#summary Pre-Supplementary Motor Area
@@[Home] -> [BiologicalLifeResearch] -> [BrainAreaNMA] -> [BrainRegionNMA_NC_SMC_F6]
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This page covers biological details of component Pre-Supplementary Motor Area.
Region is part of aHuman target integrated biological model.

  * *Top-down path to region*: Cerebral Cortex -> Anterior Lobe (NC.LOBE.ANT) -> [BrainCenterNMA_NC_SMC Supplementary Motor Cortex] (NMA.NC.SMC) -> [BrainRegionNMA_NC_SMC_F6 Pre-Supplementary Motor Area] (NMA.NC.SMC.F6) (see [OverallMindMaps Mind Maps])
  * *Type*: cortex
  * *Quality*: L0
  * *Brain area*: [BrainAreaNMA Neocortical Brain - Motor Aggregation Area] (NMA)
  * *Area circuit*: Complex Motor (SEQ)
  * *Brodmann ID*: 06
  * *Role*: cortex.generic
  * *Function*: High level motor functions; Numerical and verbal mental-operation tasks
  * *Notes to function*: 
   * from TH/VLpc, MD from caudate, CR
   *  F5/24c/46
   *  no connections with F1
(generated)
= Components =
(generated)


  * no child items defined

= Connectivity =
(generated)


http://ahuman.org/svn/ahwiki/images/dot/NMA.NC.SMC.F6.dot.png

*Inbound Region Connections:*

|| *Source Area* || *Source Region* || *Source Name* || *Type* || *Role* || *Reference* ||
|| [BrainAreaNDM NDM] || [BrainRegionNDM_NC_AL_DLPFCR NDM.NC.AL.DLPFCR] || Rostral Mid-Dorsolateral Prefrontal Cortex || feedforward-glu || uncertain ||[http://www.sciencedirect.com/science/article/pii/S0893608098000471 Primate Control of Grasping (46 -> F6, abstract)] ||
|| [BrainAreaNMA NMA] || [BrainRegionNMA_FD_TH_VA NMA.FD.TH.VA] || Ventral Anterior Nucleus || excitatory-glu || uncertain ||[http://www.sciencedirect.com/science/article/pii/S0893608098000471 Primate Control of Grasping (BTH -> F6)] ||
||  || [BrainRegionNMA_FD_TH_VL NMA.FD.TH.VL] || Ventral Lateral Nucleus || excitatory-glu || uncertain ||[http://thebrain.mcgill.ca/flash/a/a_06/a_06_cr/a_06_cr_mou/a_06_cr_mou.html Basal Ganglia Activity (VLo -> SMC, abstract)] ||

*Outbound Region Connections:*

|| *Target Area* || *Target Region* || *Target Name* || *Type* || *Role* || *Reference* ||
|| [BrainAreaFEC FEC] || [BrainRegionFEC_FD_STN_MED FEC.FD.STN.MED] || Subthalamic Nucleus Medial || excitatory-glu || uncertain || [http://www.degruyter.com/view/j/revneuro.2014.25.issue-4/revneuro-2014-0004/revneuro-2014-0004.xml Serotonin regulation of subthalamic neurons (CTX -> STN, abstract)] ||
||  || [BrainRegionFEC_FT_PU_MED FEC.FT.PU.MED] || Dorsal Putamen Medial || excitatory-glu || uncertain || [http://www.sciencedirect.com/science/article/pii/S0893608098000471 Primate Control of Grasping (F6 -> BG, abstract)] ||
|| [BrainAreaNMA NMA] || [BrainRegionNMA_NC_PMC_F4 NMA.NC.PMC.F4] || Ventral Caudal Premotor Cortex || feedforward-glu || uncertain || [http://www.sciencedirect.com/science/article/pii/S0893608098000471 Primate Control of Grasping (F6 -> F4)] ||
||  || [BrainRegionNMA_NC_PMC_F5 NMA.NC.PMC.F5] || Ventral Rostral Premotor Cortex || feedforward-glu || uncertain || [http://www.sciencedirect.com/science/article/pii/S0893608098000471 Primate Control of Grasping (F6 -> F5)] ||

= Thirdparty Circuits =
(generated)

  * [http://www.degruyter.com/view/j/revneuro.2014.25.issue-4/revneuro-2014-0004/graphic/revneuro-2014-0004_fig1.jpg Serotonin regulation of subthalamic neurons] - see [http://www.degruyter.com/view/j/revneuro.2014.25.issue-4/revneuro-2014-0004/revneuro-2014-0004.xml Reference] (CM.SUBTHALAMUS)

 CTX=Anterior Lobe,NC.LOBE.ANT
 GPe=Globus Pallidus External,FEC.FT.GPE (see [BrainCenterFEC_FT_BG Basal Ganglia])
 GPi=Globus Pallidus Internal,FEC.FT.GPI (see [BrainCenterFEC_FT_BG Basal Ganglia])
 PPN=[BrainRegionLMC_HT_TG_PPN Pedunculopontine Tegmental Nuclei,LMC.HT.TG.PPN]
 SNr=Substantia Nigra Pars Reticulata,FEC.FT.SNR (see [BrainCenterFEC_FT_BG Basal Ganglia])
 STN=Subthalamic Nucleus,FEC.FD.STN (see [BrainCenterFEC_FD_STA Subthalamus Area])
<img src="http://www.degruyter.com/view/j/revneuro.2014.25.issue-4/revneuro-2014-0004/graphic/revneuro-2014-0004_fig1.jpg" alt="unavailable" style="max-width: 100%;">

  * [http://ars.els-cdn.com/content/image/1-s2.0-S0893608098000471-gr6.gif Primate Control of Grasping] - see [http://www.sciencedirect.com/science/article/pii/S0893608098000471 Reference] (CM.GRASPING-CONTROL)

 46=Mid-Dorsolateral Prefrontal Cortex,NDM.NC.AL.DLPFC (see [BrainCenterNC_AL_LPFC Lateral Prefrontal Cortex])
 AIP=[BrainRegionNSA_NC_IPS_AIP Anterior Intraparietal Sulcus,NSA.NC.IPS.AIP]
 BG=[BrainCenterFEC_FT_BG Basal Ganglia,FEC.FT.BG]
 BTH=[BrainRegionNMA_FD_TH_VA Ventral Anterior Nucleus,NMA.FD.TH.VA]
 F1=[BrainRegionNMA_NC_MC Motor Cortex,NMA.NC.MC]
 F2=[BrainRegionNMA_NC_PMC_F2 Dorsal Caudal Premotor Cortex,NMA.NC.PMC.F2]
 F4=[BrainRegionNMA_NC_PMC_F4 Ventral Caudal Premotor Cortex,NMA.NC.PMC.F4]
 F5=[BrainRegionNMA_NC_PMC_F5 Ventral Rostral Premotor Cortex,NMA.NC.PMC.F5]
 F6=[BrainRegionNMA_NC_SMC_F6 Pre-Supplementary Motor Area,NMA.NC.SMC.F6]
 IT=[BrainCenterNSA_NC_IT Inferotemporal Area,NSA.NC.IT]
 PIP=Posterior Eye Field,NPE.NC.IPS.PEF (see [BrainCenterNSA_NC_IPS Intraparietal Sulcus])
 S1=[BrainRegionNCP_NC_PG_S1 Primary Somatosensory Cortex,NCP.NC.PG.S1]
 S2=[BrainRegionNCP_NC_PG_S1 Primary Somatosensory Cortex,NCP.NC.PG.S1]
 VC=[BrainCenterNC_LOBE_OCC Occipital Lobe,NC.LOBE.OCC]
 VIP=[BrainRegionNSA_NC_IPS_VIP Ventral Intraparietal Sulcus,NSA.NC.IPS.VIP]
<img src="http://ars.els-cdn.com/content/image/1-s2.0-S0893608098000471-gr6.gif" alt="unavailable" style="max-width: 100%;">


= References =
(generated)

  * http://www.degruyter.com/view/j/revneuro.2014.25.issue-4/revneuro-2014-0004/revneuro-2014-0004.xml
  * http://www.sciencedirect.com/science/article/pii/S0893608098000471