#summary Primary Somatosensory Cortex @@[Home] -> [BiologicalLifeResearch] -> [BrainAreaNCP] -> [BrainRegionNCP_NC_PG_S1] ---- This page covers biological details of component Primary Somatosensory Cortex. Region is part of aHuman target integrated biological model. * *Top-down path to region*: Cerebral Cortex -> Parietal Lobe (NC.LOBE.PAR) -> Postcentral Gyrus (NC.PG) -> [BrainCenterNC_PG_APC Anterior Parietal Cortex] (NC.PG.APC) -> [BrainRegionNCP_NC_PG_S1 Primary Somatosensory Cortex] (NCP.NC.PG.S1) (see [OverallMindMaps Mind Maps]) * *Type*: cortex * *Quality*: L0 * *Brain area*: [BrainAreaNCP Neocortical Brain - Conscious Personality Area] (NCP) * *Area circuit*: Neocortical Somatic Aggregation (SOM) * *Brodmann ID*: 01,02,03 * *Role*: cortex.sensory.primary * *Function*: Muscle and skin receptors (generated) = Components = (generated) * no child items defined = Connectivity = (generated) http://ahuman.org/svn/ahwiki/images/dot/NCP.NC.PG.S1.dot.png *Inbound Region Connections:* || *Source Area* || *Source Region* || *Source Name* || *Type* || *Role* || *Reference* || || [BrainAreaNCP NCP] || [BrainRegionNCP_FD_TH_VPL NCP.FD.TH.VPL] || Ventral Posterolateral Nucleus || excitatory-glu || uncertain ||[http://users.atw.hu/blp6/BLP6/HTML/C0079780323045827.htm Pain matrix (TH.VPL -> S1)] || || || [BrainRegionNCP_FD_TH_VPM NCP.FD.TH.VPM] || Ventral Posteromedial Nucleus || excitatory-glu || uncertain ||[http://users.atw.hu/blp6/BLP6/HTML/C0079780323045827.htm Pain matrix (TH.VPM -> S1)] || *Outbound Region Connections:* || *Target Area* || *Target Region* || *Target Name* || *Type* || *Role* || *Reference* || || [BrainAreaFEC FEC] || [BrainRegionFEC_FT_PU_LT FEC.FT.PU.LT] || Dorsal Putamen Lateral || excitatory-glu || uncertain || [http://thebrain.mcgill.ca/flash/a/a_06/a_06_cr/a_06_cr_mou/a_06_cr_mou.html Basal Ganglia Activity (S1 -> PU, abstract)] || || [BrainAreaLRC LRC] || [BrainRegionLRC_HL_TGS_PA5 LRC.HL.TGS.PA5] || Paratrigeminal Nucleus || excitatory-glu || uncertain || (unknown reference) || || [BrainAreaNCP NCP] || [BrainRegionNCP_NC_PG_PV NCP.NC.PG.PV] || Parietal Ventral Cortex || feedforward-glu || uncertain || (unknown reference) || || || [BrainRegionNCP_NC_PG_S2 NCP.NC.PG.S2] || Secondary Somatosensory Cortex || feedforward-glu || uncertain || [http://www.nature.com/nrn/journal/v14/n7/fig_tab/nrn3516_F2.html Afferent pain pathways (S1 -> S2)] || || || [BrainRegionNCP_NC_SPL_SA NCP.NC.SPL.SA] || Somatosensory Association Cortex || feedforward-glu || uncertain || [http://www.sciencedirect.com/science/article/pii/S1053810011000080 Cortico-Cortical Connectivity (S1 -> SA)] || || [BrainAreaNMA NMA] || [BrainRegionNMA_NC_MC NMA.NC.MC] || Motor Cortex || feedforward-glu || uncertain || [http://www.sciencedirect.com/science/article/pii/S1053810011000080 Cortico-Cortical Connectivity (S1 -> M1)] || || || [BrainRegionNMA_NC_PMC_F2 NMA.NC.PMC.F2] || Dorsal Caudal Premotor Cortex || feedforward-glu || uncertain || [http://www.sciencedirect.com/science/article/pii/S0959438808001566 Global visual system (ParietalCortex -> FrontalCortex, abstract)] || || || [BrainRegionNMA_NC_PMC_F5 NMA.NC.PMC.F5] || Ventral Rostral Premotor Cortex || feedforward-glu || uncertain || [http://www.sciencedirect.com/science/article/pii/S0893608098000471 Primate Control of Grasping (S2 -> F5)] || || [BrainAreaNPE NPE] || [BrainRegionNPE_FD_TH_OPV NPE.FD.TH.OPV] || Oral Pulvinar || excitatory-glu || uncertain || (unknown reference) || || || [BrainRegionNPE_NC_IPL_SMW NPE.NC.IPL.SMW] || Supramarginal Wernike Cortex || feedforward-glu || uncertain || [http://www.sciencedirect.com/science/article/pii/S1053810011000080 Cortico-Cortical Connectivity (S1 -> PTHA, abstract)] || || || [BrainRegionNPE_NC_SPL_PG NPE.NC.SPL.PG] || Caudal Precuneus || feedforward-glu || uncertain || [http://www.nature.com/nrn/journal/v3/n2/fig_tab/nrn726_F3.html McNaughton Spatial Processing Network (SomSensCortex -> PosteriorParietalCortex)] || = Thirdparty Circuits = (generated) * [http://www.nature.com/nrn/journal/v3/n2/images/nrn726-f3.jpg McNaughton Spatial Processing Network] - see [http://www.nature.com/nrn/journal/v3/n2/fig_tab/nrn726_F3.html Reference] (CP.VISUAL-SPATIAL-PROCESSING) EnthCortex=Entorhinal Cortex,FMM.NC.PH.ET (see [BrainCenterNC_PHA_RH Rhinal Cortex]) HF=[BrainCenterFMM_FT_HF Hippocampal Formation,FMM.FT.HF] ITCortex=[BrainCenterNSA_NC_IT Inferotemporal Area,NSA.NC.IT] PCGRSP=[BrainCenterNC_MPL Medial Parietal Lobule,NC.MPL] ParInsVestCortex=[BrainRegionNSA_NC_IPS_VIP Ventral Intraparietal Sulcus,NSA.NC.IPS.VIP] PosteriorParietalCortex=[BrainRegionNPE_NC_SPL_PG Caudal Precuneus,NPE.NC.SPL.PG] SUB=Subiculum,FMM.FT.HF.SUB (see [BrainCenterFMM_FT_HF Hippocampal Formation]) SomSensCortex=[BrainRegionNCP_NC_PG_S1 Primary Somatosensory Cortex,NCP.NC.PG.S1] VisualCortex=[BrainCenterNC_LOBE_OCC Occipital Lobe,NC.LOBE.OCC] unavailable * [http://ars.els-cdn.com/content/image/1-s2.0-S0959438808001566-gr1.jpg Global visual system] - see [http://www.sciencedirect.com/science/article/pii/S0959438808001566 Reference] (CP.GLOBAL-VISUAL-SYSTEM) ATH=Anterior Nucleus of Thalamus,FD.TH.AN (see [BrainCenterFD_TH_CR Cognitive Thalamus]) BGA=[BrainCenterFEC_FT_BG Basal Ganglia,FEC.FT.BG] FrontalCortex=Anterior Lobe,NC.LOBE.ANT LGN=[BrainRegionNSA_FD_LGN Lateral Geniculate Nucleus,NSA.FD.LGN] OPN=[BrainRegionLPC_MM_OCN Oculomotor Nucleus,LPC.MM.OCN] ParietalCortex=Parietal Lobe,NC.LOBE.PAR Pulvinar=Pulvinar,FD.PV (see [BrainCenterFD_TH_SR Sensory Thalamus]) RF=[BrainCenterHT_RF Pontine Reticular Formation,HT.RF] Retina=[BrainRegionLPC_FD_RT Retinal Nucleus,LPC.FD.RT] SCi=Superior Colliculus,MM.SC (see [BrainCenterMM_REF Reflexes Nuclei of Midbrain Mesencephalon]) SCs=Superior Colliculus,MM.SC (see [BrainCenterMM_REF Reflexes Nuclei of Midbrain Mesencephalon]) SNc=[BrainRegionFEC_FT_SNC_LT Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT] SNr=[BrainRegionFEC_FT_SNR_DL Substantia Nigra Pars Reticulata Dorsolateral,FEC.FT.SNR.DL] SpinalCord=Lamina IX,SC.VH.L9 (see [BrainCenterSC_VH Anterior/Ventral Horn]) Striatum=Striatum,FEC.FT.ST (see [BrainCenterFEC_FT_BG Basal Ganglia]) VisualCortex=[BrainCenterNC_LOBE_OCC Occipital Lobe,NC.LOBE.OCC] unavailable * [http://ars.els-cdn.com/content/image/1-s2.0-S0893608098000471-gr6.gif Primate Control of Grasping] - see [http://www.sciencedirect.com/science/article/pii/S0893608098000471 Reference] (CM.GRASPING-CONTROL) 46=Mid-Dorsolateral Prefrontal Cortex,NDM.NC.AL.DLPFC (see [BrainCenterNC_AL_LPFC Lateral Prefrontal Cortex]) AIP=[BrainRegionNSA_NC_IPS_AIP Anterior Intraparietal Sulcus,NSA.NC.IPS.AIP] BG=[BrainCenterFEC_FT_BG Basal Ganglia,FEC.FT.BG] BTH=[BrainRegionNMA_FD_TH_VA Ventral Anterior Nucleus,NMA.FD.TH.VA] F1=[BrainRegionNMA_NC_MC Motor Cortex,NMA.NC.MC] F2=[BrainRegionNMA_NC_PMC_F2 Dorsal Caudal Premotor Cortex,NMA.NC.PMC.F2] F4=[BrainRegionNMA_NC_PMC_F4 Ventral Caudal Premotor Cortex,NMA.NC.PMC.F4] F5=[BrainRegionNMA_NC_PMC_F5 Ventral Rostral Premotor Cortex,NMA.NC.PMC.F5] F6=[BrainRegionNMA_NC_SMC_F6 Pre-Supplementary Motor Area,NMA.NC.SMC.F6] IT=[BrainCenterNSA_NC_IT Inferotemporal Area,NSA.NC.IT] PIP=Posterior Eye Field,NPE.NC.IPS.PEF (see [BrainCenterNSA_NC_IPS Intraparietal Sulcus]) S1=[BrainRegionNCP_NC_PG_S1 Primary Somatosensory Cortex,NCP.NC.PG.S1] S2=[BrainRegionNCP_NC_PG_S1 Primary Somatosensory Cortex,NCP.NC.PG.S1] VC=[BrainCenterNC_LOBE_OCC Occipital Lobe,NC.LOBE.OCC] VIP=[BrainRegionNSA_NC_IPS_VIP Ventral Intraparietal Sulcus,NSA.NC.IPS.VIP] unavailable * [http://thebrain.mcgill.ca/flash/a/a_06/a_06_cr/a_06_cr_mou/a_06_cr_mou_2b.jpg Basal Ganglia Activity] - see [http://thebrain.mcgill.ca/flash/a/a_06/a_06_cr/a_06_cr_mou/a_06_cr_mou.html Reference] (CM.BASAL-GANGLIA-ACTIVITY) GPi=Globus Pallidus Internal,FEC.FT.GPI (see [BrainCenterFEC_FT_BG Basal Ganglia]) GPo=Globus Pallidus External,FEC.FT.GPE (see [BrainCenterFEC_FT_BG Basal Ganglia]) M1=[BrainRegionNMA_NC_MC Motor Cortex,NMA.NC.MC] PMC=[BrainCenterNC_PMC Premotor Cortex,NC.PMC] PU=Dorsal Putamen,FEC.FT.DPU (see [BrainCenterFEC_FT_BG Basal Ganglia]) S1=[BrainRegionNCP_NC_PG_S1 Primary Somatosensory Cortex,NCP.NC.PG.S1] SMC=[BrainCenterNMA_NC_SMC Supplementary Motor Cortex,NMA.NC.SMC] SN=Substantia Nigra,FEC.FT.SN (see [BrainCenterFEC_FT_BG Basal Ganglia]) STN=Subthalamic Nucleus,FEC.FD.STN (see [BrainCenterFEC_FD_STA Subthalamus Area]) VLo=[BrainRegionNMA_FD_TH_VL Ventral Lateral Nucleus,NMA.FD.TH.VL] unavailable * [http://ars.els-cdn.com/content/image/1-s2.0-S1053810011000080-gr3.jpg Cortico-Cortical Connectivity] - see [http://www.sciencedirect.com/science/article/pii/S1053810011000080 Reference] (CL.CORTICO-CORTICAL-CONNECTIVITY) A1=[BrainRegionNSA_NC_TTG_A1 Primary Auditory Cortex,NSA.NC.TTG.A1] AA=[BrainRegionNSA_NC_STG_A3 Wernicke's area A3,NSA.NC.STG.A3] M1=[BrainRegionNMA_NC_MC Motor Cortex,NMA.NC.MC] MA=[BrainCenterNC_PMC Premotor Cortex,NC.PMC] PFC=Prefrontal Cortex,NC.AL.PFC PTHA=[BrainCenterNC_IPL Inferior Parietal Lobule,NC.IPL] S1=[BrainRegionNCP_NC_PG_S1 Primary Somatosensory Cortex,NCP.NC.PG.S1] SA=[BrainRegionNCP_NC_SPL_SA Somatosensory Association Cortex,NCP.NC.SPL.SA] V1=[BrainRegionNSA_NC_OCC_V1 Primary Visual Cortex,NSA.NC.OCC.V1] VA=Secondary Visual Cortex,NSA.NC.OCC.V2 (see [BrainCenterNC_LOBE_OCC Occipital Lobe]) unavailable * [http://www.nature.com/nrn/journal/v14/n7/images/nrn3516-f2.jpg Afferent pain pathways] - see [http://www.nature.com/nrn/journal/v14/n7/fig_tab/nrn3516_F2.html Reference] (CF.PAIN-PATH) ACC=Anterior Cingulate Cortex,NC.AL.ACG (see [BrainCenterNC_ACG Anterior Cingulate Area]) AMY=[BrainCenterFAM_FT_AM Amygdala,FAM.FT.AM] BG=[BrainCenterFEC_FT_BG Basal Ganglia,FEC.FT.BG] Cerebellum=[BrainCenterLLC_HT_CRC Cerebellar Complex,LLC.HT.CRC] Insula=[BrainCenterNC_INS Insular Cortex,NC.INS] PAG=[BrainRegionLMC_MM_PAG Periaqueductal Gray Matter,LMC.MM.PAG] PB=[BrainRegionLPC_HT_PRF_PB Parabrachial Nucleus,LPC.HT.PRF.PB] PFC=Prefrontal Cortex,NC.AL.PFC S1=[BrainRegionNCP_NC_PG_S1 Primary Somatosensory Cortex,NCP.NC.PG.S1] S2=[BrainRegionNCP_NC_PG_S2 Secondary Somatosensory Cortex,NCP.NC.PG.S2] SC=[BrainCenterBMA_SC_PH Posterior/Dorsal Horn,BMA.SC.PH] Thalamus=[BrainCenterFD_TH_SR Sensory Thalamus,FD.TH.SR] unavailable * [http://www.biopsychology.com/6e/step/08/0801-1.jpg Somatic Senses] - see [http://www.biopsychology.com/6e/step0801.html Reference] (CM.SOMATIC-SENSES) S1=[BrainRegionNCP_NC_PG_S1 Primary Somatosensory Cortex,NCP.NC.PG.S1] unavailable * [http://www.scholarpedia.org/w/images/thumb/b/bf/PrimateS1cortexfigure1.jpg/400px-PrimateS1cortexfigure1.jpg Owl Monkey Somatic Area] - see [http://www.scholarpedia.org/article/User:Tony_J._Prescott/Proposed/Primate_S1_cortex Reference] (CM.OWL-MONKEY) S1=[BrainRegionNCP_NC_PG_S1 Primary Somatosensory Cortex,NCP.NC.PG.S1] unavailable * [http://brainmind.com/images/homunculus.jpg Homunculus S1 and M1] - see [http://brainmind.com/BasalGanglia.html Reference] (CM.HOMUNCULUS) S1=[BrainRegionNCP_NC_PG_S1 Primary Somatosensory Cortex,NCP.NC.PG.S1] unavailable * [http://what-when-how.com/wp-content/uploads/2012/04/tmp3649_thumb1_thumb.jpg Thalamocortical relationships] - see [http://what-when-how.com/neuroscience/the-thalamus-and-cerebral-cortex-integrative-systems-part-2/ Reference] (CL.THALAMUS-PROJECTIONS) A=Anterior Nucleus of Thalamus,FD.TH.AN (see [BrainCenterFD_TH_CR Cognitive Thalamus]) CM=[BrainRegionFEC_FD_TH_CM Centromedian Nucleus of Thalamus,FEC.FD.TH.CM] LD=[BrainRegionFMM_FD_TH_LD Lateral Dorsal Nucleus of Thalamus,FMM.FD.TH.LD] LGN=[BrainRegionNSA_FD_LGN Lateral Geniculate Nucleus,NSA.FD.LGN] LP=[BrainRegionNPE_FD_TH_LP Lateral Posterior Nucleus of Thalamus,NPE.FD.TH.LP] MD=Mediodorsal Nucleus of Thalamus,FD.TH.MD (see [BrainCenterFD_TH_CR Cognitive Thalamus]) MGN=[BrainRegionNSA_FD_TH_MGB Medial Geniculate Body,NSA.FD.TH.MGB] P=Ventral Posterior Nuclei,NSA.FD.TH.VP (see [BrainCenterFD_TH_SR Sensory Thalamus]) VA=[BrainRegionNMA_FD_TH_VA Ventral Anterior Nucleus,NMA.FD.TH.VA] VL=[BrainRegionNMA_FD_TH_VL Ventral Lateral Nucleus,NMA.FD.TH.VL] VPL=[BrainRegionNCP_FD_TH_VPL Ventral Posterolateral Nucleus,NCP.FD.TH.VPL] VPM=[BrainRegionNCP_FD_TH_VPM Ventral Posteromedial Nucleus,NCP.FD.TH.VPM] pA=[BrainRegionNCP_NC_MPL_PSCG Posterior Cingulate Cortex,NCP.NC.MPL.PSCG] pCM=Dorsal Putamen,FEC.FT.DPU (see [BrainCenterFEC_FT_BG Basal Ganglia]) pLD=Anterior Cingulate Cortex,NC.AL.ACG (see [BrainCenterNC_ACG Anterior Cingulate Area]) pLGN=[BrainRegionNSA_NC_OCC_V1 Primary Visual Cortex,NSA.NC.OCC.V1] pLP=[BrainCenterNC_SPL Superior Parietal Lobule,NC.SPL] pMD=Prefrontal Cortex,NC.AL.PFC pMGN=[BrainRegionNSA_NC_TTG_A1 Primary Auditory Cortex,NSA.NC.TTG.A1] pP=[BrainCenterNC_INS Insular Cortex,NC.INS] pVA=[BrainCenterNMA_NC_SMC Supplementary Motor Cortex,NMA.NC.SMC] pVL=[BrainRegionNMA_NC_MC Motor Cortex,NMA.NC.MC] pVPL=[BrainRegionNCP_NC_PG_S1 Primary Somatosensory Cortex,NCP.NC.PG.S1] pVPM=[BrainRegionNCP_NC_PO_PCC Precentral Cortex,NCP.NC.PO.PCC] s1A=Subiculum,FMM.FT.HF.SUB (see [BrainCenterFMM_FT_HF Hippocampal Formation]) s1MD=[BrainCenterFAM_FT_SEP Septal Nuclei,FAM.FT.SEP] s1P=[BrainRegionLPC_SC_IZ_CCV Central Cervical Nucleus,LPC.SC.IZ.CCV] s1VL=[BrainRegionLLC_HT_CR_DN Dentate Nucleus,LLC.HT.CR.DN] s2A=Mammillary Body,FD.MB (see [BrainCenterFD_HT Hypothalamus]) s2MD=[BrainRegionNSA_NC_PH_PIR Piriform Cortex,NSA.NC.PH.PIR] s2P=[BrainRegionLPC_HT_PN_PTR Principal Trigeminal Nucleus,LPC.HT.PN.PTR] s2VL=[BrainCenterFEC_FT_BG Basal Ganglia,FEC.FT.BG] s3MD=Prefrontal Cortex,NC.AL.PFC sCM=Globus Pallidus Internal,FEC.FT.GPI (see [BrainCenterFEC_FT_BG Basal Ganglia]) sLD=[BrainCenterNC_SPL Superior Parietal Lobule,NC.SPL] sLP=Superior Colliculus,MM.SC (see [BrainCenterMM_REF Reflexes Nuclei of Midbrain Mesencephalon]) sVA=[BrainCenterFEC_FT_BG Basal Ganglia,FEC.FT.BG] sVPL=Marginal Nucleus,LPC.SC.PH.MG (see [BrainCenterBMA_SC_PH Posterior/Dorsal Horn]) sVPM=[BrainRegionLPC_HL_SOL Solitary Nucleus,LPC.HL.SOL] unavailable * [http://users.atw.hu/blp6/BLP6/HTML/common/M9780323045827-007-f005.jpg Pain matrix] - see [http://users.atw.hu/blp6/BLP6/HTML/C0079780323045827.htm Reference] (CF.SOMATOSENSORY-THALAMUS) INS=[BrainRegionNCP_NC_INS_PIC Posterior Insular Cortex,NCP.NC.INS.PIC] S1=[BrainRegionNCP_NC_PG_S1 Primary Somatosensory Cortex,NCP.NC.PG.S1] TH.VPI=[BrainRegionNCP_FD_TH_VPI Ventral Posteroinferior Nucleus,NCP.FD.TH.VPI] TH.VPL=[BrainRegionNCP_FD_TH_VPL Ventral Posterolateral Nucleus,NCP.FD.TH.VPL] TH.VPM=[BrainRegionNCP_FD_TH_VPM Ventral Posteromedial Nucleus,NCP.FD.TH.VPM] unavailable * [http://www.springerimages.com/img/Images/Springer/JOU=10194/VOL=2006.7/ISU=4/ART=2006_307/MediaObjects/MEDIUM_10194_2006_Article_307_Fig1.jpg Pain matrix] - see [http://www.springerimages.com/Images/MedicineAndPublicHealth/1-10.1007_s10194-006-0307-1-0 Reference] (CF.PAIN-MATRIX) ACC=Anterior Cingulate Cortex,NC.AL.ACG (see [BrainCenterNC_ACG Anterior Cingulate Area]) AM=[BrainCenterFAM_FT_AM Amygdala,FAM.FT.AM] INS=[BrainCenterNC_INS Insular Cortex,NC.INS] PAG=[BrainRegionLMC_MM_PAG Periaqueductal Gray Matter,LMC.MM.PAG] PFC=Orbitofrontal Cortex,NC.AL.OPFC (see [BrainCenterNC_AL_OMPFC Orbitomedial Prefrontal Cortex]) PPC=[BrainCenterNC_SPL Superior Parietal Lobule,NC.SPL] S1=[BrainRegionNCP_NC_PG_S1 Primary Somatosensory Cortex,NCP.NC.PG.S1] SMA=[BrainCenterNMA_NC_SMC Supplementary Motor Cortex,NMA.NC.SMC] TH=Thalamus,FD.TH unavailable = References = (generated) * http://www.nature.com/nrn/journal/v3/n2/fig_tab/nrn726_F3.html * http://www.sciencedirect.com/science/article/pii/S0959438808001566 * http://www.sciencedirect.com/science/article/pii/S0893608098000471 * http://thebrain.mcgill.ca/flash/a/a_06/a_06_cr/a_06_cr_mou/a_06_cr_mou.html * http://www.sciencedirect.com/science/article/pii/S1053810011000080 * http://www.nature.com/nrn/journal/v14/n7/fig_tab/nrn3516_F2.html * http://www.biopsychology.com/6e/step0801.html * http://www.scholarpedia.org/article/User:Tony_J._Prescott/Proposed/Primate_S1_cortex * http://brainmind.com/BasalGanglia.html * http://what-when-how.com/neuroscience/the-thalamus-and-cerebral-cortex-integrative-systems-part-2/ * http://users.atw.hu/blp6/BLP6/HTML/C0079780323045827.htm * http://www.springerimages.com/Images/MedicineAndPublicHealth/1-10.1007_s10194-006-0307-1-0