summary Anterior Frontal Eye Field
@@[Home] -> [BiologicalLifeResearch] -> [BrainAreaNPE] -> [BrainRegionNPE_NC_PMC_AFEF]
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This page covers biological details of component Anterior Frontal Eye Field.
Region is part of aHuman target integrated biological model.

  * *Top-down path to region*: Cerebral Cortex -> Anterior Lobe (NC.LOBE.ANT) -> [BrainCenterNC_PMC Premotor Cortex] (NC.PMC) -> Frontal Eye Field (NMA.NC.PMC.FEF) -> [BrainRegionNPE_NC_PMC_AFEF Anterior Frontal Eye Field] (NPE.NC.PMC.AFEF) (see [OverallMindMaps Mind Maps])
  * *Type*: cortex
  * *Quality*: L0
  * *Brain area*: [BrainAreaNPE Neocortical Brain - Unimodal Execution Area] (NPE)
  * *Area circuit*: Cortical Vision Control (CVC)
  * *Brodmann ID*: 08
  * *Role*: cortex.generic
  * *Function*: Head and eye movements toward auditory stimuli
  * *Notes to function*: 
   * longer saccades, dorsomedial - 8A (8Ac, 8Am), but not 8Ar
   *  8Ac - saccades
(generated)
= Components =
(generated)


  * no child items defined

= Connectivity =
(generated)


http://ahuman.org/svn/ahwiki/images/dot/NPE.NC.PMC.AFEF.dot.png

*Inbound Region Connections:*

|| *Source Area* || *Source Region* || *Source Name* || *Type* || *Role* || *Reference* ||
|| [BrainAreaNDM NDM] || [BrainRegionNDM_NC_AL_DLPFCL NDM.NC.AL.DLPFCL] || Lateral Mid-Dorsolateral Prefrontal Cortex || feedforward-glu || uncertain ||[https://www.google.ru/search?hl=rutbo=ptbm=bksq=isbn:0080887988 Prefrontal Cortex (PFC) in motor behavior (LPFC -> PMC, abstract)] ||
|| [BrainAreaNMA NMA] || [BrainRegionNMA_FD_TH_MDL NMA.FD.TH.MDL] || Lateral Mediodorsal Nucleus of Thalamus || excitatory-glu || uncertain ||[http://www.springerimages.com/Images/LifeSciences/1-10.1007_s00359-004-0565-9-0 Oculomotor decision-making (Thalamus -> FEF, abstract)] ||
|| [BrainAreaNPE NPE] || [BrainRegionNPE_NC_BRA_PO NPE.NC.BRA.PO] || Broca's Area Pars Opercularis || feedforward-glu || uncertain ||[http://www.nature.com/neuro/journal/v12/n6/fig_tab/nn.2331_F5.html Cortical Auditory System (IFC44 -> PMC8, abstract)] ||
||  || [BrainRegionNPE_NC_PMC_CFEF NPE.NC.PMC.CFEF] || Caudal Frontal Eye Field || feedforward-glu || uncertain ||(unknown reference) ||
||  || [BrainRegionNPE_NC_SMC_SEF NPE.NC.SMC.SEF] || Supplementary Eye Field || feedforward-glu || uncertain ||[http://www.cixip.com/index.php/page/content/id/1190 Summary of eye movement control (SEF -> FEF, abstract)] ||

*Outbound Region Connections:*

|| *Target Area* || *Target Region* || *Target Name* || *Type* || *Role* || *Reference* ||
|| [BrainAreaFEC FEC] || [BrainRegionFEC_FD_STN_MED FEC.FD.STN.MED] || Subthalamic Nucleus Medial || excitatory-glu || uncertain || [http://www.neurology.org/content/70/21/1991/F2.expansion.html Functional subdivisions of the subthalamic nucleus (FEF -> STN, abstract)] ||
||  || [BrainRegionFEC_FT_CN_BD FEC.FT.CN.BD] || Caudate Nucleus Body || excitatory-glu || uncertain || [http://www.sciencedirect.com/science/article/pii/S0959438808001566 Global visual system (FrontalCortex -> BGA, abstract)] ||
|| [BrainAreaLRC LRC] || [BrainRegionLRC_HL_PRF_GCR LRC.HL.PRF.GCR] || Gigantocellular Reticular Nucleus || excitatory-glu || uncertain || [http://openagrosrl.com/www/page/292/ Motor neurons control (CTX -> MRF, abstract)] ||
||  || [BrainRegionLRC_HT_PRF_RPO LRC.HT.PRF.RPO] || Oral Pontine Reticular Nucleus || excitatory-glu || uncertain || [http://openagrosrl.com/www/page/292/ Motor neurons control (CTX -> PRF, abstract)] ||
||  || [BrainRegionLRC_MM_CJ LRC.MM.CJ] || Cajal Nucleus || excitatory-glu || uncertain || [http://www.cixip.com/index.php/page/content/id/1190 Summary of eye movement control (FEF -> riMLF, abstract)] ||
||  || [BrainRegionLRC_MM_DSCH LRC.MM.DSCH] || Darkschewitsch Nucleus || excitatory-glu || uncertain || (unknown reference) ||
||  || [BrainRegionLRC_MM_SC_INT LRC.MM.SC.INT] || Intermediate Superior Colliculus || excitatory-glu || uncertain || [http://www.cixip.com/index.php/page/content/id/1190 Summary of eye movement control (FEF -> SC, abstract)] ||
|| [BrainAreaNMA NMA] || [BrainRegionNMA_NC_PMC_F5 NMA.NC.PMC.F5] || Ventral Rostral Premotor Cortex || feedforward-glu || uncertain || [http://www.nature.com/neuro/journal/v12/n6/fig_tab/nn.2331_F5.html Cortical Auditory System (PMC8 -> PMC6, abstract)] ||
||  || [BrainRegionNMA_NC_PMC_F7 NMA.NC.PMC.F7] || Dorsal Rostral Premotor Cortex || feedforward-glu || uncertain || (unknown reference) ||

= Thirdparty Circuits =
(generated)

  * [http://ars.els-cdn.com/content/image/1-s2.0-S0959438808001566-gr1.jpg Global visual system] - see [http://www.sciencedirect.com/science/article/pii/S0959438808001566 Reference] (CP.GLOBAL-VISUAL-SYSTEM)

 ATH=Anterior Nucleus of Thalamus,FD.TH.AN (see [BrainCenterFD_TH_CR Cognitive Thalamus])
 BGA=[BrainCenterFEC_FT_BG Basal Ganglia,FEC.FT.BG]
 FrontalCortex=Anterior Lobe,NC.LOBE.ANT
 LGN=[BrainRegionNSA_FD_LGN Lateral Geniculate Nucleus,NSA.FD.LGN]
 OPN=[BrainRegionLPC_MM_OCN Oculomotor Nucleus,LPC.MM.OCN]
 ParietalCortex=Parietal Lobe,NC.LOBE.PAR
 Pulvinar=Pulvinar,FD.PV (see [BrainCenterFD_TH_SR Sensory Thalamus])
 RF=[BrainCenterHT_RF Pontine Reticular Formation,HT.RF]
 Retina=[BrainRegionLPC_FD_RT Retinal Nucleus,LPC.FD.RT]
 SCi=Superior Colliculus,MM.SC (see [BrainCenterMM_REF Reflexes Nuclei of Midbrain Mesencephalon])
 SCs=Superior Colliculus,MM.SC (see [BrainCenterMM_REF Reflexes Nuclei of Midbrain Mesencephalon])
 SNc=[BrainRegionFEC_FT_SNC_LT Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT]
 SNr=[BrainRegionFEC_FT_SNR_DL Substantia Nigra Pars Reticulata Dorsolateral,FEC.FT.SNR.DL]
 SpinalCord=Lamina IX,SC.VH.L9 (see [BrainCenterSC_VH Anterior/Ventral Horn])
 Striatum=Striatum,FEC.FT.ST (see [BrainCenterFEC_FT_BG Basal Ganglia])
 VisualCortex=[BrainCenterNC_LOBE_OCC Occipital Lobe,NC.LOBE.OCC]
<img src="http://ars.els-cdn.com/content/image/1-s2.0-S0959438808001566-gr1.jpg" alt="unavailable" style="max-width: 100%;">

  * [http://www.cixip.com/Public/kindeditor/attached/image/20121030/20121030134649_52795.jpg Summary of eye movement control] - see [http://www.cixip.com/index.php/page/content/id/1190 Reference] (CP.EYE-FIELDS)

 DLPFC=Mid-Dorsolateral Prefrontal Cortex,NDM.NC.AL.DLPFC (see [BrainCenterNC_AL_LPFC Lateral Prefrontal Cortex])
 FEF=Frontal Eye Field,NMA.NC.PMC.FEF (see [BrainCenterNC_PMC Premotor Cortex])
 PEF=Posterior Eye Field,NPE.NC.IPS.PEF (see [BrainCenterNSA_NC_IPS Intraparietal Sulcus])
 PPRF=Paramedian Pontine Reticular Formation,HT.PRF.PPRF (see [BrainCenterHT_RF Pontine Reticular Formation])
 SC=Superior Colliculus,MM.SC (see [BrainCenterMM_REF Reflexes Nuclei of Midbrain Mesencephalon])
 SEF=[BrainRegionNPE_NC_SMC_SEF Supplementary Eye Field,NPE.NC.SMC.SEF]
 riMLF=[BrainRegionLRC_MM_CJ Cajal Nucleus,LRC.MM.CJ]
<img src="http://www.cixip.com/Public/kindeditor/attached/image/20121030/20121030134649_52795.jpg" alt="unavailable" style="max-width: 100%;">

  * [http://www.nature.com/neuro/journal/v12/n6/images/nn.2331-F5.jpg Cortical Auditory System] - see [http://www.nature.com/neuro/journal/v12/n6/fig_tab/nn.2331_F5.html Reference] (CP.CORTICAL-AUDITORY-SYSTEM)

 AC22=[BrainRegionNSA_NC_STG_A4 Wernicke's area A4,NSA.NC.STG.A4]
 Belt42=[BrainRegionNSA_NC_TTG_A2 Auditory Association Area,NSA.NC.TTG.A2]
 Core41=[BrainRegionNSA_NC_TTG_A1 Primary Auditory Cortex,NSA.NC.TTG.A1]
 IFC44=Broca's Area,NPE.NC.PFC.BRA (see [BrainCenterNC_AL_LPFC Lateral Prefrontal Cortex])
 IFC45=Broca's Area,NPE.NC.PFC.BRA (see [BrainCenterNC_AL_LPFC Lateral Prefrontal Cortex])
 IPL40=Supramarginal Gyrus,NC.IPL.SMG (see [BrainCenterNC_IPL Inferior Parietal Lobule])
 PMC6=Ventral Premotor Cortex,MCA.NC.VPMC (see [BrainCenterNC_PMC Premotor Cortex])
 PMC8=[BrainRegionNPE_NC_PMC_AFEF Anterior Frontal Eye Field,NPE.NC.PMC.AFEF]
 STS22=[BrainRegionNSA_NC_STG_A3 Wernicke's area A3,NSA.NC.STG.A3]
<img src="http://www.nature.com/neuro/journal/v12/n6/images/nn.2331-F5.jpg" alt="unavailable" style="max-width: 100%;">

  * [http://www.neurology.org/content/70/21/1991/F2.large.jpg Functional subdivisions of the subthalamic nucleus] - see [http://www.neurology.org/content/70/21/1991/F2.expansion.html Reference] (CM.STN-CONN)

 ACG=Anterior Cingulate Cortex,NC.AL.ACG (see [BrainCenterNC_ACG Anterior Cingulate Area])
 FEF=Frontal Eye Field,NMA.NC.PMC.FEF (see [BrainCenterNC_PMC Premotor Cortex])
 GPe=Globus Pallidus External,FEC.FT.GPE (see [BrainCenterFEC_FT_BG Basal Ganglia])
 GPi=Globus Pallidus Internal,FEC.FT.GPI (see [BrainCenterFEC_FT_BG Basal Ganglia])
 MC=[BrainRegionNMA_NC_MC Motor Cortex,NMA.NC.MC]
 SNr=Substantia Nigra Pars Reticulata,FEC.FT.SNR (see [BrainCenterFEC_FT_BG Basal Ganglia])
 STN=Subthalamic Nucleus,FEC.FD.STN (see [BrainCenterFEC_FD_STA Subthalamus Area])
 VP=Ventral Pallidum,FEC.FT.VP (see [BrainCenterFEC_FT_BG Basal Ganglia])
<img src="http://www.neurology.org/content/70/21/1991/F2.large.jpg" alt="unavailable" style="max-width: 100%;">

  * [http://dev.epubbud.com/uploads/9/2/6/9263981/images/Medical_Physiology_A_Systems_Approach__1e_2011_pdf/index-187_1.jpg Motor neurons control] - see [http://openagrosrl.com/www/page/292/ Reference] (CM.CR-MN)

 CR=Cerebellum,LLC.HT.CR (see [BrainCenterLLC_HT_CRC Cerebellar Complex])
 CTX=Anterior Lobe,NC.LOBE.ANT
 EAMN=[BrainCenterSC_VH Anterior/Ventral Horn,SC.VH]
 EGMN=[BrainCenterSC_VH Anterior/Ventral Horn,SC.VH]
 FAMN=[BrainCenterSC_VH Anterior/Ventral Horn,SC.VH]
 FG=[BrainRegionLRC_HT_CR_FG Fastigual Nucleus,LRC.HT.CR.FG]
 IP=Interposed Nucleus,LLC.HT.CR.IP (see [BrainCenterLLC_HT_CRC Cerebellar Complex])
 LT=[BrainRegionLLC_HT_CR_DN Dentate Nucleus,LLC.HT.CR.DN]
 MRF=[BrainCenterHL_RF Medullary Reticular Formation,HL.RF]
 PRF=[BrainCenterHT_RF Pontine Reticular Formation,HT.RF]
 RD=[BrainCenterLLC_MM_RD Red Nucleus,LLC.MM.RD]
 VB=[BrainCenterLPC_HT_VBN Vestibular Nuclei,LPC.HT.VBN]
<img src="http://dev.epubbud.com/uploads/9/2/6/9263981/images/Medical_Physiology_A_Systems_Approach__1e_2011_pdf/index-187_1.jpg" alt="unavailable" style="max-width: 100%;">

  * [http://ars.els-cdn.com/content/image/1-s2.0-S1053810011000080-gr3.jpg Cortico-Cortical Connectivity] - see [http://www.sciencedirect.com/science/article/pii/S1053810011000080 Reference] (CL.CORTICO-CORTICAL-CONNECTIVITY)

 A1=[BrainRegionNSA_NC_TTG_A1 Primary Auditory Cortex,NSA.NC.TTG.A1]
 AA=[BrainRegionNSA_NC_STG_A3 Wernicke's area A3,NSA.NC.STG.A3]
 M1=[BrainRegionNMA_NC_MC Motor Cortex,NMA.NC.MC]
 MA=[BrainCenterNC_PMC Premotor Cortex,NC.PMC]
 PFC=Prefrontal Cortex,NC.AL.PFC
 PTHA=[BrainCenterNC_IPL Inferior Parietal Lobule,NC.IPL]
 S1=[BrainRegionNCP_NC_PG_S1 Primary Somatosensory Cortex,NCP.NC.PG.S1]
 SA=[BrainRegionNCP_NC_SPL_SA Somatosensory Association Cortex,NCP.NC.SPL.SA]
 V1=[BrainRegionNSA_NC_OCC_V1 Primary Visual Cortex,NSA.NC.OCC.V1]
 VA=Secondary Visual Cortex,NSA.NC.OCC.V2 (see [BrainCenterNC_LOBE_OCC Occipital Lobe])
<img src="http://ars.els-cdn.com/content/image/1-s2.0-S1053810011000080-gr3.jpg" alt="unavailable" style="max-width: 100%;">


= References =
(generated)

  * http://www.sciencedirect.com/science/article/pii/S0959438808001566
  * http://www.cixip.com/index.php/page/content/id/1190
  * http://www.nature.com/neuro/journal/v12/n6/fig_tab/nn.2331_F5.html
  * http://www.neurology.org/content/70/21/1991/F2.expansion.html
  * http://openagrosrl.com/www/page/292/
  * http://www.sciencedirect.com/science/article/pii/S1053810011000080