#summary Ventral Tegmental Area @@[Home] -> [BiologicalLifeResearch] -> [BrainAreaLMC] -> [BrainRegionLMC_MM_VTA] ---- This page covers biological details of component Ventral Tegmental Area. Region is part of aHuman target integrated biological model. * *Top-down path to region*: Midbrain Mesencephalon -> [BrainRegionLMC_MM_VTA Ventral Tegmental Area] (LMC.MM.VTA) (see [OverallMindMaps Mind Maps]) * *Type*: nucleus * *Quality*: L0 * *Brain area*: [BrainAreaLMC Lower Brain - Modulatory Contol Area] (LMC) * *Area circuit*: Dopamine - Reward-Motivated Behavior, Cognitive Alertness (DA) * *Role*: processor.autonomic * *Function*: Respond to novel stimuli, unexpected rewards, and reward predictive sensory cues (generated) = Components = (generated) *Component items*: * *Ventral Tegmental Nucleus* (*LMC.MM.VTG*): moderates hippocampal-driven rhythmic firing frequency in medial mammillary * *Parabrachial Pigmented Area* * *Paranigral Nucleus* * *Parafasciculus Retroflexus Area* = Connectivity = (generated) http://ahuman.org/svn/ahwiki/images/dot/LMC.MM.VTA.dot.png *Inbound Region Connections:* || *Source Area* || *Source Region* || *Source Name* || *Type* || *Role* || *Reference* || || [BrainAreaFAM FAM] || [BrainRegionFAM_FD_LHB_MED FAM.FD.LHB.MED] || Lateral Habenula Medial Part || excitatory-glu || uncertain ||[http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> VTA)] || || || [BrainRegionFAM_FT_BNST FAM.FT.BNST] || Bed Nucleus of Stria Terminalis || excitatory-glu || uncertain ||(unknown reference) || || [BrainAreaFEC FEC] || [BrainRegionFEC_FT_ACC_CORE FEC.FT.ACC.CORE] || Nucleus Accumbens Core || inhibitory-gaba || uncertain ||[http://neurowiki2012.wikispaces.com/Presynaptic+Mechanisms+of+Synaptic+Plasticity Reward circuit of human brain (NACC -> VTA, abstract)] || || || [BrainRegionFEC_FT_VP_VM FEC.FT.VP.VM] || Ventral Pallidum Ventromedial || inhibitory-gaba || uncertain ||[http://www.impulsecontroldisorders.org/html/cravings.html Craving (VPAL -> VTA, abstract)] || || || [BrainRegionFEC_HT_TG_IPD FEC.HT.TG.IPD] || Interpeduncular Nucleus || modulatory-ach || uncertain ||[http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (IPN -> VTA)] || || || [BrainRegionFEC_HT_TG_RMTG FEC.HT.TG.RMTG] || Rostromedial Tegmental Nucleus || inhibitory-gaba || uncertain ||[http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin Amygdala and its network (RMTG -> VTA)] || || [BrainAreaLPC LPC] || [BrainRegionLPC_HL_SOL LPC.HL.SOL] || Solitary Nucleus || excitatory-glu || uncertain ||[http://www.nature.com/nrendo/journal/v6/n8/fig_tab/nrendo.2010.93_F1.html Bowels control brain: gut hormones and obesity (NTS -> VTA)] || *Outbound Region Connections:* || *Target Area* || *Target Region* || *Target Name* || *Type* || *Role* || *Reference* || || [BrainAreaFAM FAM] || [BrainRegionFAM_FT_AM_CEC FAM.FT.AM.CEC] || Central Amygdaloid Nucleus, capsular subdivision || modulatory-da || uncertain || [http://neurowiki2012.wikispaces.com/Presynaptic+Mechanisms+of+Synaptic+Plasticity Reward circuit of human brain (VTA -> AM, abstract)] || || [BrainAreaFEC FEC] || [BrainRegionFEC_FT_ACC_SH FEC.FT.ACC.SH] || Nucleus Accumbens Shell || modulatory-da || uncertain || [http://www.impulsecontroldisorders.org/html/cravings.html Craving (VTA -> NACC, abstract)] || || || [BrainRegionFEC_FT_PU_LT FEC.FT.PU.LT] || Dorsal Putamen Lateral || modulatory-da || uncertain || [http://www.nature.com/nrendo/journal/v6/n8/fig_tab/nrendo.2010.93_F1.html Bowels control brain: gut hormones and obesity (VTA -> DS, abstract)] || || || [BrainRegionFEC_FT_PU_MED FEC.FT.PU.MED] || Dorsal Putamen Medial || modulatory-da || uncertain || [http://www.nature.com/nrendo/journal/v6/n8/fig_tab/nrendo.2010.93_F1.html Bowels control brain: gut hormones and obesity (VTA -> DS, abstract)] || || [BrainAreaFMM FMM] || [BrainRegionFMM_FD_MB_MMB FMM.FD.MB.MMB] || Medial Mammillary Nucleus || modulatory-da || uncertain || [http://www.nature.com/nrn/journal/v5/n1/fig_tab/nrn1299_F2.html Mammillary bodies: two memory systems in one (VTN -> MMB)] || || || [BrainRegionFMM_FT_HC_CA1D FMM.FT.HC.CA1D] || Distal CA1 of Hippocampus || modulatory-da || uncertain || [http://neurowiki2012.wikispaces.com/Presynaptic+Mechanisms+of+Synaptic+Plasticity Reward circuit of human brain (VTA -> HC, abstract)] || || || [BrainRegionFMM_NC_PH_LEC FMM.NC.PH.LEC] || Lateral Entorhinal Cortex || modulatory-da || uncertain || [http://www.impulsecontroldisorders.org/html/cravings.html Combining Novelty, Motivational Salience, and Reward to Control Attention and Learning (VTA -> EC, abstract)] || || [BrainAreaLAC LAC] || [BrainRegionLAC_FD_HT_PRM LAC.FD.HT.PRM] || Premammillary Nucleus || modulatory-da || uncertain || (unknown reference) || || || [BrainRegionLAC_FD_HT_PV LAC.FD.HT.PV] || Paraventricular Nucleus || modulatory-da || uncertain || [http://www.intechopen.com/books/computational-intelligence-in-electromyography-analysis-a-perspective-on-current-applications-and-future-challenges/sphincter-emg-for-diagnosing-multiple-system-atrophy-and-related-disorders Physiology and pathophysiology of lower urinary tract (VTA -> PVN)] || || [BrainAreaNDM NDM] || [BrainRegionNDM_NC_AL_DACG NDM.NC.AL.DACG] || Dorsal Anterior Cingulate Area || modulatory-da || uncertain || (unknown reference) || || || [BrainRegionNDM_NC_AL_FPC NDM.NC.AL.FPC] || Lateral Frontopolar Cortex || modulatory-da || uncertain || [http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin Amygdala and its network (VTA -> MPFC, abstract)] || = Thirdparty Circuits = (generated) * [http://brmlab.cz/lib/exe/fetch.php?hash=fca48f&media=http%3A%2F%2Fars.els-cdn.com%2Fcontent%2Fimage%2F1-s2.0-S1364661308002490-gr2.jpg Regulation of Social Brain] - see [http://brmlab.cz/project/brain_hacking/tdcs/pfc Reference] (CT.SOCIAL-BRAIN) AMG=[BrainCenterFAM_FT_AM Amygdala,FAM.FT.AM] Caud=Caudate Nucleus,FEC.FT.CN (see [BrainCenterFEC_FT_BG Basal Ganglia]) DACC=[BrainRegionNDM_NC_AL_DACG Dorsal Anterior Cingulate Area,NDM.NC.AL.DACG] DLPFC=Mid-Dorsolateral Prefrontal Cortex,NDM.NC.AL.DLPFC (see [BrainCenterNC_AL_LPFC Lateral Prefrontal Cortex]) Hipp=Hippocampus,FMM.FT.HC (see [BrainCenterFMM_FT_HF Hippocampal Formation]) IFG=[BrainRegionNDM_NC_AL_IPG Inferior Prefrontal Gyrus,NDM.NC.AL.IPG] LSN=[BrainRegionLAC_SC_LH_LSN Lateral Spinal Nucleus,LAC.SC.LH.LSN] MPFC=Orbitofrontal Cortex,NC.AL.OPFC (see [BrainCenterNC_AL_OMPFC Orbitomedial Prefrontal Cortex]) NACC=Accumbens Nucleus,FEC.FT.ACC (see [BrainCenterFEC_FT_BG Basal Ganglia]) OFC=Orbitofrontal Cortex,NC.AL.OPFC (see [BrainCenterNC_AL_OMPFC Orbitomedial Prefrontal Cortex]) PhippG=Entorhinal Cortex,FMM.NC.PH.ET (see [BrainCenterNC_PHA_RH Rhinal Cortex]) Put=Dorsal Putamen,FEC.FT.DPU (see [BrainCenterFEC_FT_BG Basal Ganglia]) SGC=[BrainRegionNCP_NC_AL_SGCG Subgenual Cingulate Cortex,NCP.NC.AL.SGCG] SN=Substantia Nigra,FEC.FT.SN (see [BrainCenterFEC_FT_BG Basal Ganglia]) VACC=[BrainRegionNDM_NC_AL_VACG Ventral Anterior Cingulate Area,NDM.NC.AL.VACG] VTA=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA] VentPal=Ventral Pallidum,FEC.FT.VP (see [BrainCenterFEC_FT_BG Basal Ganglia]) unavailable * [http://www.nature.com/nrn/journal/v5/n1/images/nrn1299-f2.jpg Mammillary bodies: two memory systems in one] - see [http://www.nature.com/nrn/journal/v5/n1/fig_tab/nrn1299_F2.html Reference] (CT.MB-MEMORY) ADTH=[BrainRegionFMM_FD_TH_AD Anterodorsal Nucleus,FMM.FD.TH.AD] AMTH=[BrainRegionNCP_FD_TH_AM Anteromedial Nucleus,NCP.FD.TH.AM] AVTH=[BrainRegionFMM_FD_TH_AV Anteroventral Nucleus,FMM.FD.TH.AV] DTN=[BrainRegionLMC_HT_TG_LDT Laterodorsal Tegmental Nucleus,LMC.HT.TG.LDT] LMB=[BrainRegionFMM_FD_MB_LMB Lateral Mammillary Nucleus,FMM.FD.MB.LMB] MMB=[BrainRegionFMM_FD_MB_MMB Medial Mammillary Nucleus,FMM.FD.MB.MMB] MedialEC=Entorhinal Cortex,FMM.NC.PH.ET (see [BrainCenterNC_PHA_RH Rhinal Cortex]) PAS=[BrainRegionFMM_NC_PH_PAS Parasubiculum,FMM.NC.PH.PAS] POS=[BrainRegionFMM_NC_PH_POS Postsubiculum,FMM.NC.PH.POS] PRS=[BrainRegionFMM_NC_PH_PRS Presubiculum,FMM.NC.PH.PRS] SEP=[BrainCenterFAM_FT_SEP Septal Nuclei,FAM.FT.SEP] SUB=Subiculum,FMM.FT.HF.SUB (see [BrainCenterFMM_FT_HF Hippocampal Formation]) SupraMM=[BrainRegionLAC_FD_HT_SUM Supramammillary Nucleus,LAC.FD.HT.SUM] TuberoMM=Lateral Tuberal Nuclei,LAC.FD.HT.LTUB (see [BrainCenterFD_HT Hypothalamus]) VTN=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA] unavailable * [http://www.impulsecontroldisorders.org/images/6-HippocampalVTA.jpg Combining Novelty, Motivational Salience, and Reward to Control Attention and Learning] - see [http://www.impulsecontroldisorders.org/html/cravings.html Reference] (CT.LONG-TERM-MEMORY-VTA) ACC=Accumbens Nucleus,FEC.FT.ACC (see [BrainCenterFEC_FT_BG Basal Ganglia]) CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (see [BrainCenterFMM_FT_HF Hippocampal Formation]) CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (see [BrainCenterFMM_FT_HF Hippocampal Formation]) DG=[BrainRegionFMM_FT_HC_DG Dentate Gyrus,FMM.FT.HC.DG] EC=Entorhinal Cortex,FMM.NC.PH.ET (see [BrainCenterNC_PHA_RH Rhinal Cortex]) PFC=Orbitofrontal Cortex,NC.AL.OPFC (see [BrainCenterNC_AL_OMPFC Orbitomedial Prefrontal Cortex]) PPTG=[BrainRegionLMC_HT_TG_PPN Pedunculopontine Tegmental Nuclei,LMC.HT.TG.PPN] SUB=Subiculum,FMM.FT.HF.SUB (see [BrainCenterFMM_FT_HF Hippocampal Formation]) VPAL=Ventral Pallidum,FEC.FT.VP (see [BrainCenterFEC_FT_BG Basal Ganglia]) VTA=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA] unavailable * [http://www.nature.com/nrendo/journal/v6/n8/images/nrendo.2010.93-f1.jpg Bowels control brain: gut hormones and obesity] - see [http://www.nature.com/nrendo/journal/v6/n8/fig_tab/nrendo.2010.93_F1.html Reference] (CP.BOWELS) AMY=[BrainCenterFAM_FT_AM Amygdala,FAM.FT.AM] ARC=[BrainRegionLAC_FD_HT_AR Arcuate Nucleus of Hypothalamus,LAC.FD.HT.AR] DS=Dorsal Striatum,FEC.FT.DST (see [BrainCenterFEC_FT_BG Basal Ganglia]) LHA=[BrainRegionLAC_FD_HT_LTN Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN] ME=[BrainRegionTARGET_TEA_ENDOCRINE Endocrine Glands,TARGET.TEA.ENDOCRINE] NAc=Accumbens Nucleus,FEC.FT.ACC (see [BrainCenterFEC_FT_BG Basal Ganglia]) NTS=[BrainRegionLPC_HL_SOL Solitary Nucleus,LPC.HL.SOL] OFC=Orbitofrontal Cortex,NC.AL.OPFC (see [BrainCenterNC_AL_OMPFC Orbitomedial Prefrontal Cortex]) PBN=[BrainRegionLPC_HT_PRF_PB Parabrachial Nucleus,LPC.HT.PRF.PB] PVN=[BrainRegionLAC_FD_HT_PV Paraventricular Nucleus,LAC.FD.HT.PV] VMN=[BrainRegionLAC_FD_HT_VM Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM] VTA=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA] unavailable * [http://www.intechopen.com/source/html/40109/media/image1.jpeg Physiology and pathophysiology of lower urinary tract] - see [http://www.intechopen.com/books/computational-intelligence-in-electromyography-analysis-a-perspective-on-current-applications-and-future-challenges/sphincter-emg-for-diagnosing-multiple-system-atrophy-and-related-disorders Reference] (CM.ONUF) CN=Caudate Nucleus,FEC.FT.CN (see [BrainCenterFEC_FT_BG Basal Ganglia]) DVM=[BrainRegionLAC_HL_VGN Vagus Nucleus,LAC.HL.VGN] IMG=[BrainRegionLAC_PN_SYM_IMG Inferior Mesenteric Ganglion,LAC.PN.SYM.IMG] IML=[BrainRegionLAC_SC_IZ_IML Intermediolateral Nucleus,LAC.SC.IZ.IML] LC=[BrainRegionLMC_HT_LC Locus Coeruleus,LMC.HT.LC] MPFC=Orbitofrontal Cortex,NC.AL.OPFC (see [BrainCenterNC_AL_OMPFC Orbitomedial Prefrontal Cortex]) MPOA=[BrainRegionLAC_FD_HT_MPO Median Preoptic Nucleus,LAC.FD.HT.MPO] NBM=[BrainRegionLMC_FT_NBM Basal Nucleus of Meynert,LMC.FT.NBM] ONF=[BrainRegionLPC_SC_VH_ONF Onuf's Nucleus,LPC.SC.VH.ONF] PBN=[BrainRegionLPC_HT_PRF_PB Parabrachial Nucleus,LPC.HT.PRF.PB] PEL=[BrainRegionLAC_PN_PSYM_PPG Pelvic Peripheral Ganglion,LAC.PN.PSYM.PPG] PU=[BrainRegionFEC_FT_PU_LT Dorsal Putamen Lateral,FEC.FT.PU.LT] PVN=[BrainRegionLAC_FD_HT_PV Paraventricular Nucleus,LAC.FD.HT.PV] SNC=[BrainRegionFEC_FT_SNC_LT Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT] SPS=[BrainRegionLAC_SC_IZ_SPS Sacral Parasympathetic Nucleus,LAC.SC.IZ.SPS] VTA=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA] ZI=[BrainRegionFEC_FD_STN_CD Subthalamic Nucleus Caudal,BGA.FD.STN.ZI] unavailable * [http://neurowiki2012.wikispaces.com/file/view/Reward_circuit.jpg/315908202/Reward_circuit.jpg Reward circuit of human brain] - see [http://neurowiki2012.wikispaces.com/Presynaptic+Mechanisms+of+Synaptic+Plasticity Reference] (CF.REWARD-CIRCUIT) AM=[BrainCenterFAM_FT_AM Amygdala,FAM.FT.AM] HC=Hippocampus,FMM.FT.HC (see [BrainCenterFMM_FT_HF Hippocampal Formation]) NACC=Accumbens Nucleus,FEC.FT.ACC (see [BrainCenterFEC_FT_BG Basal Ganglia]) PFC=Orbitofrontal Cortex,NC.AL.OPFC (see [BrainCenterNC_AL_OMPFC Orbitomedial Prefrontal Cortex]) VPAL=Ventral Pallidum,FEC.FT.VP (see [BrainCenterFEC_FT_BG Basal Ganglia]) VTA=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA] unavailable * [http://www.impulsecontroldisorders.org/images/8-Urges9proof.jpg Craving] - see [http://www.impulsecontroldisorders.org/html/cravings.html Reference] (CF.CRAVING) NACC=Accumbens Nucleus,FEC.FT.ACC (see [BrainCenterFEC_FT_BG Basal Ganglia]) OMPFC=Orbitofrontal Cortex,NC.AL.OPFC (see [BrainCenterNC_AL_OMPFC Orbitomedial Prefrontal Cortex]) SNr=[BrainRegionFEC_FT_SNR_MED Substantia Nigra Pars Reticulata Medial,FEC.FT.SNR.MED] VPAL=Ventral Pallidum,FEC.FT.VP (see [BrainCenterFEC_FT_BG Basal Ganglia]) VTA=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA] unavailable * [http://sni.wpengine.com/wp-content/uploads/2015/05/3520/SNI-3-40-g001.png Amygdala and its network] - see [http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin Reference] (CF.AM-NET) BLN=[BrainRegionFAM_FT_AM_BP Parvicellular Basal Amygdaloid Nucleus,FAM.FT.AM.BP] CEA=Central Amygdala,FAM.FT.AM.CEA (see [BrainCenterFAM_FT_AM Amygdala]) EC=Entorhinal Cortex,FMM.NC.PH.ET (see [BrainCenterNC_PHA_RH Rhinal Cortex]) HC=Hippocampus,FMM.FT.HC (see [BrainCenterFMM_FT_HF Hippocampal Formation]) HTS=[BrainRegionLAC_FD_HT_LTN Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN] ITC=[BrainRegionNSA_NC_IT_TE Inferotemporal Cortex,NSA.NC.IT.TE] LA=Lateral Amygdaloid Nucleus,FAM.FT.AM.LA (see [BrainCenterFAM_FT_AM Amygdala]) LHB=Lateral Habenula,FAM.FD.LHB (see [BrainCenterFAM_FD_HB Habenula]) MD=Mediodorsal Nucleus of Thalamus,FD.TH.MD (see [BrainCenterFD_TH_CR Cognitive Thalamus]) MPFC=[BrainCenterNC_AL_OMPFC Orbitomedial Prefrontal Cortex,NC.AL.OMPFC] NACC=Accumbens Nucleus,FEC.FT.ACC (see [BrainCenterFEC_FT_BG Basal Ganglia]) PAG=[BrainRegionLMC_MM_PAG Periaqueductal Gray Matter,LMC.MM.PAG] RMTG=[BrainRegionFEC_HT_TG_RMTG Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG] STC=[BrainRegionNSA_NC_STG_A3 Wernicke's area A3,NSA.NC.STG.A3] VGDM=[BrainRegionLAC_HL_VGN Vagus Nucleus,LAC.HL.VGN] VTA=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA] unavailable * [http://www.nature.com/nrn/journal/v5/n1/images/nrn1299-f4.jpg Medial mammillary nucleus and theta rhythm] - see [http://www.nature.com/nrn/journal/v5/n1/fig_tab/nrn1299_F4.html Reference] (CT.MMB-THETA) AVTH=[BrainRegionFMM_FD_TH_AV Anteroventral Nucleus,FMM.FD.TH.AV] HF=[BrainCenterFMM_FT_HF Hippocampal Formation,FMM.FT.HF] MMB=[BrainRegionFMM_FD_MB_MMB Medial Mammillary Nucleus,FMM.FD.MB.MMB] RSP=[BrainRegionNCP_NC_MPL_RSC Retrosplenial Cortex,NCP.NC.MPL.RSC] SEP=[BrainCenterFAM_FT_SEP Septal Nuclei,FAM.FT.SEP] SupraMM=[BrainRegionLAC_FD_HT_SUM Supramammillary Nucleus,LAC.FD.HT.SUM] VTN=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA] unavailable * [http://img.springerimages.com/Images/Springer/PUB=Springer-Verlag-Berlin-Heidelberg/JOU=00359/VOL=2005.191/ISU=3/ART=2004_565/MediaObjects/WATER_s00359-004-0565-9fhc1.jpg Oculomotor decision-making] - see [http://www.springerimages.com/Images/LifeSciences/1-10.1007_s00359-004-0565-9-0 Reference] (CP.OCULOMOTOR-DECISION-MAKING) AMYG=[BrainCenterFAM_FT_AM Amygdala,FAM.FT.AM] CGa=Anterior Cingulate Cortex,NC.AL.ACG (see [BrainCenterNC_ACG Anterior Cingulate Area]) CGp=[BrainRegionNCP_NC_MPL_PSCG Posterior Cingulate Cortex,NCP.NC.MPL.PSCG] Caudate=Caudate Nucleus,FEC.FT.CN (see [BrainCenterFEC_FT_BG Basal Ganglia]) FEF=Frontal Eye Field,NMA.NC.PMC.FEF (see [BrainCenterNC_PMC Premotor Cortex]) LIP=[BrainRegionNPE_NC_IPS_LIP Lateral Intraparietal Sulcus,NPE.NC.IPS.LIP] NAC=Accumbens Nucleus,FEC.FT.ACC (see [BrainCenterFEC_FT_BG Basal Ganglia]) OFC=Orbitofrontal Cortex,NC.AL.OPFC (see [BrainCenterNC_AL_OMPFC Orbitomedial Prefrontal Cortex]) PFC=Mid-Dorsolateral Prefrontal Cortex,NDM.NC.AL.DLPFC (see [BrainCenterNC_AL_LPFC Lateral Prefrontal Cortex]) SC=Superior Colliculus,MM.SC (see [BrainCenterMM_REF Reflexes Nuclei of Midbrain Mesencephalon]) SEF=[BrainRegionNPE_NC_SMC_SEF Supplementary Eye Field,NPE.NC.SMC.SEF] SNc=[BrainRegionFEC_FT_SNC_LT Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT] SNr=[BrainRegionFEC_FT_SNR_DL Substantia Nigra Pars Reticulata Dorsolateral,FEC.FT.SNR.DL] Thalamus=Thalamus,FD.TH VTA=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA] unavailable * [http://www.frontiersin.org/files/Articles/70852/fnhum-07-00826-HTML/image_m/fnhum-07-00826-g002.jpg Regulation of the rapid eye movement (REM) sleep by habenular projection] - see [http://journal.frontiersin.org/article/10.3389/fnhum.2013.00826/full Reference] (CF.REM-HB) DBB=[BrainRegionFAM_FT_SEP_DBB Diagonal Band of Broca,FAM.FT.SEP.DBB] DTG=[BrainRegionLMC_HT_TG_LDT Laterodorsal Tegmental Nucleus,LMC.HT.TG.DTG] EPN=[BrainRegionFAM_FT_EPF Endopiriform Nucleus,FAM.FT.EPF] GPi=Globus Pallidus Internal,FEC.FT.GPI (see [BrainCenterFEC_FT_BG Basal Ganglia]) LHT=[BrainRegionLAC_FD_HT_LTN Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN] LHbL=[BrainRegionFAM_FD_LHB_LT Lateral Habenula Lateral Part,FAM.FD.LHB.LT] LHbM=[BrainRegionFAM_FD_LHB_MED Lateral Habenula Medial Part,FAM.FD.LHB.MED] NI=[BrainRegionFAM_HT_TG_NI Incertus Nucleus,FAM.HT.TG.NI] RMTg=[BrainRegionFEC_HT_TG_RMTG Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG] Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (see [BrainCenterHL_RF Medullary Reticular Formation]) SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see [BrainCenterFEC_FT_BG Basal Ganglia]) VTA=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA] VTG=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTG] unavailable * [http://www.nature.com/neuro/journal/v17/n9/images/nn.3779-F2.jpg Both LHb and MHb control the dopaminergic and serotonergic systems] - see [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Reference] (CF.HB-DA5HT) DBB=[BrainRegionFAM_FT_SEP_DBB Diagonal Band of Broca,FAM.FT.SEP.DBB] DRN=[BrainRegionLMC_MM_RP_DRN Dorsal Raphe Nucleus,LMC.MM.RP.DRN] GPb=Dorsal Pallidum,FEC.FT.DP (see [BrainCenterFEC_FT_BG Basal Ganglia]) IPN=[BrainRegionFEC_HT_TG_IPD Interpeduncular Nucleus,FEC.HT.TG.IPD] LHA=[BrainRegionLAC_FD_HT_LTN Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN] LHbL=[BrainRegionFAM_FD_LHB_LT Lateral Habenula Lateral Part,FAM.FD.LHB.LT] LHbM=[BrainRegionFAM_FD_LHB_MED Lateral Habenula Medial Part,FAM.FD.LHB.MED] LPO=[BrainRegionLAC_FD_HT_VLPO Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO] LS=[BrainRegionFAM_FT_SEP_LT Lateral Septal Nucleus,FAM.FT.SEP.LT] MHb=[BrainRegionFAM_FD_MHB Medial Habenula,FAM.FD.MHB] MRN=Raphe Nuclei of Medulla,LMC.HL.RP (see [BrainCenterHL_RF Medullary Reticular Formation]) MS=[BrainRegionFAM_FT_SEP_MED Medial Septal Nucleus,FAM.FT.SEP.MED] PS=Posterior Septal Group,FAM.FT.SEP.PG (see [BrainCenterFAM_FT_SEP Septal Nuclei]) RMTg=[BrainRegionFEC_HT_TG_RMTG Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG] SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see [BrainCenterFEC_FT_BG Basal Ganglia]) VP=Ventral Pallidum,FEC.FT.VP (see [BrainCenterFEC_FT_BG Basal Ganglia]) VTA=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA] unavailable * [http://www.scholarpedia.org/w/images/thumb/2/2d/Hb-connections-small.jpg/800px-Hb-connections-small.jpg Habenula Connections] - see [http://www.scholarpedia.org/article/Habenula Reference] (CF.HB-CONNECTIONS) CPu=Striatum,FEC.FT.ST (see [BrainCenterFEC_FT_BG Basal Ganglia]) DBB=[BrainRegionFAM_FT_SEP_DBB Diagonal Band of Broca,FAM.FT.SEP.DBB] DR=[BrainRegionLMC_MM_RP_DRN Dorsal Raphe Nucleus,LMC.MM.RP.DRN] GPi=Globus Pallidus Internal,FEC.FT.GPI (see [BrainCenterFEC_FT_BG Basal Ganglia]) IP=[BrainRegionFEC_HT_TG_IPD Interpeduncular Nucleus,FEC.HT.TG.IPD] LH=Lateral Hypothalamic Area,LAC.FD.HT.LT (see [BrainCenterFD_HT Hypothalamus]) LHb=Lateral Habenula,FAM.FD.LHB (see [BrainCenterFAM_FD_HB Habenula]) LPO=[BrainRegionLAC_FD_HT_VLPO Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO] MHb=[BrainRegionFAM_FD_MHB Medial Habenula,FAM.FD.MHB] MR=[BrainRegionLMC_MM_RP_SUC Superior Central Raphe Nucleus,LMC.MM.RP.SUC] PB=[BrainRegionTARGET_TEA_ENDOCRINE Endocrine Glands,TARGET.TEA.ENDOCRINE] S=[BrainCenterFAM_FT_SEP Septal Nuclei,FAM.FT.SEP] SNc=[BrainRegionFEC_FT_SNC_LT Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT] VTA=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA] unavailable * [http://d2avczb82rh8fa.cloudfront.net/content/jn/107/10/2633/F1.large.jpg Connectivity map of the habenula] - see [http://jn.physiology.org/content/107/10/2633 Reference] (CF.HB-CONN) CPu=Striatum,FEC.FT.ST (see [BrainCenterFEC_FT_BG Basal Ganglia]) EP=[BrainRegionFAM_FT_EPF Endopiriform Nucleus,FAM.FT.EPF] Hippo=Hippocampus,FMM.FT.HC (see [BrainCenterFMM_FT_HF Hippocampal Formation]) IPN=[BrainRegionFEC_HT_TG_IPD Interpeduncular Nucleus,FEC.HT.TG.IPD] L=Lateral Habenula,FAM.FD.LHB (see [BrainCenterFAM_FD_HB Habenula]) LH=[BrainRegionLAC_FD_HT_LTN Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN] M=[BrainRegionFAM_FD_MHB Medial Habenula,FAM.FD.MHB] NAc=Accumbens Nucleus,FEC.FT.ACC (see [BrainCenterFEC_FT_BG Basal Ganglia]) PAG=[BrainRegionLMC_MM_PAG Periaqueductal Gray Matter,LMC.MM.PAG] Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (see [BrainCenterHL_RF Medullary Reticular Formation]) SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see [BrainCenterFEC_FT_BG Basal Ganglia]) Septum=[BrainCenterFAM_FT_SEP Septal Nuclei,FAM.FT.SEP] VTA=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA] unavailable = References = (generated) * http://brmlab.cz/project/brain_hacking/tdcs/pfc * http://www.nature.com/nrn/journal/v5/n1/fig_tab/nrn1299_F2.html * http://www.impulsecontroldisorders.org/html/cravings.html * http://www.nature.com/nrendo/journal/v6/n8/fig_tab/nrendo.2010.93_F1.html * http://www.intechopen.com/books/computational-intelligence-in-electromyography-analysis-a-perspective-on-current-applications-and-future-challenges/sphincter-emg-for-diagnosing-multiple-system-atrophy-and-related-disorders * http://neurowiki2012.wikispaces.com/Presynaptic+Mechanisms+of+Synaptic+Plasticity * http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin * http://www.nature.com/nrn/journal/v5/n1/fig_tab/nrn1299_F4.html * http://www.springerimages.com/Images/LifeSciences/1-10.1007_s00359-004-0565-9-0 * http://journal.frontiersin.org/article/10.3389/fnhum.2013.00826/full * http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html * http://www.scholarpedia.org/article/Habenula * http://jn.physiology.org/content/107/10/2633